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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins DTX3L (from a repository: Wed Nov 16 14:16:07 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)36
The number (and %) of the onco-proteins9 (25.00 %)
The number (and %) of the tumor suppressors4 (11.11 %)
Total number of binary PPIs (saturation %)131 (20.79 %)
The number (and %) of affected PPIs36 (27.48 %)
The number of possible different fusions13
PPI diameter2
PPI radius1
The average degree of PPI6.000
Assortativity coefficient-0.3735
The network average Clustering coefficient0.718
The number (and %) of a zero Clustering coefficients0 (0.00 %)
The number (and %) of a zero Betweenness Centrality11 (30.56 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: DTX3L All fusions
Proteins found in more fusions JAK2 (see 3 fusions); UBE2R2 (see 1 fusions); JAK1 (see 1 fusions); UBE2D2 (see 2 fusions); UBE2H (see 4 fusions); RNF111 (see 1 fusions); PARP1 (see 1 fusions); UBE2E1 (see 2 fusions); UBE2E2 (see 1 fusions); RPA1 (see 1 fusions); DTX3L (see 2 fusions); STAT1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DTX3Lparental protein360.123844.552KH_1 (PF00013, IPR004088, SM00322): KH domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
2 DTX1interactor80.5246.067WWE (PF02825, IPR004170, SM00678): WWE domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger
PRIMA1 (PF16101): Proline-rich membrane anchor 1
3 ELAVL1oncoprotein120.30937.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
4 H2AFVinteractor21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
5 HGSinteractor40.6671.400FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
6 HIST1H2BJinteractor31.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
7 HIST1H4Ainteractor31.0000CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
8 IFNGR1interactor40.8330.667IFNGR1 (PF07140, IPR021126): Interferon gamma receptor (IFNGR1)
Interfer-bind (PF09294, IPR015373): Interferon-alpha/beta receptor, fibronectin type III
Tissue_fac (PF01108, IPR003961): Tissue factor
9 ITCHinteractor120.32729.733C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
10 JAK1oncoprotein41.0000FERM_M (PF00373, IPR019748): FERM central domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
11 JAK2oncoprotein50.6672.000FERM_M (PF00373, IPR019748): FERM central domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
12 NCAPGinteractor21.0000P16-Arc (PF04699, IPR006789): ARP2/3 complex 16 kDa subunit (p16-Arc)
Terminase_2 (PF03592, IPR005335): Terminase small subunit
UVR (PF02151, IPR001943): UvrB/uvrC motif
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Cnd3 (PF12719, IPR025977): Nuclear condensing complex subunits, C-term domain
HEAT_2 (PF13646): HEAT repeats
13 PARP1suppressor100.50017.067BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain
WGR (PF05406, IPR008893, SM00773): WGR domain
zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
14 PARP14interactor51.0000Macro (PF01661, IPR002589, SM00506): Macro domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
S-AdoMet_synt_N (PF00438, IPR022628): S-adenosylmethionine synthetase, N-terminal domain
WWE (PF02825, IPR004170, SM00678): WWE domain
Syntaxin_2 (PF14523): Syntaxin-like protein
15 PARP9interactor80.60710.067Macro (PF01661, IPR002589, SM00506): Macro domain
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
16 PHF7interactor31.0000zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
17 RNF111suppressor130.25840.733zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
RNF111_N (PF15303, IPR029306): E3 ubiquitin-protein ligase Arkadia N-terminus
18 RPA1suppressor80.8571.300Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
19 RPA2oncoprotein70.8571.300RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
20 RPA3interactor80.8571.300Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
21 SPG21interactor21.0000Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold
22 STAMinteractor40.6672.000GAT (PF03127, IPR004152): GAT domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
23 STAT1suppressor80.42911.333SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
24 TRIM9interactor31.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
DUF2203 (PF09969, IPR018699): Uncharacterized conserved protein (DUF2203)
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Fer4_4 (PF12800, IPR001450): 4Fe-4S binding domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
25 UBE2D1interactor60.8000.619UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
26 UBE2D2oncoprotein90.5369.519UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
27 UBE2D3interactor60.6001.786UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
28 UBE2D4interactor50.6671.333UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
29 UBE2E1protein found in more fusions60.6001.686UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
30 UBE2E2protein found in more fusions40.6670.500UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
31 UBE2E3interactor40.6670.286UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
32 UBE2Hprotein found in more fusions31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
Uteroglobin (PF01099, IPR016126, SM00096): Uteroglobin family
33 UBE2Iinteractor100.36120.567UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
34 UBE2Kinteractor50.8000.686UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
35 UBE2R2protein found in more fusions31.0000NOA36 (PF06524, IPR010531): NOA36 protein
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
36 UBE2Winteractor40.6670.500UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme

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