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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins DIDO1, BSPRY (from a repository: Tue Mar 14 04:59:00 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)35
The number (and %) of the onco-proteins12 (34.29 %)
The number (and %) of the tumor suppressors4 (11.43 %)
Total number of binary PPIs (saturation %)115 (19.33 %)
The number (and %) of affected PPIs33 (28.70 %)
The number of possible different fusions7
PPI diameter4
PPI radius2
The average degree of PPI5.714
Assortativity coefficient-0.2550
The network average Clustering coefficient0.491
The number (and %) of a zero Clustering coefficients7 (20.00 %)
The number (and %) of a zero Betweenness Centrality11 (31.43 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: DIDO1,BSPRY All fusions
: BE078256;
Proteins found in more fusions RPA1 (see 1 fusions); DVL3 (see 1 fusions); APP (see 4 fusions); SRPK2 (see 1 fusions); SRSF1 (see 1 fusions); WWP1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DIDO1parental protein320.129772.529PHD (PF00628, IPR019787, SM00249): PHD-finger
SlyX (PF04102, IPR007236): SlyX
SPOC (PF07744, IPR012921): SPOC domain
TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
2 BSPRYparental protein100SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
3 APPprotein found in more fusions80.38112.205APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 ARAFoncoprotein21.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
5 BMI1oncoprotein80.6195.000zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
6 CEP162interactor40.50066.000DivIC (PF04977, IPR007060): Septum formation initiator
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Methyltransf_14 (PF08484, IPR013691): C-methyltransferase C-terminal domain
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Phage_GP20 (PF06810, IPR009636): Phage minor structural protein GP20
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
DUF2553 (PF10830, IPR020140): Protein of unknown function (DUF2553)
DUF3073 (PF11273, IPR021426): Protein of unknown function (DUF3073)
PIP49_N (PF14875, IPR029244): N-term cysteine-rich ER, FAM69
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
FAM76 (PF16046, IPR032017): FAM76 protein
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
7 DVL3protein found in more fusions31.0000DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Dishevelled (PF02377, IPR003351): Dishevelled specific domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DIX (PF00778, IPR001158, SM00021): DIX domain
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
8 EEDsuppressor140.32143.067WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
9 FBXW7suppressor40.6671.000Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
10 GNL3interactor50.8001.067GN3L_Grn1 (PF08701, IPR014813): GNL3L/Grn1 putative GTPase
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
FAM176 (PF14851): FAM176 family
11 H2AFYinteractor50.7002.167DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Macro (PF01661, IPR002589, SM00506): Macro domain
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
12 H2AFY2interactor40.5003.000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Macro (PF01661, IPR002589, SM00506): Macro domain
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
13 HECW2interactor200C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
14 HIST3H3interactor50.8001.167Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
15 HNRNPKoncoprotein110.40032.481ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
16 KCNK4interactor100CcmD (PF04995, IPR007078): Heme exporter protein D (CcmD)
Ion_trans_2 (PF07885, IPR013099): Ion channel
17 KLHDC3interactor100Kelch_2 (PF07646, IPR011498): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
Kelch_6 (PF13964): Kelch motif
18 KRASoncoprotein80.42913.405Ras (PF00071, IPR001806, SM00173): Ras family
19 KRT7interactor100Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
20 PCDHA2interactor100Cadherin_2 (PF08266, IPR013164): Cadherin-like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cadherin_tail (PF15974, IPR031904): Cadherin C-terminal cytoplasmic tail, catenin-binding region
Cadherin_3 (PF16184): Cadherin-like
Cadherin_C_2 (PF16492, IPR032455): Cadherin cytoplasmic C-terminal
21 PCGF1interactor41.0000zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
22 RBM15oncoprotein70.4769.467RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SPOC (PF07744, IPR012921): SPOC domain
Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain
23 RPA1suppressor80.66736.752Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
24 RPA2oncoprotein90.50056.529RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
25 RPA3interactor80.66736.752Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
26 RPL18Ainteractor90.47219.481Ribosomal_L18A (PF01775, IPR023573): Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A
27 RRS1interactor60.6004.833GRP (PF07172, IPR010800): Glycine rich protein family
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
RRS1 (PF04939, IPR007023): Ribosome biogenesis regulatory protein (RRS1)
28 SIRT7interactor70.4297.833DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
29 SONinteractor60.6003.633Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
G-patch (PF01585, IPR000467, SM00443): G-patch domain
tRNA_synt_1c_R2 (PF04557, IPR007638): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
DND1_DSRM (PF14709): double strand RNA binding domain from DEAD END PROTEIN 1
GREB1 (PF15782, IPR028422): Gene regulated by oestrogen in breast cancer
RSRP (PF17069): Arginine/Serine-Rich protein 1
30 SRPK2oncoprotein100.5289.900DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
31 SRSF1protein found in more fusions70.7332.067Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
32 U2AF1oncoprotein60.6004.667DUF1509 (PF07420, IPR010883): Protein of unknown function (DUF1509)
KMP11 (PF03037, IPR004132): Kinetoplastid membrane protein 11
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
33 WWOXsuppressor30.6671.000adh_short (PF00106, IPR002198): short chain dehydrogenase
WW (PF00397, IPR001202, SM00456): WW domain
34 WWP1oncoprotein31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
35 WWP2interactor200WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ARAFoncoproteinPkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
BE078256
2 BMI1oncoproteinzf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
BE078256
3 BSPRYparental proteinSPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
BE078256
4 CEP162interactorDivIC (PF04977, IPR007060): Septum formation initiator
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Methyltransf_14 (PF08484, IPR013691): C-methyltransferase C-terminal domain
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Phage_GP20 (PF06810, IPR009636): Phage minor structural protein GP20
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
DUF2553 (PF10830, IPR020140): Protein of unknown function (DUF2553)
DUF3073 (PF11273, IPR021426): Protein of unknown function (DUF3073)
PIP49_N (PF14875, IPR029244): N-term cysteine-rich ER, FAM69
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
FAM76 (PF16046, IPR032017): FAM76 protein
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
BE078256
5 DIDO1parental proteinPHD (PF00628, IPR019787, SM00249): PHD-finger
SlyX (PF04102, IPR007236): SlyX
SPOC (PF07744, IPR012921): SPOC domain
TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
BE078256
6 DVL3interactorDEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Dishevelled (PF02377, IPR003351): Dishevelled specific domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DIX (PF00778, IPR001158, SM00021): DIX domain
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
BE078256
7 EEDsuppressorWD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
BE078256
8 FBXW7suppressorMem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
BE078256
9 GNL3interactorGN3L_Grn1 (PF08701, IPR014813): GNL3L/Grn1 putative GTPase
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
FAM176 (PF14851): FAM176 family
BE078256
10 HECW2interactorC2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
BE078256
11 HIST3H3interactorHistone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4BE078256
12 HNRNPKoncoproteinROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
BE078256
13 KCNK4interactorCcmD (PF04995, IPR007078): Heme exporter protein D (CcmD)
Ion_trans_2 (PF07885, IPR013099): Ion channel
BE078256
14 KRASoncoproteinRas (PF00071, IPR001806, SM00173): Ras familyBE078256
15 KRT7interactorFilament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
BE078256
16 PCDHA2interactorCadherin_2 (PF08266, IPR013164): Cadherin-like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cadherin_tail (PF15974, IPR031904): Cadherin C-terminal cytoplasmic tail, catenin-binding region
Cadherin_3 (PF16184): Cadherin-like
Cadherin_C_2 (PF16492, IPR032455): Cadherin cytoplasmic C-terminal
BE078256
17 PCGF1interactorzf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
BE078256
18 RBM15oncoproteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SPOC (PF07744, IPR012921): SPOC domain
Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain
BE078256
19 RPA1suppressorRep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
BE078256
20 RPA2oncoproteinRPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
BE078256
21 RPA3interactorRep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3BE078256
22 RPL18AinteractorRibosomal_L18A (PF01775, IPR023573): Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18ABE078256
23 RRS1interactorGRP (PF07172, IPR010800): Glycine rich protein family
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
RRS1 (PF04939, IPR007023): Ribosome biogenesis regulatory protein (RRS1)
BE078256
24 SIRT7interactorDUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
BE078256
25 SONinteractorAsp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
G-patch (PF01585, IPR000467, SM00443): G-patch domain
tRNA_synt_1c_R2 (PF04557, IPR007638): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
DND1_DSRM (PF14709): double strand RNA binding domain from DEAD END PROTEIN 1
GREB1 (PF15782, IPR028422): Gene regulated by oestrogen in breast cancer
RSRP (PF17069): Arginine/Serine-Rich protein 1
BE078256
26 SRPK2oncoproteinDUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
BE078256
27 SRSF1interactorCorona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
BE078256
28 U2AF1oncoproteinDUF1509 (PF07420, IPR010883): Protein of unknown function (DUF1509)
KMP11 (PF03037, IPR004132): Kinetoplastid membrane protein 11
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
BE078256
29 WWOXsuppressoradh_short (PF00106, IPR002198): short chain dehydrogenase
WW (PF00397, IPR001202, SM00456): WW domain
BE078256
30 WWP1oncoproteinC2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
BE078256
31 WWP2interactorWW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
BE078256

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