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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)63
The number (and %) of the onco-proteins11 (17.46 %)
The number (and %) of the tumor suppressors6 (9.52 %)
Total number of binary PPIs (saturation %)337 (17.26 %)
The number (and %) of affected PPIs63 (18.69 %)
The number of possible different fusions12
PPI diameter2
PPI radius1
The average degree of PPI10.032
Assortativity coefficient-0.2404
The network average Clustering coefficient0.564
The number (and %) of a zero Clustering coefficients4 (6.35 %)
The number (and %) of a zero Betweenness Centrality15 (23.81 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: DHX8 All fusions
: AA347223;
Proteins found in more fusions DHX8/SRPK2 (see 1 fusions); AHCYL1 (see 3 fusions); BAG3 (see 4 fusions); PRPF19 (see 2 fusions); THOC1 (see 3 fusions); CUL3 (see 1 fusions); SRPK2 (see 1 fusions); DHX8 (see 1 fusions); PRPF40A (see 2 fusions); SMAD3 (see 3 fusions); SNW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DHX8parental protein630.1342180.633DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
2 AHCYL1suppressor60.6001.087AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515)
Big_3_5 (PF16640, IPR032109): Bacterial Ig-like domain (group 3)
3 AHCYL2interactor100AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
4 AQRinteractor110.6186.181AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
Mif2_N (PF15624, IPR028929): Kinetochore CENP-C fungal homologue, Mif2, N-terminal
Aquarius_N (PF16399, IPR032174): Intron-binding protein aquarius N-terminus
5 BAG3oncoprotein50.6671.667BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
6 C11orf57interactor21.0000Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
RAMP4 (PF06624, IPR010580): Ribosome associated membrane protein RAMP4
SRP72 (PF08492, IPR013699): SRP72 RNA-binding domain
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
FAM60A (PF15396, IPR026065): Protein Family FAM60A
RRP14 (PF15459, IPR029188): 60S ribosome biogenesis protein Rrp14
NKAP (PF15692): NF-kappa-B-activating protein
7 CACTINinteractor21.0000TT_ORF2 (PF02957, IPR004118): TT viral ORF2
CactinC_cactus (PF09732, IPR019134, SM01050): Cactus-binding C-terminus of cactin protein
Cactin_mid (PF10312, IPR018816): Conserved mid region of cactin
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
DUF2992 (PF11208, IPR016787): Protein of unknown function (DUF2992)
8 CAND1interactor270.326120.036Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
9 CCDC12interactor41.0000cwf18 (PF08315, IPR013169): cwf18 pre-mRNA splicing factor
10 CDC40interactor100.6008.575AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
11 CDC5Linteractor160.46732.106OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
12 CHERPinteractor120.47017.050CTD_bind (PF04818, IPR006903): RNA polymerase II-binding domain.
G-patch (PF01585, IPR000467, SM00443): G-patch domain
HpaP (PF09483, IPR013390): Type III secretion protein (HpaP)
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
TP2 (PF01254, IPR000678): Nuclear transition protein 2
Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain
Surp (PF01805, IPR000061, SM00648): Surp module
13 CRNKL1interactor120.53013.541NRDE-2 (PF08424, IPR013633): NRDE-2, necessary for RNA interference
HAT (PF02184, IPR003107, SM00386): HAT (Half-A-TPR) repeat
Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
Suf (PF05843, IPR008847): Suppressor of forked protein (Suf)
U3_assoc_6 (PF08640, IPR013949): U3 small nucleolar RNA-associated protein 6
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
14 CUL3protein found in more fusions260.33399.198Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
15 ENO1oncoprotein70.8100.533Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
16 FTSJ3interactor100.6225.096DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
FtsJ (PF01728, IPR002877): FtsJ-like methyltransferase
M16C_assoc (PF08367, IPR013578): Peptidase M16C associated
Orthopox_F8 (PF05886, IPR008726): Orthopoxvirus F8 protein
Spb1_C (PF07780, IPR012920): Spb1 C-terminal domain
DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381)
RRP14 (PF15459, IPR029188): 60S ribosome biogenesis protein Rrp14
17 IFI16suppressor100.24416.506HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
18 ISY1interactor120.49110.585Isy1 (PF06246, IPR009360): Isy1-like splicing family
19 JMJD6interactor80.3938.040AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
20 KANSL1interactor30.6670.667PEHE (PF15275, IPR029332): PEHE domain
21 LIN28Ainteractor60.6001.559CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
zf-CCHC (PF00098, IPR001878): Zinc knuckle
zf-CCHC_6 (PF15288): Zinc knuckle
22 MFAP1interactor70.4764.569MFAP1 (PF06991, IPR009730): Microfibril-associated/Pre-mRNA processing
DUF3464 (PF11947, IPR021855): Protein of unknown function (DUF3464)
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
23 MORC2interactor21.0000Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
zf-CW (PF07496, IPR011124): CW-type Zinc Finger
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
24 MOV10interactor130.39721.517AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
25 MYPNinteractor100Senescence_reg (PF04520, IPR007608): Senescence regulator
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
26 NKAPinteractor70.6003.786SynMuv_product (PF06047, IPR009269): Ras-induced vulval development antagonist
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
NKAP (PF15692): NF-kappa-B-activating protein
27 NOP2interactor170.54423.385BSP_II (PF05432, IPR008412): Bone sialoprotein II (BSP-II)
Methyltr_RsmB-F (PF01189, IPR001678): 16S rRNA methyltransferase RsmB/F
P120R (PF08062, IPR012586): P120R (NUC006) repeat
Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
DUF2477 (PF10631, IPR018904): Protein of unknown function (DUF2477)
FAM176 (PF14851): FAM176 family
Methyltr_RsmF_N (PF17125, IPR031341): N-terminal domain of 16S rRNA methyltransferase RsmF
28 NOTCH1suppressor80.4768.500Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
29 NTRK1oncoprotein310.253196.995I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
30 NUDCD1interactor21.0000CS (PF04969, IPR007052): CS domain
31 NXF1interactor180.31649.556NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
32 OBSL1interactor230.25578.670BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
33 PHF5Ainteractor100PHF5 (PF03660, IPR005345): PHF5-like protein
34 POLR1Binteractor31.0000RNA_pol_Rpa2_4 (PF06883, IPR009674): RNA polymerase I, Rpa2 specific domain
RNA_pol_Rpb2_1 (PF04563, IPR007644): RNA polymerase beta subunit
RNA_pol_Rpb2_3 (PF04565, IPR007645): RNA polymerase Rpb2, domain 3
RNA_pol_Rpb2_6 (PF00562, IPR007120): RNA polymerase Rpb2, domain 6
RNA_pol_Rpb2_7 (PF04560, IPR007641): RNA polymerase Rpb2, domain 7
35 PRPF19protein found in more fusions160.50523.456Prp19 (PF08606, IPR013915): Prp19/Pso4-like
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
36 PRPF38Ainteractor90.42910.000PRP38 (PF03371, IPR005037): PRP38 family
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
37 PRPF40Aprotein found in more fusions140.33330.853FF (PF01846, IPR002713, SM00441): FF domain
MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain
Transformer (PF06495, IPR010519): Fruit fly transformer protein
WW (PF00397, IPR001202, SM00456): WW domain
YqzE (PF14038, IPR025622): YqzE-like protein
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus
SOBP (PF15279, IPR026092): Sine oculis-binding protein
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
38 RBM28interactor100.5336.977CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27
DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Nop25 (PF09805, IPR019186): Nucleolar protein 12 (25kDa)
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
Phage_TAC_13 (PF16459, IPR024410): Phage tail assembly chaperone, TAC
39 RBM7interactor40.8330.250RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
40 RBMX2interactor31.0000DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
41 RPL10Ainteractor120.59115.136Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
42 RPL15interactor120.6368.603Ribosomal_L15e (PF00827, IPR000439): Ribosomal L15
43 RPL26oncoprotein50.9000.143TP2 (PF01254, IPR000678): Nuclear transition protein 2
Ribosomal_L26 (PF16906, IPR005756): Ribosomal proteins L26 eukaryotic, L24P archaeal
44 RPL26L1interactor61.0000Ribosomal_L26 (PF16906, IPR005756): Ribosomal proteins L26 eukaryotic, L24P archaeal
45 RPL32interactor51.0000Ribosomal_L32e (PF01655, IPR001515): Ribosomal protein L32
46 RPL36ALinteractor21.0000NOB1_Zn_bind (PF08772, IPR014881): Nin one binding (NOB1) Zn-ribbon like
Ribosomal_L44 (PF00935, IPR000552): Ribosomal protein L44
47 RPL5suppressor150.61513.159Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region
Ribosomal_L5e (PF17144): Ribosomal large subunit proteins 60S L5, and 50S L18
48 RSL1D1interactor80.6791.603Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
49 SAP30BPinteractor60.4674.210Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HCNGP (PF07818, IPR012479): HCNGP-like protein
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
50 SHMT2interactor100.4678.722SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
51 SIRT7interactor190.28150.060DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
52 SMAD2suppressor50.8330.667MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
53 SMAD3oncoprotein70.4677.000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
54 SNIP1interactor140.35241.446FHA (PF00498, IPR000253, SM00240): FHA domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
FAM176 (PF14851): FAM176 family
55 SNW1protein found in more fusions220.40569.712SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
56 SRPK1interactor120.45516.851FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
57 SRPK2oncoprotein150.42932.713DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
58 TAF9interactor100TFIID-31kDa (PF02291, IPR003162): Transcription initiation factor IID, 31kD subunit
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
59 THOC1protein found in more fusions40.6670.500Death (PF00531, IPR000488, SM00005): Death domain
efThoc1 (PF11957, IPR021861): THO complex subunit 1 transcription elongation factor
60 USP12suppressor21.0000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
61 XAB2interactor120.5618.799NRDE-2 (PF08424, IPR013633): NRDE-2, necessary for RNA interference
HAT (PF02184, IPR003107, SM00386): HAT (Half-A-TPR) repeat
Suf (PF05843, IPR008847): Suppressor of forked protein (Suf)
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
62 XRN2interactor130.55112.306XRN_N (PF03159, IPR004859): XRN 5'-3' exonuclease N-terminus
63 ZCCHC10interactor40.6670.800Macoilin (PF09726, IPR019130): Transmembrane protein
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
zf-CCHC_3 (PF13917): Zinc knuckle

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