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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins DHPS (from a repository: Sun Dec 4 12:03:49 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)38
The number (and %) of the onco-proteins9 (23.68 %)
The number (and %) of the tumor suppressors1 (2.63 %)
Total number of binary PPIs (saturation %)79 (11.24 %)
The number (and %) of affected PPIs38 (48.10 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI3.632
Assortativity coefficient-0.5091
The network average Clustering coefficient0.451
The number (and %) of a zero Clustering coefficients14 (36.84 %)
The number (and %) of a zero Betweenness Centrality24 (63.16 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: DHPS All fusions
: CV364179; BQ436553;
Proteins found in more fusions ARIH1 (see 4 fusions); HSF1 (see 3 fusions); CTPS2 (see 1 fusions); DHPS (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DHPSparental protein380.0481210.833DS (PF01916, IPR002773): Deoxyhypusine synthase
2 AAMPinteractor41.0000PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
3 ACTR2interactor60.4007.667Actin (PF00022, IPR004000, SM00268): Actin
4 ANKMY2interactor60.4677.667zf-MYND (PF01753, IPR002893): MYND finger
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
zf-C6H2 (PF15801, IPR031615): zf-MYND-like zinc finger, mRNA-binding
5 ANP32Boncoprotein31.0000FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
SDA1 (PF05285, IPR007949): SDA1
LRR_9 (PF14580): Leucine-rich repeat
6 ARF6oncoprotein100Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
7 ARIH1protein found in more fusions31.0000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
Med14 (PF08638, IPR013947): Mediator complex subunit MED14
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
8 ARPC1Binteractor50.5004.167WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
9 BRCA1suppressor31.0000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
10 BYSLinteractor100Bystin (PF05291, IPR007955): Bystin
MEA1 (PF06910, IPR009685): Male enhanced antigen 1 (MEA1)
11 CDK17interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
12 CTPS2protein found in more fusions41.0000CTP_synth_N (PF06418, IPR017456): CTP synthase N-terminus
GATase (PF00117, IPR017926): Glutamine amidotransferase class-I
13 DPP8interactor21.0000DPPIV_N (PF00930, IPR002469): Dipeptidyl peptidase IV (DPP IV) N-terminal region
Peptidase_S15 (PF02129, IPR000383): X-Pro dipeptidyl-peptidase (S15 family)
Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
14 EIF5Ainteractor21.0000EFP_N (PF08207, IPR013185): Elongation factor P (EF-P) KOW-like domain
eIF-5a (PF01287, IPR020189): Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold
15 EIF5A2interactor30.6671.000EFP_N (PF08207, IPR013185): Elongation factor P (EF-P) KOW-like domain
eIF-5a (PF01287, IPR020189): Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold
16 HNRNPFinteractor40.5003.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14
zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
17 HSF1protein found in more fusions90.46412.000DUF247 (PF03140, IPR004158): Plant protein of unknown function
Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor
HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
18 KCNAB3interactor100Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
19 MAPK3oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
20 NIF3L1interactor60.4005.667NIF3 (PF01784, IPR002678): NIF3 (NGG1p interacting factor 3)
21 NUDT18interactor100NUDIX (PF00293, IPR000086): NUDIX domain
22 PLIN3interactor70.6673.333Perilipin (PF03036, IPR004279): Perilipin family
23 PPP2R5Dinteractor30.6670.667B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
24 PTPRHoncoprotein100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
SusE (PF14292, IPR025970): SusE outer membrane protein
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
25 RAB27Boncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
26 RELoncoprotein30.6671.000RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
27 RPA3interactor50.5003.000Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
28 RPL9interactor21.0000Ribosomal_L6 (PF00347, IPR020040): Ribosomal protein L6
29 SAE1interactor100ThiF (PF00899, IPR000594): ThiF family
30 SPHK1interactor100DAGK_cat (PF00781, IPR001206, SM00046): Diacylglycerol kinase catalytic domain
31 SRP9interactor60.5336.500SRP9-21 (PF05486): Signal recognition particle 9 kDa protein (SRP9)
32 SRRM2interactor21.0000cwf21 (PF08312, IPR013170, SM01115): cwf21 domain
DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Pap_E4 (PF02711, IPR003861): E4 protein
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
33 SURF2interactor40.6671.500SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
34 SUSD4interactor100Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
35 TIRAPinteractor200TIR_2 (PF13676, IPR000157): TIR domain
36 VASH1interactor100Vasohibin (PF14822, IPR028131): Vasohibin
37 WDYHV1interactor100Nt_Gln_amidase (PF09764, IPR023128): N-terminal glutamine amidase
38 ZNF138interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain

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