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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FAM105A, DHCR24 (from a repository: Mon Mar 20 11:53:10 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)22
The number (and %) of the onco-proteins5 (22.73 %)
The number (and %) of the tumor suppressors1 (4.55 %)
Total number of binary PPIs (saturation %)44 (19.05 %)
The number (and %) of affected PPIs20 (45.45 %)
The number of possible different fusions4
PPI diameter4
PPI radius2
The average degree of PPI2.909
Assortativity coefficient-0.4995
The network average Clustering coefficient0.442
The number (and %) of a zero Clustering coefficients9 (40.91 %)
The number (and %) of a zero Betweenness Centrality14 (63.64 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: DHCR24,FAM105A All fusions
: DA046822;
Proteins found in more fusions EGFR (see 2 fusions); IKBKB (see 2 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DHCR24parental protein190.064360.000FAD_binding_4 (PF01565, IPR006094): FAD binding domain
2 FAM105Aparental protein100Peptidase_C101 (PF16218, IPR023235): Peptidase family C101
3 ACTA2interactor40.6674.000Actin (PF00022, IPR004000, SM00268): Actin
4 ATP12Ainteractor100Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
FA_desaturase (PF00487, IPR005804): Fatty acid desaturase
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
HAD (PF12710): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
5 CISD3interactor200zf-CDGSH (PF09360, IPR018967, SM00704): Iron-binding zinc finger CDGSH type
MOLO1 (PF17175): Modulator of levamisole receptor-1
6 CKAP5interactor200HEAT (PF02985, IPR000357): HEAT repeat
PAS_6 (PF08348, IPR013559): YheO-like PAS domain
UME (PF08064, IPR012993, SM00802): UME (NUC010) domain
CLASP_N (PF12348, IPR024395): CLASP N terminal
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
7 COQ9interactor31.0000COQ9 (PF08511, IPR013718): COQ9
8 EGFRoncoprotein50.6674.000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
9 ELAVL1oncoprotein3040.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
10 ERAP1interactor100Peptidase_M1 (PF01433, IPR014782): Peptidase family M1
ERAP1_C (PF11838, IPR024571): ERAP1-like C-terminal domain
11 FUNDC2interactor31.0000FUN14 (PF04930, IPR007014): FUN14 family
12 GBAinteractor21.0000Glyco_hydro_30 (PF02055, IPR001139): Glycosyl hydrolase family 30 TIM-barrel domain
Glyco_hydro_30C (PF17189): Glycosyl hydrolase family 30 beta sandwich domain
13 HRASoncoprotein21.0000Ras (PF00071, IPR001806, SM00173): Ras family
14 IKBKBprotein found in more fusions31.0000FliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
15 LUZP1interactor100Trimer_CC (PF08954, IPR015049, SM01167): Trimerisation motif
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
TMA7 (PF09072, IPR015157): Translation machinery associated TMA7
HD_assoc (PF13286, IPR026875): Phosphohydrolase-associated domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
16 NANOGinteractor200Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
17 NDUFA4interactor40.6671.000B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
18 POU5F1oncoprotein31.0000Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
19 REEP5interactor100Phage_holin_3_6 (PF07332, IPR009937): Putative Actinobacterial Holin-X, holin superfamily III
TB2_DP1_HVA22 (PF03134, IPR004345): TB2/DP1, HVA22 family
20 SNCAinteractor40.6671.000Synuclein (PF01387, IPR001058): Synuclein
21 TP53suppressor70.33381.000DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
22 UBL4Ainteractor30.6671.000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ACTA2interactorActin (PF00022, IPR004000, SM00268): ActinDA046822
2 ATP12AinteractorCation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
FA_desaturase (PF00487, IPR005804): Fatty acid desaturase
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
HAD (PF12710): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
DA046822
3 CISD3interactorzf-CDGSH (PF09360, IPR018967, SM00704): Iron-binding zinc finger CDGSH type
MOLO1 (PF17175): Modulator of levamisole receptor-1
DA046822
4 CKAP5interactorHEAT (PF02985, IPR000357): HEAT repeat
PAS_6 (PF08348, IPR013559): YheO-like PAS domain
UME (PF08064, IPR012993, SM00802): UME (NUC010) domain
CLASP_N (PF12348, IPR024395): CLASP N terminal
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
DA046822
5 COQ9interactorCOQ9 (PF08511, IPR013718): COQ9DA046822
6 DHCR24parental proteinFAD_binding_4 (PF01565, IPR006094): FAD binding domainDA046822
7 EGFRoncoproteinFurin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
DA046822
8 ERAP1interactorPeptidase_M1 (PF01433, IPR014782): Peptidase family M1
ERAP1_C (PF11838, IPR024571): ERAP1-like C-terminal domain
DA046822
9 FAM105Aparental proteinPeptidase_C101 (PF16218, IPR023235): Peptidase family C101DA046822
10 FUNDC2interactorFUN14 (PF04930, IPR007014): FUN14 familyDA046822
11 GBAinteractorGlyco_hydro_30 (PF02055, IPR001139): Glycosyl hydrolase family 30 TIM-barrel domain
Glyco_hydro_30C (PF17189): Glycosyl hydrolase family 30 beta sandwich domain
DA046822
12 HRASoncoproteinRas (PF00071, IPR001806, SM00173): Ras familyDA046822
13 IKBKBinteractorFliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
DA046822
14 LUZP1interactorTrimer_CC (PF08954, IPR015049, SM01167): Trimerisation motif
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
TMA7 (PF09072, IPR015157): Translation machinery associated TMA7
HD_assoc (PF13286, IPR026875): Phosphohydrolase-associated domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
DA046822
15 NANOGinteractorHomeobox (PF00046, IPR001356, SM00389): Homeobox domainDA046822
16 NDUFA4interactorB12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunitDA046822
17 POU5F1oncoproteinPou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
DA046822
18 REEP5interactorPhage_holin_3_6 (PF07332, IPR009937): Putative Actinobacterial Holin-X, holin superfamily III
TB2_DP1_HVA22 (PF03134, IPR004345): TB2/DP1, HVA22 family
DA046822
19 SNCAinteractorSynuclein (PF01387, IPR001058): SynucleinDA046822
20 TP53suppressorDEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
DA046822

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