Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins DDX5 (from a repository: Sun Dec 4 13:56:46 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 203 The number (and %) of the onco-proteins 59 (29.06 %) The number (and %) of the tumor suppressors 32 (15.76 %) Total number of binary PPIs (saturation %) 3240 (15.80 %) The number (and %) of affected PPIs 203 (6.27 %) The number of possible different fusions 47 PPI diameter 2 PPI radius 1 The average degree of PPI 30.966 Assortativity coefficient -0.1513 The network average Clustering coefficient 0.473 The number (and %) of a zero Clustering coefficients 3 (1.48 %) The number (and %) of a zero Betweenness Centrality 9 (4.43 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: DDX5	All fusions : CA314781;
Proteins found in more fusions	PRPF19 (see 2 fusions); U2AF2 (see 2 fusions); CUL1 (see 3 fusions); VHL (see 1 fusions); SYN1 (see 1 fusions); PRKDC (see 3 fusions); PIAS1 (see 2 fusions); EP300 (see 1 fusions); DDX5 (see 1 fusions); DAPK1 (see 1 fusions); RPA1 (see 1 fusions); SUZ12 (see 2 fusions); SNW1 (see 1 fusions); CUL4A (see 4 fusions); COPS5/HNRNPH3 (see 3 fusions); DDX5/PIK3CA (see 1 fusions); YY1 (see 2 fusions); RBFOX2 (see 2 fusions); MYOD1 (see 1 fusions); POLR2A (see 2 fusions); CHD3 (see 1 fusions); SHC1 (see 1 fusions); DDX17 (see 3 fusions); EZH2 (see 1 fusions); CDC37 (see 2 fusions); TNNT1 (see 1 fusions); RBMX (see 3 fusions); STAU1 (see 2 fusions); HNRNPH3 (see 1 fusions); CUL7 (see 2 fusions); CUL3 (see 1 fusions); SKI (see 1 fusions); COPS5 (see 1 fusions); PRPF40A (see 2 fusions); TP53 (see 3 fusions); ILK (see 1 fusions); MCM7 (see 2 fusions); LUC7L2 (see 2 fusions); FRS3 (see 1 fusions); SP1 (see 1 fusions); CREBBP (see 6 fusions); KHDRBS1 (see 1 fusions); MCM2 (see 1 fusions); SRSF1 (see 1 fusions); SMAD3 (see 3 fusions); CDK9 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	DDX5	parental protein	203	0.145	13444.265	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase P68HR (PF08061, IPR012587): P68HR (NUC004) repeat ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
2	ABL1	oncoprotein	16	0.457	19.756	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
3	AIRE	interactor	13	0.455	5.974	PHD (PF00628, IPR019787, SM00249): PHD-finger SAND (PF01342, IPR000770, SM00258): SAND domain HSR (PF03172, IPR004865): HSR domain; Sp100 domain zf-PHD-like (PF15446): PHD/FYVE-zinc-finger like domain
4	AKAP8	interactor	18	0.458	11.306	AKAP95 (PF04988, IPR007071): A-kinase anchoring protein 95 (AKAP95) Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
5	AKT1	oncoprotein	22	0.286	66.882	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
6	ARAF	oncoprotein	7	0.476	2.645	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
7	ARRB2	interactor	30	0.409	61.084	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
8	ATXN2	interactor	15	0.543	9.211	LsmAD (PF06741, IPR009604): LsmAD domain PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446) Spt20 (PF12090, IPR021950): Spt20 family SM-ATX (PF14438, IPR025852): Ataxin 2 SM domain
9	ATXN2L	interactor	11	0.618	4.046	LsmAD (PF06741, IPR009604): LsmAD domain PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region SM-ATX (PF14438, IPR025852): Ataxin 2 SM domain
10	AURKA	oncoprotein	25	0.366	42.680	Pkinase (PF00069, IPR000719): Protein kinase domain MTBP_C (PF14920, IPR029418): MDM2-binding
11	AURKB	interactor	22	0.400	33.350	Pkinase (PF00069, IPR000719): Protein kinase domain
12	C14orf166	interactor	28	0.593	31.682	RLL (PF10036, IPR019265): Putative carnitine deficiency-associated protein
13	CALM1	interactor	20	0.289	53.020	EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
14	CAND1	interactor	76	0.381	338.281	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
15	CCDC8	interactor	41	0.397	85.536	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA
16	CD4	suppressor	6	0.700	1.036	ATP1G1_PLM_MAT8 (PF02038, IPR000272): ATP1G1/PLM/MAT8 family C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain CD4-extracel (PF09191, IPR015274): CD4, extracellular ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Tcell_CD4_C (PF12104, IPR021963): T cell CD4 receptor C terminal region
17	CD81	interactor	21	0.500	24.803	Tetraspannin (PF00335, IPR018499): Tetraspanin family
18	CDC37	protein found in more fusions	18	0.272	33.857	CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
19	CDC5L	interactor	69	0.392	335.922	OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
20	CDK2	suppressor	51	0.402	153.290	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
21	CDK9	protein found in more fusions	21	0.500	25.781	Pkinase (PF00069, IPR000719): Protein kinase domain
22	CENPA	interactor	12	0.509	4.776	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
23	CEP250	interactor	22	0.403	46.364	ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1 DivIC (PF04977, IPR007060): Septum formation initiator DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) EHN (PF06441, IPR010497): Epoxide hydrolase N terminus ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family IncA (PF04156, IPR007285): IncA protein Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain SlyX (PF04102, IPR007236): SlyX Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal TSC22 (PF01166, IPR000580): TSC-22/dip/bun family CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Endonuc_Holl (PF10107, IPR019287): Endonuclease related to archaeal Holliday junction resolvase DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570) DGF-1_C (PF11040, IPR021053): Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
24	CHD3	oncoprotein	18	0.324	40.315	CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086) DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087) DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) PHD (PF00628, IPR019787, SM00249): PHD-finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956) FAM176 (PF14851): FAM176 family
25	COPS5	protein found in more fusions	77	0.326	510.841	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
26	COPS6	interactor	30	0.539	38.237	DUF320 (PF03777, IPR005528): Small secreted domain (DUF320) JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
27	CPSF6	interactor	23	0.427	27.122	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term PRIMA1 (PF16101): Proline-rich membrane anchor 1
28	CREBBP	suppressor	27	0.400	68.793	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain MAS20 (PF02064, IPR002056): MAS20 protein import receptor TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
29	CRK	oncoprotein	12	0.333	21.831	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
30	CTNNB1	oncoprotein	38	0.339	121.251	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat
31	CUL1	suppressor	69	0.399	318.434	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
32	CUL2	suppressor	42	0.540	52.431	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
33	CUL3	protein found in more fusions	98	0.290	955.143	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
34	CUL4A	protein found in more fusions	29	0.532	32.043	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
35	CUL4B	oncoprotein	39	0.517	53.847	Cullin (PF00888, IPR001373, SM00182): Cullin family EBP50_C (PF09007, IPR015098): EBP50, C-terminal Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain MDFI (PF15316, IPR026134): MyoD family inhibitor
36	CUL5	suppressor	44	0.500	95.714	Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
37	CUL7	protein found in more fusions	60	0.392	164.753	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
38	DAPK1	suppressor	7	0.667	0.910	ABC_tran (PF00005, IPR003439): ABC transporter Death (PF00531, IPR000488, SM00005): Death domain Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) AAA_23 (PF13476): AAA domain Ank_5 (PF13857): Ankyrin repeats (many copies) COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
39	DBNL	interactor	6	0.600	3.733	RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein SH3_9 (PF14604, IPR001452): Variant SH3 domain
40	DCUN1D1	interactor	29	0.638	23.292	Cullin_binding (PF03556, IPR005176): Cullin binding UBA_4 (PF14555): UBA-like domain
41	DDX17	protein found in more fusions	79	0.264	752.801	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Ferritin (PF00210, IPR008331): Ferritin-like domain GRP (PF07172, IPR010800): Glycine rich protein family Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
42	DDX18	interactor	22	0.537	11.918	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3 Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF4217 (PF13959, IPR025313, SM01178): Domain of unknown function (DUF4217)
43	DGCR8	interactor	12	0.500	13.796	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif WW (PF00397, IPR001202, SM00456): WW domain
44	DHX15	interactor	67	0.393	255.920	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain AAA_29 (PF13555): P-loop containing region of AAA domain
45	DHX36	interactor	15	0.476	9.380	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
46	DHX38	interactor	10	0.644	2.824	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87 Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956)
47	DHX9	oncoprotein	79	0.327	508.015	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold T2SSE (PF00437, IPR001482): Type II/IV secretion system protein HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
48	DNAJC2	interactor	3	0.667	0.049	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain Mnd1 (PF03962, IPR005647): Mnd1 family Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain S1FA (PF04689, IPR006779): DNA binding protein S1FA DUF2058 (PF09831, IPR018636): Uncharacterized protein conserved in bacteria (DUF2058) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain GHBP (PF12772, IPR025871): Growth hormone receptor binding RAC_head (PF16717, IPR032003): Ribosome-associated complex head domain
49	DROSHA	interactor	10	0.467	5.698	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Ribonuclease_3 (PF00636, IPR000999, SM00535): Ribonuclease III domain Ribonucleas_3_3 (PF14622, IPR000999): Ribonuclease-III-like DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
50	EDC4	interactor	13	0.423	8.647	DUF445 (PF04286, IPR007383): Protein of unknown function (DUF445) SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein DUF2756 (PF10956, IPR020158): Protein of unknown function (DUF2756) DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446) Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
51	EED	suppressor	56	0.370	193.366	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
52	EEF2	interactor	38	0.401	102.573	EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
53	EIF2A	interactor	6	0.400	3.254	Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
54	EIF4A3	interactor	57	0.471	150.141	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
55	ELAC2	oncoprotein	8	0.643	4.617	Synthase_beta (PF11421, IPR020971): ATP synthase F1 beta subunit Lactamase_B_2 (PF12706, IPR001279): Beta-lactamase superfamily domain Lactamase_B_4 (PF13691, IPR027794): tRNase Z endonuclease
56	EP300	oncoprotein	31	0.386	87.027	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
57	EPRS	interactor	27	0.305	44.389	GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain ProRS-C_1 (PF09180, IPR016061, SM00946): Prolyl-tRNA synthetase, C-terminal tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C (PF03950, IPR020059): tRNA synthetases class I (E and Q), anti-codon binding domain tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T) WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
58	ERG	oncoprotein	17	0.456	27.167	Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
59	ERO1A	interactor	6	0.533	4.463	ERO1 (PF04137, IPR007266): Endoplasmic Reticulum Oxidoreductin 1 (ERO1)
60	ESR1	suppressor	71	0.269	580.814	Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
61	EZH2	suppressor	34	0.324	97.795	CDC45 (PF02724, IPR003874): CDC45-like protein TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain SET (PF00856, IPR001214, SM00317): SET domain EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2 Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
62	FBL	interactor	44	0.375	116.579	Fibrillarin (PF01269, IPR000692): Fibrillarin
63	FBXO46	interactor	5	1.000	0	BTK (PF00779, IPR001562, SM00107): BTK motif CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal CHORD (PF04968, IPR007051): CHORD DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) F-box-like (PF12937, IPR001810): F-box-like
64	FBXO6	interactor	39	0.340	146.522	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like
65	FBXW4	oncoprotein	7	0.667	1.537	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat F-box-like (PF12937, IPR001810): F-box-like F-box_4 (PF15966, IPR001810): F-box
66	FKBP10	interactor	1	0	0	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_5 (PF13202, IPR002048): EF hand
67	FN1	oncoprotein	55	0.343	175.553	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
68	FRS3	suppressor	2	0	0	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
69	FUS	suppressor	63	0.354	348.712	Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Limkain-b1 (PF11608, IPR024582): Limkain b1 FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
70	GMPS	oncoprotein	11	0.364	9.195	GATase (PF00117, IPR017926): Glutamine amidotransferase class-I GMP_synt_C (PF00958, IPR001674): GMP synthase C terminal domain NAD_synthase (PF02540, IPR022310): NAD synthase
71	GOLIM4	interactor	3	1.000	0	Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) DDRGK (PF09756, IPR019153, SM01128): DDRGK domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region DUF3410 (PF11890, IPR024531): Domain of unknown function (DUF3410) DUF3584 (PF12128, IPR021979): Protein of unknown function (DUF3584) DUF4525 (PF15027, IPR027833): Domain of unknown function (DUF4525)
72	GTPBP4	suppressor	19	0.532	6.812	DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258 MRC1 (PF09444, IPR018564): MRC1-like domain NOG1 (PF06858, IPR010674): Nucleolar GTP-binding protein 1 (NOG1) NOGCT (PF08155, IPR012973): NOGCT (NUC087) domain Lip_prot_lig_C (PF10437, IPR019491): Bacterial lipoate protein ligase C-terminus AAA_16 (PF13191): AAA ATPase domain
73	HDAC1	suppressor	35	0.314	139.898	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
74	HDAC2	suppressor	34	0.292	104.300	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
75	HDAC3	suppressor	17	0.442	19.211	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
76	HDGF	interactor	25	0.423	27.787	PWWP (PF00855, IPR000313, SM00293): PWWP domain
77	HNRNPA0	interactor	49	0.513	111.351	SAP130_C (PF16014, IPR031963): Histone deacetylase complex subunit SAP130 C-terminus
78	HNRNPA1	interactor	92	0.350	639.822	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
79	HNRNPF	interactor	63	0.420	221.688	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14 zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
80	HNRNPH1	oncoprotein	77	0.322	569.004	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
81	HNRNPH2	interactor	41	0.504	72.141	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
82	HNRNPH3	protein found in more fusions	44	0.457	93.880	Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
83	HNRNPK	oncoprotein	81	0.394	389.997	ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain KH_1 (PF00013, IPR004088, SM00322): KH domain
84	HNRNPM	interactor	79	0.329	548.665	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNP_M (PF11532, IPR024666): Heterogeneous nuclear ribonucleoprotein M Collagen_mid (PF15984, IPR031929): Bacterial collagen, middle region
85	HNRNPR	interactor	73	0.390	347.101	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1
86	HNRNPU	interactor	94	0.287	813.135	CDC45 (PF02724, IPR003874): CDC45-like protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SAP (PF02037, IPR003034, SM00513): SAP domain SPRY (PF00622, IPR003877, SM00449): SPRY domain AAA_33 (PF13671): AAA domain WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
87	IGF2BP3	interactor	25	0.467	31.088	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KH_1 (PF00013, IPR004088, SM00322): KH domain KH_4 (PF13083): KH domain
88	IGSF8	oncoprotein	19	0.532	14.823	V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain
89	IL7R	interactor	18	0.425	11.523	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
90	ILK	suppressor	23	0.437	32.976	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
91	IMPDH1	interactor	3	1.000	0	IMPDH (PF00478, IPR001093): IMP dehydrogenase / GMP reductase domain
92	INPPL1	oncoprotein	11	0.509	10.217	Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SH2 (PF00017, IPR000980, SM00252): SH2 domain
93	IPO11	interactor	7	0.667	0.683	DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539) HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein HEAT_2 (PF13646): HEAT repeats
94	ITGA4	interactor	46	0.391	118.369	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
95	KHDRBS1	protein found in more fusions	38	0.429	109.718	KH_1 (PF00013, IPR004088, SM00322): KH domain Qua1 (PF16274, IPR032571): Qua1 domain Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
96	KHDRBS2	interactor	16	0.600	9.510	KH_1 (PF00013, IPR004088, SM00322): KH domain Qua1 (PF16274, IPR032571): Qua1 domain Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
97	LRSAM1	interactor	4	1.000	0	Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) LRR_8 (PF13855, IPR001611): Leucine rich repeat zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
98	LUC7L2	protein found in more fusions	32	0.452	56.884	LUC7 (PF03194, IPR004882): LUC7 N_terminus Paramyxo_ncap (PF00973, IPR002021): Paramyxovirus nucleocapsid protein Methyltransf_32 (PF13679, IPR025714): Methyltransferase domain
99	LUZP4	interactor	10	0.472	2.784	Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
100	MAP1LC3A	interactor	9	0.500	1.971	Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
101	MAPK10	suppressor	6	0.700	0.933	Pkinase (PF00069, IPR000719): Protein kinase domain
102	MAPKAPK2	oncoprotein	10	0.611	3.185	Pkinase (PF00069, IPR000719): Protein kinase domain
103	MAST3	interactor	5	0.500	1.872	DUF1908 (PF08926, IPR015022): Domain of unknown function (DUF1908) PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Pkinase (PF00069, IPR000719): Protein kinase domain ACTL7A_N (PF16840, IPR031769): Actin-like protein 7A N-terminus
104	MATR3	interactor	54	0.427	183.516	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAM60A (PF15396, IPR026065): Protein Family FAM60A
105	MBD3	interactor	11	0.422	6.996	DUF2201_N (PF13203, IPR025154): Putative metallopeptidase domain
106	MBNL1	interactor	12	0.742	2.395	zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 (PF15663): Zinc-finger containing family
107	MCM2	oncoprotein	59	0.362	280.528	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
108	MCM5	oncoprotein	33	0.472	60.753	MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
109	MCM7	protein found in more fusions	28	0.336	30.567	MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
110	MDM2	oncoprotein	42	0.299	192.611	Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
111	MEPCE	interactor	28	0.524	23.233	Bin3 (PF06859, IPR010675): Bicoid-interacting protein 3 (Bin3) Methyltransf_23 (PF13489): Methyltransferase domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7
112	MGMT	interactor	8	0.750	1.308	DNA_binding_1 (PF01035, IPR014048): 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_1N (PF02870, IPR008332): 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
113	MYOD1	oncoprotein	10	0.694	1.933	Basic (PF01586, IPR002546, SM00520): Myogenic Basic domain HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Mfp-3 (PF04202, IPR007328): Foot protein 3 Myf5 (PF12232, IPR022032): Myogenic determination factor 5
114	NACA	oncoprotein	11	0.491	3.398	NAC (PF01849, IPR002715): NAC domain RNA_pol_Rpo13 (PF12136, IPR021985): RNA polymerase Rpo13 subunit HTH domain CitT (PF12431, IPR028141): Transcriptional regulator
115	NDRG1	suppressor	15	0.457	7.372	Ndr (PF03096, IPR004142): Ndr family
116	NEDD8	interactor	34	0.602	33.109	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
117	NFX1	interactor	7	0.667	0.537	R3H (PF01424, IPR001374, SM00393): R3H domain XPG_I (PF00867, IPR006086, SM00484): XPG I-region zf-NF-X1 (PF01422, IPR000967, SM00438): NF-X1 type zinc finger
118	NTRK1	oncoprotein	100	0.240	1457.025	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
119	NXF1	interactor	59	0.240	488.482	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
120	OBSL1	interactor	61	0.366	195.228	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
121	OTUB1	interactor	14	0.363	15.098	Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
122	PABPC4	interactor	39	0.387	88.641	ApbA_C (PF08546, IPR013752): Ketopantoate reductase PanE/ApbA C terminal RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain HHV-5_US34A (PF17087, IPR031384): Herpesvirus US34A protein family
123	PARK2	suppressor	32	0.366	81.479	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
124	PIAS1	suppressor	10	0.556	4.767	Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger PINIT (PF14324, IPR023321): PINIT domain UPF0544 (PF15749, IPR032739): Uncharacterised protein family UPF0544
125	PIK3CA	oncoprotein	8	0.464	5.224	PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2 PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF2321 (PF10083, IPR016891): Uncharacterized protein conserved in bacteria (DUF2321) PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
126	PIN1	suppressor	23	0.447	33.795	Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain WW (PF00397, IPR001202, SM00456): WW domain
127	POLR2A	protein found in more fusions	38	0.305	123.868	RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
128	PRKDC	protein found in more fusions	48	0.247	288.377	FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain NUC194 (PF08163, IPR012582): NUC194 domain PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
129	PRPF19	protein found in more fusions	49	0.449	109.208	Prp19 (PF08606, IPR013915): Prp19/Pso4-like WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat U-box (PF04564, IPR003613, SM00504): U-box domain ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
130	PRPF40A	protein found in more fusions	38	0.509	75.312	FF (PF01846, IPR002713, SM00441): FF domain MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain Transformer (PF06495, IPR010519): Fruit fly transformer protein WW (PF00397, IPR001202, SM00456): WW domain YqzE (PF14038, IPR025622): YqzE-like protein SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6 SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus SOBP (PF15279, IPR026092): Sine oculis-binding protein IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
131	PRPSAP1	interactor	6	0.900	0.087	Pribosyltran_N (PF13793, IPR029099): N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth (PF14572, IPR005946): Phosphoribosyl synthetase-associated domain
132	PRSS1	interactor	2	1.000	0	Trypsin (PF00089, IPR001254, SM00020): Trypsin
133	PSMA3	interactor	19	0.438	17.432	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
134	RBFOX2	protein found in more fusions	20	0.491	19.205	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Fox-1_C (PF12414, IPR025670): Calcitonin gene-related peptide regulator C terminal
135	RBM10	interactor	26	0.543	21.595	G-patch (PF01585, IPR000467, SM00443): G-patch domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others GSIII_N (PF12437, IPR022147): Glutamine synthetase type III N terminal G-patch_2 (PF12656, IPR026822): DExH-box splicing factor binding site zf-C2H2_4 (PF13894): C2H2-type zinc finger DUF4337 (PF14235, IPR025570): Domain of unknown function (DUF4337) FAM176 (PF14851): FAM176 family
136	RBM4	suppressor	34	0.558	26.876	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC (PF00098, IPR001878): Zinc knuckle CompInhib_SCIN (PF11546, IPR021612): Staphylococcal complement inhibitor SCIN
137	RBMX	suppressor	49	0.481	98.238	RBM1CTR (PF08081, IPR012604): RBM1CTR (NUC064) family RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
138	RNF2	interactor	56	0.304	279.552	zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
139	RPA1	suppressor	58	0.387	231.045	Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
140	RPA2	oncoprotein	45	0.443	93.187	RPA_C (PF08784, IPR014892): Replication protein A C terminal tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
141	RPA3	interactor	43	0.458	72.583	Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
142	RPL10	suppressor	39	0.395	103.636	Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
143	RPL19	interactor	35	0.417	56.762	DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682) Ribosomal_L19e (PF01280, IPR000196): Ribosomal protein L19e
144	RPS16	interactor	37	0.371	100.629	Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
145	RPS20	interactor	32	0.387	75.177	Ribosomal_S10 (PF00338, IPR027486): Ribosomal protein S10p/S20e
146	RPS6KB2	interactor	13	0.538	5.644	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
147	SART1	interactor	36	0.580	32.477	SART-1 (PF03343, IPR005011): SART-1 family Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
148	SBDS	oncoprotein	4	0.833	0.069	SBDS (PF01172, IPR019783): Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C (PF09377, IPR018978): SBDS protein C-terminal domain
149	SCARNA22	interactor	21	0.552	9.953	NA
150	SF3A1	interactor	49	0.487	113.549	TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit Surp (PF01805, IPR000061, SM00648): Surp module ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
151	SF3A2	interactor	31	0.654	23.869	Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32 PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like Totivirus_coat (PF05518, IPR008871): Totivirus coat protein zf-met (PF12874): Zinc-finger of C2H2 type ARL6IP6 (PF15062, IPR029383): Haemopoietic lineage transmembrane helix SF3A2 (PF16835, IPR031781): Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11)
152	SF3B3	interactor	56	0.429	163.073	CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
153	SFN	suppressor	24	0.364	57.252	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
154	SGK2	interactor	1	0	0	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
155	SHC1	oncoprotein	15	0.462	13.296	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017, IPR000980, SM00252): SH2 domain
156	SKI	oncoprotein	13	0.530	7.164	c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family SlyX (PF04102, IPR007236): SlyX HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
157	SKIV2L2	interactor	24	0.504	29.594	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase DSHCT (PF08148, IPR012961, SM01142): DSHCT (NUC185) domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain rRNA_proc-arch (PF13234, IPR025696): rRNA-processing arch domain
158	SMAD3	oncoprotein	26	0.377	68.999	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
159	SMARCA4	suppressor	26	0.351	56.758	DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) HSA (PF07529, IPR014012, SM00573): HSA QLQ (PF08880, IPR014978, SM00951): QLQ SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain BRK (PF07533, IPR006576, SM00592): BRK domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065) SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
160	SMARCAD1	interactor	22	0.567	15.545	CUE (PF02845, IPR003892, SM00546): CUE domain Pox_D5 (PF03288, IPR004968): Poxvirus D5 protein-like SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
161	SMN1	interactor	25	0.428	24.259	SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
162	SMURF1	interactor	30	0.401	37.104	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
163	SNRPA1	interactor	37	0.515	50.838	LRR_9 (PF14580): Leucine-rich repeat
164	SNRPD1	interactor	48	0.429	105.575	API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5) LSM (PF01423, IPR001163): LSM domain
165	SNRPD2	interactor	43	0.437	74.985	LSM (PF01423, IPR001163): LSM domain
166	SNW1	protein found in more fusions	69	0.361	437.883	SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain
167	SP1	protein found in more fusions	21	0.532	24.645	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Miga (PF10265, IPR019392): Mitoguardin zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
168	SPRTN	interactor	7	0.857	0.197	GreA_GreB (PF01272, IPR001437): Transcription elongation factor, GreA/GreB, C-term SprT-like (PF10263, IPR006640, SM00731): SprT-like family PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
169	SRP14	interactor	22	0.494	33.413	SRP14 (PF02290, IPR003210): Signal recognition particle 14kD protein
170	SRPK1	interactor	26	0.480	40.317	FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) Pkinase (PF00069, IPR000719): Protein kinase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
171	SRRM1	interactor	24	0.685	11.608	DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP) Hepatitis_core (PF00906, IPR002006): Hepatitis core antigen MAP65_ASE1 (PF03999, IPR007145): Microtubule associated protein (MAP65/ASE1 family) PWI (PF01480, IPR002483, SM00311): PWI domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
172	SRRM2	interactor	50	0.469	156.662	cwf21 (PF08312, IPR013170, SM01115): cwf21 domain DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Pap_E4 (PF02711, IPR003861): E4 protein RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4 DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
173	SRSF1	protein found in more fusions	60	0.435	216.922	Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
174	STAU1	protein found in more fusions	46	0.494	75.303	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
175	STK24	interactor	7	0.400	1.657	DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241) Pkinase (PF00069, IPR000719): Protein kinase domain
176	SUZ12	suppressor	39	0.380	87.336	DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070) VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
177	SYN1	protein found in more fusions	6	0.400	3.241	Synapsin_C (PF02750, IPR020898): Synapsin, ATP binding domain Synapsin_N (PF10581, IPR019736): Synapsin N-terminal DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076) Synapsin (PF02078, IPR020897): Synapsin, N-terminal domain
178	SYNCRIP	interactor	68	0.397	266.976	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1
179	TADA2A	interactor	16	0.500	8.921	SWIRM (PF04433, IPR007526): SWIRM domain Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
180	TARDBP	interactor	62	0.398	237.846	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
181	TBP	interactor	14	0.641	8.454	TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP) EPL1 (PF10513, IPR019542): Enhancer of polycomb-like Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
182	TCEA1	oncoprotein	10	0.444	7.667	Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain TFIIS_C (PF01096, IPR001222): Transcription factor S-II (TFIIS) TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain
183	THRAP3	oncoprotein	29	0.431	49.721	API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5) FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal DUF4228 (PF14009, IPR025322): Domain of unknown function (DUF4228) THRAP3_BCLAF1 (PF15440, IPR029199): THRAP3/BCLAF1 family
184	TNK1	suppressor	6	0.700	0.773	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH3_9 (PF14604, IPR001452): Variant SH3 domain HOIP-UBA (PF16678, IPR032065): UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
185	TNNT1	protein found in more fusions	4	1.000	0	Troponin (PF00992, IPR001978): Troponin DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050)
186	TP53	suppressor	62	0.249	526.443	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
187	TRMT6	interactor	9	0.667	3.937	Gcd10p (PF04189, IPR007316): Gcd10p family Presenilin (PF01080, IPR001108): Presenilin INTS5_C (PF14838, IPR029444): Integrator complex subunit 5 C-terminus
188	TUBGCP3	interactor	12	0.636	2.543	Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
189	TYK2	interactor	7	0.800	0.515	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
190	U2AF1	oncoprotein	41	0.533	62.024	DUF1509 (PF07420, IPR010883): Protein of unknown function (DUF1509) KMP11 (PF03037, IPR004132): Kinetoplastid membrane protein 11 RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
191	U2AF2	protein found in more fusions	69	0.424	235.929	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
192	UBE2I	interactor	30	0.409	63.337	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
193	UNK	interactor	20	0.347	23.726	MbeD_MobD (PF04899, IPR006983): MbeD/MobD like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger Torus (PF16131, IPR032297): Torus domain
194	UPF1	interactor	31	0.510	41.615	UPF1_Zn_bind (PF09416, IPR018999): RNA helicase (UPF2 interacting domain) AAA_11 (PF13086): AAA domain AAA_12 (PF13087): AAA domain
195	VCAM1	interactor	41	0.372	92.734	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
196	VHL	suppressor	30	0.448	59.279	Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein VHL_C (PF17211): VHL box domain
197	VTN	interactor	16	0.817	1.400	Hemopexin (PF00045, IPR018487, SM00120): Hemopexin Somatomedin_B (PF01033, IPR001212, SM00201): Somatomedin B domain
198	WBP11	interactor	8	0.643	1.181	BUD22 (PF09073, IPR015158): BUD22 Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region SspB (PF04386, IPR007481): Stringent starvation protein B Wbp11 (PF09429, IPR019007): WW domain binding protein 11 ABC_trans_N (PF14510, IPR029481): ABC-transporter extracellular N-terminal
199	WDR4	interactor	6	0.400	5.319	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
200	XPO1	interactor	57	0.221	496.851	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
201	XRCC4	interactor	6	0.500	1.917	XRCC4 (PF06632, IPR010585): DNA double-strand break repair and V(D)J recombination protein XRCC4
202	YY1	protein found in more fusions	17	0.567	11.610	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
203	ZWINT	interactor	8	0.762	1.017	Zwint (PF15556, IPR029092): ZW10 interactor

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