1 |
DDX5 | parental protein | 203 | 0.145 | 13444.265 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase P68HR (PF08061, IPR012587): P68HR (NUC004) repeat ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain |
2 |
ABL1 | oncoprotein | 16 | 0.457 | 19.756 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2 |
3 |
AIRE | interactor | 13 | 0.455 | 5.974 | PHD (PF00628, IPR019787, SM00249): PHD-finger SAND (PF01342, IPR000770, SM00258): SAND domain HSR (PF03172, IPR004865): HSR domain; Sp100 domain zf-PHD-like (PF15446): PHD/FYVE-zinc-finger like domain |
4 |
AKAP8 | interactor | 18 | 0.458 | 11.306 | AKAP95 (PF04988, IPR007071): A-kinase anchoring protein 95 (AKAP95) Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein |
5 |
AKT1 | oncoprotein | 22 | 0.286 | 66.882 | PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain |
6 |
ARAF | oncoprotein | 7 | 0.476 | 2.645 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
7 |
ARRB2 | interactor | 30 | 0.409 | 61.084 | Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain |
8 |
ATXN2 | interactor | 15 | 0.543 | 9.211 | LsmAD (PF06741, IPR009604): LsmAD domain PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446) Spt20 (PF12090, IPR021950): Spt20 family SM-ATX (PF14438, IPR025852): Ataxin 2 SM domain |
9 |
ATXN2L | interactor | 11 | 0.618 | 4.046 | LsmAD (PF06741, IPR009604): LsmAD domain PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region SM-ATX (PF14438, IPR025852): Ataxin 2 SM domain |
10 |
AURKA | oncoprotein | 25 | 0.366 | 42.680 | Pkinase (PF00069, IPR000719): Protein kinase domain MTBP_C (PF14920, IPR029418): MDM2-binding |
11 |
AURKB | interactor | 22 | 0.400 | 33.350 | Pkinase (PF00069, IPR000719): Protein kinase domain |
12 |
C14orf166 | interactor | 28 | 0.593 | 31.682 | RLL (PF10036, IPR019265): Putative carnitine deficiency-associated protein |
13 |
CALM1 | interactor | 20 | 0.289 | 53.020 | EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
14 |
CAND1 | interactor | 76 | 0.381 | 338.281 | Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II |
15 |
CCDC8 | interactor | 41 | 0.397 | 85.536 | Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA |
16 |
CD4 | suppressor | 6 | 0.700 | 1.036 | ATP1G1_PLM_MAT8 (PF02038, IPR000272): ATP1G1/PLM/MAT8 family C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain CD4-extracel (PF09191, IPR015274): CD4, extracellular ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Tcell_CD4_C (PF12104, IPR021963): T cell CD4 receptor C terminal region |
17 |
CD81 | interactor | 21 | 0.500 | 24.803 | Tetraspannin (PF00335, IPR018499): Tetraspanin family |
18 |
CDC37 | protein found in more fusions | 18 | 0.272 | 33.857 | CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding |
19 |
CDC5L | interactor | 69 | 0.392 | 335.922 | OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain |
20 |
CDK2 | suppressor | 51 | 0.402 | 153.290 | Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain |
21 |
CDK9 | protein found in more fusions | 21 | 0.500 | 25.781 | Pkinase (PF00069, IPR000719): Protein kinase domain |
22 |
CENPA | interactor | 12 | 0.509 | 4.776 | Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 |
23 |
CEP250 | interactor | 22 | 0.403 | 46.364 | ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1 DivIC (PF04977, IPR007060): Septum formation initiator DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) EHN (PF06441, IPR010497): Epoxide hydrolase N terminus ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family IncA (PF04156, IPR007285): IncA protein Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain SlyX (PF04102, IPR007236): SlyX Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal TSC22 (PF01166, IPR000580): TSC-22/dip/bun family CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Endonuc_Holl (PF10107, IPR019287): Endonuclease related to archaeal Holliday junction resolvase DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570) DGF-1_C (PF11040, IPR021053): Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 |
24 |
CHD3 | oncoprotein | 18 | 0.324 | 40.315 | CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086) DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087) DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) PHD (PF00628, IPR019787, SM00249): PHD-finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956) FAM176 (PF14851): FAM176 family |
25 |
COPS5 | protein found in more fusions | 77 | 0.326 | 510.841 | JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease |
26 |
COPS6 | interactor | 30 | 0.539 | 38.237 | DUF320 (PF03777, IPR005528): Small secreted domain (DUF320) JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function |
27 |
CPSF6 | interactor | 23 | 0.427 | 27.122 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
28 |
CREBBP | suppressor | 27 | 0.400 | 68.793 | Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain MAS20 (PF02064, IPR002056): MAS20 protein import receptor TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834) |
29 |
CRK | oncoprotein | 12 | 0.333 | 21.831 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
30 |
CTNNB1 | oncoprotein | 38 | 0.339 | 121.251 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat |
31 |
CUL1 | suppressor | 69 | 0.399 | 318.434 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
32 |
CUL2 | suppressor | 42 | 0.540 | 52.431 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
33 |
CUL3 | protein found in more fusions | 98 | 0.290 | 955.143 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal |
34 |
CUL4A | protein found in more fusions | 29 | 0.532 | 32.043 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
35 |
CUL4B | oncoprotein | 39 | 0.517 | 53.847 | Cullin (PF00888, IPR001373, SM00182): Cullin family EBP50_C (PF09007, IPR015098): EBP50, C-terminal Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain MDFI (PF15316, IPR026134): MyoD family inhibitor |
36 |
CUL5 | suppressor | 44 | 0.500 | 95.714 | Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
37 |
CUL7 | protein found in more fusions | 60 | 0.392 | 164.753 | ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7 |
38 |
DAPK1 | suppressor | 7 | 0.667 | 0.910 | ABC_tran (PF00005, IPR003439): ABC transporter Death (PF00531, IPR000488, SM00005): Death domain Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) AAA_23 (PF13476): AAA domain Ank_5 (PF13857): Ankyrin repeats (many copies) COR (PF16095, IPR032171): C-terminal of Roc, COR, domain |
39 |
DBNL | interactor | 6 | 0.600 | 3.733 | RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein SH3_9 (PF14604, IPR001452): Variant SH3 domain |
40 |
DCUN1D1 | interactor | 29 | 0.638 | 23.292 | Cullin_binding (PF03556, IPR005176): Cullin binding UBA_4 (PF14555): UBA-like domain |
41 |
DDX17 | protein found in more fusions | 79 | 0.264 | 752.801 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Ferritin (PF00210, IPR008331): Ferritin-like domain GRP (PF07172, IPR010800): Glycine rich protein family Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain |
42 |
DDX18 | interactor | 22 | 0.537 | 11.918 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3 Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF4217 (PF13959, IPR025313, SM01178): Domain of unknown function (DUF4217) |
43 |
DGCR8 | interactor | 12 | 0.500 | 13.796 | dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif WW (PF00397, IPR001202, SM00456): WW domain |
44 |
DHX15 | interactor | 67 | 0.393 | 255.920 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain AAA_29 (PF13555): P-loop containing region of AAA domain |
45 |
DHX36 | interactor | 15 | 0.476 | 9.380 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain |
46 |
DHX38 | interactor | 10 | 0.644 | 2.824 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87 Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956) |
47 |
DHX9 | oncoprotein | 79 | 0.327 | 508.015 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold T2SSE (PF00437, IPR001482): Type II/IV secretion system protein HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain |
48 |
DNAJC2 | interactor | 3 | 0.667 | 0.049 | DnaJ (PF00226, IPR001623, SM00271): DnaJ domain Mnd1 (PF03962, IPR005647): Mnd1 family Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain S1FA (PF04689, IPR006779): DNA binding protein S1FA DUF2058 (PF09831, IPR018636): Uncharacterized protein conserved in bacteria (DUF2058) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain GHBP (PF12772, IPR025871): Growth hormone receptor binding RAC_head (PF16717, IPR032003): Ribosome-associated complex head domain |
49 |
DROSHA | interactor | 10 | 0.467 | 5.698 | dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Ribonuclease_3 (PF00636, IPR000999, SM00535): Ribonuclease III domain Ribonucleas_3_3 (PF14622, IPR000999): Ribonuclease-III-like DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614) |
50 |
EDC4 | interactor | 13 | 0.423 | 8.647 | DUF445 (PF04286, IPR007383): Protein of unknown function (DUF445) SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein DUF2756 (PF10956, IPR020158): Protein of unknown function (DUF2756) DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446) Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein |
51 |
EED | suppressor | 56 | 0.370 | 193.366 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
52 |
EEF2 | interactor | 38 | 0.401 | 102.573 | EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II |
53 |
EIF2A | interactor | 6 | 0.400 | 3.254 | Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A |
54 |
EIF4A3 | interactor | 57 | 0.471 | 150.141 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain |
55 |
ELAC2 | oncoprotein | 8 | 0.643 | 4.617 | Synthase_beta (PF11421, IPR020971): ATP synthase F1 beta subunit Lactamase_B_2 (PF12706, IPR001279): Beta-lactamase superfamily domain Lactamase_B_4 (PF13691, IPR027794): tRNase Z endonuclease |
56 |
EP300 | oncoprotein | 31 | 0.386 | 87.027 | Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type |
57 |
EPRS | interactor | 27 | 0.305 | 44.389 | GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain ProRS-C_1 (PF09180, IPR016061, SM00946): Prolyl-tRNA synthetase, C-terminal tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C (PF03950, IPR020059): tRNA synthetases class I (E and Q), anti-codon binding domain tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T) WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain |
58 |
ERG | oncoprotein | 17 | 0.456 | 27.167 | Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain |
59 |
ERO1A | interactor | 6 | 0.533 | 4.463 | ERO1 (PF04137, IPR007266): Endoplasmic Reticulum Oxidoreductin 1 (ERO1) |
60 |
ESR1 | suppressor | 71 | 0.269 | 580.814 | Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal |
61 |
EZH2 | suppressor | 34 | 0.324 | 97.795 | CDC45 (PF02724, IPR003874): CDC45-like protein TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain SET (PF00856, IPR001214, SM00317): SET domain EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2 Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal |
62 |
FBL | interactor | 44 | 0.375 | 116.579 | Fibrillarin (PF01269, IPR000692): Fibrillarin |
63 |
FBXO46 | interactor | 5 | 1.000 | 0 | BTK (PF00779, IPR001562, SM00107): BTK motif CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal CHORD (PF04968, IPR007051): CHORD DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) F-box-like (PF12937, IPR001810): F-box-like |
64 |
FBXO6 | interactor | 39 | 0.340 | 146.522 | FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like |
65 |
FBXW4 | oncoprotein | 7 | 0.667 | 1.537 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat F-box-like (PF12937, IPR001810): F-box-like F-box_4 (PF15966, IPR001810): F-box |
66 |
FKBP10 | interactor | 1 | 0 | 0 | FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_5 (PF13202, IPR002048): EF hand |
67 |
FN1 | oncoprotein | 55 | 0.343 | 175.553 | fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) |
68 |
FRS3 | suppressor | 2 | 0 | 0 | IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) |
69 |
FUS | suppressor | 63 | 0.354 | 348.712 | Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Limkain-b1 (PF11608, IPR024582): Limkain b1 FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head |
70 |
GMPS | oncoprotein | 11 | 0.364 | 9.195 | GATase (PF00117, IPR017926): Glutamine amidotransferase class-I GMP_synt_C (PF00958, IPR001674): GMP synthase C terminal domain NAD_synthase (PF02540, IPR022310): NAD synthase |
71 |
GOLIM4 | interactor | 3 | 1.000 | 0 | Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) DDRGK (PF09756, IPR019153, SM01128): DDRGK domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region DUF3410 (PF11890, IPR024531): Domain of unknown function (DUF3410) DUF3584 (PF12128, IPR021979): Protein of unknown function (DUF3584) DUF4525 (PF15027, IPR027833): Domain of unknown function (DUF4525) |
72 |
GTPBP4 | suppressor | 19 | 0.532 | 6.812 | DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258 MRC1 (PF09444, IPR018564): MRC1-like domain NOG1 (PF06858, IPR010674): Nucleolar GTP-binding protein 1 (NOG1) NOGCT (PF08155, IPR012973): NOGCT (NUC087) domain Lip_prot_lig_C (PF10437, IPR019491): Bacterial lipoate protein ligase C-terminus AAA_16 (PF13191): AAA ATPase domain |
73 |
HDAC1 | suppressor | 35 | 0.314 | 139.898 | FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain |
74 |
HDAC2 | suppressor | 34 | 0.292 | 104.300 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1 |
75 |
HDAC3 | suppressor | 17 | 0.442 | 19.211 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain |
76 |
HDGF | interactor | 25 | 0.423 | 27.787 | PWWP (PF00855, IPR000313, SM00293): PWWP domain |
77 |
HNRNPA0 | interactor | 49 | 0.513 | 111.351 | SAP130_C (PF16014, IPR031963): Histone deacetylase complex subunit SAP130 C-terminus |
78 |
HNRNPA1 | interactor | 92 | 0.350 | 639.822 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1 |
79 |
HNRNPF | interactor | 63 | 0.420 | 221.688 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14 zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger |
80 |
HNRNPH1 | oncoprotein | 77 | 0.322 | 569.004 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger |
81 |
HNRNPH2 | interactor | 41 | 0.504 | 72.141 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger |
82 |
HNRNPH3 | protein found in more fusions | 44 | 0.457 | 93.880 | Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
83 |
HNRNPK | oncoprotein | 81 | 0.394 | 389.997 | ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain KH_1 (PF00013, IPR004088, SM00322): KH domain |
84 |
HNRNPM | interactor | 79 | 0.329 | 548.665 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNP_M (PF11532, IPR024666): Heterogeneous nuclear ribonucleoprotein M Collagen_mid (PF15984, IPR031929): Bacterial collagen, middle region |
85 |
HNRNPR | interactor | 73 | 0.390 | 347.101 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1 |
86 |
HNRNPU | interactor | 94 | 0.287 | 813.135 | CDC45 (PF02724, IPR003874): CDC45-like protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SAP (PF02037, IPR003034, SM00513): SAP domain SPRY (PF00622, IPR003877, SM00449): SPRY domain AAA_33 (PF13671): AAA domain WRNPLPNID (PF15017): Putative WW-binding domain and destruction box |
87 |
IGF2BP3 | interactor | 25 | 0.467 | 31.088 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KH_1 (PF00013, IPR004088, SM00322): KH domain KH_4 (PF13083): KH domain |
88 |
IGSF8 | oncoprotein | 19 | 0.532 | 14.823 | V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain |
89 |
IL7R | interactor | 18 | 0.425 | 11.523 | fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain |
90 |
ILK | suppressor | 23 | 0.437 | 32.976 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies) |
91 |
IMPDH1 | interactor | 3 | 1.000 | 0 | IMPDH (PF00478, IPR001093): IMP dehydrogenase / GMP reductase domain |
92 |
INPPL1 | oncoprotein | 11 | 0.509 | 10.217 | Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SH2 (PF00017, IPR000980, SM00252): SH2 domain |
93 |
IPO11 | interactor | 7 | 0.667 | 0.683 | DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539) HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein HEAT_2 (PF13646): HEAT repeats |
94 |
ITGA4 | interactor | 46 | 0.391 | 118.369 | FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha |
95 |
KHDRBS1 | protein found in more fusions | 38 | 0.429 | 109.718 | KH_1 (PF00013, IPR004088, SM00322): KH domain Qua1 (PF16274, IPR032571): Qua1 domain Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68 |
96 |
KHDRBS2 | interactor | 16 | 0.600 | 9.510 | KH_1 (PF00013, IPR004088, SM00322): KH domain Qua1 (PF16274, IPR032571): Qua1 domain Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68 |
97 |
LRSAM1 | interactor | 4 | 1.000 | 0 | Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) LRR_8 (PF13855, IPR001611): Leucine rich repeat zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
98 |
LUC7L2 | protein found in more fusions | 32 | 0.452 | 56.884 | LUC7 (PF03194, IPR004882): LUC7 N_terminus Paramyxo_ncap (PF00973, IPR002021): Paramyxovirus nucleocapsid protein Methyltransf_32 (PF13679, IPR025714): Methyltransferase domain |
99 |
LUZP4 | interactor | 10 | 0.472 | 2.784 | Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570) |
100 |
MAP1LC3A | interactor | 9 | 0.500 | 1.971 | Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like |
101 |
MAPK10 | suppressor | 6 | 0.700 | 0.933 | Pkinase (PF00069, IPR000719): Protein kinase domain |
102 |
MAPKAPK2 | oncoprotein | 10 | 0.611 | 3.185 | Pkinase (PF00069, IPR000719): Protein kinase domain |
103 |
MAST3 | interactor | 5 | 0.500 | 1.872 | DUF1908 (PF08926, IPR015022): Domain of unknown function (DUF1908) PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Pkinase (PF00069, IPR000719): Protein kinase domain ACTL7A_N (PF16840, IPR031769): Actin-like protein 7A N-terminus |
104 |
MATR3 | interactor | 54 | 0.427 | 183.516 | DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAM60A (PF15396, IPR026065): Protein Family FAM60A |
105 |
MBD3 | interactor | 11 | 0.422 | 6.996 | DUF2201_N (PF13203, IPR025154): Putative metallopeptidase domain |
106 |
MBNL1 | interactor | 12 | 0.742 | 2.395 | zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 (PF15663): Zinc-finger containing family |
107 |
MCM2 | oncoprotein | 59 | 0.362 | 280.528 | AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain |
108 |
MCM5 | oncoprotein | 33 | 0.472 | 60.753 | MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain |
109 |
MCM7 | protein found in more fusions | 28 | 0.336 | 30.567 | MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain |
110 |
MDM2 | oncoprotein | 42 | 0.299 | 192.611 | Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
111 |
MEPCE | interactor | 28 | 0.524 | 23.233 | Bin3 (PF06859, IPR010675): Bicoid-interacting protein 3 (Bin3) Methyltransf_23 (PF13489): Methyltransferase domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7 |
112 |
MGMT | interactor | 8 | 0.750 | 1.308 | DNA_binding_1 (PF01035, IPR014048): 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_1N (PF02870, IPR008332): 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain |
113 |
MYOD1 | oncoprotein | 10 | 0.694 | 1.933 | Basic (PF01586, IPR002546, SM00520): Myogenic Basic domain HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Mfp-3 (PF04202, IPR007328): Foot protein 3 Myf5 (PF12232, IPR022032): Myogenic determination factor 5 |
114 |
NACA | oncoprotein | 11 | 0.491 | 3.398 | NAC (PF01849, IPR002715): NAC domain RNA_pol_Rpo13 (PF12136, IPR021985): RNA polymerase Rpo13 subunit HTH domain CitT (PF12431, IPR028141): Transcriptional regulator |
115 |
NDRG1 | suppressor | 15 | 0.457 | 7.372 | Ndr (PF03096, IPR004142): Ndr family |
116 |
NEDD8 | interactor | 34 | 0.602 | 33.109 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
117 |
NFX1 | interactor | 7 | 0.667 | 0.537 | R3H (PF01424, IPR001374, SM00393): R3H domain XPG_I (PF00867, IPR006086, SM00484): XPG I-region zf-NF-X1 (PF01422, IPR000967, SM00438): NF-X1 type zinc finger |
118 |
NTRK1 | oncoprotein | 100 | 0.240 | 1457.025 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain |
119 |
NXF1 | interactor | 59 | 0.240 | 488.482 | NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat |
120 |
OBSL1 | interactor | 61 | 0.366 | 195.228 | BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain |
121 |
OTUB1 | interactor | 14 | 0.363 | 15.098 | Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain |
122 |
PABPC4 | interactor | 39 | 0.387 | 88.641 | ApbA_C (PF08546, IPR013752): Ketopantoate reductase PanE/ApbA C terminal RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain HHV-5_US34A (PF17087, IPR031384): Herpesvirus US34A protein family |
123 |
PARK2 | suppressor | 32 | 0.366 | 81.479 | IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
124 |
PIAS1 | suppressor | 10 | 0.556 | 4.767 | Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger PINIT (PF14324, IPR023321): PINIT domain UPF0544 (PF15749, IPR032739): Uncharacterised protein family UPF0544 |
125 |
PIK3CA | oncoprotein | 8 | 0.464 | 5.224 | PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2 PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF2321 (PF10083, IPR016891): Uncharacterized protein conserved in bacteria (DUF2321) PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase |
126 |
PIN1 | suppressor | 23 | 0.447 | 33.795 | Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain WW (PF00397, IPR001202, SM00456): WW domain |
127 |
POLR2A | protein found in more fusions | 38 | 0.305 | 123.868 | RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat |
128 |
PRKDC | protein found in more fusions | 48 | 0.247 | 288.377 | FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain NUC194 (PF08163, IPR012582): NUC194 domain PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase |
129 |
PRPF19 | protein found in more fusions | 49 | 0.449 | 109.208 | Prp19 (PF08606, IPR013915): Prp19/Pso4-like WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat U-box (PF04564, IPR003613, SM00504): U-box domain ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
130 |
PRPF40A | protein found in more fusions | 38 | 0.509 | 75.312 | FF (PF01846, IPR002713, SM00441): FF domain MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain Transformer (PF06495, IPR010519): Fruit fly transformer protein WW (PF00397, IPR001202, SM00456): WW domain YqzE (PF14038, IPR025622): YqzE-like protein SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6 SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus SOBP (PF15279, IPR026092): Sine oculis-binding protein IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal |
131 |
PRPSAP1 | interactor | 6 | 0.900 | 0.087 | Pribosyltran_N (PF13793, IPR029099): N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth (PF14572, IPR005946): Phosphoribosyl synthetase-associated domain |
132 |
PRSS1 | interactor | 2 | 1.000 | 0 | Trypsin (PF00089, IPR001254, SM00020): Trypsin |
133 |
PSMA3 | interactor | 19 | 0.438 | 17.432 | Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature |
134 |
RBFOX2 | protein found in more fusions | 20 | 0.491 | 19.205 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Fox-1_C (PF12414, IPR025670): Calcitonin gene-related peptide regulator C terminal |
135 |
RBM10 | interactor | 26 | 0.543 | 21.595 | G-patch (PF01585, IPR000467, SM00443): G-patch domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others GSIII_N (PF12437, IPR022147): Glutamine synthetase type III N terminal G-patch_2 (PF12656, IPR026822): DExH-box splicing factor binding site zf-C2H2_4 (PF13894): C2H2-type zinc finger DUF4337 (PF14235, IPR025570): Domain of unknown function (DUF4337) FAM176 (PF14851): FAM176 family |
136 |
RBM4 | suppressor | 34 | 0.558 | 26.876 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC (PF00098, IPR001878): Zinc knuckle CompInhib_SCIN (PF11546, IPR021612): Staphylococcal complement inhibitor SCIN |
137 |
RBMX | suppressor | 49 | 0.481 | 98.238 | RBM1CTR (PF08081, IPR012604): RBM1CTR (NUC064) family RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
138 |
RNF2 | interactor | 56 | 0.304 | 279.552 | zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like |
139 |
RPA1 | suppressor | 58 | 0.387 | 231.045 | Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain |
140 |
RPA2 | oncoprotein | 45 | 0.443 | 93.187 | RPA_C (PF08784, IPR014892): Replication protein A C terminal tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2 |
141 |
RPA3 | interactor | 43 | 0.458 | 72.583 | Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3 |
142 |
RPL10 | suppressor | 39 | 0.395 | 103.636 | Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e |
143 |
RPL19 | interactor | 35 | 0.417 | 56.762 | DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682) Ribosomal_L19e (PF01280, IPR000196): Ribosomal protein L19e |
144 |
RPS16 | interactor | 37 | 0.371 | 100.629 | Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16 |
145 |
RPS20 | interactor | 32 | 0.387 | 75.177 | Ribosomal_S10 (PF00338, IPR027486): Ribosomal protein S10p/S20e |
146 |
RPS6KB2 | interactor | 13 | 0.538 | 5.644 | Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain |
147 |
SART1 | interactor | 36 | 0.580 | 32.477 | SART-1 (PF03343, IPR005011): SART-1 family Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal |
148 |
SBDS | oncoprotein | 4 | 0.833 | 0.069 | SBDS (PF01172, IPR019783): Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C (PF09377, IPR018978): SBDS protein C-terminal domain |
149 |
SCARNA22 | interactor | 21 | 0.552 | 9.953 | NA |
150 |
SF3A1 | interactor | 49 | 0.487 | 113.549 | TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit Surp (PF01805, IPR000061, SM00648): Surp module ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein |
151 |
SF3A2 | interactor | 31 | 0.654 | 23.869 | Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32 PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like Totivirus_coat (PF05518, IPR008871): Totivirus coat protein zf-met (PF12874): Zinc-finger of C2H2 type ARL6IP6 (PF15062, IPR029383): Haemopoietic lineage transmembrane helix SF3A2 (PF16835, IPR031781): Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) |
152 |
SF3B3 | interactor | 56 | 0.429 | 163.073 | CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term |
153 |
SFN | suppressor | 24 | 0.364 | 57.252 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
154 |
SGK2 | interactor | 1 | 0 | 0 | Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain |
155 |
SHC1 | oncoprotein | 15 | 0.462 | 13.296 | PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017, IPR000980, SM00252): SH2 domain |
156 |
SKI | oncoprotein | 13 | 0.530 | 7.164 | c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family SlyX (PF04102, IPR007236): SlyX HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 |
157 |
SKIV2L2 | interactor | 24 | 0.504 | 29.594 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase DSHCT (PF08148, IPR012961, SM01142): DSHCT (NUC185) domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain rRNA_proc-arch (PF13234, IPR025696): rRNA-processing arch domain |
158 |
SMAD3 | oncoprotein | 26 | 0.377 | 68.999 | MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain |
159 |
SMARCA4 | suppressor | 26 | 0.351 | 56.758 | DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) HSA (PF07529, IPR014012, SM00573): HSA QLQ (PF08880, IPR014978, SM00951): QLQ SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain BRK (PF07533, IPR006576, SM00592): BRK domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065) SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex WRNPLPNID (PF15017): Putative WW-binding domain and destruction box |
160 |
SMARCAD1 | interactor | 22 | 0.567 | 15.545 | CUE (PF02845, IPR003892, SM00546): CUE domain Pox_D5 (PF03288, IPR004968): Poxvirus D5 protein-like SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain |
161 |
SMN1 | interactor | 25 | 0.428 | 24.259 | SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) |
162 |
SMURF1 | interactor | 30 | 0.401 | 37.104 | C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) |
163 |
SNRPA1 | interactor | 37 | 0.515 | 50.838 | LRR_9 (PF14580): Leucine-rich repeat |
164 |
SNRPD1 | interactor | 48 | 0.429 | 105.575 | API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5) LSM (PF01423, IPR001163): LSM domain |
165 |
SNRPD2 | interactor | 43 | 0.437 | 74.985 | LSM (PF01423, IPR001163): LSM domain |
166 |
SNW1 | protein found in more fusions | 69 | 0.361 | 437.883 | SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain |
167 |
SP1 | protein found in more fusions | 21 | 0.532 | 24.645 | zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Miga (PF10265, IPR019392): Mitoguardin zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 |
168 |
SPRTN | interactor | 7 | 0.857 | 0.197 | GreA_GreB (PF01272, IPR001437): Transcription elongation factor, GreA/GreB, C-term SprT-like (PF10263, IPR006640, SM00731): SprT-like family PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein |
169 |
SRP14 | interactor | 22 | 0.494 | 33.413 | SRP14 (PF02290, IPR003210): Signal recognition particle 14kD protein |
170 |
SRPK1 | interactor | 26 | 0.480 | 40.317 | FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) Pkinase (PF00069, IPR000719): Protein kinase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1 |
171 |
SRRM1 | interactor | 24 | 0.685 | 11.608 | DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP) Hepatitis_core (PF00906, IPR002006): Hepatitis core antigen MAP65_ASE1 (PF03999, IPR007145): Microtubule associated protein (MAP65/ASE1 family) PWI (PF01480, IPR002483, SM00311): PWI domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein |
172 |
SRRM2 | interactor | 50 | 0.469 | 156.662 | cwf21 (PF08312, IPR013170, SM01115): cwf21 domain DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Pap_E4 (PF02711, IPR003861): E4 protein RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4 DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614) |
173 |
SRSF1 | protein found in more fusions | 60 | 0.435 | 216.922 | Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 |
174 |
STAU1 | protein found in more fusions | 46 | 0.494 | 75.303 | dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Staufen_C (PF16482, IPR032478): Staufen C-terminal domain |
175 |
STK24 | interactor | 7 | 0.400 | 1.657 | DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241) Pkinase (PF00069, IPR000719): Protein kinase domain |
176 |
SUZ12 | suppressor | 39 | 0.380 | 87.336 | DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070) VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein |
177 |
SYN1 | protein found in more fusions | 6 | 0.400 | 3.241 | Synapsin_C (PF02750, IPR020898): Synapsin, ATP binding domain Synapsin_N (PF10581, IPR019736): Synapsin N-terminal DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076) Synapsin (PF02078, IPR020897): Synapsin, N-terminal domain |
178 |
SYNCRIP | interactor | 68 | 0.397 | 266.976 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1 |
179 |
TADA2A | interactor | 16 | 0.500 | 8.921 | SWIRM (PF04433, IPR007526): SWIRM domain Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain |
180 |
TARDBP | interactor | 62 | 0.398 | 237.846 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
181 |
TBP | interactor | 14 | 0.641 | 8.454 | TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP) EPL1 (PF10513, IPR019542): Enhancer of polycomb-like Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal |
182 |
TCEA1 | oncoprotein | 10 | 0.444 | 7.667 | Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain TFIIS_C (PF01096, IPR001222): Transcription factor S-II (TFIIS) TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain |
183 |
THRAP3 | oncoprotein | 29 | 0.431 | 49.721 | API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5) FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal DUF4228 (PF14009, IPR025322): Domain of unknown function (DUF4228) THRAP3_BCLAF1 (PF15440, IPR029199): THRAP3/BCLAF1 family |
184 |
TNK1 | suppressor | 6 | 0.700 | 0.773 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH3_9 (PF14604, IPR001452): Variant SH3 domain HOIP-UBA (PF16678, IPR032065): UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase |
185 |
TNNT1 | protein found in more fusions | 4 | 1.000 | 0 | Troponin (PF00992, IPR001978): Troponin DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050) |
186 |
TP53 | suppressor | 62 | 0.249 | 526.443 | DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif |
187 |
TRMT6 | interactor | 9 | 0.667 | 3.937 | Gcd10p (PF04189, IPR007316): Gcd10p family Presenilin (PF01080, IPR001108): Presenilin INTS5_C (PF14838, IPR029444): Integrator complex subunit 5 C-terminus |
188 |
TUBGCP3 | interactor | 12 | 0.636 | 2.543 | Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family |
189 |
TYK2 | interactor | 7 | 0.800 | 0.515 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase |
190 |
U2AF1 | oncoprotein | 41 | 0.533 | 62.024 | DUF1509 (PF07420, IPR010883): Protein of unknown function (DUF1509) KMP11 (PF03037, IPR004132): Kinetoplastid membrane protein 11 RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) |
191 |
U2AF2 | protein found in more fusions | 69 | 0.424 | 235.929 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein |
192 |
UBE2I | interactor | 30 | 0.409 | 63.337 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
193 |
UNK | interactor | 20 | 0.347 | 23.726 | MbeD_MobD (PF04899, IPR006983): MbeD/MobD like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger Torus (PF16131, IPR032297): Torus domain |
194 |
UPF1 | interactor | 31 | 0.510 | 41.615 | UPF1_Zn_bind (PF09416, IPR018999): RNA helicase (UPF2 interacting domain) AAA_11 (PF13086): AAA domain AAA_12 (PF13087): AAA domain |
195 |
VCAM1 | interactor | 41 | 0.372 | 92.734 | C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain |
196 |
VHL | suppressor | 30 | 0.448 | 59.279 | Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein VHL_C (PF17211): VHL box domain |
197 |
VTN | interactor | 16 | 0.817 | 1.400 | Hemopexin (PF00045, IPR018487, SM00120): Hemopexin Somatomedin_B (PF01033, IPR001212, SM00201): Somatomedin B domain |
198 |
WBP11 | interactor | 8 | 0.643 | 1.181 | BUD22 (PF09073, IPR015158): BUD22 Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region SspB (PF04386, IPR007481): Stringent starvation protein B Wbp11 (PF09429, IPR019007): WW domain binding protein 11 ABC_trans_N (PF14510, IPR029481): ABC-transporter extracellular N-terminal |
199 |
WDR4 | interactor | 6 | 0.400 | 5.319 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat |
200 |
XPO1 | interactor | 57 | 0.221 | 496.851 | CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region |
201 |
XRCC4 | interactor | 6 | 0.500 | 1.917 | XRCC4 (PF06632, IPR010585): DNA double-strand break repair and V(D)J recombination protein XRCC4 |
202 |
YY1 | protein found in more fusions | 17 | 0.567 | 11.610 | zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail |
203 |
ZWINT | interactor | 8 | 0.762 | 1.017 | Zwint (PF15556, IPR029092): ZW10 interactor |