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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins DDX18, DKC1 (from a repository: Tue Jul 30 17:41:57 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)158
The number (and %) of the onco-proteins29 (18.35 %)
The number (and %) of the tumor suppressors15 (9.49 %)
Total number of binary PPIs (saturation %)2357 (19.00 %)
The number (and %) of affected PPIs195 (8.27 %)
The number of possible different fusions22
PPI diameter3
PPI radius2
The average degree of PPI29.367
Assortativity coefficient-0.0484
The network average Clustering coefficient0.437
The number (and %) of a zero Clustering coefficients4 (2.53 %)
The number (and %) of a zero Betweenness Centrality2 (1.27 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: DDX18,DKC1 All fusions
Proteins found in more fusions EEF1G (see 1 fusions); RUVBL1 (see 1 fusions); CUL1 (see 3 fusions); DDX5 (see 1 fusions); SUZ12 (see 2 fusions); APP (see 5 fusions); RPL27/RPS6 (see 1 fusions); HNRNPD (see 1 fusions); SHQ1 (see 4 fusions); DKC1 (see 2 fusions); PRPF6 (see 1 fusions); CSNK2A1 (see 2 fusions); NTRK1/RPL7A (see 1 fusions); DDX18/DKC1 (see 1 fusions); CUL7 (see 2 fusions); CUL3 (see 1 fusions); COPS5 (see 1 fusions); UBC (see 7 fusions); PRPF40A (see 2 fusions); SFN (see 1 fusions); RPL5 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DDX18parental protein980.2731853.168DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF4217 (PF13959, IPR025313, SM01178): Domain of unknown function (DUF4217)
2 DKC1parental protein980.1773796.835DKCLD (PF08068, IPR012960, SM01136): DKCLD (NUC011) domain
PUA (PF01472, IPR002478, SM00359): PUA domain
RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5
TruB_N (PF01509, IPR002501): TruB family pseudouridylate synthase (N terminal domain)
TruB_C_2 (PF16198, IPR032819): tRNA pseudouridylate synthase B C-terminal domain
3 ABCE1interactor160.36236.221ABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
4 ABCF2interactor130.42313.724ABC_tran (PF00005, IPR003439): ABC transporter
VIT1 (PF01988, IPR008217): VIT family
Rop (PF01815, IPR000769): Rop protein
ABC_tran_Xtn (PF12848, IPR032781): ABC transporter
AAA_21 (PF13304, IPR003959): AAA domain, putative AbiEii toxin, Type IV TA system
5 APPprotein found in more fusions360.220263.485APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 ARRB1interactor140.42924.592Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
7 ARRB2interactor290.352106.066Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
8 BCCIPinteractor100.6224.720DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
BCIP (PF13862, IPR025602): p21-C-terminal region-binding protein
9 BMI1oncoprotein210.34759.954zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
10 BRIX1interactor390.55776.794Brix (PF04427, IPR007109, SM00879): Brix domain
11 BYSLinteractor190.39232.247Bystin (PF05291, IPR007955): Bystin
MEA1 (PF06910, IPR009685): Male enhanced antigen 1 (MEA1)
12 CAND1interactor700.356439.162Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
13 COPS5protein found in more fusions580.387354.936JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
14 CSNK2A1oncoprotein340.294172.061Pkinase (PF00069, IPR000719): Protein kinase domain
15 CUL1suppressor530.421189.848Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
16 CUL3protein found in more fusions710.330573.779Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
17 CUL7protein found in more fusions590.355244.985ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
18 DAXXoncoprotein110.33316.295Daxx (PF03344, IPR005012): Daxx N-terminal Rassf1C-interacting domain
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Nop14 (PF04147, IPR007276): Nop14-like family
RF-1 (PF00472, IPR000352): RF-1 domain
Vpu (PF00558, IPR008187): Vpu protein
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
19 DCAF13interactor170.50730.557eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
Sof1 (PF04158, IPR007287): Sof1-like domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
20 DCAF4interactor200.214WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
DUF4221 (PF13970, IPR025316): Domain of unknown function (DUF4221)
21 DDX24interactor570.392380.431DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Sec62 (PF03839, IPR004728): Translocation protein Sec62
Tti2 (PF10521, IPR018870): Tti2 family
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
22 DDX27interactor370.45990.428Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
23 DDX31interactor150.47612.870DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Strep_SA_rep (PF06696, IPR009578): Streptococcal surface antigen repeat
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF4217 (PF13959, IPR025313, SM01178): Domain of unknown function (DUF4217)
24 DDX47interactor170.52211.990DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
25 DDX5oncoprotein300.44646.952DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
P68HR (PF08061, IPR012587): P68HR (NUC004) repeat
ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
26 DDX55interactor120.5766.645DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF4217 (PF13959, IPR025313, SM01178): Domain of unknown function (DUF4217)
MCM3AP_GANP (PF16769, IPR031907): MCM3AP domain of GANP
27 DDX56interactor400.50673.316DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
28 DHX15interactor380.417121.403DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
AAA_29 (PF13555): P-loop containing region of AAA domain
29 DIMT1interactor100.4449.383RrnaAD (PF00398, IPR001737, SM00650): Ribosomal RNA adenine dimethylase
30 DPF2interactor60.4004.425PHD (PF00628, IPR019787, SM00249): PHD-finger
zf-C2H2_4 (PF13894): C2H2-type zinc finger
Requiem_N (PF14051, IPR025750): N-terminal domain of DPF2/REQ.
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
Zf_RING (PF16744, IPR031946): KIAA1045 RING finger
31 EBNA1BP2interactor500.479139.365Ebp2 (PF05890, IPR008610): Eukaryotic rRNA processing protein EBP2
32 EEDsuppressor600.317337.977WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
33 EEF1Gprotein found in more fusions150.5714.883EF1G (PF00647, IPR001662): Elongation factor 1 gamma, conserved domain
GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain
SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
34 EIF3Fsuppressor120.43913.051JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
35 EIF5Binteractor160.35851.824GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
MIase (PF02426, IPR026029): Muconolactone delta-isomerase
NOA36 (PF06524, IPR010531): NOA36 protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
IF-2 (PF11987, IPR023115): Translation-initiation factor 2
DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807)
GTP_EFTU_D4 (PF14578, IPR029459): Elongation factor Tu domain 4
DUF4632 (PF15451, IPR027952): Domain of unknown function (DUF4632)
Coilin_N (PF15862, IPR031722): Coilin N-terminus
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
36 ELAVL1oncoprotein310.214218.917RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
37 ENDOGinteractor100Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
38 EPB41L3suppressor100.40013.1544_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD)
FA (PF08736, IPR014847): FERM adjacent (FA)
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
SAB (PF04382, IPR007477): SAB domain
39 ERGoncoprotein110.3648.319Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
40 ESF1interactor100.5783.756Agouti (PF05039, IPR007733, SM00792): Agouti protein
CDC45 (PF02724, IPR003874): CDC45-like protein
Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region
NOA36 (PF06524, IPR010531): NOA36 protein
NUC153 (PF08159, IPR012580): NUC153 domain
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
41 ESR1suppressor480.403163.401Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
42 FBLinteractor680.387423.495Fibrillarin (PF01269, IPR000692): Fibrillarin
43 FBXO6interactor260.29589.923FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
44 FBXW11interactor190.35923.171WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
45 FN1oncoprotein480.348289.212fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
46 FTSJ3interactor500.460168.962DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
FtsJ (PF01728, IPR002877): FtsJ-like methyltransferase
M16C_assoc (PF08367, IPR013578): Peptidase M16C associated
Orthopox_F8 (PF05886, IPR008726): Orthopoxvirus F8 protein
Spb1_C (PF07780, IPR012920): Spb1 C-terminal domain
DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381)
RRP14 (PF15459, IPR029188): 60S ribosome biogenesis protein Rrp14
47 GAR1interactor180.281102.186Gar1 (PF04410, IPR007504): Gar1/Naf1 RNA binding region
48 GLYR1interactor160.5179.375AT_hook (PF02178, IPR017956, SM00384): AT hook motif
NAD_binding_2 (PF03446, IPR006115): NAD binding domain of 6-phosphogluconate dehydrogenase
PWWP (PF00855, IPR000313, SM00293): PWWP domain
NAD_binding_11 (PF14833, IPR029154): NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
49 GNL1interactor80.5362.613HbrB (PF08539, IPR013745): HbrB-like
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
50 GNL2interactor210.45220.199DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
NGP1NT (PF08153, IPR012971): NGP1NT (NUC091) domain
SDA1 (PF05285, IPR007949): SDA1
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
51 GNL3interactor410.60749.560GN3L_Grn1 (PF08701, IPR014813): GNL3L/Grn1 putative GTPase
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
FAM176 (PF14851): FAM176 family
52 GRWD1interactor220.33390.744Voldacs (PF03517): Regulator of volume decrease after cellular swelling
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
53 GTPBP4suppressor510.425212.923DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
MRC1 (PF09444, IPR018564): MRC1-like domain
NOG1 (PF06858, IPR010674): Nucleolar GTP-binding protein 1 (NOG1)
NOGCT (PF08155, IPR012973): NOGCT (NUC087) domain
Lip_prot_lig_C (PF10437, IPR019491): Bacterial lipoate protein ligase C-terminus
AAA_16 (PF13191): AAA ATPase domain
54 HDAC11interactor110.43617.654Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
55 HIST1H1Ainteractor230.45137.646Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
56 HNRNPDoncoprotein250.37780.586CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
57 HNRNPRinteractor280.50838.059RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
58 HNRNPUinteractor790.339719.892CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
59 IFI16suppressor490.275302.955HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
60 ILF2interactor530.420234.637DZF (PF07528, IPR006561, SM00572): DZF domain
61 KMT2Einteractor60.6001.093CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PHD (PF00628, IPR019787, SM00249): PHD-finger
SET (PF00856, IPR001214, SM00317): SET domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
DUF4124 (PF13511, IPR025392): Domain of unknown function (DUF4124)
PHD_3 (PF13922, IPR026905): PHD domain of transcriptional enhancer, Asx
DUF4666 (PF15697, IPR031421): Domain of unknown function (DUF4666)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
62 KRR1interactor390.436117.771Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
KH_1 (PF00013, IPR004088, SM00322): KH domain
63 LIN28Ainteractor160.26728.636CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
zf-CCHC (PF00098, IPR001878): Zinc knuckle
zf-CCHC_6 (PF15288): Zinc knuckle
64 LSM2interactor100LSM (PF01423, IPR001163): LSM domain
65 LYPLA2interactor200.491Abhydrolase_2 (PF02230, IPR003140): Phospholipase/Carboxylesterase
66 MAPK6oncoprotein60.2004.647Pkinase (PF00069, IPR000719): Protein kinase domain
67 MOV10interactor300.43473.862AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
68 MPHOSPH10interactor250.52740.614Mpp10 (PF04006, IPR007151): Mpp10 protein
69 MPP1oncoprotein40.5001.745PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
P33MONOX (PF15302, IPR026759): P33 mono-oxygenase
70 NAF1interactor130.33344.484AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
Gar1 (PF04410, IPR007504): Gar1/Naf1 RNA binding region
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
71 NASPinteractor50.5002.406Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
SlyX (PF04102, IPR007236): SlyX
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TraV (PF09676, IPR014118): Type IV conjugative transfer system lipoprotein (TraV)
SHNi-TPR (PF10516, IPR019544): SHNi-TPR
XhlA (PF10779, IPR019715): Haemolysin XhlA
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
72 NAT10interactor320.409120.466DUF1726 (PF08351, IPR013562): Domain of unknown function (DUF1726)
Helicase_RecD (PF05127, IPR007807): Helicase
GNAT_acetyltr_2 (PF13718, IPR000182): GNAT acetyltransferase 2
tRNA_bind_2 (PF13725, IPR027992): Possible tRNA binding domain
73 NEMFinteractor80.5007.001DUF814 (PF05670, IPR008532): Domain of unknown function (DUF814)
FbpA (PF05833, IPR008616): Fibronectin-binding protein A N-terminus (FbpA)
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
PGA2 (PF07543, IPR011431): Protein trafficking PGA2
DUF3441 (PF11923, IPR021846): Domain of unknown function (DUF3441)
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
74 NHP2interactor200.29579.219Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
75 NIFKinteractor480.513108.214RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
hNIFK_binding (PF12196, IPR021043): FHA Ki67 binding domain of hNIFK
76 NIP7interactor130.5917.789UPF0113 (PF03657, IPR005155): Uncharacterised protein family (UPF0113)
77 NMD3interactor70.5712.332DUF1816 (PF08846, IPR014945): Domain of unknown function (DUF1816)
NMD3 (PF04981, IPR007064): NMD3 family
HGTP_anticodon2 (PF12745, IPR024435): Anticodon binding domain of tRNAs
78 NOC2Linteractor400.499113.575CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
Noc2 (PF03715, IPR005343): Noc2p family
CEND1 (PF15677, IPR020162): Cell cycle exit and neuronal differentiation protein 1
79 NOC4Linteractor120.5306.580CBF (PF03914, IPR005612, SM00521): CBF/Mak21 family
80 NOL10interactor110.4735.598NUC153 (PF08159, IPR012580): NUC153 domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
81 NOL12interactor220.46832.979DUF2357 (PF09823, IPR018633): Domain of unknown function (DUF2357)
Nop25 (PF09805, IPR019186): Nucleolar protein 12 (25kDa)
82 NOL6interactor250.55332.893Nrap (PF03813, IPR005554): Nrap protein
83 NOP10interactor130.28227.844Nop10p (PF04135, IPR007264): Nucleolar RNA-binding protein, Nop10p family
84 NOP2interactor640.463266.350BSP_II (PF05432, IPR008412): Bone sialoprotein II (BSP-II)
Methyltr_RsmB-F (PF01189, IPR001678): 16S rRNA methyltransferase RsmB/F
P120R (PF08062, IPR012586): P120R (NUC006) repeat
Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
DUF2477 (PF10631, IPR018904): Protein of unknown function (DUF2477)
FAM176 (PF14851): FAM176 family
Methyltr_RsmF_N (PF17125, IPR031341): N-terminal domain of 16S rRNA methyltransferase RsmF
85 NOP56interactor770.351633.968Cytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region
Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin
NOP5NT (PF08156, IPR012974): NOP5NT (NUC127) domain
RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
86 NOP58interactor600.396370.850Cellulose_synt (PF03552, IPR005150): Cellulose synthase
Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin
NOP5NT (PF08156, IPR012974): NOP5NT (NUC127) domain
Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
87 NSA2oncoprotein250.63718.470Ribosomal_S8e (PF01201, IPR022309): Ribosomal protein S8e
RRP14 (PF15459, IPR029188): 60S ribosome biogenesis protein Rrp14
88 NTRK1oncoprotein710.276752.375I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
89 NXF1interactor350.38993.658NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
90 OBSL1interactor650.305378.375BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
91 PAXIP1interactor160.29253.048BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
SURF6 (PF04935, IPR007019): Surfeit locus protein 6
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
92 PES1interactor500.422192.875Pescadillo_N (PF06732, IPR010613): Pescadillo N-terminus
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
DUF3347 (PF11827, IPR021782): Protein of unknown function (DUF3347)
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
93 POLR1Binteractor130.46218.353RNA_pol_Rpa2_4 (PF06883, IPR009674): RNA polymerase I, Rpa2 specific domain
RNA_pol_Rpb2_1 (PF04563, IPR007644): RNA polymerase beta subunit
RNA_pol_Rpb2_3 (PF04565, IPR007645): RNA polymerase Rpb2, domain 3
RNA_pol_Rpb2_6 (PF00562, IPR007120): RNA polymerase Rpb2, domain 6
RNA_pol_Rpb2_7 (PF04560, IPR007641): RNA polymerase Rpb2, domain 7
94 POLR1Cinteractor250.273140.462RNA_pol_A_bac (PF01000, IPR011262): RNA polymerase Rpb3/RpoA insert domain
95 POLR1Dinteractor60.6002.438RNA_pol_L_2 (PF13656): RNA polymerase Rpb3/Rpb11 dimerisation domain
96 POLR1Einteractor70.3335.033RNA_pol_I_A49 (PF06870, IPR009668): A49-like RNA polymerase I associated factor
97 PRPF40Aprotein found in more fusions240.41945.863FF (PF01846, IPR002713, SM00441): FF domain
MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain
Transformer (PF06495, IPR010519): Fruit fly transformer protein
WW (PF00397, IPR001202, SM00456): WW domain
YqzE (PF14038, IPR025622): YqzE-like protein
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus
SOBP (PF15279, IPR026092): Sine oculis-binding protein
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
98 PRPF6protein found in more fusions100.2785.359PRP1_N (PF06424, IPR010491): PRP1 splicing factor, N-terminal
Suf (PF05843, IPR008847): Suppressor of forked protein (Suf)
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
99 PRR11interactor240.40245.689CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
PRIMA1 (PF16101): Proline-rich membrane anchor 1
100 PTGES3interactor90.32112.802CS (PF04969, IPR007052): CS domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
101 PUM3interactor480.500127.439CPL (PF08144, IPR012959): CPL (NUC119) domain
102 PWP1interactor200.52121.501WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
103 PWP2interactor160.5089.429Utp12 (PF04003, IPR007148): Dip2/Utp12 Family
Utp13 (PF08625, IPR013934): Utp13 specific WD40 associated domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
104 RBM28interactor290.45655.310CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27
DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Nop25 (PF09805, IPR019186): Nucleolar protein 12 (25kDa)
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
Phage_TAC_13 (PF16459, IPR024410): Phage tail assembly chaperone, TAC
105 RNF2interactor650.282490.136zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
106 RPF2interactor330.54553.307Brix (PF04427, IPR007109, SM00879): Brix domain
107 RPL10suppressor650.388497.549Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
108 RPL11suppressor470.593107.116Ribosomal_L5 (PF00281, IPR002132): Ribosomal protein L5
Ribosomal_L5_C (PF00673, IPR002132): ribosomal L5P family C-terminus
109 RPL14interactor530.530150.081KOW (PF00467, IPR005824, SM00739): KOW motif
Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14
UPF0688 (PF15772, IPR031530): UPF0688 family
110 RPL18Ainteractor420.66930.062Ribosomal_L18A (PF01775, IPR023573): Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A
111 RPL23interactor430.60197.171Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
112 RPL27protein found in more fusions330.66729.497Ribosomal_L27e (PF01777, IPR001141): Ribosomal L27e protein family
113 RPL36interactor320.69424.049Ribosomal_L36e (PF01158, IPR000509): Ribosomal protein L36e
114 RPL5suppressor560.520174.320Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region
Ribosomal_L5e (PF17144): Ribosomal large subunit proteins 60S L5, and 50S L18
115 RPL7Aprotein found in more fusions390.59858.167Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
116 RPL8interactor490.56490.351Ribosomal_L2 (PF00181, IPR022666): Ribosomal Proteins L2, RNA binding domain
Ribosomal_L2_C (PF03947, IPR022669): Ribosomal Proteins L2, C-terminal domain
117 RPL9interactor400.66040.785Ribosomal_L6 (PF00347, IPR020040): Ribosomal protein L6
118 RPLP0P6interactor240.77910.337NA
119 RPS15Ainteractor410.63266.279Ribosomal_S8 (PF00410, IPR000630): Ribosomal protein S8
120 RPS2interactor480.55798.864Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain
Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
121 RPS4Xinteractor520.555111.347KOW (PF00467, IPR005824, SM00739): KOW motif
Ribosomal_S4e (PF00900, IPR013845): Ribosomal family S4e
RS4NT (PF08071, IPR013843): RS4NT (NUC023) domain
S4 (PF01479, IPR002942, SM00363): S4 domain
40S_S4_C (PF16121, IPR032277): 40S ribosomal protein S4 C-terminus
122 RPS6protein found in more fusions470.59892.569Ribosomal_S6e (PF01092, IPR001377): Ribosomal protein S6e
DUF4574 (PF15141, IPR027896): Domain of unknown function (DUF4574)
123 RPS7interactor460.57394.655Ribosomal_S7e (PF01251, IPR000554): Ribosomal protein S7e
124 RPS8interactor550.499185.950Ribosomal_S8e (PF01201, IPR022309): Ribosomal protein S8e
125 RPSAinteractor400.55195.753Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2
40S_SA_C (PF16122, IPR032281): 40S ribosomal protein SA C-terminus
126 RRP15interactor150.6194.835Rrp15p (PF07890, IPR012459): Rrp15p
127 RRS1interactor390.506110.844GRP (PF07172, IPR010800): Glycine rich protein family
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
RRS1 (PF04939, IPR007023): Ribosome biogenesis regulatory protein (RRS1)
128 RUVBL1oncoprotein220.41965.214TIP49 (PF06068, IPR010339): TIP49 C-terminus
129 RUVBL2oncoprotein280.413108.034TIP49 (PF06068, IPR010339): TIP49 C-terminus
130 SCARNA22interactor190.35733.196NA
131 SFNsuppressor190.51614.89714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
132 SHMT2interactor170.44128.767SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
133 SHQ1suppressor70.4673.698SHQ1 (PF04925, IPR007009): SHQ1 protein
134 SIRT7interactor710.271623.254DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
135 SNU13interactor390.49193.798Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
136 SRP14interactor180.49716.987SRP14 (PF02290, IPR003210): Signal recognition particle 14kD protein
137 SRSF3oncoprotein240.52225.836DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
138 SSR1interactor80.4296.983TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
139 SURF2interactor70.6670.984SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
140 SUZ12suppressor260.43044.152DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
141 SYNCRIPinteractor350.44287.167RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
142 TBL3interactor280.57947.577SdiA-regulated (PF06977, IPR009722): SdiA-regulated
Utp13 (PF08625, IPR013934): Utp13 specific WD40 associated domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_like (PF17005, IPR031544): WD40-like domain
143 TERCinteractor60.6002.733NA
144 TERF2interactor100.30612.943Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif
145 TERToncoprotein70.3818.907RVT_1 (PF00078, IPR000477): Reverse transcriptase (RNA-dependent DNA polymerase)
Telomerase_RBD (PF12009, IPR021891, SM00975): Telomerase ribonucleoprotein complex - RNA binding domain
146 TSR1interactor250.42084.285AARP2CN (PF08142, IPR012948, SM00785): AARP2CN (NUC121) domain
RIBIOP_C (PF04950, IPR007034): 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal
NUSAP (PF16006, IPR026756): Nucleolar and spindle-associated protein
147 UBCprotein found in more fusions330.415120.294ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
148 UQCRC2oncoprotein60.4673.051Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
149 UTP14Ainteractor290.45673.531Utp14 (PF04615, IPR006709): Utp14 protein
150 UTP20interactor130.5906.321BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DRIM (PF07539, IPR011430): Down-regulated in metastasis
151 WDR3interactor130.7053.359YbaB_DNA_bd (PF02575, IPR004401): YbaB/EbfC DNA-binding family
Nucleoporin_N (PF08801, IPR014908): Nup133 N terminal like
Utp12 (PF04003, IPR007148): Dip2/Utp12 Family
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_like (PF17005, IPR031544): WD40-like domain
152 WDR36interactor320.45098.722Utp21 (PF04192, IPR007319): Utp21 specific WD40 associated putative domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_like (PF17005, IPR031544): WD40-like domain
153 WDR48suppressor110.40019.236WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF3337 (PF11816, IPR021772): Domain of unknown function (DUF3337)
154 WRAP53oncoprotein40.3332.277WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
155 WWOXsuppressor90.4445.085adh_short (PF00106, IPR002198): short chain dehydrogenase
WW (PF00397, IPR001202, SM00456): WW domain
156 XPO1interactor410.321255.430CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
157 ZBTB38interactor50.4002.863BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_7 (PF15269): Zinc-finger
zf-C2H2_8 (PF15909, IPR031799): C2H2-type zinc ribbon
158 ZC3H3interactor190.40432.583zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
CCDC24 (PF15669, IPR031367): Coiled-coil domain-containing protein 24 family

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