1 |
DDB1 | parental protein | 241 | 0.060 | 35209.222 | CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term |
2 |
ABL1 | oncoprotein | 17 | 0.383 | 32.750 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2 |
3 |
ACAT1 | interactor | 12 | 0.491 | 9.018 | Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain |
4 |
ACTR5 | interactor | 3 | 0.667 | 1.000 | Actin (PF00022, IPR004000, SM00268): Actin DUF1542 (PF07564, IPR011439): Domain of Unknown Function (DUF1542) UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449 |
5 |
AHR | suppressor | 6 | 0.700 | 1.134 | HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold PAS_4 (PF08448, IPR013656): PAS fold |
6 |
ALB | interactor | 3 | 0.667 | 0.333 | Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family |
7 |
AMBRA1 | interactor | 15 | 0.419 | 30.535 | Acyl_CoA_thio (PF02551, IPR025652): Acyl-CoA thioesterase eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Spt20 (PF12090, IPR021950): Spt20 family ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
8 |
APEX1 | interactor | 16 | 0.383 | 34.924 | Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family |
9 |
ARID4B | interactor | 10 | 0.889 | 1.344 | ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain CDC45 (PF02724, IPR003874): CDC45-like protein DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755) E7 (PF00527, IPR000148): E7 protein, Early protein NOA36 (PF06524, IPR010531): NOA36 protein PWWP (PF00855, IPR000313, SM00293): PWWP domain RBB1NT (PF08169, IPR012603): RBB1NT (NUC162) domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain WRNPLPNID (PF15017): Putative WW-binding domain and destruction box |
10 |
ASB4 | interactor | 4 | 1.000 | 0 | Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies) SOCS_box (PF07525, IPR001496): SOCS box |
11 |
ATP6V1F | interactor | 6 | 0.467 | 5.400 | ATP-synt_F (PF01990, IPR008218): ATP synthase (F/14-kDa) subunit |
12 |
AURKA | oncoprotein | 18 | 0.294 | 53.082 | Pkinase (PF00069, IPR000719): Protein kinase domain MTBP_C (PF14920, IPR029418): MDM2-binding |
13 |
AURKB | interactor | 19 | 0.327 | 43.105 | Pkinase (PF00069, IPR000719): Protein kinase domain |
14 |
BANF1 | interactor | 12 | 0.509 | 11.464 | BAF (PF02961, IPR004122, SM01023): Barrier to autointegration factor |
15 |
BCOR | oncoprotein | 8 | 0.429 | 7.098 | Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) BCOR (PF15808, IPR031628): BCL-6 co-repressor, non-ankyrin-repeat region PUFD (PF16553, IPR032365): BCORL-PCGF1-binding domain |
16 |
BECN1 | suppressor | 6 | 0.800 | 0.800 | APG6 (PF04111, IPR007243): Autophagy protein Apg6 Ima1_N (PF09779, IPR018617): Ima1 N-terminal domain BH3 (PF15285, IPR029318): Beclin-1 BH3 domain, Bcl-2-interacting |
17 |
BRCA1 | suppressor | 46 | 0.176 | 520.157 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT |
18 |
BRWD1 | interactor | 5 | 0.900 | 0.167 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex |
19 |
BTRC | oncoprotein | 26 | 0.370 | 83.280 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like |
20 |
CAMKK1 | interactor | 1 | 0 | 0 | Pkinase (PF00069, IPR000719): Protein kinase domain |
21 |
CAND1 | interactor | 35 | 0.335 | 148.977 | Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II |
22 |
CDC5L | interactor | 36 | 0.225 | 239.637 | OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain |
23 |
CDKN1A | suppressor | 22 | 0.346 | 56.285 | CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor |
24 |
CDKN1B | suppressor | 16 | 0.433 | 29.101 | CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor Multi-haem_cyto (PF13447): Seven times multi-haem cytochrome CxxCH |
25 |
CDT1 | oncoprotein | 14 | 0.484 | 14.938 | CDT1 (PF08839, IPR014939, SM01075): DNA replication factor CDT1 like CDT1_C (PF16679, IPR032054): DNA replication factor Cdt1 C-terminal domain |
26 |
CENPA | interactor | 10 | 0.417 | 8.450 | Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 |
27 |
CEP250 | interactor | 13 | 0.295 | 26.381 | ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1 DivIC (PF04977, IPR007060): Septum formation initiator DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) EHN (PF06441, IPR010497): Epoxide hydrolase N terminus ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family IncA (PF04156, IPR007285): IncA protein Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain SlyX (PF04102, IPR007236): SlyX Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal TSC22 (PF01166, IPR000580): TSC-22/dip/bun family CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Endonuc_Holl (PF10107, IPR019287): Endonuclease related to archaeal Holliday junction resolvase DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570) DGF-1_C (PF11040, IPR021053): Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 |
28 |
CEP57 | interactor | 5 | 0.400 | 2.436 | Cep57_MT_bd (PF06657, IPR024957): Centrosome microtubule-binding domain of Cep57 Tup_N (PF08581, IPR013890): Tup N-terminal CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57 TRIQK (PF15168, IPR024842): Triple QxxK/R motif-containing protein family |
29 |
CEP72 | interactor | 3 | 0.667 | 0.667 | LRR_9 (PF14580): Leucine-rich repeat FAM76 (PF16046, IPR032017): FAM76 protein |
30 |
CGGBP1 | interactor | 3 | 1.000 | 0 | AKAP95 (PF04988, IPR007071): A-kinase anchoring protein 95 (AKAP95) Mei5 (PF10376, IPR018468): Double-strand recombination repair protein |
31 |
CHEK1 | suppressor | 13 | 0.500 | 12.837 | Pkinase (PF00069, IPR000719): Protein kinase domain |
32 |
CLCN1 | interactor | 4 | 1.000 | 0 | CBS (PF00571, IPR000644, SM00116): CBS domain Voltage_CLC (PF00654, IPR001807): Voltage gated chloride channel |
33 |
CLIC1 | interactor | 6 | 0.533 | 2.952 | GST_N_2 (PF13409, IPR004045): Glutathione S-transferase, N-terminal domain GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain |
34 |
CLIC4 | oncoprotein | 4 | 0.833 | 0.667 | GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain |
35 |
CMAS | interactor | 3 | 0.667 | 0.222 | CTP_transf_3 (PF02348, IPR003329): Cytidylyltransferase Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase |
36 |
CNOT2 | interactor | 3 | 0.667 | 1.000 | NOT2_3_5 (PF04153, IPR007282): NOT2 / NOT3 / NOT5 family |
37 |
COPS2 | suppressor | 30 | 0.533 | 68.281 | YozE_SAM_like (PF06855, IPR023089): YozE SAM-like fold TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat DUF2087 (PF09860, IPR018656): Uncharacterized protein conserved in bacteria (DUF2087) PCI (PF01399, IPR000717, SM00088): PCI domain TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat |
38 |
COPS3 | interactor | 34 | 0.535 | 69.892 | RasGEF (PF00617, IPR001895, SM00147): RasGEF domain TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat PCI (PF01399, IPR000717, SM00088): PCI domain |
39 |
COPS4 | interactor | 35 | 0.534 | 77.242 | DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) PCI (PF01399, IPR000717, SM00088): PCI domain TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_14 (PF13428): Tetratricopeptide repeat |
40 |
COPS5 | protein found in more fusions | 63 | 0.269 | 617.468 | JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease |
41 |
COPS6 | interactor | 50 | 0.341 | 288.913 | DUF320 (PF03777, IPR005528): Small secreted domain (DUF320) JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function |
42 |
COPS7A | interactor | 29 | 0.626 | 54.754 | PCI (PF01399, IPR000717, SM00088): PCI domain |
43 |
COPS7B | interactor | 21 | 0.867 | 3.833 | PCI (PF01399, IPR000717, SM00088): PCI domain |
44 |
COPS8 | interactor | 25 | 0.721 | 22.307 | CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family |
45 |
CORO1B | interactor | 8 | 0.250 | 19.667 | DUF1899 (PF08953, IPR015048, SM01166): Domain of unknown function (DUF1899) Trimer_CC (PF08954, IPR015049, SM01167): Trimerisation motif WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain WD40_4 (PF16300): Type of WD40 repeat |
46 |
CRBN | interactor | 13 | 0.538 | 17.733 | LON_substr_bdg (PF02190, IPR003111, SM00464): ATP-dependent protease La (LON) substrate-binding domain Yippee-Mis18 (PF03226, IPR004910): Yippee zinc-binding/DNA-binding /Mis18, centromere assembly |
47 |
CRY2 | protein found in more fusions | 10 | 0.417 | 5.767 | DNA_photolyase (PF00875, IPR006050): DNA photolyase FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase |
48 |
CSTF2 | interactor | 6 | 0.800 | 0.582 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C (PF14304, IPR026896): Transcription termination and cleavage factor C-terminal CSTF2_hinge (PF14327, IPR025742): Hinge domain of cleavage stimulation factor subunit 2 |
49 |
CTNNB1 | oncoprotein | 28 | 0.233 | 139.884 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat |
50 |
CUL1 | suppressor | 64 | 0.237 | 668.945 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
51 |
CUL3 | protein found in more fusions | 57 | 0.261 | 534.713 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal |
52 |
CUL4A | protein found in more fusions | 102 | 0.139 | 2745.674 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
53 |
CUL4B | oncoprotein | 71 | 0.222 | 1008.074 | Cullin (PF00888, IPR001373, SM00182): Cullin family EBP50_C (PF09007, IPR015098): EBP50, C-terminal Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain MDFI (PF15316, IPR026134): MyoD family inhibitor |
54 |
CUL5 | suppressor | 40 | 0.418 | 173.077 | Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain |
55 |
CUL7 | protein found in more fusions | 38 | 0.210 | 274.490 | ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7 |
56 |
DCAF1 | protein found in more fusions | 51 | 0.212 | 651.537 | DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) LisH (PF08513, IPR013720, SM00667): LisH ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated |
57 |
DCAF10 | interactor | 7 | 0.762 | 3.667 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
58 |
DCAF11 | interactor | 15 | 0.819 | 6.947 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
59 |
DCAF12 | interactor | 5 | 1.000 | 0 | ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain WD40_like (PF17005, IPR031544): WD40-like domain |
60 |
DCAF13 | interactor | 3 | 0.667 | 0.118 | eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A Sof1 (PF04158, IPR007287): Sof1-like domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
61 |
DCAF15 | interactor | 4 | 0.667 | 1.167 | DCAF15_WD40 (PF14939, IPR032734): DDB1-and CUL4-substrate receptor 15, WD repeat |
62 |
DCAF16 | interactor | 6 | 1.000 | 0 | DCA16 (PF15349, IPR028216): DDB1- and CUL4-associated factor 16 |
63 |
DCAF17 | interactor | 5 | 1.000 | 0 | DCAF17 (PF15802, IPR031620): DDB1- and CUL4-associated factor 17 |
64 |
DCAF4 | interactor | 8 | 1.000 | 0 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain DUF4221 (PF13970, IPR025316): Domain of unknown function (DUF4221) |
65 |
DCAF5 | interactor | 6 | 0.533 | 3.054 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat DUF2634 (PF10934, IPR020288): Protein of unknown function (DUF2634) IMUP (PF15761, IPR026621): Immortalisation up-regulated protein |
66 |
DCAF6 | interactor | 7 | 0.800 | 0.639 | Herpes_pp85 (PF04637, IPR006731): Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408) ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain ATAD4 (PF15321, IPR028237): ATPase family AAA domain containing 4 MRI (PF15325, IPR028278): Modulator of retrovirus infection WD40_like (PF17005, IPR031544): WD40-like domain |
67 |
DCAF7 | interactor | 10 | 0.311 | 20.367 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat |
68 |
DCAF8 | interactor | 13 | 0.782 | 4.383 | DUF1635 (PF07795, IPR012862): Protein of unknown function (DUF1635) WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain DUF4661 (PF15576, IPR029073): Domain of unknown function (DUF4661) |
69 |
DCLRE1C | interactor | 5 | 0.500 | 1.208 | DRMBL (PF07522, IPR011084): DNA repair metallo-beta-lactamase DUF3290 (PF11694, IPR021707): Protein of unknown function (DUF3290) Lactamase_B_2 (PF12706, IPR001279): Beta-lactamase superfamily domain |
70 |
DCUN1D1 | interactor | 26 | 0.628 | 36.698 | Cullin_binding (PF03556, IPR005176): Cullin binding UBA_4 (PF14555): UBA-like domain |
71 |
DCUN1D5 | interactor | 8 | 0.964 | 0.057 | Cullin_binding (PF03556, IPR005176): Cullin binding |
72 |
DDA1 | interactor | 34 | 0.367 | 150.143 | DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase |
73 |
DDB2 | suppressor | 29 | 0.437 | 112.088 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat |
74 |
DDIT4 | interactor | 4 | 0.667 | 0.383 | RTP801_C (PF07809, IPR012918): RTP801 C-terminal region |
75 |
DET1 | interactor | 8 | 0.857 | 0.839 | Det1 (PF09737, IPR019138): De-etiolated protein 1 Det1 |
76 |
DLC1 | suppressor | 5 | 1.000 | 0 | RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) START (PF01852, IPR002913, SM00234): START domain DUF4561 (PF15120, IPR027818): Domain of unknown function (DUF4561) |
77 |
DPPA4 | interactor | 11 | 0.489 | 9.773 | Ribosomal_L40e (PF01020, IPR001975): Ribosomal L40e family DCR (PF14047, IPR025891): Dppa2/4 conserved region Dppa2_A (PF14049, IPR025892): Dppa2/4 conserved region in higher vertebrates |
78 |
DTL | interactor | 20 | 0.479 | 38.439 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat |
79 |
DYRK1B | oncoprotein | 6 | 0.400 | 3.033 | Pkinase (PF00069, IPR000719): Protein kinase domain |
80 |
DYRK2 | interactor | 10 | 0.356 | 18.809 | Pkinase (PF00069, IPR000719): Protein kinase domain |
81 |
E2F1 | suppressor | 17 | 0.412 | 32.787 | Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain |
82 |
EED | suppressor | 35 | 0.198 | 245.012 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
83 |
EP300 | oncoprotein | 43 | 0.197 | 401.918 | Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type |
84 |
EPB41L3 | suppressor | 8 | 0.429 | 6.850 | 4_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD) FA (PF08736, IPR014847): FERM adjacent (FA) FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 SAB (PF04382, IPR007477): SAB domain |
85 |
ERCC6 | oncoprotein | 19 | 0.474 | 24.891 | Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain |
86 |
ERCC8 | oncoprotein | 29 | 0.433 | 119.894 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain DUF4859 (PF16151, IPR032339): Domain of unknown function (DUF4859) |
87 |
EWSR1 | oncoprotein | 40 | 0.283 | 268.992 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head |
88 |
FAF2 | interactor | 14 | 0.423 | 27.694 | DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682) UBX (PF00789, IPR001012, SM00166): UBX domain Thioredoxin_7 (PF13899): Thioredoxin-like UBA_4 (PF14555): UBA-like domain |
89 |
FBXO44 | interactor | 9 | 0.639 | 5.674 | FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like |
90 |
FBXW5 | interactor | 6 | 0.800 | 1.667 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat F-box-like (PF12937, IPR001810): F-box-like |
91 |
FBXW8 | interactor | 11 | 0.655 | 4.885 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like |
92 |
FLNC | interactor | 9 | 0.472 | 6.631 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Filamin (PF00630, IPR017868): Filamin/ABP280 repeat PapC_N (PF13954, IPR025885): PapC N-terminal domain |
93 |
FTSJ3 | interactor | 14 | 0.473 | 15.108 | DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) FtsJ (PF01728, IPR002877): FtsJ-like methyltransferase M16C_assoc (PF08367, IPR013578): Peptidase M16C associated Orthopox_F8 (PF05886, IPR008726): Orthopoxvirus F8 protein Spb1_C (PF07780, IPR012920): Spb1 C-terminal domain DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381) RRP14 (PF15459, IPR029188): 60S ribosome biogenesis protein Rrp14 |
94 |
FZR1 | suppressor | 10 | 0.489 | 10.555 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
95 |
GNB2 | interactor | 9 | 0.472 | 8.755 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat CALM_bind (PF16025): Calcium-dependent calmodulin binding WD40_like (PF17005, IPR031544): WD40-like domain |
96 |
GPN1 | interactor | 9 | 0.500 | 8.912 | ATP_bind_1 (PF03029, IPR004130): Conserved hypothetical ATP binding protein NB-ARC (PF00931, IPR002182): NB-ARC domain |
97 |
GPS1 | interactor | 28 | 0.545 | 57.656 | RPN7 (PF10602, IPR019585): 26S proteasome subunit RPN7 PCI (PF01399, IPR000717, SM00088): PCI domain |
98 |
GRK5 | protein found in more fusions | 16 | 0.410 | 30.003 | Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain |
99 |
GRK6 | interactor | 1 | 0 | 0 | Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain |
100 |
GRWD1 | interactor | 14 | 0.626 | 13.687 | Voldacs (PF03517): Regulator of volume decrease after cellular swelling WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex |
101 |
HDAC1 | suppressor | 39 | 0.262 | 265.733 | FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain |
102 |
HDAC2 | suppressor | 34 | 0.328 | 148.299 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1 |
103 |
HDAC3 | suppressor | 17 | 0.258 | 48.443 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain |
104 |
HDAC5 | protein found in more fusions | 23 | 0.277 | 84.585 | Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4 |
105 |
HDAC8 | interactor | 4 | 0.667 | 1.333 | DNase-RNase (PF02577, IPR003729): Bifunctional nuclease Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain |
106 |
HIST1H1A | interactor | 12 | 0.394 | 18.138 | Mucin (PF01456, IPR000458): Mucin-like glycoprotein Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal |
107 |
HIST1H1C | oncoprotein | 21 | 0.452 | 41.967 | Amelin (PF05111, IPR007798, SM00817): Ameloblastin precursor (Amelin) Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family DUF4349 (PF14257, IPR025645): Domain of unknown function (DUF4349) |
108 |
HIST1H3A | interactor | 29 | 0.233 | 171.101 | Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 |
109 |
HOXB4 | interactor | 3 | 1.000 | 0 | DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106) |
110 |
HOXD3 | interactor | 1 | 0 | 0 | Homeobox (PF00046, IPR001356, SM00389): Homeobox domain DUF4074 (PF13293, IPR025281): Domain of unknown function (DUF4074) |
111 |
HUWE1 | oncoprotein | 35 | 0.225 | 230.390 | BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414) |
112 |
INO80 | interactor | 4 | 0.667 | 2.000 | Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein RNA_pol_Rbc25 (PF08292, IPR013238): RNA polymerase III subunit Rpc25 SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain POTRA (PF07244, IPR010827): Surface antigen variable number repeat Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DBINO (PF13892, IPR020838): DNA-binding domain FAM176 (PF14851): FAM176 family MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 |
113 |
INVS | interactor | 2 | 1.000 | 0 | IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) |
114 |
IP6K1 | interactor | 5 | 0.900 | 0.095 | IPK (PF03770, IPR005522): Inositol polyphosphate kinase SIN1 (PF05422, IPR008828): Stress-activated map kinase interacting protein 1 (SIN1) |
115 |
KAT2A | interactor | 13 | 0.424 | 17.816 | Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain NICE-1 (PF15845, IPR031698): Cysteine-rich C-terminal 1 family |
116 |
KATNA1 | interactor | 5 | 0.800 | 0.750 | AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) ABC_tran (PF00005, IPR003439): ABC transporter Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat AAA_22 (PF13401, IPR003593): AAA domain |
117 |
KCND3 | interactor | 2 | 1.000 | 0 | Ion_trans (PF00520, IPR005821): Ion transport protein BTB_2 (PF02214, IPR003131): BTB/POZ domain Shal-type (PF11601, IPR021645): Shal-type voltage-gated potassium channels, N-terminal DUF3399 (PF11879, IPR024587): Domain of unknown function (DUF3399) |
118 |
KMT5A | interactor | 7 | 0.571 | 3.415 | ATP-synt_Eps (PF04627, IPR006721): Mitochondrial ATP synthase epsilon chain ERp29 (PF07749, IPR011679): Endoplasmic reticulum protein ERp29, C-terminal domain SET (PF00856, IPR001214, SM00317): SET domain |
119 |
LASP1 | oncoprotein | 3 | 0.667 | 0.286 | LIM (PF00412, IPR001781, SM00132): LIM domain Nebulin (PF00880, IPR000900, SM00227): Nebulin repeat SH3_9 (PF14604, IPR001452): Variant SH3 domain |
120 |
LMO4 | interactor | 5 | 0.800 | 0.354 | LIM (PF00412, IPR001781, SM00132): LIM domain zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger |
121 |
LRWD1 | interactor | 7 | 0.667 | 1.343 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat |
122 |
LSM2 | interactor | 2 | 1.000 | 0 | LSM (PF01423, IPR001163): LSM domain |
123 |
MAFB | oncoprotein | 3 | 1.000 | 0 | bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor Maf_N (PF08383, IPR013592): Maf N-terminal region |
124 |
MBD3 | interactor | 15 | 0.319 | 42.956 | DUF2201_N (PF13203, IPR025154): Putative metallopeptidase domain |
125 |
MCM10 | interactor | 8 | 0.500 | 7.185 | Mcm10 (PF09332, IPR015411): Mcm10 replication factor zf-primase (PF09329, IPR015408): Primase zinc finger AATF-Che1 (PF13339, IPR025160): Apoptosis antagonizing transcription factor |
126 |
MCM5 | oncoprotein | 15 | 0.343 | 27.774 | MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain |
127 |
MDM2 | oncoprotein | 35 | 0.262 | 213.344 | Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
128 |
MEF2A | oncoprotein | 6 | 0.667 | 1.510 | TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat |
129 |
MIB1 | protein found in more fusions | 6 | 0.800 | 0.556 | Ank (PF00023, IPR002110, SM00248): Ankyrin repeat MIB_HERC2 (PF06701, IPR010606): Mib_herc2 ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
130 |
MTOR | oncoprotein | 15 | 0.341 | 36.203 | DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104) EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats TPR_19 (PF14559): Tetratricopeptide repeat |
131 |
MYB | oncoprotein | 9 | 0.361 | 12.862 | Cmyb_C (PF09316, IPR015395): C-myb, C-terminal LMSTEN (PF07988, IPR012642): LMSTEN motif Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain |
132 |
MYC | oncoprotein | 34 | 0.235 | 225.408 | HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region |
133 |
NANOG | interactor | 13 | 0.333 | 19.476 | Homeobox (PF00046, IPR001356, SM00389): Homeobox domain |
134 |
NCOA5 | suppressor | 5 | 0.833 | 0.182 | Macoilin (PF09726, IPR019130): Transmembrane protein |
135 |
NEDD8 | interactor | 31 | 0.522 | 87.640 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
136 |
NF2 | suppressor | 14 | 0.359 | 17.075 | ERM (PF00769, IPR011259): Ezrin/radixin/moesin family FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain |
137 |
NPHP4 | interactor | 2 | 1.000 | 0 | Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein |
138 |
NR1I2 | suppressor | 4 | 0.667 | 1.333 | zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor |
139 |
NR2C2 | suppressor | 9 | 0.536 | 5.927 | Flagellin_N (PF00669, IPR001029): Bacterial flagellin N-terminal helical region zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor |
140 |
NTRK1 | oncoprotein | 64 | 0.158 | 1017.095 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain |
141 |
NUMA1 | oncoprotein | 16 | 0.292 | 35.876 | Colicin (PF01024, IPR000293): Colicin pore forming domain Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32 DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF848 (PF05852, IPR008566): Gammaherpesvirus protein of unknown function (DUF848) Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Tup_N (PF08581, IPR013890): Tup N-terminal CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082) |
142 |
NUP133 | oncoprotein | 9 | 0.389 | 8.330 | Nucleoporin_C (PF03177, IPR007187): Non-repetitive/WGA-negative nucleoporin C-terminal |
143 |
NUP43 | interactor | 7 | 0.476 | 5.715 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat |
144 |
NXF1 | interactor | 45 | 0.152 | 516.364 | NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat |
145 |
OBSL1 | interactor | 30 | 0.234 | 137.169 | BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain |
146 |
PCGF1 | interactor | 12 | 0.436 | 18.172 | zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like |
147 |
PCNA | oncoprotein | 38 | 0.272 | 231.274 | PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain |
148 |
PHIP | oncoprotein | 11 | 0.455 | 9.536 | DTHCT (PF08070, IPR012542): DTHCT (NUC029) region DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) E7 (PF00527, IPR000148): E7 protein, Early protein WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
149 |
PIDD1 | interactor | 2 | 1.000 | 0 | Death (PF00531, IPR000488, SM00005): Death domain ZU5 (PF00791, IPR000906, SM00218): ZU5 domain Peptidase_S68 (PF10461, IPR019502): Peptidase S68 LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat |
150 |
PIN1 | suppressor | 11 | 0.527 | 8.670 | Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain WW (PF00397, IPR001202, SM00456): WW domain |
151 |
PMS2 | oncoprotein | 6 | 0.667 | 1.285 | DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain MORN_2 (PF07661, IPR011652): MORN repeat variant MutL_C (PF08676, IPR014790, SM00853): MutL C terminal dimerisation domain HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase |
152 |
POLR2A | protein found in more fusions | 30 | 0.273 | 135.135 | RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat |
153 |
POLR2J | interactor | 4 | 1.000 | 0 | RNA_pol_L_2 (PF13656): RNA polymerase Rpb3/Rpb11 dimerisation domain |
154 |
POU5F1 | oncoprotein | 20 | 0.234 | 74.452 | Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain |
155 |
PSMA1 | interactor | 15 | 0.385 | 34.163 | Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature |
156 |
PTEN | suppressor | 8 | 0.464 | 6.136 | DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein |
157 |
PTPN14 | oncoprotein | 6 | 0.533 | 1.808 | FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase |
158 |
PUF60 | protein found in more fusions | 18 | 0.397 | 27.301 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Titin_Z (PF09042, IPR015129): Titin Z TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence |
159 |
PWP1 | interactor | 11 | 0.691 | 3.794 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
160 |
PYGO2 | interactor | 10 | 0.528 | 8.339 | PHD (PF00628, IPR019787, SM00249): PHD-finger |
161 |
RAD21 | oncoprotein | 20 | 0.363 | 40.253 | Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein FAM176 (PF14851): FAM176 family WRNPLPNID (PF15017): Putative WW-binding domain and destruction box |
162 |
RAG1 | interactor | 8 | 0.667 | 3.029 | zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-RAG1 (PF10426, IPR019485): Recombination-activating protein 1 zinc-finger domain RAG1_imp_bd (PF12560): RAG1 importin binding RAG1 (PF12940, IPR024627): Recombination-activation protein 1 (RAG1), recombinase |
163 |
RAG2 | interactor | 4 | 0.667 | 0.722 | RAG2 (PF03089, IPR004321): Recombination activating protein 2 RAG2_PHD (PF13341, IPR025162): RAG2 PHD domain |
164 |
RANBP9 | suppressor | 13 | 0.409 | 23.863 | Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator LisH (PF08513, IPR013720, SM00667): LisH SPRY (PF00622, IPR003877, SM00449): SPRY domain CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain |
165 |
RASSF1 | suppressor | 10 | 0.583 | 3.916 | RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain |
166 |
RASSF10 | suppressor | 2 | 1.000 | 0 | DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) FliJ (PF02050, IPR012823): Flagellar FliJ protein Mt_ATP-synt_B (PF05405, IPR008688): Mitochondrial ATP synthase B chain precursor (ATP-synt_B) PAP_RNA-bind (PF04926, IPR007010): Poly(A) polymerase predicted RNA binding domain RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain IMUP (PF15761, IPR026621): Immortalisation up-regulated protein |
167 |
RASSF9 | interactor | 3 | 0.667 | 0.182 | RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain Spore_III_AB (PF09548, IPR014198): Stage III sporulation protein AB (spore_III_AB) DUF3087 (PF11286, IPR021438): Protein of unknown function (DUF3087) |
168 |
RBBP4 | oncoprotein | 33 | 0.269 | 206.156 | eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex |
169 |
RBBP5 | oncoprotein | 13 | 0.394 | 21.258 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457) ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
170 |
RBBP7 | suppressor | 26 | 0.369 | 98.183 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex |
171 |
RBP1 | suppressor | 3 | 1.000 | 0 | Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family |
172 |
RBX1 | oncoprotein | 45 | 0.311 | 290.142 | zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain |
173 |
RECQL | oncoprotein | 6 | 0.467 | 2.200 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Lipoprotein_3 (PF00938, IPR001595): Lipoprotein RQC (PF09382, IPR018982, SM00956): RQC domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2 |
174 |
RFWD2 | suppressor | 24 | 0.696 | 17.285 | Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein IncA (PF04156, IPR007285): IncA protein WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) WD40_like (PF17005, IPR031544): WD40-like domain |
175 |
RGS2 | oncoprotein | 3 | 1.000 | 0 | RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain |
176 |
RICTOR | interactor | 6 | 0.533 | 3.284 | RasGEF_N_2 (PF14663, IPR029453): Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_N (PF14664, IPR028267): Rapamycin-insensitive companion of mTOR, N-term RICTOR_phospho (PF14665, IPR029259): Rapamycin-insensitive companion of mTOR, phosphorylation-site RICTOR_M (PF14666, IPR029451): Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V (PF14668, IPR029452): Rapamycin-insensitive companion of mTOR, domain 5 |
177 |
RORA | interactor | 4 | 0.667 | 0.376 | zf-C3HC (PF07967, IPR012935): C3HC zinc finger-like zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor |
178 |
RPA1 | suppressor | 34 | 0.282 | 189.617 | Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain |
179 |
RPA2 | oncoprotein | 27 | 0.328 | 96.385 | RPA_C (PF08784, IPR014892): Replication protein A C terminal tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2 |
180 |
RPA3 | interactor | 21 | 0.416 | 38.361 | Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3 |
181 |
RPS6KB2 | interactor | 9 | 0.306 | 9.469 | Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain |
182 |
RPS7 | interactor | 23 | 0.308 | 69.559 | Ribosomal_S7e (PF01251, IPR000554): Ribosomal protein S7e |
183 |
RPTOR | protein found in more fusions | 12 | 0.418 | 14.305 | HEAT (PF02985, IPR000357): HEAT repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain HEAT_2 (PF13646): HEAT repeats Raptor_N (PF14538, IPR029347): Raptor N-terminal CASPase like domain |
184 |
RTN4 | suppressor | 9 | 0.500 | 5.535 | CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain Reticulon (PF02453, IPR003388): Reticulon Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein |
185 |
SALL2 | suppressor | 7 | 0.619 | 2.360 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type MPP6 (PF10175, IPR019324): M-phase phosphoprotein 6 zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding Astro_capsid_p (PF12226, IPR022027): Turkey astrovirus capsid protein zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger |
186 |
SAMHD1 | interactor | 10 | 0.833 | 0.942 | HD (PF01966, IPR006674): HD domain SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) |
187 |
SAP130 | interactor | 16 | 0.500 | 27.823 | SAP130_C (PF16014, IPR031963): Histone deacetylase complex subunit SAP130 C-terminus |
188 |
SAP30 | interactor | 12 | 0.682 | 12.085 | Titin_Z (PF09042, IPR015129): Titin Z zf-SAP30 (PF13866, IPR025717): SAP30 zinc-finger SAP30_Sin3_bdg (PF13867, IPR025718): Sin3 binding region of histone deacetylase complex subunit SAP30 |
189 |
SAP30BP | interactor | 10 | 0.311 | 12.843 | Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein HCNGP (PF07818, IPR012479): HCNGP-like protein Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal |
190 |
SF3A3 | interactor | 19 | 0.386 | 40.331 | DUF3449 (PF11931, IPR024598): Domain of unknown function (DUF3449) SF3a60_bindingd (PF12108, IPR021966): Splicing factor SF3a60 binding domain Telomere_Sde2_2 (PF13297): Telomere stability C-terminal PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal SF3A3 (PF16837, IPR031774): Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 |
191 |
SHC1 | oncoprotein | 7 | 0.533 | 3.520 | PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017, IPR000980, SM00252): SH2 domain |
192 |
SIN3A | oncoprotein | 23 | 0.372 | 74.415 | Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein |
193 |
SIRT6 | suppressor | 11 | 0.327 | 18.478 | SIR2 (PF02146, IPR003000): Sir2 family TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain |
194 |
SIRT7 | interactor | 34 | 0.207 | 224.053 | DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family |
195 |
SKP2 | suppressor | 25 | 0.353 | 92.635 | LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRR_2 (PF07723, IPR013101): Leucine Rich Repeat LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) F-box-like (PF12937, IPR001810): F-box-like LRR_6 (PF13516, IPR001611): Leucine Rich repeat LRR_8 (PF13855, IPR001611): Leucine rich repeat |
196 |
SLX4 | suppressor | 7 | 0.476 | 5.535 | BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Slx4 (PF09494, IPR018574): Slx4 endonuclease zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
197 |
SNU13 | interactor | 11 | 0.378 | 13.444 | Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family |
198 |
SNW1 | protein found in more fusions | 33 | 0.284 | 142.945 | SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain |
199 |
SNX2 | interactor | 5 | 0.700 | 1.119 | PX (PF00787, IPR001683, SM00312): PX domain Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain Vps5 (PF09325, IPR015404): Vps5 C terminal like |
200 |
SRSF9 | interactor | 12 | 0.515 | 9.290 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
201 |
STAT1 | suppressor | 14 | 0.346 | 24.630 | SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain |
202 |
STRIP1 | interactor | 4 | 0.833 | 0.087 | ELM2 (PF01448, IPR000949): ELM2 domain N1221 (PF07923, IPR012486): N1221-like protein DUF3402 (PF11882, IPR021819): Domain of unknown function (DUF3402) |
203 |
STRN4 | interactor | 4 | 0.833 | 0.087 | CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Striatin (PF08232, IPR013258): Striatin family WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
204 |
SUDS3 | interactor | 10 | 1.000 | 0 | Sds3 (PF08598, IPR013907): Sds3-like |
205 |
SUPT3H | interactor | 8 | 0.571 | 5.023 | TFIID-18kDa (PF02269, IPR003195): Transcription initiation factor IID, 18kD subunit DUF4093 (PF13331, IPR025156): Domain of unknown function (DUF4093) |
206 |
TADA2A | interactor | 14 | 0.374 | 28.136 | SWIRM (PF04433, IPR007526): SWIRM domain Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain |
207 |
TAF15 | oncoprotein | 25 | 0.343 | 74.493 | API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5) GRP (PF07172, IPR010800): Glycine rich protein family Presenilin (PF01080, IPR001108): Presenilin RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others |
208 |
TCERG1 | interactor | 11 | 0.418 | 15.818 | FF (PF01846, IPR002713, SM00441): FF domain WW (PF00397, IPR001202, SM00456): WW domain Folliculin (PF11704, IPR021713): Vesicle coat protein involved in Golgi to plasma membrane transport DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807) DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886) Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO FAM150 (PF15129, IPR029364): FAM150 family |
209 |
TERF1 | interactor | 17 | 0.250 | 58.723 | TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain |
210 |
TERF2 | interactor | 12 | 0.527 | 10.944 | Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif |
211 |
TERT | oncoprotein | 8 | 0.571 | 6.428 | RVT_1 (PF00078, IPR000477): Reverse transcriptase (RNA-dependent DNA polymerase) Telomerase_RBD (PF12009, IPR021891, SM00975): Telomerase ribonucleoprotein complex - RNA binding domain |
212 |
TET1 | oncoprotein | 3 | 0.667 | 0.333 | zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain Tet_JBP (PF12851, IPR024779): Oxygenase domain of the 2OGFeDO superfamily |
213 |
TET2 | suppressor | 2 | 1.000 | 0 | Tet_JBP (PF12851, IPR024779): Oxygenase domain of the 2OGFeDO superfamily |
214 |
TET3 | interactor | 2 | 1.000 | 0 | zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain Tet_JBP (PF12851, IPR024779): Oxygenase domain of the 2OGFeDO superfamily |
215 |
TOPBP1 | protein found in more fusions | 12 | 0.327 | 17.513 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain PTCB-BRCT (PF12738, IPR001357): twin BRCT domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain |
216 |
TOR1AIP2 | interactor | 10 | 0.889 | 0.615 | LAP1C (PF05609, IPR008662): Lamina-associated polypeptide 1C (LAP1C) |
217 |
TP53 | suppressor | 65 | 0.189 | 866.104 | DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif |
218 |
TP73 | suppressor | 15 | 0.516 | 15.269 | P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) |
219 |
TPM2 | protein found in more fusions | 7 | 0.733 | 4.000 | DASH_Spc19 (PF08287, IPR013251): Spc19 Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like |
220 |
TPR | oncoprotein | 14 | 0.374 | 17.470 | Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus ZapB (PF06005, IPR009252): Cell division protein ZapB Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family IncA (PF04156, IPR007285): IncA protein Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 XhlA (PF10779, IPR019715): Haemolysin XhlA ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein DUF3373 (PF11853, IPR021803): Protein of unknown function (DUF3373) DUF4107 (PF13389, IPR025180): Protein of unknown function (DUF4107) JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082) |
221 |
TRAF6 | protein found in more fusions | 12 | 0.436 | 20.061 | SlyX (PF04102, IPR007236): SlyX zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) |
222 |
TRPC4AP | interactor | 7 | 0.810 | 1.033 | Put_DNA-bind_N (PF06971, IPR009718): Putative DNA-binding protein N-terminus DUF3689 (PF12463, IPR022162): Protein of unknown function (DUF3689) |
223 |
TUBGCP2 | interactor | 10 | 0.467 | 13.116 | Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family zf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger |
224 |
UBA1 | protein found in more fusions | 14 | 0.385 | 14.748 | ThiF (PF00899, IPR000594): ThiF family E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site |
225 |
UBC | protein found in more fusions | 63 | 0.185 | 890.191 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
226 |
UBE2E3 | interactor | 13 | 0.545 | 10.131 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
227 |
UBR5 | protein found in more fusions | 25 | 0.225 | 137.085 | CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain SDA1 (PF05285, IPR007949): SDA1 HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain E3_UbLigase_EDD (PF11547, IPR024725): E3 ubiquitin ligase EDD PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein |
228 |
UBXN1 | interactor | 16 | 0.495 | 24.439 | Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS) UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain UBX (PF00789, IPR001012, SM00166): UBX domain |
229 |
UBXN7 | interactor | 17 | 0.500 | 29.342 | UBX (PF00789, IPR001012, SM00166): UBX domain UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif Thioredoxin_7 (PF13899): Thioredoxin-like UBA_4 (PF14555): UBA-like domain |
230 |
UCHL1 | suppressor | 13 | 0.474 | 14.639 | Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1 |
231 |
UNG | interactor | 7 | 0.619 | 2.983 | UDG (PF03167, IPR005122, SM00986): Uracil DNA glycosylase superfamily |
232 |
UVSSA | interactor | 2 | 1.000 | 0 | DUF2043 (PF09740, IPR018610): Uncharacterized conserved protein (DUF2043) DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) |
233 |
VASP | interactor | 10 | 0.417 | 9.865 | ASD2 (PF08687, IPR014799): Apx/Shroom domain ASD2 CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal VASP_tetra (PF08776, IPR014885): VASP tetramerisation domain WH1 (PF00568, IPR000697, SM00461): WH1 domain |
234 |
VTN | interactor | 6 | 0.600 | 1.597 | Hemopexin (PF00045, IPR018487, SM00120): Hemopexin Somatomedin_B (PF01033, IPR001212, SM00201): Somatomedin B domain |
235 |
WDTC1 | interactor | 5 | 0.600 | 1.784 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat |
236 |
WSB1 | interactor | 4 | 1.000 | 0 | PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain SOCS_box (PF07525, IPR001496): SOCS box |
237 |
WSB2 | interactor | 3 | 1.000 | 0 | PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 SOCS_box (PF07525, IPR001496): SOCS box |
238 |
XPA | oncoprotein | 10 | 0.422 | 11.966 | XPA_C (PF05181, IPR022656): XPA protein C-terminus XPA_N (PF01286, IPR022652): XPA protein N-terminal MscS_TM (PF12794, IPR025692): Mechanosensitive ion channel inner membrane domain 1 zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain |
239 |
XPC | oncoprotein | 12 | 0.379 | 17.685 | Rad4 (PF03835, IPR018325): Rad4 transglutaminase-like domain BHD_1 (PF10403, IPR018326, SM01030): Rad4 beta-hairpin domain 1 BHD_2 (PF10404, IPR018327, SM01031): Rad4 beta-hairpin domain 2 BHD_3 (PF10405, IPR018328, SM01032): Rad4 beta-hairpin domain 3 Macoilin (PF09726, IPR019130): Transmembrane protein SOG2 (PF10428, IPR019487): RAM signalling pathway protein Abdominal-A (PF12407, IPR022132): Homeobox protein DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820) |
240 |
YARS | interactor | 3 | 0.667 | 0.087 | tRNA-synt_1b (PF00579, IPR002305): tRNA synthetases class I (W and Y) tRNA_bind (PF01588, IPR002547): Putative tRNA binding domain |
241 |
ZNF277 | interactor | 2 | 1.000 | 0 | zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies) |