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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins DCXR (from a repository: Sat Dec 17 12:14:08 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)15
The number (and %) of the onco-proteins1 (6.67 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)25 (23.81 %)
The number (and %) of affected PPIs15 (60.00 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI2.933
Assortativity coefficient-0.2846
The network average Clustering coefficient0.528
The number (and %) of a zero Clustering coefficients5 (33.33 %)
The number (and %) of a zero Betweenness Centrality11 (73.33 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: DCXR All fusions
: BF761196; BF761198;
Proteins found in more fusions APP (see 4 fusions); DCXR (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DCXRparental protein150.088160.000adh_short_C2 (PF13561): Enoyl-(Acyl carrier protein) reductase
2 ABCE1interactor200ABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
3 APPprotein found in more fusions50.5003.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 C11orf54interactor40.6672.000DUF1907 (PF08925, IPR015021, SM01168): Domain of Unknown Function (DUF1907)
5 C4orf33interactor100NA
6 CAB39interactor30.6671.000Mo25 (PF08569, IPR013878): Mo25-like
7 CAB39Linteractor21.0000Mo25 (PF08569, IPR013878): Mo25-like
8 CRADDinteractor21.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Death (PF00531, IPR000488, SM00005): Death domain
9 CRYZinteractor21.0000ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
10 DEF6interactor21.0000ArgK (PF03308, IPR005129): ArgK protein
HSP70 (PF00012, IPR013126): Hsp70 protein
PH (PF00169, IPR001849, SM00233): PH domain
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
EF-hand_6 (PF13405, IPR002048): EF-hand domain
11 DMWDinteractor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
12 GOT1interactor31.0000Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
13 GPIinteractor100PGI (PF00342, IPR001672): Phosphoglucose isomerase
14 PIRinteractor31.0000Pirin (PF02678, IPR003829): Pirin
Pirin_C (PF05726, IPR008778): Pirin C-terminal cupin domain
15 SPHK1interactor100DAGK_cat (PF00781, IPR001206, SM00046): Diacylglycerol kinase catalytic domain

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ABCE1interactorABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
BF761196
2 APPinteractorAPP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
BF761196
3 C11orf54interactorDUF1907 (PF08925, IPR015021, SM01168): Domain of Unknown Function (DUF1907)BF761196
4 C4orf33interactorNABF761196, BF761198
5 CAB39interactorMo25 (PF08569, IPR013878): Mo25-likeBF761196, BF761198
6 CAB39LinteractorMo25 (PF08569, IPR013878): Mo25-likeBF761196, BF761198
7 CRADDinteractorCARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Death (PF00531, IPR000488, SM00005): Death domain
BF761196
8 CRYZinteractorADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
BF761196
9 DCXRparental proteinadh_short_C2 (PF13561): Enoyl-(Acyl carrier protein) reductaseBF761196, BF761198
10 DEF6interactorArgK (PF03308, IPR005129): ArgK protein
HSP70 (PF00012, IPR013126): Hsp70 protein
PH (PF00169, IPR001849, SM00233): PH domain
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
EF-hand_6 (PF13405, IPR002048): EF-hand domain
BF761196
11 GOT1interactorAminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and IIBF761196
12 GPIinteractorPGI (PF00342, IPR001672): Phosphoglucose isomeraseBF761196
13 PIRinteractorPirin (PF02678, IPR003829): Pirin
Pirin_C (PF05726, IPR008778): Pirin C-terminal cupin domain
BF761196
14 SPHK1interactorDAGK_cat (PF00781, IPR001206, SM00046): Diacylglycerol kinase catalytic domainBF761196

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