1 |
DAPK1 | parental protein | 49 | 0.085 | 1718.102 | ABC_tran (PF00005, IPR003439): ABC transporter Death (PF00531, IPR000488, SM00005): Death domain Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) AAA_23 (PF13476): AAA domain Ank_5 (PF13857): Ankyrin repeats (many copies) COR (PF16095, IPR032171): C-terminal of Roc, COR, domain |
2 |
ACTC1 | interactor | 1 | 0 | 0 | Actin (PF00022, IPR004000, SM00268): Actin |
3 |
BAG2 | protein found in more fusions | 6 | 0.600 | 2.119 | IncA (PF04156, IPR007285): IncA protein Mnd1 (PF03962, IPR005647): Mnd1 family ParD_antitoxin (PF03693, IPR022789): Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH |
4 |
BECN1 | suppressor | 4 | 0.667 | 1.000 | APG6 (PF04111, IPR007243): Autophagy protein Apg6 Ima1_N (PF09779, IPR018617): Ima1 N-terminal domain BH3 (PF15285, IPR029318): Beclin-1 BH3 domain, Bcl-2-interacting |
5 |
CALM1 | interactor | 8 | 0.500 | 9.483 | EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
6 |
CAPZA2 | interactor | 9 | 0.361 | 19.667 | F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit |
7 |
CAPZB | interactor | 5 | 0.700 | 1.900 | Cytochrom_B562 (PF07361, IPR009155): Cytochrome b562 F_actin_cap_B (PF01115, IPR001698): F-actin capping protein, beta subunit |
8 |
CCNDBP1 | suppressor | 1 | 0 | 0 | CheF-arch (PF04283, IPR007381): Chemotaxis signal transduction system protein F from archaea GCIP (PF13324): Grap2 and cyclin-D-interacting |
9 |
CORO1C | oncoprotein | 3 | 0.667 | 0.500 | DUF1899 (PF08953, IPR015048, SM01166): Domain of unknown function (DUF1899) WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat WD40_4 (PF16300): Type of WD40 repeat |
10 |
CUL3 | protein found in more fusions | 14 | 0.295 | 40.933 | Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal |
11 |
DDX5 | oncoprotein | 7 | 0.667 | 2.252 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase P68HR (PF08061, IPR012587): P68HR (NUC004) repeat ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain |
12 |
EEF2 | interactor | 9 | 0.583 | 8.419 | EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II |
13 |
FADD | suppressor | 5 | 0.500 | 3.417 | Death (PF00531, IPR000488, SM00005): Death domain DED (PF01335, IPR001875, SM00031): Death effector domain Hpt (PF01627, IPR008207, SM00073): Hpt domain |
14 |
HSP90AA1 | oncoprotein | 16 | 0.286 | 61.702 | HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein |
15 |
IFI30 | oncoprotein | 1 | 0 | 0 | GILT (PF03227, IPR004911): Gamma interferon inducible lysosomal thiol reductase (GILT) |
16 |
IKBKG | interactor | 7 | 0.467 | 6.167 | CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator |
17 |
IVNS1ABP | protein found in more fusions | 3 | 1.000 | 0 | BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif |
18 |
KLHL20 | interactor | 4 | 0.667 | 1.000 | BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif |
19 |
KRIT1 | suppressor | 1 | 0 | 0 | FERM_M (PF00373, IPR019748): FERM central domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies) NUDIX_5 (PF16705, IPR032022): NUDIX, or N-terminal NPxY motif-rich, region of KRIT |
20 |
LNX1 | interactor | 4 | 0.667 | 0.667 | PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) |
21 |
LRRK1 | interactor | 4 | 0.667 | 0.250 | Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain TniB (PF05621, IPR008868): Bacterial TniB protein Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain |
22 |
LRRK2 | oncoprotein | 15 | 0.253 | 57.400 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043) T2SSE (PF00437, IPR001482): Type II/IV secretion system protein Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) PQQ_2 (PF13360, IPR002372): PQQ-like domain LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain |
23 |
MAPK1 | oncoprotein | 6 | 0.500 | 5.000 | Pkinase (PF00069, IPR000719): Protein kinase domain |
24 |
MAPK3 | oncoprotein | 5 | 0.667 | 1.667 | Pkinase (PF00069, IPR000719): Protein kinase domain |
25 |
MDM2 | oncoprotein | 7 | 0.733 | 1.567 | Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
26 |
MIB1 | protein found in more fusions | 2 | 0 | 0 | Ank (PF00023, IPR002110, SM00248): Ankyrin repeat MIB_HERC2 (PF06701, IPR010606): Mib_herc2 ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
27 |
MYL12B | interactor | 3 | 1.000 | 0 | EF-hand_11 (PF08976, IPR015070): EF-hand domain EF-hand_6 (PF13405, IPR002048): EF-hand domain DDE_Tnp_IS66_C (PF13817): IS66 C-terminal element EF-hand_8 (PF13833, IPR002048): EF-hand domain pair |
28 |
MYO1B | interactor | 3 | 1.000 | 0 | IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding RNA_pol (PF00940, IPR002092): DNA-dependent RNA polymerase Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) AAA_23 (PF13476): AAA domain |
29 |
MYO1D | interactor | 2 | 1.000 | 0 | IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) |
30 |
PDCD6 | oncoprotein | 4 | 0.667 | 0.500 | EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
31 |
PPP2CA | suppressor | 9 | 0.472 | 14.333 | Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain |
32 |
PPP2R1A | oncoprotein | 10 | 0.511 | 14.602 | TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain HEAT (PF02985, IPR000357): HEAT repeat HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat HEAT_2 (PF13646): HEAT repeats |
33 |
PPP2R1B | suppressor | 9 | 0.571 | 8.000 | HEAT (PF02985, IPR000357): HEAT repeat Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_2 (PF13646): HEAT repeats |
34 |
PPP2R2D | interactor | 6 | 0.733 | 3.067 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Y_phosphatase2 (PF03162, IPR004861): Tyrosine phosphatase family ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
35 |
PPP2R5A | interactor | 5 | 1.000 | 0 | B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family) |
36 |
ST13 | suppressor | 2 | 1.000 | 0 | Hox9_act (PF04617, IPR006711): Hox9 activation region TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat RhoGEF67_u2 (PF16614): Unstructured region two on RhoGEF 6 and 7 |
37 |
SVIL | interactor | 4 | 0.667 | 1.167 | Gelsolin (PF00626, IPR007123): Gelsolin repeat VHP (PF02209, IPR003128, SM00153): Villin headpiece domain DUF4695 (PF15766, IPR031521): Domain of unknown function (DUF4695) |
38 |
TMOD3 | interactor | 4 | 1.000 | 0 | Tropomodulin (PF03250, IPR004934): Tropomodulin Usher (PF00577, IPR000015): Outer membrane usher protein LRR_6 (PF13516, IPR001611): Leucine Rich repeat |
39 |
TNFRSF1A | oncoprotein | 5 | 0.667 | 2.000 | Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region |
40 |
TP53 | suppressor | 14 | 0.282 | 47.467 | DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif |
41 |
TPM3 | oncoprotein | 7 | 0.600 | 2.936 | Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like |
42 |
TSC1 | suppressor | 4 | 0.667 | 1.000 | Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) Hamartin (PF04388, IPR007483): Hamartin protein |
43 |
TSC2 | suppressor | 6 | 0.400 | 8.667 | Rap_GAP (PF02145, IPR000331): Rap/ran-GAP Tuberin (PF03542, IPR018515): Tuberin DUF3384 (PF11864, IPR024584): Domain of unknown function (DUF3384) Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 |
44 |
TTLL3 | oncoprotein | 1 | 0 | 0 | TTL (PF03133, IPR004344): Tubulin-tyrosine ligase family |
45 |
TWF1 | interactor | 2 | 1.000 | 0 | Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein |
46 |
UNC5A | suppressor | 1 | 0 | 0 | Death (PF00531, IPR000488, SM00005): Death domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ZU5 (PF00791, IPR000906, SM00218): ZU5 domain TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain DUF3377 (PF11857, IPR021805): Domain of unknown function (DUF3377) Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain UPA (PF17217): UPA domain |
47 |
UNC5B | suppressor | 3 | 1.000 | 0 | Death (PF00531, IPR000488, SM00005): Death domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain SKG6 (PF08693, IPR014805): Transmembrane alpha-helix domain ZU5 (PF00791, IPR000906, SM00218): ZU5 domain TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain Ig_3 (PF13927): Immunoglobulin domain UPA (PF17217): UPA domain |
48 |
UNC5C | suppressor | 1 | 0 | 0 | Death (PF00531, IPR000488, SM00005): Death domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ZU5 (PF00791, IPR000906, SM00218): ZU5 domain TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain UPA (PF17217): UPA domain |
49 |
YWHAQ | interactor | 9 | 0.389 | 17.050 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |