Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins DAPK1 (from a repository: Sun Dec 4 17:05:42 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 49 The number (and %) of the onco-proteins 17 (34.69 %) The number (and %) of the tumor suppressors 13 (26.53 %) Total number of binary PPIs (saturation %) 166 (14.12 %) The number (and %) of affected PPIs 49 (29.52 %) The number of possible different fusions 14 PPI diameter 2 PPI radius 1 The average degree of PPI 5.878 Assortativity coefficient -0.4033 The network average Clustering coefficient 0.534 The number (and %) of a zero Clustering coefficients 8 (16.33 %) The number (and %) of a zero Betweenness Centrality 17 (34.69 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: DAPK1	All fusions
Proteins found in more fusions	TPM3 (see 2 fusions); CUL3 (see 1 fusions); LRRK2 (see 1 fusions); DDX5 (see 1 fusions); DAPK1 (see 1 fusions); PDCD6 (see 1 fusions); MIB1 (see 3 fusions); HSP90AA1 (see 2 fusions); MAPK1 (see 1 fusions); IVNS1ABP (see 2 fusions); TP53 (see 3 fusions); TNFRSF1A (see 2 fusions); BAG2 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	DAPK1	parental protein	49	0.085	1718.102	ABC_tran (PF00005, IPR003439): ABC transporter Death (PF00531, IPR000488, SM00005): Death domain Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) AAA_23 (PF13476): AAA domain Ank_5 (PF13857): Ankyrin repeats (many copies) COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
2	ACTC1	interactor	1	0	0	Actin (PF00022, IPR004000, SM00268): Actin
3	BAG2	protein found in more fusions	6	0.600	2.119	IncA (PF04156, IPR007285): IncA protein Mnd1 (PF03962, IPR005647): Mnd1 family ParD_antitoxin (PF03693, IPR022789): Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH
4	BECN1	suppressor	4	0.667	1.000	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Ima1_N (PF09779, IPR018617): Ima1 N-terminal domain BH3 (PF15285, IPR029318): Beclin-1 BH3 domain, Bcl-2-interacting
5	CALM1	interactor	8	0.500	9.483	EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
6	CAPZA2	interactor	9	0.361	19.667	F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
7	CAPZB	interactor	5	0.700	1.900	Cytochrom_B562 (PF07361, IPR009155): Cytochrome b562 F_actin_cap_B (PF01115, IPR001698): F-actin capping protein, beta subunit
8	CCNDBP1	suppressor	1	0	0	CheF-arch (PF04283, IPR007381): Chemotaxis signal transduction system protein F from archaea GCIP (PF13324): Grap2 and cyclin-D-interacting
9	CORO1C	oncoprotein	3	0.667	0.500	DUF1899 (PF08953, IPR015048, SM01166): Domain of unknown function (DUF1899) WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat WD40_4 (PF16300): Type of WD40 repeat
10	CUL3	protein found in more fusions	14	0.295	40.933	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
11	DDX5	oncoprotein	7	0.667	2.252	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase P68HR (PF08061, IPR012587): P68HR (NUC004) repeat ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
12	EEF2	interactor	9	0.583	8.419	EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
13	FADD	suppressor	5	0.500	3.417	Death (PF00531, IPR000488, SM00005): Death domain DED (PF01335, IPR001875, SM00031): Death effector domain Hpt (PF01627, IPR008207, SM00073): Hpt domain
14	HSP90AA1	oncoprotein	16	0.286	61.702	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
15	IFI30	oncoprotein	1	0	0	GILT (PF03227, IPR004911): Gamma interferon inducible lysosomal thiol reductase (GILT)
16	IKBKG	interactor	7	0.467	6.167	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
17	IVNS1ABP	protein found in more fusions	3	1.000	0	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
18	KLHL20	interactor	4	0.667	1.000	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
19	KRIT1	suppressor	1	0	0	FERM_M (PF00373, IPR019748): FERM central domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies) NUDIX_5 (PF16705, IPR032022): NUDIX, or N-terminal NPxY motif-rich, region of KRIT
20	LNX1	interactor	4	0.667	0.667	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
21	LRRK1	interactor	4	0.667	0.250	Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain TniB (PF05621, IPR008868): Bacterial TniB protein Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
22	LRRK2	oncoprotein	15	0.253	57.400	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043) T2SSE (PF00437, IPR001482): Type II/IV secretion system protein Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) PQQ_2 (PF13360, IPR002372): PQQ-like domain LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
23	MAPK1	oncoprotein	6	0.500	5.000	Pkinase (PF00069, IPR000719): Protein kinase domain
24	MAPK3	oncoprotein	5	0.667	1.667	Pkinase (PF00069, IPR000719): Protein kinase domain
25	MDM2	oncoprotein	7	0.733	1.567	Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
26	MIB1	protein found in more fusions	2	0	0	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat MIB_HERC2 (PF06701, IPR010606): Mib_herc2 ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
27	MYL12B	interactor	3	1.000	0	EF-hand_11 (PF08976, IPR015070): EF-hand domain EF-hand_6 (PF13405, IPR002048): EF-hand domain DDE_Tnp_IS66_C (PF13817): IS66 C-terminal element EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
28	MYO1B	interactor	3	1.000	0	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding RNA_pol (PF00940, IPR002092): DNA-dependent RNA polymerase Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) AAA_23 (PF13476): AAA domain
29	MYO1D	interactor	2	1.000	0	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
30	PDCD6	oncoprotein	4	0.667	0.500	EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
31	PPP2CA	suppressor	9	0.472	14.333	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
32	PPP2R1A	oncoprotein	10	0.511	14.602	TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain HEAT (PF02985, IPR000357): HEAT repeat HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
33	PPP2R1B	suppressor	9	0.571	8.000	HEAT (PF02985, IPR000357): HEAT repeat Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_2 (PF13646): HEAT repeats
34	PPP2R2D	interactor	6	0.733	3.067	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Y_phosphatase2 (PF03162, IPR004861): Tyrosine phosphatase family ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
35	PPP2R5A	interactor	5	1.000	0	B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
36	ST13	suppressor	2	1.000	0	Hox9_act (PF04617, IPR006711): Hox9 activation region TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat RhoGEF67_u2 (PF16614): Unstructured region two on RhoGEF 6 and 7
37	SVIL	interactor	4	0.667	1.167	Gelsolin (PF00626, IPR007123): Gelsolin repeat VHP (PF02209, IPR003128, SM00153): Villin headpiece domain DUF4695 (PF15766, IPR031521): Domain of unknown function (DUF4695)
38	TMOD3	interactor	4	1.000	0	Tropomodulin (PF03250, IPR004934): Tropomodulin Usher (PF00577, IPR000015): Outer membrane usher protein LRR_6 (PF13516, IPR001611): Leucine Rich repeat
39	TNFRSF1A	oncoprotein	5	0.667	2.000	Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
40	TP53	suppressor	14	0.282	47.467	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
41	TPM3	oncoprotein	7	0.600	2.936	Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
42	TSC1	suppressor	4	0.667	1.000	Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) Hamartin (PF04388, IPR007483): Hamartin protein
43	TSC2	suppressor	6	0.400	8.667	Rap_GAP (PF02145, IPR000331): Rap/ran-GAP Tuberin (PF03542, IPR018515): Tuberin DUF3384 (PF11864, IPR024584): Domain of unknown function (DUF3384) Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
44	TTLL3	oncoprotein	1	0	0	TTL (PF03133, IPR004344): Tubulin-tyrosine ligase family
45	TWF1	interactor	2	1.000	0	Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
46	UNC5A	suppressor	1	0	0	Death (PF00531, IPR000488, SM00005): Death domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ZU5 (PF00791, IPR000906, SM00218): ZU5 domain TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain DUF3377 (PF11857, IPR021805): Domain of unknown function (DUF3377) Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain UPA (PF17217): UPA domain
47	UNC5B	suppressor	3	1.000	0	Death (PF00531, IPR000488, SM00005): Death domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain SKG6 (PF08693, IPR014805): Transmembrane alpha-helix domain ZU5 (PF00791, IPR000906, SM00218): ZU5 domain TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain Ig_3 (PF13927): Immunoglobulin domain UPA (PF17217): UPA domain
48	UNC5C	suppressor	1	0	0	Death (PF00531, IPR000488, SM00005): Death domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ZU5 (PF00791, IPR000906, SM00218): ZU5 domain TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain UPA (PF17217): UPA domain
49	YWHAQ	interactor	9	0.389	17.050	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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