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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CXCL12 (from a repository: Sun Nov 13 00:30:12 2016)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)6
The number (and %) of the onco-proteins3 (50.00 %)
The number (and %) of the tumor suppressors1 (16.67 %)
Total number of binary PPIs (saturation %)9 (60.00 %)
The number (and %) of affected PPIs6 (66.67 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI2.000
Assortativity coefficient-0.4472
The network average Clustering coefficient0.350
The number (and %) of a zero Clustering coefficients3 (50.00 %)
The number (and %) of a zero Betweenness Centrality5 (83.33 %)


List of the fusions

PPI for parental proteins: CXCL12 All fusions
: AA678668;
Proteins found in more fusions CXCL12 (see 1 fusions); DAZAP2 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 CXCL12parental protein60.10018.000IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
2 CXCR4interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
COX2_TM (PF02790, IPR011759): Cytochrome C oxidase subunit II, transmembrane domain
CXCR4_N (PF12109, IPR022726): CXCR4 Chemokine receptor N terminal
3 DAZAP2protein found in more fusions200DAZAP2 (PF11029, IPR022730): DAZ associated protein 2 (DAZAP2)
4 FN1oncoprotein100fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
5 PF4suppressor31.0000IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
6 VCANoncoprotein21.0000EGF (PF00008, IPR000742, SM00181): EGF-like domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
Xlink (PF00193, IPR000538, SM00445): Extracellular link domain

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