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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)15
The number (and %) of the onco-proteins4 (26.67 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)29 (27.62 %)
The number (and %) of affected PPIs15 (51.72 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI2.800
Assortativity coefficient-0.3618
The network average Clustering coefficient0.472
The number (and %) of a zero Clustering coefficients6 (40.00 %)
The number (and %) of a zero Betweenness Centrality11 (73.33 %)


List of the fusions

PPI for parental proteins: CXADR All fusions
Proteins found in more fusions CXADR (see 1 fusions); EWSR1 (see 2 fusions); NCOA1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 CXADRparental protein150.077163.000Syndecan (PF01034, IPR027789): Syndecan domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Shisa (PF13908, IPR026910): Wnt and FGF inhibitory regulator
Ig_3 (PF13927): Immunoglobulin domain
2 ACOT1interactor100BAAT_C (PF08840, IPR014940): BAAT / Acyl-CoA thioester hydrolase C terminal
Bile_Hydr_Trans (PF04775, IPR006862): Acyl-CoA thioester hydrolase/BAAT N-terminal region
3 CCDC8interactor41.0000Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
4 ELAVL1oncoprotein50.6672.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
5 EWSR1oncoprotein50.6672.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
6 GRHPRinteractor1002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
7 JAMLinteractor100V-set (PF07686, IPR013106): Immunoglobulin V-set domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
8 LNX1interactor31.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
9 LNX2interactor31.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DZR (PF12773, IPR025874): Double zinc ribbon
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
10 NCOA1oncoprotein31.0000DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
PAS_11 (PF14598): PAS domain
DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927)
NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
11 NCOR1oncoprotein30.6671.000BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
Hid1 (PF12722): High-temperature-induced dauer-formation protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
RBR (PF17208): RNA binding Region
12 TMEM17interactor100Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
13 TMEM185Ainteractor100Tmemb_185A (PF10269, IPR019396): Transmembrane Fragile-X-F protein
14 TMEM216interactor21.0000Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
15 VKORC1interactor200VKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase family

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