Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CTPS2 (from a repository: Sat Nov 12 16:34:24 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins7 (25.00 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)79 (20.90 %)
The number (and %) of affected PPIs28 (35.44 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI4.714
Assortativity coefficient-0.3972
The network average Clustering coefficient0.501
The number (and %) of a zero Clustering coefficients8 (28.57 %)
The number (and %) of a zero Betweenness Centrality13 (46.43 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CTPS2 All fusions
Proteins found in more fusions HSF1 (see 3 fusions); CTBP2 (see 2 fusions); CTPS2 (see 1 fusions); PRKDC (see 3 fusions); FGFR1 (see 1 fusions); DHPS (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CTPS2parental protein280.111559.300CTP_synth_N (PF06418, IPR017456): CTP synthase N-terminus
GATase (PF00117, IPR017926): Glutamine amidotransferase class-I
2 COL9A1interactor100Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF826 (PF05696, IPR008544): Protein of unknown function (DUF826)
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
3 CTBP2protein found in more fusions2002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
4 DHPSprotein found in more fusions41.0000DS (PF01916, IPR002773): Deoxyhypusine synthase
5 EHD1interactor70.7332.233Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EHD_N (PF16880, IPR031692): N-terminal EH-domain containing protein
6 EHD4interactor60.6006.000GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EHD_N (PF16880, IPR031692): N-terminal EH-domain containing protein
7 ENPP6interactor100Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
8 FGFR1oncoprotein200I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
9 GTF2Iinteractor70.5716.467GTF2I (PF02946, IPR004212): GTF2I-like repeat
10 HSF1protein found in more fusions70.6005.333DUF247 (PF03140, IPR004158): Plant protein of unknown function
Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor
HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
11 KTN1oncoprotein41.0000ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP)
Fez1 (PF06818): Fez1
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
IncA (PF04156, IPR007285): IncA protein
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
PTPS (PF01242, IPR007115): 6-pyruvoyl tetrahydropterin synthase
Spectrin (PF00435, IPR002017): Spectrin repeat
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Fimbrial_PilY2 (PF14481, IPR029497): Type 4 fimbrial biogenesis protein PilY2
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
12 LRSAM1interactor60.8001.333Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
13 METTL1interactor41.0000Methyltransf_4 (PF02390, IPR003358): Putative methyltransferase
14 MTMR2interactor60.8001.333GRAM (PF02893, IPR004182, SM00568): GRAM domain
Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain
3-PAP (PF12578, IPR022587): Myotubularin-associated protein
NYD-SP28_assoc (PF14775, IPR029440): Sperm tail C-terminal domain
15 NASPinteractor21.0000Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
SlyX (PF04102, IPR007236): SlyX
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TraV (PF09676, IPR014118): Type IV conjugative transfer system lipoprotein (TraV)
SHNi-TPR (PF10516, IPR019544): SHNi-TPR
XhlA (PF10779, IPR019715): Haemolysin XhlA
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
16 NTRK1oncoprotein100.44415.900I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
17 NUCB1interactor60.6003.900DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104)
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
DUF2967 (PF11179, IPR021349): Protein of unknown function (DUF2967)
DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552)
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
18 OTUD5interactor100OTU (PF02338, IPR003323): OTU-like cysteine protease
Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
19 PLIN3interactor60.8001.333Perilipin (PF03036, IPR004279): Perilipin family
20 PRKDCprotein found in more fusions80.5248.233FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
21 RNF2interactor50.6671.500zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
22 RPL23Ainteractor40.6672.000Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23
Ribosomal_L23eN (PF03939, IPR005633): Ribosomal protein L23, N-terminal domain
23 RPL37Ainteractor21.0000Ribosomal_L37ae (PF01780, IPR002674): Ribosomal L37ae protein family
24 SLAMF1interactor200ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
SLAM (PF06214, IPR010407): Signaling lymphocytic activation molecule (SLAM) protein
25 SNX3interactor100PX (PF00787, IPR001683, SM00312): PX domain
26 SPG21interactor100Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold
27 WARSinteractor70.6195.400tRNA-synt_1b (PF00579, IPR002305): tRNA synthetases class I (W and Y)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
28 XPO1interactor50.5003.733CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

B a c k    t o    T o p ⇑