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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CTH (from a repository: Wed Nov 16 19:22:59 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)35
The number (and %) of the onco-proteins10 (28.57 %)
The number (and %) of the tumor suppressors1 (2.86 %)
Total number of binary PPIs (saturation %)74 (12.44 %)
The number (and %) of affected PPIs35 (47.30 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI3.600
Assortativity coefficient-0.4836
The network average Clustering coefficient0.433
The number (and %) of a zero Clustering coefficients13 (37.14 %)
The number (and %) of a zero Betweenness Centrality19 (54.29 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CTH All fusions
Proteins found in more fusions TPD52L2 (see 2 fusions); SDCBP2 (see 1 fusions); CTBP1 (see 2 fusions); PFKM (see 1 fusions); CTH (see 3 fusions); CBS (see 1 fusions); GMDS (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CTHparental protein350.0521012.000Cys_Met_Meta_PP (PF01053, IPR000277): Cys/Met metabolism PLP-dependent enzyme
2 ACLYinteractor21.0000ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain
Citrate_synt (PF00285, IPR002020): Citrate synthase, C-terminal domain
CoA_binding (PF02629, IPR003781, SM00881): CoA binding domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
Citrate_bind (PF16114, IPR032263): ATP citrate lyase citrate-binding
3 ATIConcoprotein50.7002.667AICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme
MGS (PF02142, IPR011607, SM00851): MGS-like domain
4 CAPN2interactor41.0000Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
5 CBSprotein found in more fusions40.6670.667CBS (PF00571, IPR000644, SM00116): CBS domain
DUF1414 (PF07208, IPR009857): Protein of unknown function (DUF1414)
PALP (PF00291, IPR001926): Pyridoxal-phosphate dependent enzyme
6 CTBP1protein found in more fusions60.5004.3332-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
7 DLDinteractor100Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
8 DUTinteractor40.6671.667dUTPase (PF00692, IPR008180): dUTPase
9 ELAVL1oncoprotein90.28619.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
10 ENO2interactor50.5004.333Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
11 FDPSinteractor21.0000polyprenyl_synt (PF00348, IPR000092): Polyprenyl synthetase
12 FOLH1interactor100PA (PF02225, IPR003137): PA domain
Peptidase_M28 (PF04389, IPR007484): Peptidase family M28
TFR_dimer (PF04253, IPR007365): Transferrin receptor-like dimerisation domain
UNC-79 (PF14776): Cation-channel complex subunit UNC-79
13 FOXI2interactor100Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
14 FSD1interactor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
PLAC9 (PF15205, IPR027941): Placenta-specific protein 9
DUF4945 (PF16303, IPR032544): Domain of unknown function (DUF4945)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
15 GMDSprotein found in more fusions60.7003.000GDP_Man_Dehyd (PF16363, IPR016040): GDP-mannose 4,6 dehydratase
16 GUCD1interactor21.0000Guanylate_cyc_2 (PF09778, IPR018616): Guanylylate cyclase
17 HSPE1interactor40.6671.667Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
18 NUTF2interactor40.6671.000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
19 PAPSS2interactor100APS_kinase (PF01583, IPR002891): Adenylylsulphate kinase
ATP-sulfurylase (PF01747, IPR024951): ATP-sulfurylase
DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
YscJ_FliF (PF01514, IPR006182): Secretory protein of YscJ/FliF family
PUA_2 (PF14306, IPR025980): PUA-like domain
20 PFKMprotein found in more fusions200PFK (PF00365, IPR000023): Phosphofructokinase
21 PREPinteractor100Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
Peptidase_S9_N (PF02897, IPR023302): Prolyl oligopeptidase, N-terminal beta-propeller domain
22 PTMAoncoprotein50.7002.667Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
23 RECKsuppressor100DB (PF01682, IPR002602): DB module
DNA_pol_E_B (PF04042, IPR007185): DNA polymerase alpha/epsilon subunit B
Kazal_1 (PF00050, IPR002350): Kazal-type serine protease inhibitor domain
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
Kazal_2 (PF07648, IPR002350, SM00280): Kazal-type serine protease inhibitor domain
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
24 RPEinteractor40.6671.000OMPdecase (PF00215, IPR001754, SM00934): Orotidine 5'-phosphate decarboxylase / HUMPS family
Ribul_P_3_epim (PF00834, IPR000056): Ribulose-phosphate 3 epimerase family
25 SDCBP2protein found in more fusions200PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
26 SEC31Ainteractor50.4005.667P3A (PF08727, IPR014838): Poliovirus 3A protein like
SRA1 (PF07304, IPR009917): Steroid receptor RNA activator (SRA1)
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
27 SERPINB8interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
28 SGTAinteractor100TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
XPC-binding (PF09280, IPR015360): XPC-binding domain
TPR_17 (PF13431): Tetratricopeptide repeat
SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA
29 SLC25A32interactor21.0000Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
30 SLC25A41interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
31 TP53RKoncoprotein30.6671.000APH (PF01636, IPR002575): Phosphotransferase enzyme family
Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
32 TPD52L2protein found in more fusions40.6671.000TPD52 (PF04201, IPR007327): Tumour protein D52 family
33 WDR1interactor40.6671.667eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
34 WDYHV1interactor21.0000Nt_Gln_amidase (PF09764, IPR023128): N-terminal glutamine amidase
35 ZSCAN32interactor200KRAB (PF01352, IPR001909, SM00349): KRAB box
SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Mu-like_Com (PF10122, IPR019294): Mu-like prophage protein Com
DUF3613 (PF12266, IPR022053): Protein of unknown function (DUF3613)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
Myb_DNA-bind_4 (PF13837): Myb/SANT-like DNA-binding domain

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