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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)41
The number (and %) of the onco-proteins12 (29.27 %)
The number (and %) of the tumor suppressors3 (7.32 %)
Total number of binary PPIs (saturation %)88 (10.73 %)
The number (and %) of affected PPIs39 (44.32 %)
The number of possible different fusions7
PPI diameter5
PPI radius3
The average degree of PPI3.805
Assortativity coefficient-0.4113
The network average Clustering coefficient0.280
The number (and %) of a zero Clustering coefficients18 (43.90 %)
The number (and %) of a zero Betweenness Centrality18 (43.90 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CTDSP2,PDAP1 All fusions
: BG828185;
Proteins found in more fusions POLR2A (see 2 fusions); CSNK2A1 (see 1 fusions); HUWE1 (see 2 fusions); APP (see 4 fusions); LMNA (see 3 fusions); U2AF2 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CTDSP2parental protein220.022852.249NIF (PF03031, IPR004274): NLI interacting factor-like phosphatase
2 PDAP1parental protein170.140434.898PP28 (PF10252, IPR019380): Casein kinase substrate phosphoprotein PP28
3 ANKRD13Ainteractor2022.512UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
GPCR_chapero_1 (PF11904, IPR021832): GPCR-chaperone
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)
4 APPprotein found in more fusions80.190125.526APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 ATP12Ainteractor100Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
FA_desaturase (PF00487, IPR005804): Fatty acid desaturase
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
HAD (PF12710): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
6 ATP2B3interactor100Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
ATP_Ca_trans_C (PF12424, IPR022141): Plasma membrane calcium transporter ATPase C terminal
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
7 CDCA3interactor30.33326.741NA
8 CLTBinteractor21.0000Clathrin_lg_ch (PF01086, IPR000996): Clathrin light chain
9 CSNK2A1oncoprotein70.33355.083Pkinase (PF00069, IPR000719): Protein kinase domain
10 CTDSP1interactor40.50013.335NIF (PF03031, IPR004274): NLI interacting factor-like phosphatase
11 CWC22interactor100CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
MA3 (PF02847, IPR003891, SM00544): MA3 domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
DUF2992 (PF11208, IPR016787): Protein of unknown function (DUF2992)
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
DUF4349 (PF14257, IPR025645): Domain of unknown function (DUF4349)
SOBP (PF15279, IPR026092): Sine oculis-binding protein
12 DPPA4interactor41.0000Ribosomal_L40e (PF01020, IPR001975): Ribosomal L40e family
DCR (PF14047, IPR025891): Dppa2/4 conserved region
Dppa2_A (PF14049, IPR025892): Dppa2/4 conserved region in higher vertebrates
13 ENDOD1interactor100DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
Endonuclease_NS (PF01223, IPR001604, SM00892): DNA/RNA non-specific endonuclease
14 FN1oncoprotein60.40027.045fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
15 HIST1H2BGoncoprotein100Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
16 HUWE1oncoprotein80.38124.902BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
17 IFI16suppressor80.32182.041HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
18 INTS6suppressor21.0000VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
INT_SG_DDX_CT_C (PF15300, IPR029307): INTS6/SAGE1/DDX26B/CT45 C-terminus
DUF4596 (PF15363, IPR027907): Domain of unknown function (DUF4596)
19 LMNAprotein found in more fusions40.33336.045Filament (PF00038, IPR001664): Intermediate filament protein
LTD (PF00932, IPR001322): Lamin Tail Domain
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
20 MAP7interactor100Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
PH_5 (PF15405): Pleckstrin homology domain
21 MAP7D1interactor2065.872BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family
NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain
SOBP (PF15279, IPR026092): Sine oculis-binding protein
DUF4887 (PF16228, IPR032615): Domain of unknown function (DUF4887)
22 MED4interactor30.33321.470Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
23 NEK4interactor2022.512Pkinase (PF00069, IPR000719): Protein kinase domain
Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain
24 PDGFAoncoprotein100PDGF (PF00341, IPR000072, SM00141): PDGF/VEGF domain
PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
SyrA (PF11089, IPR024239): Exopolysaccharide production repressor
25 PDGFBoncoprotein200PDGF (PF00341, IPR000072, SM00141): PDGF/VEGF domain
PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
26 PLEKHH3interactor100FERM_M (PF00373, IPR019748): FERM central domain
MyTH4 (PF00784, IPR000857, SM00139): MyTH4 domain
PH (PF00169, IPR001849, SM00233): PH domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
27 POLR2Aprotein found in more fusions100.139248.758RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
28 POM121interactor2044.662Ice_nucleation (PF00818, IPR000258): Ice nucleation protein repeat
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
POM121 (PF15229): POM121 family
29 POU5F1oncoprotein50.50057.572Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
30 PRR14interactor2020.742CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Tantalus (PF15386, IPR028149): Drosophila Tantalus-like
31 RBM8Ainteractor41.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
32 RPL10suppressor40.50018.064Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
33 SETD1Ainteractor21.0000E7 (PF00527, IPR000148): E7 protein, Early protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SET (PF00856, IPR001214, SM00317): SET domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
N-SET (PF11764, IPR024657): COMPASS (Complex proteins associated with Set1p) component N
DUF4632 (PF15451, IPR027952): Domain of unknown function (DUF4632)
DUF4667 (PF15700, IPR031426): Domain of unknown function (DUF4667)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
34 SLC25A20interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
35 SNAI1oncoprotein21.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
36 TBC1D4interactor100DUF632 (PF04782, IPR006867): Protein of unknown function (DUF632)
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
RecR (PF02132, IPR023628): RecR protein
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
DUF3350 (PF11830, IPR021785): Domain of unknown function (DUF3350)
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
DUF4806 (PF16064, IPR032071): Domain of unknown function (DUF4806)
37 U2AF2protein found in more fusions50.66721.470RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
38 UBTFinteractor40.16790.766Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HMG_box_2 (PF09011, IPR009071): HMG-box domain
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
DUF4473 (PF14747, IPR027913): Domain of unknown function (DUF4473)
HMG_box_5 (PF14887, IPR029215): HMG (high mobility group) box 5
39 XPO1interactor70.238120.994CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
40 ZC3H3interactor2020.742zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
CCDC24 (PF15669, IPR031367): Coiled-coil domain-containing protein 24 family
41 ZMYM6interactor100Dimer_Tnp_hAT (PF05699, IPR008906): hAT family C-terminal dimerisation region
YHS (PF04945, IPR007029): YHS domain
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
DUF2116 (PF09889, IPR019216): Uncharacterized protein containing a Zn-ribbon (DUF2116)
zf-FCS (PF06467, IPR010507): MYM-type Zinc finger with FCS sequence motif
zinc_ribbon_4 (PF13717): zinc-ribbon domain
zinc_ribbon_5 (PF13719, IPR011723): zinc-ribbon domain
DUF4371 (PF14291, IPR025398): Domain of unknown function (DUF4371)

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