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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CRTAC1, GNG12 (from a repository: Thu Aug 22 05:39:22 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)25
The number (and %) of the onco-proteins7 (28.00 %)
The number (and %) of the tumor suppressors3 (12.00 %)
Total number of binary PPIs (saturation %)51 (17.00 %)
The number (and %) of affected PPIs23 (45.10 %)
The number of possible different fusions3
PPI diameter2
PPI radiusinf
The average degree of PPI3.600
Assortativity coefficient-0.1870
The network average Clustering coefficient0.478
The number (and %) of a zero Clustering coefficients9 (36.00 %)
The number (and %) of a zero Betweenness Centrality15 (60.00 %)


List of the fusions

PPI for parental proteins: GNG12,CRTAC1 All fusions
Proteins found in more fusions SLC12A2 (see 2 fusions); MAPRE2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 GNG12parental protein200.116301.400G-gamma (PF00631, IPR015898, SM00224): GGL domain
2 CRTAC1parental protein306.000EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
FG-GAP (PF01839, IPR013517): FG-GAP repeat
LacI (PF00356, IPR000843, SM00354): Bacterial regulatory proteins, lacI family
UnbV_ASPIC (PF07593, IPR011519): ASPIC and UnbV
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
3 ADRB2interactor60.5003.3337tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
4 AQP1interactor200MIP (PF00230, IPR000425): Major intrinsic protein
5 BLKoncoprotein100Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
6 FHL2oncoprotein200LIM (PF00412, IPR001781, SM00132): LIM domain
zf-ribbon_3 (PF13248): zinc-ribbon domain
7 FLNAsuppressor70.5717.067CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
8 FLOT1interactor40.8330.667CrtC (PF07143, IPR010791): CrtC N-terminal lipocalin domain
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
Flot (PF15975, IPR031905): Flotillin
9 FLOT2interactor31.0000YjbH (PF06082, IPR010344): Exopolysaccharide biosynthesis protein YbjH
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
Flot (PF15975, IPR031905): Flotillin
10 GNB1interactor40.5002.400Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
11 GNB2interactor70.5249.067WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
CALM_bind (PF16025): Calcium-dependent calmodulin binding
WD40_like (PF17005, IPR031544): WD40-like domain
12 GNB3interactor100Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
13 GNB4interactor30.6670.400Spore_YhcN_YlaJ (PF09580, IPR019076): Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
14 MAPRE2protein found in more fusions200ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EB1 (PF03271, IPR004953): EB1-like C-terminal motif
15 MED20interactor21.0000Med20 (PF08612, IPR013921): TATA-binding related factor (TRF) of subunit 20 of Mediator complex
16 MED23interactor21.0000Med23 (PF11573, IPR021629): Mediator complex subunit 23
17 MEF2Aoncoprotein31.0000TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
18 METoncoprotein100Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
PSI (PF01437, IPR002165, SM00423): Plexin repeat
Sema (PF01403, IPR001627, SM00630): Sema domain
TIG (PF01833, IPR002909): IPT/TIG domain
19 MORN4interactor100MORN (PF02493, IPR003409, SM00698): MORN repeat
20 MYH9suppressor50.8001.333IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
21 PAN2interactor70.42910.333RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
22 PKMoncoprotein21.0000PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
23 RAP1Asuppressor21.0000Ras (PF00071, IPR001806, SM00173): Ras family
24 SLC12A2protein found in more fusions200AA_permease (PF00324, IPR004841): Amino acid permease
AA_permease_N (PF08403, IPR013612): Amino acid permease N-terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SLC12 (PF03522, IPR018491): Solute carrier family 12
25 TBPinteractor41.0000TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal

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