Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CRLF3 (from a repository: Wed Nov 16 10:49:32 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)15
The number (and %) of the onco-proteins2 (13.33 %)
The number (and %) of the tumor suppressors2 (13.33 %)
Total number of binary PPIs (saturation %)39 (37.14 %)
The number (and %) of affected PPIs15 (38.46 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI4.533
Assortativity coefficient-0.6202
The network average Clustering coefficient0.465
The number (and %) of a zero Clustering coefficients7 (46.67 %)
The number (and %) of a zero Betweenness Centrality9 (60.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CRLF3 All fusions
Proteins found in more fusions KDM1A (see 2 fusions); CRLF3 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CRLF3parental protein150.220140.333Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
2 APPL2interactor100PH (PF00169, IPR001849, SM00233): PH domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
BAR_3 (PF16746): BAR domain of APPL family
3 DOCK6interactor61.0000DHR-2 (PF06920, IPR010703): Dock homology region 2
DUF3398 (PF11878, IPR021816): Domain of unknown function (DUF3398)
DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins
DOCK_N (PF16172, IPR032376): DOCK N-terminus
4 DOCK7interactor70.9520.333DHR-2 (PF06920, IPR010703): Dock homology region 2
DUF3398 (PF11878, IPR021816): Domain of unknown function (DUF3398)
DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins
DOCK_N (PF16172, IPR032376): DOCK N-terminus
5 DOCK8interactor80.9520.333DHR-2 (PF06920, IPR010703): Dock homology region 2
DUF3398 (PF11878, IPR021816): Domain of unknown function (DUF3398)
DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins
DOCK_N (PF16172, IPR032376): DOCK N-terminus
6 ELAVL1oncoprotein200RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
7 ENPP6interactor100Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
8 KDM1Aprotein found in more fusions200Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
9 LGALS14interactor100Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
10 LRCH2interactor61.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
11 LRCH3interactor70.9520.333CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
12 MOB1Asuppressor70.9520.333Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
13 MOB1Bsuppressor70.9520.333Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
14 SNRPD2interactor100LSM (PF01423, IPR001163): LSM domain
15 VPS25interactor200ESCRT-II (PF05871, IPR008570): ESCRT-II complex subunit

B a c k    t o    T o p ⇑