Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins CREBZF (from a repository: Fri Dec 2 11:13:35 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 15 The number (and %) of the onco-proteins 6 (40.00 %) The number (and %) of the tumor suppressors 1 (6.67 %) Total number of binary PPIs (saturation %) 34 (32.38 %) The number (and %) of affected PPIs 15 (44.12 %) The number of possible different fusions 7 PPI diameter 2 PPI radius 1 The average degree of PPI 3.067 Assortativity coefficient -0.3431 The network average Clustering coefficient 0.429 The number (and %) of a zero Clustering coefficients 5 (33.33 %) The number (and %) of a zero Betweenness Centrality 7 (46.67 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: CREBZF	All fusions
Proteins found in more fusions	TP53 (see 3 fusions); CTNNBL1 (see 1 fusions); CREBZF (see 1 fusions); XBP1 (see 2 fusions); NFE2L1 (see 1 fusions); HCFC1 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	CREBZF	parental protein	15	0.099	154.333	bZIP_1 (PF00170, IPR004827): bZIP transcription factor TSC22 (PF01166, IPR000580): TSC-22/dip/bun family Fungus-induced (PF10917, IPR024415): Fungus-induced protein
2	ACYP2	interactor	1	0	0	Acylphosphatase (PF00708, IPR001792): Acylphosphatase
3	ATF4	oncoprotein	4	0.667	0.667	bZIP_1 (PF00170, IPR004827): bZIP transcription factor
4	ATF6B	interactor	5	0.500	2.667	bZIP_1 (PF00170, IPR004827): bZIP transcription factor NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
5	CREB3L3	interactor	2	0	0	bZIP_1 (PF00170, IPR004827): bZIP transcription factor
6	CTNNBL1	protein found in more fusions	2	0	0	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat DASH_Dad4 (PF08650, IPR013959): DASH complex subunit Dad4 CTNNBL (PF08216, IPR013180, SM01156): Catenin-beta-like, Arm-motif containing nuclear Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
7	ELAVL1	oncoprotein	4	0.667	1.000	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
8	HCFC1	protein found in more fusions	4	0.667	1.000	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_3 (PF13415): Galactose oxidase, central domain Kelch_5 (PF13854): Kelch motif zf-tcix (PF14952, IPR029269): Putative treble-clef, zinc-finger, Zn-binding
9	MOV10	interactor	4	0.500	2.667	AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain
10	NFE2L1	protein found in more fusions	3	1.000	0	bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
11	NXF1	interactor	4	0.667	0.667	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
12	TP53	suppressor	4	0.667	1.000	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
13	TTC23	interactor	1	0	0	DUF3856 (PF12968, IPR024552): Domain of Unknown Function (DUF3856) TPR_12 (PF13424): Tetratricopeptide repeat
14	XBP1	protein found in more fusions	3	1.000	0	DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper DUF2630 (PF10944, IPR020311): Protein of unknown function (DUF2630)
15	ZNF512B	interactor	1	0	0	YTV (PF07639, IPR011521): YTV zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type zf-Nse (PF11789, IPR004181): Zinc-finger of the MIZ type in Nse subunit Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_aberr (PF17017, IPR031514): Aberrant zinc-finger

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