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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CREBZF (from a repository: Fri Dec 2 11:13:35 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)15
The number (and %) of the onco-proteins6 (40.00 %)
The number (and %) of the tumor suppressors1 (6.67 %)
Total number of binary PPIs (saturation %)34 (32.38 %)
The number (and %) of affected PPIs15 (44.12 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI3.067
Assortativity coefficient-0.3431
The network average Clustering coefficient0.429
The number (and %) of a zero Clustering coefficients5 (33.33 %)
The number (and %) of a zero Betweenness Centrality7 (46.67 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CREBZF All fusions
Proteins found in more fusions TP53 (see 3 fusions); CTNNBL1 (see 1 fusions); CREBZF (see 1 fusions); XBP1 (see 2 fusions); NFE2L1 (see 1 fusions); HCFC1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CREBZFparental protein150.099154.333bZIP_1 (PF00170, IPR004827): bZIP transcription factor
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
Fungus-induced (PF10917, IPR024415): Fungus-induced protein
2 ACYP2interactor100Acylphosphatase (PF00708, IPR001792): Acylphosphatase
3 ATF4oncoprotein40.6670.667bZIP_1 (PF00170, IPR004827): bZIP transcription factor
4 ATF6Binteractor50.5002.667bZIP_1 (PF00170, IPR004827): bZIP transcription factor
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
5 CREB3L3interactor200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
6 CTNNBL1protein found in more fusions200Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DASH_Dad4 (PF08650, IPR013959): DASH complex subunit Dad4
CTNNBL (PF08216, IPR013180, SM01156): Catenin-beta-like, Arm-motif containing nuclear
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
7 ELAVL1oncoprotein40.6671.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
8 HCFC1protein found in more fusions40.6671.000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
zf-tcix (PF14952, IPR029269): Putative treble-clef, zinc-finger, Zn-binding
9 MOV10interactor40.5002.667AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
10 NFE2L1protein found in more fusions31.0000bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
11 NXF1interactor40.6670.667NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
12 TP53suppressor40.6671.000DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
13 TTC23interactor100DUF3856 (PF12968, IPR024552): Domain of Unknown Function (DUF3856)
TPR_12 (PF13424): Tetratricopeptide repeat
14 XBP1protein found in more fusions31.0000DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
DUF2630 (PF10944, IPR020311): Protein of unknown function (DUF2630)
15 ZNF512Binteractor100YTV (PF07639, IPR011521): YTV
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
zf-Nse (PF11789, IPR004181): Zinc-finger of the MIZ type in Nse subunit
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_aberr (PF17017, IPR031514): Aberrant zinc-finger

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