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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)17
The number (and %) of the onco-proteins7 (41.18 %)
The number (and %) of the tumor suppressors3 (17.65 %)
Total number of binary PPIs (saturation %)43 (31.62 %)
The number (and %) of affected PPIs15 (34.88 %)
The number of possible different fusions7
PPI diameter5
PPI radius3
The average degree of PPI3.882
Assortativity coefficient-0.1893
The network average Clustering coefficient0.430
The number (and %) of a zero Clustering coefficients4 (23.53 %)
The number (and %) of a zero Betweenness Centrality4 (23.53 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: KCNAB1,CPEB4 All fusions
: AI973221;
Proteins found in more fusions APP (see 5 fusions); NEDD4 (see 1 fusions); RACK1 (see 3 fusions); NEDD4L (see 4 fusions); KCNAB2 (see 1 fusions); UBE3C (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 KCNAB1parental protein110.21895.362Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
2 CPEB4parental protein4034.800RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
RRM_7 (PF16367, IPR000504): RNA recognition motif
3 APPprotein found in more fusions40.3339.571APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 ARRB2interactor21.0000Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
5 ATIConcoprotein21.0000AICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme
MGS (PF02142, IPR011607, SM00851): MGS-like domain
6 BMI1oncoprotein40.33315.643zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
7 ELAVL1oncoprotein80.19052.281RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
8 KCNA2interactor41.0000Ion_trans (PF00520, IPR005821): Ion transport protein
BTB_2 (PF02214, IPR003131): BTB/POZ domain
Sigma_reg_N (PF13800, IPR029101): Sigma factor regulator N-terminal
9 KCNA5interactor50.6673.667Ion_trans (PF00520, IPR005821): Ion transport protein
BTB_2 (PF02214, IPR003131): BTB/POZ domain
10 KCNAB2protein found in more fusions70.40011.905Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
11 NDST1interactor100Sulfotransfer_1 (PF00685, IPR000863): Sulfotransferase domain
HSNSD (PF12062, IPR021930): heparan sulfate-N-deacetylase
12 NEDD4suppressor50.33320.876Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
13 NEDD4Lsuppressor40.6672.167WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
14 RACK1suppressor50.50016.638WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
15 SAV1oncoprotein3023.214WW (PF00397, IPR001202, SM00456): WW domain
16 SRPK1interactor30.6671.467FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
17 UBE3Cprotein found in more fusions4014.410IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 APPinteractorAPP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
AI973221
2 ARRB2interactorArrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
AI973221
3 ATIConcoproteinAICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme
MGS (PF02142, IPR011607, SM00851): MGS-like domain
AI973221
4 BMI1oncoproteinzf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
AI973221
5 CPEB4parental proteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
RRM_7 (PF16367, IPR000504): RNA recognition motif
AI973221
6 ELAVL1oncoproteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)AI973221
7 KCNA2interactorIon_trans (PF00520, IPR005821): Ion transport protein
BTB_2 (PF02214, IPR003131): BTB/POZ domain
Sigma_reg_N (PF13800, IPR029101): Sigma factor regulator N-terminal
AI973221
8 KCNA5interactorIon_trans (PF00520, IPR005821): Ion transport protein
BTB_2 (PF02214, IPR003131): BTB/POZ domain
AI973221
9 KCNAB1parental proteinAldo_ket_red (PF00248, IPR023210): Aldo/keto reductase familyAI973221
10 KCNAB2interactorAldo_ket_red (PF00248, IPR023210): Aldo/keto reductase familyAI973221
11 NDST1interactorSulfotransfer_1 (PF00685, IPR000863): Sulfotransferase domain
HSNSD (PF12062, IPR021930): heparan sulfate-N-deacetylase
AI973221
12 NEDD4suppressorRota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
AI973221
13 NEDD4LsuppressorWW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
AI973221
14 RACK1suppressorWD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
AI973221
15 SAV1oncoproteinWW (PF00397, IPR001202, SM00456): WW domainAI973221
16 SRPK1interactorFYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
AI973221

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