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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FHL1, COX6C (from a repository: Wed Nov 14 11:56:55 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)54
The number (and %) of the onco-proteins19 (35.19 %)
The number (and %) of the tumor suppressors10 (18.52 %)
Total number of binary PPIs (saturation %)190 (13.28 %)
The number (and %) of affected PPIs52 (27.37 %)
The number of possible different fusions12
PPI diameter5
PPI radius3
The average degree of PPI5.889
Assortativity coefficient-0.2670
The network average Clustering coefficient0.513
The number (and %) of a zero Clustering coefficients11 (20.37 %)
The number (and %) of a zero Betweenness Centrality18 (33.33 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: COX6C,FHL1 All fusions
: BF827394; BF825718;
Proteins found in more fusions CREBBP (see 6 fusions); NDUFS3 (see 1 fusions); EWSR1 (see 2 fusions); EP300 (see 1 fusions); LMNA (see 3 fusions); SMAD4 (see 2 fusions); UBC (see 1 fusions); TXNIP (see 2 fusions); RING1 (see 1 fusions); SP1 (see 1 fusions); SMAD3 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 COX6Cparental protein200.132676.941COX6C (PF02937, IPR004204): Cytochrome c oxidase subunit VIc
2 FHL1parental protein320.1371200.934LIM (PF00412, IPR001781, SM00132): LIM domain
zf-FCS (PF06467, IPR010507): MYM-type Zinc finger with FCS sequence motif
3 AKAP12suppressor2041.536OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
ROS_MUCR (PF05443, IPR008807): ROS/MUCR transcriptional regulator protein
RII_binding_1 (PF10522, IPR018459): RII binding domain
WSK (PF03832, IPR001573): WSK motif
4 AKT1oncoprotein80.9520.477PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
5 APOOLinteractor50.8330.400ApoO (PF09769, IPR019166): Apolipoprotein O
6 C15orf48interactor60.7334.238B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
7 CAPZA2interactor3097.712F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
8 CHCHD10interactor41.0000CHCH (PF06747, IPR010625): CHCH domain
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
9 CHCHD2interactor90.50011.671CHCH (PF06747, IPR010625): CHCH domain
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
10 CISD3interactor41.0000zf-CDGSH (PF09360, IPR018967, SM00704): Iron-binding zinc finger CDGSH type
MOLO1 (PF17175): Modulator of levamisole receptor-1
11 COQ2interactor200UbiA (PF01040, IPR000537): UbiA prenyltransferase family
12 COQ9interactor51.0000COQ9 (PF08511, IPR013718): COQ9
13 COX6B1interactor40.6672.222COX6B (PF02297, IPR003213): Cytochrome oxidase c subunit VIb
14 CREBBPsuppressor120.7099.391Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
15 CRKoncoprotein3031.044SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
16 CSNK1Dinteractor41.0000Pkinase (PF00069, IPR000719): Protein kinase domain
17 DBN1oncoprotein50.40049.462Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
18 DEAF1interactor100Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAND (PF01342, IPR000770, SM00258): SAND domain
zf-MYND (PF01753, IPR002893): MYND finger
19 EEDsuppressor50.50035.672WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
20 EP300oncoprotein120.69143.650Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
21 ESR1suppressor150.407165.006Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
22 EWSR1oncoprotein80.5718.592RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
23 FHL2oncoprotein130.394164.663LIM (PF00412, IPR001781, SM00132): LIM domain
zf-ribbon_3 (PF13248): zinc-ribbon domain
24 HES1oncoprotein100Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
25 HIVEP3suppressor21.0000Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
26 KCNA5interactor200Ion_trans (PF00520, IPR005821): Ion transport protein
BTB_2 (PF02214, IPR003131): BTB/POZ domain
27 LMNAprotein found in more fusions60.30046.644Filament (PF00038, IPR001664): Intermediate filament protein
LTD (PF00932, IPR001322): Lamin Tail Domain
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
28 MYBPC1interactor21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
29 NDUFA12interactor60.5337.671NDUFA12 (PF05071, IPR007763): NADH ubiquinone oxidoreductase subunit NDUFA12
30 NDUFA4interactor60.7001.733B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
31 NDUFS3protein found in more fusions110.400299.042Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
32 NELFCDoncoprotein30.333126.959TH1 (PF04858, IPR006942): TH1 protein
33 NRIP1oncoprotein21.0000ALMT (PF11744, IPR020966): Aluminium activated malate transporter
NRIP1_repr_1 (PF15687, IPR031405): Nuclear receptor-interacting protein 1 repression 1
NRIP1_repr_2 (PF15688, IPR031406): Nuclear receptor-interacting protein 1 repression 2
NRIP1_repr_3 (PF15689, IPR031407): Nuclear receptor-interacting protein 1 repression 3
NRIP1_repr_4 (PF15690, IPR031408): Nuclear receptor-interacting protein 1 repression 4
34 OCIAD1interactor50.66733.781OCIA (PF07051, IPR009764): Ovarian carcinoma immunoreactive antigen (OCIA)
35 PDE4DIPoncoprotein21.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
Med9 (PF07544, IPR011425): RNA polymerase II transcription mediator complex subunit 9
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1220 (PF06758, IPR010630, SM01148): Repeat of unknown function (DUF1220)
DUF1515 (PF07439, IPR010889): Protein of unknown function (DUF1515)
IncA (PF04156, IPR007285): IncA protein
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
Nup54 (PF13874, IPR025712): Nucleoporin complex subunit 54
FAM76 (PF16046, IPR032017): FAM76 protein
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
36 PHBsuppressor80.143303.526Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290)
37 PRNPinteractor21.0000Prion (PF00377, IPR022416): Prion/Doppel alpha-helical domain
Prion_octapep (PF03991, IPR020949): Copper binding octapeptide repeat
Prion_bPrPp (PF11587, IPR025860): Major prion protein bPrPp - N terminal
38 PTNoncoprotein200PTN_MK_C (PF01091, IPR020090): PTN/MK heparin-binding protein family, C-terminal domain
PTN_MK_N (PF05196, IPR020089): PTN/MK heparin-binding protein family, N-terminal domain
39 RAB2Aoncoprotein30.33337.703Ras (PF00071, IPR001806, SM00173): Ras family
40 RBPJinteractor100BTD (PF09270, IPR015350): Beta-trefoil DNA-binding domain
LAG1-DNAbind (PF09271, IPR015351): LAG1, DNA binding
TIG (PF01833, IPR002909): IPT/TIG domain
41 RCHY1suppressor3011.010C1_2 (PF03107, IPR004146): C1 domain
zf-CHY (PF05495, IPR008913): CHY zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zinc_ribbon_6 (PF14599): Zinc-ribbon
42 RING1protein found in more fusions31.0000zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
43 SMAD2suppressor130.65211.818MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
44 SMAD3oncoprotein130.65211.818MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
45 SMAD4suppressor140.487171.881MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
46 SMURF1interactor80.71411.904C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
47 SP1protein found in more fusions110.55616.566zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Miga (PF10265, IPR019392): Mitoguardin
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
48 SRFinteractor50.8330.222SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
49 SRPK1interactor31.0000FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
50 TTNinteractor40.5001.139DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
51 TXNIPsuppressor200Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
52 UBCprotein found in more fusions120.145584.628ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
53 USP15oncoprotein80.61916.193UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
54 VAPAinteractor40.50016.149DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 AKAP12suppressorOAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
ROS_MUCR (PF05443, IPR008807): ROS/MUCR transcriptional regulator protein
RII_binding_1 (PF10522, IPR018459): RII binding domain
WSK (PF03832, IPR001573): WSK motif
BF825718, BF827394
2 APOOLinteractorApoO (PF09769, IPR019166): Apolipoprotein OBF827394
3 C15orf48interactorB12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunitBF825718, BF827394
4 CAPZA2interactorF-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunitBF827394
5 CHCHD10interactorCHCH (PF06747, IPR010625): CHCH domain
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
BF827394
6 CHCHD2interactorCHCH (PF06747, IPR010625): CHCH domain
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
BF827394
7 CISD3interactorzf-CDGSH (PF09360, IPR018967, SM00704): Iron-binding zinc finger CDGSH type
MOLO1 (PF17175): Modulator of levamisole receptor-1
BF827394
8 COQ2interactorUbiA (PF01040, IPR000537): UbiA prenyltransferase familyBF827394
9 COQ9interactorCOQ9 (PF08511, IPR013718): COQ9BF827394
10 COX6B1interactorCOX6B (PF02297, IPR003213): Cytochrome oxidase c subunit VIbBF827394
11 COX6Cparental proteinCOX6C (PF02937, IPR004204): Cytochrome c oxidase subunit VIcBF825718, BF827394
12 EEDsuppressorWD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
BF825718, BF827394
13 EWSR1oncoproteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
BF825718, BF827394
14 FHL1parental proteinLIM (PF00412, IPR001781, SM00132): LIM domain
zf-FCS (PF06467, IPR010507): MYM-type Zinc finger with FCS sequence motif
BF825718, BF827394
15 NDUFA12interactorNDUFA12 (PF05071, IPR007763): NADH ubiquinone oxidoreductase subunit NDUFA12BF827394
16 NDUFA4interactorB12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunitBF825718, BF827394
17 NDUFS3interactorComplex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunitBF827394
18 NELFCDoncoproteinTH1 (PF04858, IPR006942): TH1 proteinBF827394
19 NRIP1oncoproteinALMT (PF11744, IPR020966): Aluminium activated malate transporter
NRIP1_repr_1 (PF15687, IPR031405): Nuclear receptor-interacting protein 1 repression 1
NRIP1_repr_2 (PF15688, IPR031406): Nuclear receptor-interacting protein 1 repression 2
NRIP1_repr_3 (PF15689, IPR031407): Nuclear receptor-interacting protein 1 repression 3
NRIP1_repr_4 (PF15690, IPR031408): Nuclear receptor-interacting protein 1 repression 4
BF825718, BF827394
20 OCIAD1interactorOCIA (PF07051, IPR009764): Ovarian carcinoma immunoreactive antigen (OCIA)BF827394
21 PHBsuppressorBand_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290)
BF827394
22 PRNPinteractorPrion (PF00377, IPR022416): Prion/Doppel alpha-helical domain
Prion_octapep (PF03991, IPR020949): Copper binding octapeptide repeat
Prion_bPrPp (PF11587, IPR025860): Major prion protein bPrPp - N terminal
BF825718, BF827394
23 PTNoncoproteinPTN_MK_C (PF01091, IPR020090): PTN/MK heparin-binding protein family, C-terminal domain
PTN_MK_N (PF05196, IPR020089): PTN/MK heparin-binding protein family, N-terminal domain
BF827394
24 RAB2AoncoproteinRas (PF00071, IPR001806, SM00173): Ras familyBF827394
25 RCHY1suppressorC1_2 (PF03107, IPR004146): C1 domain
zf-CHY (PF05495, IPR008913): CHY zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zinc_ribbon_6 (PF14599): Zinc-ribbon
BF827394
26 SRFinteractorSRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)BF825718, BF827394
27 USP15oncoproteinUCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
BF825718, BF827394
28 VAPAinteractorDUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
BF827394

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