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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ISM1, COX6A1 (from a repository: Thu Aug 22 05:47:48 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)15
The number (and %) of the onco-proteins4 (26.67 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)46 (43.81 %)
The number (and %) of affected PPIs13 (28.26 %)
The number of possible different fusions5
PPI diameter2
PPI radiusinf
The average degree of PPI4.533
Assortativity coefficient-0.6585
The network average Clustering coefficient0.665
The number (and %) of a zero Clustering coefficients3 (20.00 %)
The number (and %) of a zero Betweenness Centrality11 (73.33 %)


List of the fusions

PPI for parental proteins: COX6A1,ISM1 All fusions
Proteins found in more fusions CISD3 (see 1 fusions); GRB2 (see 1 fusions); NDUFS3 (see 2 fusions); NDUFAF8 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 COX6A1parental protein130.26974.667COX6A (PF02046, IPR001349): Cytochrome c oxidase subunit VIa
2 ISM1interactor000AMOP (PF03782, IPR005533, SM00723): AMOP domain
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
3 C15orf48interactor51.0000B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
4 CHCHD10interactor41.0000CHCH (PF06747, IPR010625): CHCH domain
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
5 CHCHD2interactor110.42220.000CHCH (PF06747, IPR010625): CHCH domain
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
6 CISD3protein found in more fusions41.0000zf-CDGSH (PF09360, IPR018967, SM00704): Iron-binding zinc finger CDGSH type
MOLO1 (PF17175): Modulator of levamisole receptor-1
7 COQ8Ainteractor61.0000ABC1 (PF03109, IPR004147): ABC1 family
CbtA (PF09490, IPR012666): Probable cobalt transporter subunit (CbtA)
8 COQ9interactor61.0000COQ9 (PF08511, IPR013718): COQ9
9 COX6B1interactor200COX6B (PF02297, IPR003213): Cytochrome oxidase c subunit VIb
10 GRB2oncoprotein200SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
11 NDUFA4interactor50.8330.667B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
12 NDUFAF8protein found in more fusions41.0000ZU5 (PF00791, IPR000906, SM00218): ZU5 domain
13 NDUFS3protein found in more fusions110.44418.667Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
14 NME4interactor31.0000NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
15 OCIAD1interactor41.0000OCIA (PF07051, IPR009764): Ovarian carcinoma immunoreactive antigen (OCIA)

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