Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins COPB1 (from a repository: Sat Nov 12 16:46:45 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 85 The number (and %) of the onco-proteins 26 (30.59 %) The number (and %) of the tumor suppressors 8 (9.41 %) Total number of binary PPIs (saturation %) 514 (14.40 %) The number (and %) of affected PPIs 85 (16.54 %) The number of possible different fusions 18 PPI diameter 2 PPI radius 1 The average degree of PPI 11.224 Assortativity coefficient -0.2190 The network average Clustering coefficient 0.491 The number (and %) of a zero Clustering coefficients 8 (9.41 %) The number (and %) of a zero Betweenness Centrality 16 (18.82 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: COPB1	All fusions : BX484531; BG393843;
Proteins found in more fusions	APP (see 4 fusions); NPM1 (see 1 fusions); COPB1 (see 2 fusions); GRB2 (see 1 fusions); SACM1L (see 1 fusions); ARF1 (see 2 fusions); FMNL1 (see 1 fusions); COPA (see 2 fusions); ERBIN (see 4 fusions); KDELR1 (see 2 fusions); YWHAZ (see 1 fusions); SKI (see 1 fusions); HDAC5 (see 1 fusions); EZH2 (see 1 fusions); UBC (see 1 fusions); COPG1 (see 1 fusions); SNW1 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	COPB1	parental protein	85	0.113	4108.053	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region Coatamer_beta_C (PF07718, IPR011710): Coatomer beta C-terminal region Coatomer_b_Cpla (PF14806, IPR029446): Coatomer beta subunit appendage platform
2	ACACA	interactor	11	0.527	8.391	ACC_central (PF08326, IPR013537): Acetyl-CoA carboxylase, central region Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme Carboxyl_trans (PF01039, IPR000022): Carboxyl transferase domain Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain DUF445 (PF04286, IPR007383): Protein of unknown function (DUF445)
3	ADAM19	interactor	1	0	0	Adeno_E3_CR2 (PF02439, IPR003470): Adenovirus E3 region protein CR2 EGF_2 (PF07974, IPR013111): EGF-like domain Pep_M12B_propep (PF01562, IPR002870): Reprolysin family propeptide Reprolysin (PF01421, IPR001590): Reprolysin (M12B) family zinc metalloprotease ADAM_CR (PF08516, IPR006586, SM00608): ADAM cysteine-rich Disintegrin (PF00200, IPR001762, SM00050): Disintegrin
4	APP	protein found in more fusions	18	0.250	66.008	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5	ARCN1	interactor	23	0.468	52.441	Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
6	ARF1	suppressor	8	0.381	7.423	Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
7	ASF1A	interactor	1	0	0	ASF1_hist_chap (PF04729, IPR006818): ASF1 like histone chaperone
8	ATAD3A	interactor	11	0.273	18.073	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) DUF3523 (PF12037, IPR021911): Domain of unknown function (DUF3523)
9	CAD	oncoprotein	15	0.333	36.109	Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 (PF02787, IPR005480, SM01096): Carbamoyl-phosphate synthetase large chain, oligomerisation domain CPSase_sm_chain (PF00988, IPR002474, SM01097): Carbamoyl-phosphate synthase small chain, CPSase domain GATase (PF00117, IPR017926): Glutamine amidotransferase class-I MGS (PF02142, IPR011607, SM00851): MGS-like domain OTCace (PF00185, IPR006131): Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N (PF02729, IPR006132): Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain ATPgrasp_Ter (PF15632, IPR011226): ATP-grasp in the biosynthetic pathway with Ter operon
10	CANX	interactor	14	0.330	29.150	Calreticulin (PF00262, IPR001580): Calreticulin family DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
11	CCDC8	interactor	17	0.275	37.028	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA
12	CDC5L	interactor	19	0.497	28.800	OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
13	CDK2	suppressor	14	0.385	24.329	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
14	CFTR	suppressor	8	0.476	5.991	ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region ABC_tran (PF00005, IPR003439): ABC transporter Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
15	COPA	protein found in more fusions	29	0.352	116.135	Coatomer_WDAD (PF04053, IPR006692): Coatomer WD associated region COPI_C (PF06957, IPR010714): Coatomer (COPI) alpha subunit C-terminus WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
16	COPB2	interactor	19	0.536	24.468	Coatomer_WDAD (PF04053, IPR006692): Coatomer WD associated region WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
17	COPE	interactor	19	0.484	32.683	Coatomer_E (PF04733, IPR006822): Coatomer epsilon subunit TPR_19 (PF14559): Tetratricopeptide repeat
18	COPG1	protein found in more fusions	31	0.317	174.169	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region COP-gamma_platf (PF08752, IPR013040): Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla (PF16381, IPR032154): Coatomer subunit gamma-1 C-terminal appendage platform
19	COPG2	interactor	18	0.574	20.341	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region COP-gamma_platf (PF08752, IPR013040): Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla (PF16381, IPR032154): Coatomer subunit gamma-1 C-terminal appendage platform
20	COPZ1	interactor	16	0.505	22.755	Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
21	DIAPH1	interactor	10	0.489	12.231	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Drf_DAD (PF06345, IPR010465): DRF Autoregulatory Domain Drf_FH1 (PF06346, IPR009408): Formin Homology Region 1 Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain Glucan_synthase (PF02364, IPR003440): 1,3-beta-glucan synthase component Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
22	ENO1	oncoprotein	11	0.618	6.534	Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
23	ERBIN	oncoprotein	4	1.000	0	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
24	EZH2	suppressor	8	0.333	9.233	CDC45 (PF02724, IPR003874): CDC45-like protein TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain SET (PF00856, IPR001214, SM00317): SET domain EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2 Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
25	FBXO6	interactor	16	0.267	37.045	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like
26	FMNL1	protein found in more fusions	6	0.500	1.686	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain SlyX (PF04102, IPR007236): SlyX FNIP_M (PF14637, IPR028085): Folliculin-interacting protein middle domain PRIMA1 (PF16101): Proline-rich membrane anchor 1 ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
27	FN1	oncoprotein	15	0.429	22.230	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
28	FOXB1	interactor	6	0.733	1.567	Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
29	GRB2	oncoprotein	12	0.473	17.981	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
30	HDAC10	interactor	1	0	0	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
31	HDAC5	protein found in more fusions	15	0.341	20.082	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
32	HLA-A	oncoprotein	9	0.500	9.084	DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202) MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2 MHC_I_C (PF06623, IPR010579): MHC_I C-terminus C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
33	HLA-DPB1	interactor	2	1.000	0	MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
34	HLA-G	interactor	3	1.000	0	MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2 SNO (PF01174, IPR002161): SNO glutamine amidotransferase family C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
35	HSD17B12	interactor	5	0.700	1.125	adh_short (PF00106, IPR002198): short chain dehydrogenase
36	ID1	interactor	1	0	0	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
37	IPO9	interactor	12	0.455	18.607	IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Xpo1 (PF08389, IPR013598): Exportin 1-like protein UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central HEAT_EZ (PF13513): HEAT-like repeat
38	IRAK3	interactor	1	0	0	Death (PF00531, IPR000488, SM00005): Death domain Pkinase (PF00069, IPR000719): Protein kinase domain
39	KCNK3	interactor	1	0	0	GP38 (PF05268, IPR007932): Phage tail fibre adhesin Gp38 Ion_trans (PF00520, IPR005821): Ion transport protein Ion_trans_2 (PF07885, IPR013099): Ion channel
40	KCNK9	interactor	1	0	0	Ion_trans (PF00520, IPR005821): Ion transport protein Ion_trans_2 (PF07885, IPR013099): Ion channel
41	KDELR1	protein found in more fusions	3	1.000	0	ER_lumen_recept (PF00810, IPR000133): ER lumen protein retaining receptor
42	KLC1	interactor	9	0.583	7.650	Gly_radical (PF01228, IPR001150): Glycine radical SOGA (PF11365, IPR027881): Protein SOGA TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
43	KPNA3	interactor	5	0.900	0.333	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat IBB (PF01749, IPR002652): Importin beta binding domain Arm_3 (PF16186, IPR032413): Atypical Arm repeat
44	KPNA4	interactor	7	0.619	4.067	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat IBB (PF01749, IPR002652): Importin beta binding domain Arm_3 (PF16186, IPR032413): Atypical Arm repeat
45	LLGL1	suppressor	3	1.000	0	Lgl_C (PF08596, IPR013905): Lethal giant larvae(Lgl) like, C-terminal LLGL (PF08366, IPR013577): LLGL2 WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
46	LMAN1	interactor	11	0.436	15.479	Lectin_leg-like (PF03388, IPR005052): Legume-like lectin family Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 KxDL (PF10241, IPR019371): Uncharacterized conserved protein DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
47	LZTS2	suppressor	5	0.400	3.968	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal DUF1127 (PF06568, IPR009506): Domain of unknown function (DUF1127) Fez1 (PF06818): Fez1 ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding DUF4250 (PF14056, IPR025346): Domain of unknown function (DUF4250)
48	MKS1	interactor	6	0.667	2.039	B9-C2 (PF07162, IPR010796): Ciliary basal body-associated, B9 protein
49	MOV10	interactor	12	0.485	11.779	AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain
50	NPM1	suppressor	26	0.293	110.553	Nucleoplasmin (PF03066): Nucleoplasmin SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
51	NTRK1	oncoprotein	42	0.216	404.751	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
52	NUB1	interactor	3	0.667	0.250	Glyphos_transf (PF04464, IPR007554): CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain TPR_12 (PF13424): Tetratricopeptide repeat HOIP-UBA (PF16678, IPR032065): UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
53	NUDCD1	interactor	10	0.844	1.650	CS (PF04969, IPR007052): CS domain
54	NXF1	interactor	14	0.423	19.839	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
55	PC	interactor	7	0.667	2.486	Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain HMGL-like (PF00682, IPR000891): HMGL-like PYC_OADA (PF02436, IPR003379): Conserved carboxylase domain
56	PMS2	oncoprotein	6	0.533	2.080	DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain MORN_2 (PF07661, IPR011652): MORN repeat variant MutL_C (PF08676, IPR014790, SM00853): MutL C terminal dimerisation domain HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
57	POU5F1	oncoprotein	10	0.444	11.341	Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
58	PSMD2	oncoprotein	18	0.301	61.276	PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat THAP (PF05485, IPR006612, SM00980): THAP domain HEAT_2 (PF13646): HEAT repeats
59	RANBP6	interactor	3	1.000	0	HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_2 (PF13646): HEAT repeats
60	RNF126	interactor	6	0.700	0.737	Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger zinc_ribbon_9 (PF14369): zinc-ribbon
61	RNF2	interactor	20	0.345	48.745	zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
62	SACM1L	protein found in more fusions	7	0.867	0.833	DSS1_SEM1 (PF05160, IPR007834): DSS1/SEM1 family Syja_N (PF02383, IPR002013): SacI homology domain
63	SERTAD1	interactor	1	0	0	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal SERTA (PF06031, IPR009263): SERTA motif
64	SF3B1	oncoprotein	18	0.425	34.714	Dopey_N (PF04118, IPR007249): Dopey, N-terminal HEAT (PF02985, IPR000357): HEAT repeat SF3b1 (PF08920, IPR015016): Splicing factor 3B subunit 1 UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
65	SF3B2	interactor	13	0.474	14.094	DUF382 (PF04037, IPR007180): Domain of unknown function (DUF382) PAPA-1 (PF04795, IPR006880): PAPA-1-like conserved region PSP (PF04046, IPR006568, SM00581): PSP SAP (PF02037, IPR003034, SM00513): SAP domain Usp (PF00582, IPR006016): Universal stress protein family Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19 Vma12 (PF11712, IPR021013): Endoplasmic reticulum-based factor for assembly of V-ATPase FAM176 (PF14851): FAM176 family WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
66	SHMT2	interactor	10	0.489	9.303	SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
67	SIRT7	interactor	22	0.312	71.278	DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family
68	SKI	oncoprotein	6	0.600	2.067	c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family SlyX (PF04102, IPR007236): SlyX HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
69	SNTA1	interactor	3	0.667	0.333	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) PH (PF00169, IPR001849, SM00233): PH domain
70	SNW1	protein found in more fusions	19	0.444	44.504	SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain
71	TANK	suppressor	3	1.000	0	DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713) TBD (PF12845, IPR024581): TBD domain
72	TAP1	oncoprotein	6	0.600	4.917	ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region ABC_tran (PF00005, IPR003439): ABC transporter SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
73	TAPBP	interactor	6	0.533	3.671	C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
74	TCF20	interactor	3	0.667	0.333	tRNA_synt_1c_R2 (PF04557, IPR007638): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
75	TLE3	interactor	9	0.679	4.122	TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
76	TMED10	interactor	12	0.636	7.886	EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
77	TMEM216	interactor	5	0.700	0.722	Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
78	TRIM37	oncoprotein	4	0.667	1.000	MATH (PF00917, IPR002083, SM00061): MATH domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) MRFAP1 (PF15155, IPR029254): MORF4 family-associated protein1 PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain DUF5071 (PF16804, IPR031837): Domain of unknown function (DUF5071)
79	UBC	protein found in more fusions	20	0.275	77.198	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
80	UBQLN4	interactor	5	0.833	0.250	CRF (PF00473, IPR000187, SM00039): Corticotropin-releasing factor family DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) Arm_2 (PF04826, IPR006911): Armadillo-like NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B partial_CstF (PF15861, IPR031721): Partial cleavage stimulation factor domain
81	UQCRC2	oncoprotein	14	0.396	30.460	Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16) Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
82	VPS18	interactor	2	1.000	0	Pep3_Vps18 (PF05131, IPR007810): Pep3/Vps18/deep orange family Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
83	XPO1	interactor	25	0.307	124.915	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
84	XRCC6	oncoprotein	16	0.343	33.505	Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain SAP (PF02037, IPR003034, SM00513): SAP domain
85	YWHAZ	protein found in more fusions	20	0.404	41.118	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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