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Visible interactions: all affected independent (normal) nothing (blank)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)16
The number (and %) of the onco-proteins5 (31.25 %)
The number (and %) of the tumor suppressors2 (12.50 %)
Total number of binary PPIs (saturation %)64 (53.33 %)
The number (and %) of affected PPIs16 (25.00 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI7.375
Assortativity coefficient-0.4421
The network average Clustering coefficient0.765
The number (and %) of a zero Clustering coefficients1 (6.25 %)
The number (and %) of a zero Betweenness Centrality5 (31.25 %)


List of the fusions

PPI for parental proteins: COMMD6 All fusions
: CB242821;
Proteins found in more fusions VCP (see 4 fusions); NFKB1 (see 2 fusions); COMMD6 (see 1 fusions); COMMD1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 COMMD6parental protein160.41970.690COMM_domain (PF07258): COMM domain
2 CCDC22interactor90.8332.271DUF812 (PF05667, IPR008530): Protein of unknown function (DUF812)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
3 CCDC93interactor80.9290.571Cir_Bir_Yir (PF06022, IPR006477): Plasmodium variant antigen protein Cir/Yir/Bir
Iron_permease (PF04120, IPR007251): Low affinity iron permease
Adaptin_binding (PF10199, IPR019341): Alpha and gamma adaptin binding protein p34
KOG2701 (PF09762, IPR019159): Coiled-coil domain-containing protein (DUF2037)
DUF4107 (PF13389, IPR025180): Protein of unknown function (DUF4107)
DUF4239 (PF14023, IPR025333): Protein of unknown function (DUF4239)
4 COMMD1protein found in more fusions120.65511.119COMMD1_N (PF17221): COMMD1 N-terminal domain
COMM_domain (PF07258): COMM domain
5 COMMD10interactor90.8332.086BPL_N (PF09825, IPR019197): Biotin-protein ligase, N terminal
COMM_domain (PF07258): COMM domain
6 COMMD3interactor100.7783.724COMM_domain (PF07258): COMM domain
7 COMMD4interactor120.62116.024COMM_domain (PF07258): COMM domain
8 COMMD7interactor90.8332.205COMM_domain (PF07258): COMM domain
9 COMMD9interactor70.8570.952COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
CDT1_C (PF16679, IPR032054): DNA replication factor Cdt1 C-terminal domain
COMM_domain (PF07258): COMM domain
10 E2F6oncoprotein21.0000BRCA-2_OB3 (PF09104, IPR015188): BRCA2, oligonucleotide/oligosaccharide-binding, domain 3
E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
11 NFKB1suppressor100.55612.071Death (PF00531, IPR000488, SM00005): Death domain
GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
12 RELAoncoprotein70.9330.286DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
13 SCLT1oncoprotein51.0000DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
SlyX (PF04102, IPR007236): SlyX
XhlA (PF10779, IPR019715): Haemolysin XhlA
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
Imm7 (PF15585, IPR028965): Immunity protein 7
CCCAP (PF15964, IPR031887): Centrosomal colon cancer autoantigen protein family
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
14 UNKinteractor100MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
15 VCPprotein found in more fusions41.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
16 ZFP36suppressor21.0000zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)

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