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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)55
The number (and %) of the onco-proteins20 (36.36 %)
The number (and %) of the tumor suppressors12 (21.82 %)
Total number of binary PPIs (saturation %)263 (17.71 %)
The number (and %) of affected PPIs55 (20.91 %)
The number of possible different fusions13
PPI diameter2
PPI radius1
The average degree of PPI8.727
Assortativity coefficient-0.2271
The network average Clustering coefficient0.626
The number (and %) of a zero Clustering coefficients4 (7.27 %)
The number (and %) of a zero Betweenness Centrality12 (21.82 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: COMMD1 All fusions
Proteins found in more fusions CUL4A (see 4 fusions); VCP (see 4 fusions); CUL7 (see 2 fusions); COMMD1 (see 1 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); EP300 (see 1 fusions); SLC12A2 (see 1 fusions); NFKB1 (see 2 fusions); SGK1 (see 2 fusions); CLU (see 5 fusions); COMMD6 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 COMMD1parental protein550.1301855.233COMMD1_N (PF17221): COMMD1 N-terminal domain
COMM_domain (PF07258): COMM domain
2 AKT1oncoprotein70.6672.150PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
3 ATP7Ainteractor21.0000E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Fer2_BFD (PF04324, IPR007419): BFD-like [2Fe-2S] binding domain
HMA (PF00403, IPR006121): Heavy-metal-associated domain
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
4 ATP7Binteractor21.0000E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
HMA (PF00403, IPR006121): Heavy-metal-associated domain
Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
5 BAHCC1interactor100BAH (PF01426, IPR001025, SM00439): BAH domain
DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
DUF3441 (PF11923, IPR021846): Domain of unknown function (DUF3441)
DUF4537 (PF15057, IPR032770): Domain of unknown function (DUF4537)
6 BARD1suppressor60.7001.036BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
7 BIRC3oncoprotein50.6671.333BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
8 BRCA1suppressor100.5009.756BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
9 C16orf62interactor51.0000HSCB_C (PF07743, IPR009073): HSCB C-terminal oligomerisation domain
IL4 (PF00727, IPR002354): Interleukin 4
TFIIE_beta (PF02186, IPR003166): TFIIE beta subunit core domain
10 CCDC22interactor150.54326.710DUF812 (PF05667, IPR008530): Protein of unknown function (DUF812)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
11 CCDC93interactor110.8003.572Cir_Bir_Yir (PF06022, IPR006477): Plasmodium variant antigen protein Cir/Yir/Bir
Iron_permease (PF04120, IPR007251): Low affinity iron permease
Adaptin_binding (PF10199, IPR019341): Alpha and gamma adaptin binding protein p34
KOG2701 (PF09762, IPR019159): Coiled-coil domain-containing protein (DUF2037)
DUF4107 (PF13389, IPR025180): Protein of unknown function (DUF4107)
DUF4239 (PF14023, IPR025333): Protein of unknown function (DUF4239)
12 CDKN2Asuppressor60.8000.936Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
13 CFTRsuppressor50.6670.733ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
14 CLUsuppressor80.38112.222Clusterin (PF01093, IPR000753): Clusterin
15 COMMD10interactor130.7954.377BPL_N (PF09825, IPR019197): Biotin-protein ligase, N terminal
COMM_domain (PF07258): COMM domain
16 COMMD2interactor130.7189.410COMM_domain (PF07258): COMM domain
17 COMMD3interactor130.7317.021COMM_domain (PF07258): COMM domain
18 COMMD4interactor150.68612.301COMM_domain (PF07258): COMM domain
19 COMMD5interactor110.8552.119COMM_domain (PF07258): COMM domain
20 COMMD6protein found in more fusions120.6558.265COMM_domain (PF07258): COMM domain
21 COMMD7interactor90.8890.894COMM_domain (PF07258): COMM domain
22 COMMD8interactor150.61917.617COMM_domain (PF07258): COMM domain
23 CUL1suppressor130.40927.419Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
24 CUL2suppressor110.43619.111Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
25 CUL3protein found in more fusions130.56114.097Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
26 CUL4Aprotein found in more fusions90.6795.389Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
27 CUL4Boncoprotein60.8670.667Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
28 CUL5suppressor100.6676.475Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
29 CUL7protein found in more fusions40.6671.000ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
30 EP300oncoprotein80.6194.133Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
31 HIF1Asuppressor90.5837.358Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
32 HSPA4interactor180.26882.797Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
33 KAT2Ainteractor50.6671.000Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
NICE-1 (PF15845, IPR031698): Cysteine-rich C-terminal 1 family
34 LIG4interactor21.0000APG17 (PF04108, IPR007240): Autophagy protein Apg17
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
35 NAIPinteractor100BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
NACHT (PF05729): NACHT domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
Fer4_9 (PF13187, IPR017896): 4Fe-4S dicluster domain
36 NFKB1suppressor230.359102.821Death (PF00531, IPR000488, SM00005): Death domain
GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
37 NFKB2oncoprotein90.7862.522Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Death (PF00531, IPR000488, SM00005): Death domain
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
38 NFKBIAoncoprotein100.55611.278Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
39 NMRAL1interactor100NmrA (PF05368, IPR008030): NmrA-like family
40 PARK2suppressor60.8000.833IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
41 RELoncoprotein100.55612.186RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
42 RELAoncoprotein230.329114.979DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
43 RELBoncoprotein110.7456.300RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
RelB_leu_zip (PF16180, IPR032399): RelB leucine zipper
RelB_transactiv (PF16181, IPR032400): RelB transactivation domain
44 SCLT1oncoprotein80.7143.322DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
SlyX (PF04102, IPR007236): SlyX
XhlA (PF10779, IPR019715): Haemolysin XhlA
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
Imm7 (PF15585, IPR028965): Immunity protein 7
CCCAP (PF15964, IPR031887): Centrosomal colon cancer autoantigen protein family
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
45 SCNN1Boncoprotein30.6671.000ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
46 SCNN1Dinteractor21.0000ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
PRIMA1 (PF16101): Proline-rich membrane anchor 1
47 SCNN1Ginteractor21.0000ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
48 SGK1oncoprotein50.6672.000Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
49 SLC12A2protein found in more fusions31.0000AA_permease (PF00324, IPR004841): Amino acid permease
AA_permease_N (PF08403, IPR013612): Amino acid permease N-terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SLC12 (PF03522, IPR018491): Solute carrier family 12
50 SOCS1suppressor30.6670.500SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
51 SOD1interactor31.0000Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
52 SPP1oncoprotein100Osteopontin (PF00865, IPR002038, SM00017): Osteopontin
53 TCEB1oncoprotein70.4767.300Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
54 VCPprotein found in more fusions190.30177.077AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
55 XIAPinteractor60.6002.750BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)

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