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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins COL4A2 (from a repository: Sat Nov 12 09:36:19 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)26
The number (and %) of the onco-proteins4 (15.38 %)
The number (and %) of the tumor suppressors4 (15.38 %)
Total number of binary PPIs (saturation %)39 (12.00 %)
The number (and %) of affected PPIs26 (66.67 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI2.385
Assortativity coefficient-0.7440
The network average Clustering coefficient0.273
The number (and %) of a zero Clustering coefficients17 (65.38 %)
The number (and %) of a zero Betweenness Centrality23 (88.46 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: COL4A2 All fusions
Proteins found in more fusions VHL (see 1 fusions); DAZAP2 (see 2 fusions); COL4A1 (see 3 fusions); COL4A2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 COL4A2parental protein260.020581.000C4 (PF01413, IPR001442, SM00111): C-terminal tandem repeated domain in type 4 procollagen
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
2 ANXA7suppressor100Annexin (PF00191, IPR018502, SM00335): Annexin
3 C1QBinteractor21.0000C1q (PF00386, IPR001073, SM00110): C1q domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
4 C1QTNF2interactor21.0000C1q (PF00386, IPR001073, SM00110): C1q domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
5 C1QTNF9oncoprotein100C1q (PF00386, IPR001073, SM00110): C1q domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
6 CELA2Binteractor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
7 CLPSL1interactor100Toxin_3 (PF00537, IPR002061): Scorpion toxin-like domain
8 COL4A1protein found in more fusions31.0000C4 (PF01413, IPR001442, SM00111): C-terminal tandem repeated domain in type 4 procollagen
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
9 COL8A2interactor100C1q (PF00386, IPR001073, SM00110): C1q domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
10 COL9A1interactor21.0000Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF826 (PF05696, IPR008544): Protein of unknown function (DUF826)
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
11 CSNK2Binteractor31.0000CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
12 DAZAP2protein found in more fusions200DAZAP2 (PF11029, IPR022730): DAZ associated protein 2 (DAZAP2)
13 FAM46Ainteractor100NTP_transf_7 (PF07984, IPR012937, SM01153): Nucleotidyltransferase
14 FBXO6interactor100FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
15 FGL1interactor100Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
16 ITLN2interactor100Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
17 PTPRKsuppressor30.6671.000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Protocadherin (PF08374, IPR013585): Protocadherin
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
18 SEMG1interactor100Semenogelin (PF05474, IPR008836): Semenogelin
19 SERPINA6interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
20 SKILsuppressor200c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115)
21 SMN1interactor200SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
22 STBD1interactor100CBM_20 (PF00686, IPR002044): Starch binding domain
23 TK1oncoprotein31.0000TK (PF00265, IPR001267, SM00203): Thymidine kinase
24 TMEM25interactor100C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
DUF4674 (PF15719, IPR029779): Domain of unknown function (DUF4674)
25 TNPO3interactor100HEAT (PF02985, IPR000357): HEAT repeat
IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD)
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
26 VHLsuppressor60.4006.000Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
VHL_C (PF17211): VHL box domain

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