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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins NFATC3, CLCN3 (from a repository: Mon Dec 19 08:03:23 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)23
The number (and %) of the onco-proteins8 (34.78 %)
The number (and %) of the tumor suppressors6 (26.09 %)
Total number of binary PPIs (saturation %)45 (17.79 %)
The number (and %) of affected PPIs22 (48.89 %)
The number of possible different fusions9
PPI diameter5
PPI radius3
The average degree of PPI2.957
Assortativity coefficient-0.5311
The network average Clustering coefficient0.442
The number (and %) of a zero Clustering coefficients8 (34.78 %)
The number (and %) of a zero Betweenness Centrality14 (60.87 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: CLCN3,NFATC3 All fusions
: AI917646;
Proteins found in more fusions CLCN3 (see 3 fusions); HSPB1 (see 4 fusions); SUFU (see 1 fusions); MAPK9 (see 3 fusions); CDK6 (see 1 fusions); GOPC (see 2 fusions); LGALS3 (see 2 fusions); SLC9A3R1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CLCN3parental protein100.194178.000CBS (PF00571, IPR000644, SM00116): CBS domain
Voltage_CLC (PF00654, IPR001807): Voltage gated chloride channel
2 NFATC3parental protein120.061294.333DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
3 CDK6suppressor200Pkinase (PF00069, IPR000719): Protein kinase domain
4 CEP128interactor30.6677.667DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SpoOE-like (PF09388, IPR018540): Spo0E like sporulation regulatory protein
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
TraF_2 (PF13729, IPR032811): F plasmid transfer operon, TraF, protein
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
5 CFTRsuppressor70.40061.000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
6 CSNK1A1suppressor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
7 ENO1oncoprotein100Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
8 GOPConcoprotein50.167235.000DUF903 (PF06004, IPR010305): Bacterial protein of unknown function (DUF903)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
DUF3209 (PF11483, IPR021577): Protein of unknown function (DUF3209)
9 HSPB1oncoprotein31.0000HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
10 LGALS3oncoprotein40.6671.000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
11 LGALS8interactor100Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
12 LGALS9interactor21.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
13 LYPD3oncoprotein100DUF753 (PF05444, IPR008472): Protein of unknown function (DUF753)
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
14 MAPK8oncoprotein40.6671.000DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
15 MAPK9suppressor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
16 MOV10interactor2096.667AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
17 NCOA3oncoprotein21.0000DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator
PAS (PF00989, IPR013767, SM00091): PAS fold
PAS_3 (PF08447, IPR013655): PAS fold
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
PAS_11 (PF14598): PAS domain
DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927)
NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
18 NXF1interactor40.333123.333NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
19 PDZK1interactor31.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF4265 (PF14085, IPR025361): Domain of unknown function (DUF4265)
20 SHMT2interactor100SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
21 SLC9A3R1suppressor41.0000EBP50_C (PF09007, IPR015098): EBP50, C-terminal
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
22 SUFUsuppressor200SUFU (PF05076, IPR020941): Suppressor of fused protein (SUFU)
SUFU_C (PF12470, IPR024314): Suppressor of Fused Gli/Ci N terminal binding domain
23 ZMIZ1oncoprotein100zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CLCN3parental proteinCBS (PF00571, IPR000644, SM00116): CBS domain
Voltage_CLC (PF00654, IPR001807): Voltage gated chloride channel
AI917646
2 LGALS3oncoproteinGal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectinAI917646
3 LGALS8interactorGal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectinAI917646
4 LGALS9interactorGal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
AI917646
5 LYPD3oncoproteinDUF753 (PF05444, IPR008472): Protein of unknown function (DUF753)
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
AI917646
6 NFATC3parental proteinDUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
AI917646
7 PDZK1interactorPDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF4265 (PF14085, IPR025361): Domain of unknown function (DUF4265)
AI917646
8 SLC9A3R1suppressorEBP50_C (PF09007, IPR015098): EBP50, C-terminal
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
AI917646

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