Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CKAP4 (from a repository: Mon Dec 5 03:32:49 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)73
The number (and %) of the onco-proteins18 (24.66 %)
The number (and %) of the tumor suppressors10 (13.70 %)
Total number of binary PPIs (saturation %)265 (10.08 %)
The number (and %) of affected PPIs73 (27.55 %)
The number of possible different fusions12
PPI diameter2
PPI radius1
The average degree of PPI6.575
Assortativity coefficient-0.3502
The network average Clustering coefficient0.477
The number (and %) of a zero Clustering coefficients13 (17.81 %)
The number (and %) of a zero Betweenness Centrality23 (31.51 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CKAP4 All fusions
: BF802120; AI056664; BE715033; BE715024; AI741356;
Proteins found in more fusions LGALS3 (see 2 fusions); EWSR1 (see 2 fusions); CRY2 (see 3 fusions); SH3KBP1 (see 1 fusions); CKAP4 (see 5 fusions); MCM2 (see 1 fusions); CUL7 (see 2 fusions); COPS5 (see 1 fusions); CUL3 (see 1 fusions); MYC (see 1 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CKAP4parental protein730.0664101.656DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
FPP (PF05911, IPR008587): Filament-like plant protein, long coiled-coil
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
2 ABL1oncoprotein90.42910.886Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
3 ADRA1Dinteractor21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
4 ARRB1interactor30.6670.500Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
5 ASCC2interactor31.0000CUE (PF02845, IPR003892, SM00546): CUE domain
BLOC1S3 (PF15753, IPR017245): Biogenesis of lysosome-related organelles complex 1 subunit 3
6 ATF4oncoprotein50.5002.222bZIP_1 (PF00170, IPR004827): bZIP transcription factor
7 ATP6AP2interactor100.36114.702Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
Renin_r (PF07850, IPR012493): Renin receptor-like protein
8 B3GAT3interactor31.0000Glyco_transf_43 (PF03360, IPR005027): Glycosyltransferase family 43
9 CCDC53interactor100DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
10 CCDC8interactor100.5837.600Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
11 CHRNA9interactor21.0000Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
12 CLN3interactor21.0000CLN3 (PF02487, IPR003492): CLN3 protein
13 COLEC10interactor100Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
14 COPS5protein found in more fusions100.6394.997JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
15 CRY2protein found in more fusions31.0000DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
16 CUL3protein found in more fusions110.46717.644Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
17 CUL7protein found in more fusions100.6675.389ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
18 ECT2suppressor30.6670.667BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
19 ELAVL1oncoprotein220.229134.588RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
20 EMC2interactor150.24861.036TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_19 (PF14559): Tetratricopeptide repeat
Alkyl_sulf_dimr (PF14863, IPR029228): Alkyl sulfatase dimerisation
21 EVC2interactor40.5000.952HBS1_N (PF08938, IPR015033): HBS1 N-terminus
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
Histone_HNS (PF00816, IPR001801): H-NS histone family
EVC2_like (PF12297, IPR022076): Ellis van Creveld protein 2 like protein
22 EWSR1oncoprotein140.53817.241RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
23 FUSsuppressor120.43920.433Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
24 GOLT1Binteractor90.5009.138Got1 (PF04178, IPR007305): Got1/Sft2-like family
25 HAMPinteractor100Hepcidin (PF06446, IPR010500): Hepcidin
26 HAUS7interactor40.5003.000M3 (PF09213, IPR015296): M3
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
27 HDGFinteractor70.3818.489PWWP (PF00855, IPR000313, SM00293): PWWP domain
28 HIST1H3Einteractor30.6670.500Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
29 HS2ST1interactor21.0000Sulfotransfer_2 (PF03567, IPR005331): Sulfotransferase family
DICT (PF10069, IPR019278): Sensory domain in DIguanylate Cyclases and Two-component system
30 INTS4P2interactor100NA
31 LGALS3oncoprotein40.6671.000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
32 LPAR1oncoprotein30.6671.0007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
33 LYPD3oncoprotein30.6671.000DUF753 (PF05444, IPR008472): Protein of unknown function (DUF753)
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
34 LYPD6interactor21.0000UPAR_LY6_2 (PF16975): Ly6/PLAUR domain-containing protein 6, Lypd6
35 MAST3interactor100DUF1908 (PF08926, IPR015022): Domain of unknown function (DUF1908)
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase (PF00069, IPR000719): Protein kinase domain
ACTL7A_N (PF16840, IPR031769): Actin-like protein 7A N-terminus
36 MCM2oncoprotein100.44415.067AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
37 MLH1suppressor40.6671.667DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Mlh1_C (PF16413, IPR032189): DNA mismatch repair protein Mlh1 C-terminus
38 MMGT1interactor110.49114.155MMgT (PF10270, IPR018937): Membrane magnesium transporter
39 MOV10interactor110.29124.686AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
40 MVPoncoprotein40.6670.400Vault (PF01505, IPR002499): Major Vault Protein repeat
DUF2543 (PF10820, IPR020251): Protein of unknown function (DUF2543)
MVP_shoulder (PF11978, IPR021870): Shoulder domain
41 MYConcoprotein80.4768.752HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
42 NDUFB7interactor50.7001.119DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
NDUF_B7 (PF05676, IPR008698): NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)
OrfB_IS605 (PF01385, IPR001959): Probable transposase
43 NKX3-1suppressor100Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
44 NTRK1oncoprotein170.33357.008I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
45 NXF1interactor130.19739.600NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
46 OBSL1interactor100.6396.389BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
47 PARK2suppressor80.4298.056IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
48 PKN2interactor31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
49 PRELPinteractor100LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
50 PRKCZinteractor40.6670.667PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
51 RAB5Concoprotein100.35618.522Ras (PF00071, IPR001806, SM00173): Ras family
52 RAB7Asuppressor130.30839.158Ras (PF00071, IPR001806, SM00173): Ras family
53 RNF144Asuppressor200IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
54 SELENOSinteractor100Selenoprotein_S (PF06936, IPR009703): Selenoprotein S (SelS)
DUF3326 (PF11805, IPR021763): Protein of unknown function (DUF3326)
55 SH3KBP1protein found in more fusions70.4004.789Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
56 SLC33A1interactor60.3333.869Acatn (PF13000, IPR024371): Acetyl-coenzyme A transporter 1
57 SLC39A4suppressor31.0000Zip (PF02535, IPR003689): ZIP Zinc transporter
Class_IIIsignal (PF04021, IPR007166): Class III signal peptide
58 SPRTNinteractor30.6670.667GreA_GreB (PF01272, IPR001437): Transcription elongation factor, GreA/GreB, C-term
SprT-like (PF10263, IPR006640, SM00731): SprT-like family
PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
59 TCTN1interactor100DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
60 TCTN2interactor90.38913.390DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
61 TCTN3interactor90.33314.160DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
62 THOC7interactor30.6670.222EcoEI_R_C (PF08463, IPR013670): EcoEI R protein C-terminal
THOC7 (PF05615, IPR008501): Tho complex subunit 7
UPF0193 (PF05250, IPR007914): Uncharacterised protein family (UPF0193)
63 TMEM17interactor80.39311.771Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
64 TMEM216interactor90.4728.390Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
65 TMEM237interactor50.8001.000TMEM237 (PF15383, IPR029409): Transmembrane protein 237
66 TMEM63Binteractor40.6671.286RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
Wzy_C (PF04932, IPR007016): O-Antigen ligase
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
RSN1_TM (PF13967, IPR032880): Late exocytosis, associated with Golgi transport
PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter
67 TMEM67interactor40.5002.286Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
Tme5_EGF_like (PF09064, IPR015149): Thrombomodulin like fifth domain, EGF-like
Meckelin (PF09773, IPR019170): Meckelin (Transmembrane protein 67)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
68 TNFRSF10Bsuppressor30.6671.000Death (PF00531, IPR000488, SM00005): Death domain
RskA (PF10099, IPR018764): Anti-sigma-K factor rskA
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
69 TP53suppressor130.39428.800DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
70 TSNAXinteractor100Translin (PF01997, IPR002848): Translin family
71 USP50interactor100UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
72 VAPAinteractor110.40024.483DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
73 XRCC3oncoprotein100Rad51 (PF08423, IPR013632): Rad51
RNA_pol_A_CTD (PF03118, IPR011260): Bacterial RNA polymerase, alpha chain C terminal domain

B a c k    t o    T o p ⇑