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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)71
The number (and %) of the onco-proteins5 (7.04 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)183 (7.36 %)
The number (and %) of affected PPIs71 (38.80 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI4.986
Assortativity coefficient-0.5930
The network average Clustering coefficient0.574
The number (and %) of a zero Clustering coefficients20 (28.17 %)
The number (and %) of a zero Betweenness Centrality49 (69.01 %)


List of the fusions

PPI for parental proteins: CISD3 All fusions
Proteins found in more fusions NDUFS3 (see 1 fusions); CISD3 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 CISD3parental protein710.0443784.440zf-CDGSH (PF09360, IPR018967, SM00704): Iron-binding zinc finger CDGSH type
MOLO1 (PF17175): Modulator of levamisole receptor-1
2 ABHD10interactor100Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold
Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
3 AFG3L2interactor50.7000.905AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
FtsH_ext (PF06480, IPR011546): FtsH Extracellular
Peptidase_M41 (PF01434, IPR000642): Peptidase family M41
TniB (PF05621, IPR008868): Bacterial TniB protein
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
4 ATP5C1interactor70.7621.488ATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
5 ATP5F1interactor110.50914.383Mt_ATP-synt_B (PF05405, IPR008688): Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
DUF2105 (PF09878, IPR019212): Predicted membrane protein (DUF2105)
6 ATP5F1Einteractor21.0000ATP-synt_Eps (PF04627, IPR006721): Mitochondrial ATP synthase epsilon chain
7 ATP5Hinteractor60.8001.250Mt_ATP-synt_D (PF05873, IPR008689): ATP synthase D chain, mitochondrial (ATP5H)
8 ATP5Jinteractor70.5247.369ATP-synt_F6 (PF05511, IPR008387): Mitochondrial ATP synthase coupling factor 6
9 ATP5POinteractor90.5009.338OSCP (PF00213, IPR000711): ATP synthase delta (OSCP) subunit
10 BCKDHAinteractor21.0000E1_dh (PF00676, IPR001017): Dehydrogenase E1 component
11 C1QBPinteractor90.41716.452MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
12 CHCHD2interactor290.135272.619CHCH (PF06747, IPR010625): CHCH domain
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
13 CHCHD4interactor100CHCH (PF06747, IPR010625): CHCH domain
Voldacs (PF03517): Regulator of volume decrease after cellular swelling
14 CLPBinteractor21.0000AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
Torsin (PF06309, IPR010448): Torsin
ClpB_D2-small (PF10431, IPR019489, SM01086): C-terminal, D2-small domain, of ClpB protein
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
AAA_33 (PF13671): AAA domain
Ank_5 (PF13857): Ankyrin repeats (many copies)
15 CLPXinteractor41.0000AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
ClpB_D2-small (PF10431, IPR019489, SM01086): C-terminal, D2-small domain, of ClpB protein
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
Sigma54_activ_2 (PF14532, IPR002078): Sigma-54 interaction domain
16 COASYinteractor100CoaE (PF01121, IPR001977): Dephospho-CoA kinase
CTP_transf_like (PF01467, IPR004821): Cytidylyltransferase-like
17 COX5Ainteractor30.6670.400COX5A (PF02284, IPR003204): Cytochrome c oxidase subunit Va
18 COX6A1interactor31.0000COX6A (PF02046, IPR001349): Cytochrome c oxidase subunit VIa
19 COX6Concoprotein31.0000COX6C (PF02937, IPR004204): Cytochrome c oxidase subunit VIc
20 COX7A2interactor21.0000COX7a (PF02238, IPR003177): Cytochrome c oxidase subunit VII
21 DHCR24interactor100FAD_binding_4 (PF01565, IPR006094): FAD binding domain
22 DHX30interactor30.6671.000Bombolitin (PF08096, IPR012534): Bombolitin family
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Dicer_dimer (PF03368, IPR005034): Dicer dimerisation domain
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
23 DLATinteractor21.00002-oxoacid_dh (PF00198, IPR001078): 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
E3_binding (PF02817, IPR004167): e3 binding domain
Rib_recp_KP_reg (PF05104, IPR007794): Ribosome receptor lysine/proline rich region
Stm1_N (PF09598, IPR019084): Stm1
NICE-1 (PF15845, IPR031698): Cysteine-rich C-terminal 1 family
24 ECH1interactor31.0000ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
25 ERAL1interactor21.0000GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
KH_1 (PF00013, IPR004088, SM00322): KH domain
26 GLRX5interactor31.0000Glutaredoxin (PF00462, IPR002109): Glutaredoxin
27 GLSinteractor100Glutaminase (PF04960, IPR015868): Glutaminase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
28 GRSF1interactor60.4676.417RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
VWA_N2 (PF16164, IPR032361): VWA N-terminal
29 GSTK1interactor200DSBA (PF01323, IPR001853): DSBA-like thioredoxin domain
30 IDEinteractor30.6670.286Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
Peptidase_M16_M (PF16187, IPR032632): Middle or third domain of peptidase_M16
31 MAVSinteractor200Ice_nucleation (PF00818, IPR000258): Ice nucleation protein repeat
CARD_2 (PF16739, IPR031964): Caspase recruitment domain
32 MIPEPinteractor100Peptidase_M3 (PF01432, IPR001567): Peptidase family M3
33 MMADHCinteractor100MMADHC (PF10229, IPR019362): Methylmalonic aciduria and homocystinuria type D protein
34 MRPL22interactor31.0000Ribosomal_L22 (PF00237, IPR001063): Ribosomal protein L22p/L17e
35 MRPS10interactor31.0000Ribosomal_S10 (PF00338, IPR027486): Ribosomal protein S10p/S20e
36 MRPS33interactor100MRP-S33 (PF08293, IPR013219): Mitochondrial ribosomal subunit S27
37 MTERF3interactor100mTERF (PF02536, IPR003690, SM00733): mTERF
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
38 MTX1interactor100Tom37 (PF10568, IPR019564): Outer mitochondrial membrane transport complex protein
GST_C_6 (PF17171): Glutathione S-transferase, C-terminal domain
39 NCAPD3interactor100DUF3013 (PF11217, IPR021380): Protein of unknown function (DUF3013)
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Cnd3 (PF12719, IPR025977): Nuclear condensing complex subunits, C-term domain
40 NDUFA2interactor50.6003.500L51_S25_CI-B8 (PF05047, IPR007741, SM00916): Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
41 NDUFA5interactor21.0000ETC_C1_NDUFA5 (PF04716, IPR006806): ETC complex I subunit conserved region
42 NDUFA8interactor90.44413.283CHCH (PF06747, IPR010625): CHCH domain
Pet191_N (PF10203, IPR018793): Cytochrome c oxidase assembly protein PET191
Cdd1 (PF11731, IPR021725): Pathogenicity locus
43 NDUFC2interactor21.0000NDUF_C2 (PF06374, IPR009423): NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2)
44 NDUFS1interactor90.6395.971NADH_dhqG_C (PF09326, IPR015405): NADH-ubiquinone oxidoreductase subunit G, C-terminal
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
Molybdopterin (PF00384, IPR006656): Molybdopterin oxidoreductase
NADH-G_4Fe-4S_3 (PF10588, IPR019574, SM00929): NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
Fer2_4 (PF13510): 2Fe-2S iron-sulfur cluster binding domain
45 NDUFS2interactor60.6674.286Complex1_49kDa (PF00346, IPR001135): Respiratory-chain NADH dehydrogenase, 49 Kd subunit
NiFeSe_Hases (PF00374, IPR001501): Nickel-dependent hydrogenase
46 NDUFS3protein found in more fusions360.139444.974Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
47 NIPSNAP1interactor31.0000NIPSNAP (PF07978, IPR012577): NIPSNAP
48 NRDCinteractor31.0000Cnd2 (PF05786, IPR022816): Condensin complex subunit 2
Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
Tom22 (PF04281, IPR005683): Mitochondrial import receptor subunit Tom22
Peptidase_M16_M (PF16187, IPR032632): Middle or third domain of peptidase_M16
49 NT5DC2interactor1005_nucleotid (PF05761, IPR008380): 5' nucleotidase family
50 PITRM1interactor31.0000M16C_assoc (PF08367, IPR013578): Peptidase M16C associated
Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
51 PMPCAinteractor41.0000Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
52 PMPCBinteractor41.0000Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
53 POLDIP2interactor31.0000DUF525 (PF04379, IPR007474): ApaG domain
YccV-like (PF08755, IPR011722, SM00992): Hemimethylated DNA-binding protein YccV like
54 POLRMTinteractor21.0000DUF615 (PF04751, IPR006839): Protein of unknown function (DUF615)
PSD2 (PF07624, IPR011478): Protein of unknown function (DUF1585)
RNA_pol (PF00940, IPR002092): DNA-dependent RNA polymerase
PPR_3 (PF13812, IPR002885): Pentatricopeptide repeat domain
RPOL_N (PF14700, IPR029262): DNA-directed RNA polymerase N-terminal
55 SARS2interactor21.0000tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
DUF2312 (PF10073, IPR018753): Uncharacterized protein conserved in bacteria (DUF2312)
DUF4445 (PF14574, IPR027980): Domain of unknown function (DUF4445)
56 SCO1interactor21.0000SCO1-SenC (PF02630, IPR003782): SCO1/SenC
57 SCO2interactor21.0000SCO1-SenC (PF02630, IPR003782): SCO1/SenC
58 SLC16A1oncoprotein21.0000MFS_1 (PF07690, IPR011701): Major Facilitator Superfamily
59 SLC25A1interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
60 SPG20interactor100MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
Senescence (PF06911, IPR009686): Senescence-associated protein
61 STOML2oncoprotein41.0000Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4769 (PF15992, IPR031934): Domain of unknown function (DUF4769)
Band_7_C (PF16200, IPR032435): C-terminal region of band_7
62 TARS2interactor100HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
TGS (PF02824, IPR004095): TGS domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
63 TBRG4interactor100FAST_1 (PF06743, IPR010622): FAST kinase-like protein, subdomain 1
FAST_2 (PF08368, IPR013579): FAST kinase-like protein, subdomain 2
FATC (PF02260, IPR003152): FATC domain
RAP (PF08373, IPR013584, SM00952): RAP domain
64 TIMM44interactor50.6003.500Tim44 (PF04280, IPR007379, SM00978): Tim44-like domain
DUF4211 (PF13926, IPR025451): Domain of unknown function (DUF4211)
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
RecG_N (PF17190): RecG N-terminal helical domain
65 TIMM50interactor21.0000NIF (PF03031, IPR004274): NLI interacting factor-like phosphatase
66 TOMM5interactor100TOM_sub5 (PF15178, IPR029179): Mitochondrial import receptor subunit TOM5 homolog
67 TRMT10Cinteractor31.0000tRNA_m1G_MT (PF01746, IPR016009): tRNA (Guanine-1)-methyltransferase
PPR_2 (PF13041, IPR002885): PPR repeat family
68 UQCRBinteractor80.5368.471UCR_14kD (PF02271, IPR003197): Ubiquinol-cytochrome C reductase complex 14kD subunit
69 UQCRC2oncoprotein100.44415.167Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
70 UQCRFS1interactor40.8330.500Rieske (PF00355, IPR017941): Rieske [2Fe-2S] domain
Ubiq-Cytc-red_N (PF09165, IPR015248): Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region
71 YARS2interactor100S4 (PF01479, IPR002942, SM00363): S4 domain
tRNA-synt_1b (PF00579, IPR002305): tRNA synthetases class I (W and Y)

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