Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CHST10, CNTNAP1 (from a repository: Sat Jan 18 10:35:49 2020)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)17
The number (and %) of the onco-proteins1 (5.88 %)
The number (and %) of the tumor suppressors5 (29.41 %)
Total number of binary PPIs (saturation %)24 (17.65 %)
The number (and %) of affected PPIs16 (66.67 %)
The number of possible different fusions3
PPI diameter4
PPI radius2
The average degree of PPI2.471
Assortativity coefficient-0.6622
The network average Clustering coefficient0.244
The number (and %) of a zero Clustering coefficients10 (58.82 %)
The number (and %) of a zero Betweenness Centrality12 (70.59 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: CHST10,CNTNAP1 All fusions
: BP392914;
Proteins found in more fusions HSF1 (see 3 fusions); RTN4 (see 11 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CHST10parental protein110.018189.000Sulfotransfer_2 (PF03567, IPR005331): Sulfotransferase family
SLC3A2_N (PF16028, IPR031984): Solute carrier family 3 member 2 N-terminus
2 CNTNAP1parental protein50.30059.000EGF (PF00008, IPR000742, SM00181): EGF-like domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
3 ECT2suppressor100BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
4 FBXO6interactor30.33363.000FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
5 HLA-DPB1interactor2037.000MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
6 HS6ST2interactor100Sulfotransfer_2 (PF03567, IPR005331): Sulfotransferase family
Clr2 (PF10383, IPR018839): Transcription-silencing protein Clr2
7 HSF1protein found in more fusions200DUF247 (PF03140, IPR004158): Plant protein of unknown function
Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor
HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
8 KCNA1interactor31.0000Ion_trans (PF00520, IPR005821): Ion transport protein
BTB_2 (PF02214, IPR003131): BTB/POZ domain
Sigma_reg_N (PF13800, IPR029101): Sigma factor regulator N-terminal
9 KCNA2interactor41.0000Ion_trans (PF00520, IPR005821): Ion transport protein
BTB_2 (PF02214, IPR003131): BTB/POZ domain
Sigma_reg_N (PF13800, IPR029101): Sigma factor regulator N-terminal
10 NPTX1interactor100IncA (PF04156, IPR007285): IncA protein
MRP-S27 (PF10037, IPR019266): Mitochondrial 28S ribosomal protein S27
Pentaxin (PF00354, IPR001759, SM00159): Pentaxin family
11 PARLinteractor100Rhomboid (PF01694, IPR022764): Rhomboid family
12 PON2interactor21.0000Arylesterase (PF01731, IPR002640): Arylesterase
13 PPM1Asuppressor100PP2C (PF00481, IPR001932): Protein phosphatase 2C
PP2C_C (PF07830, IPR012911, SM00332): Protein serine/threonine phosphatase 2C, C-terminal domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
14 PTPRKsuppressor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Protocadherin (PF08374, IPR013585): Protocadherin
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
15 RTN4suppressor50.50026.000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Reticulon (PF02453, IPR003388): Reticulon
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
16 SGPP1interactor100DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
PAP2 (PF01569, IPR000326, SM00014): PAP2 superfamily
17 SPINT2suppressor100Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain

B a c k    t o    T o p ⇑


List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CHST10parental proteinSulfotransfer_2 (PF03567, IPR005331): Sulfotransferase family
SLC3A2_N (PF16028, IPR031984): Solute carrier family 3 member 2 N-terminus
BP392914
2 CNTNAP1parental proteinEGF (PF00008, IPR000742, SM00181): EGF-like domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
BP392914
3 ECT2suppressorBRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
BP392914
4 FBXO6interactorFBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
BP392914
5 HLA-DPB1interactorMHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
BP392914
6 HS6ST2interactorSulfotransfer_2 (PF03567, IPR005331): Sulfotransferase family
Clr2 (PF10383, IPR018839): Transcription-silencing protein Clr2
BP392914
7 HSF1interactorDUF247 (PF03140, IPR004158): Plant protein of unknown function
Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor
HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
BP392914
8 KCNA1interactorIon_trans (PF00520, IPR005821): Ion transport protein
BTB_2 (PF02214, IPR003131): BTB/POZ domain
Sigma_reg_N (PF13800, IPR029101): Sigma factor regulator N-terminal
BP392914
9 KCNA2interactorIon_trans (PF00520, IPR005821): Ion transport protein
BTB_2 (PF02214, IPR003131): BTB/POZ domain
Sigma_reg_N (PF13800, IPR029101): Sigma factor regulator N-terminal
BP392914
10 NPTX1interactorIncA (PF04156, IPR007285): IncA protein
MRP-S27 (PF10037, IPR019266): Mitochondrial 28S ribosomal protein S27
Pentaxin (PF00354, IPR001759, SM00159): Pentaxin family
BP392914
11 PARLinteractorRhomboid (PF01694, IPR022764): Rhomboid familyBP392914
12 PON2interactorArylesterase (PF01731, IPR002640): ArylesteraseBP392914
13 PPM1AsuppressorPP2C (PF00481, IPR001932): Protein phosphatase 2C
PP2C_C (PF07830, IPR012911, SM00332): Protein serine/threonine phosphatase 2C, C-terminal domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
BP392914
14 PTPRKsuppressorfn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Protocadherin (PF08374, IPR013585): Protocadherin
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
BP392914
15 RTN4suppressorCENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Reticulon (PF02453, IPR003388): Reticulon
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
BP392914
16 SGPP1interactorDUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
PAP2 (PF01569, IPR000326, SM00014): PAP2 superfamily
BP392914
17 SPINT2suppressorKunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domainBP392914

B a c k    t o    T o p ⇑