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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)22
The number (and %) of the onco-proteins7 (31.82 %)
The number (and %) of the tumor suppressors1 (4.55 %)
Total number of binary PPIs (saturation %)60 (25.97 %)
The number (and %) of affected PPIs22 (36.67 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI4.455
Assortativity coefficient-0.2303
The network average Clustering coefficient0.536
The number (and %) of a zero Clustering coefficients5 (22.73 %)
The number (and %) of a zero Betweenness Centrality9 (40.91 %)


List of the fusions

Proteins found in more fusions APP (see 4 fusions); CHMP2B (see 1 fusions); VPS4A (see 1 fusions); CHMP3 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 CHMP3parental protein220.133316.400Snf7 (PF03357, IPR005024): Snf7
2 APPprotein found in more fusions50.5003.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
3 ATP6V1B1interactor40.8330.667ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
4 CHMP1Binteractor80.4768.200Snf7 (PF03357, IPR005024): Snf7
5 CHMP2Ainteractor80.5246.867Snf7 (PF03357, IPR005024): Snf7
6 CHMP2Bprotein found in more fusions50.8330.667Involucrin (PF00904, IPR000354): Involucrin repeat
Snf7 (PF03357, IPR005024): Snf7
7 CHMP4Ainteractor60.7001.200Snf7 (PF03357, IPR005024): Snf7
8 CHMP4Binteractor110.46717.733Snf7 (PF03357, IPR005024): Snf7
9 CXorf56interactor21.0000DUF4410 (PF14366, IPR025522): Domain of unknown function (DUF4410)
10 DAXXoncoprotein31.0000Daxx (PF03344, IPR005012): Daxx N-terminal Rassf1C-interacting domain
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Nop14 (PF04147, IPR007276): Nop14-like family
RF-1 (PF00472, IPR000352): RF-1 domain
Vpu (PF00558, IPR008187): Vpu protein
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
11 IGFBP7suppressor100IGFBP (PF00219, IPR000867, SM00121): Insulin-like growth factor binding protein
Kazal_2 (PF07648, IPR002350, SM00280): Kazal-type serine protease inhibitor domain
Ig_3 (PF13927): Immunoglobulin domain
12 MEPCEinteractor100Bin3 (PF06859, IPR010675): Bicoid-interacting protein 3 (Bin3)
Methyltransf_23 (PF13489): Methyltransferase domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7
13 RAB11Aoncoprotein21.0000Ras (PF00071, IPR001806, SM00173): Ras family
14 SMAD1interactor40.6671.000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
15 SMAD5interactor21.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
16 STAMBPinteractor50.7001.200USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
DUF3526 (PF12040, IPR021913): Domain of unknown function (DUF3526)
17 TFGoncoprotein60.7001.200ARS2 (PF04959, IPR007042): Arsenite-resistance protein 2
MucBP (PF06458, IPR009459): MucBP domain
PB1 (PF00564, IPR000270, SM00666): PB1 domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
18 TNPO3interactor100HEAT (PF02985, IPR000357): HEAT repeat
IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD)
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
19 VAV2oncoprotein100PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
CotJB (PF12652, IPR024207): CotJB protein
20 VAX2interactor100Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
21 VPS4Aprotein found in more fusions70.6003.867AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
TIP49 (PF06068, IPR010339): TIP49 C-terminus
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
YCII (PF03795, IPR005545): YCII-related domain
22 VTA1interactor40.6672.000Vta1 (PF04652): Vta1 like

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