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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CHMP2B (from a repository: Tue Dec 6 01:12:56 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)25
The number (and %) of the onco-proteins6 (24.00 %)
The number (and %) of the tumor suppressors3 (12.00 %)
Total number of binary PPIs (saturation %)57 (19.00 %)
The number (and %) of affected PPIs25 (43.86 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI3.600
Assortativity coefficient-0.4757
The network average Clustering coefficient0.500
The number (and %) of a zero Clustering coefficients9 (36.00 %)
The number (and %) of a zero Betweenness Centrality17 (68.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CHMP2B All fusions
: BU608643;
Proteins found in more fusions CHMP2B (see 1 fusions); VHL (see 1 fusions); CHMP3 (see 1 fusions); TERF2IP (see 1 fusions); SQSTM1 (see 5 fusions); PAFAH1B1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CHMP2Bparental protein250.076469.667Involucrin (PF00904, IPR000354): Involucrin repeat
Snf7 (PF03357, IPR005024): Snf7
2 ATP5C1interactor21.0000ATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
3 ATP6AP2interactor41.0000Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
Renin_r (PF07850, IPR012493): Renin receptor-like protein
4 ATP6V1B1interactor40.6672.000ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
5 CHMP2Ainteractor100.36121.667Snf7 (PF03357, IPR005024): Snf7
6 CHMP3protein found in more fusions50.8330.667Snf7 (PF03357, IPR005024): Snf7
7 CHMP4Binteractor80.5717.333Snf7 (PF03357, IPR005024): Snf7
8 GOLT1Binteractor31.0000Got1 (PF04178, IPR007305): Got1/Sft2-like family
9 LTN1interactor100zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
10 MAD2L1oncoprotein200HORMA (PF02301, IPR003511): HORMA domain
11 MALSU1interactor100RsfS (PF02410, IPR025656): Ribosomal silencing factor during starvation
12 MYH14interactor100IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
13 PAFAH1B1suppressor200LisH (PF08513, IPR013720, SM00667): LisH
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
14 PHGDHinteractor21.00002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
15 PNMA1oncoprotein100PNMA (PF14893, IPR026523): PNMA
16 RAB5Concoprotein50.8001.333Ras (PF00071, IPR001806, SM00173): Ras family
17 RAB7Asuppressor50.8001.333Ras (PF00071, IPR001806, SM00173): Ras family
18 SGO1interactor100DUF778 (PF05608, IPR008496): Protein of unknown function (DUF778)
Menin (PF05053, IPR007747): Menin
Shugoshin_C (PF07557, IPR011515): Shugoshin C terminus
Shugoshin_N (PF07558, IPR011516): Shugoshin N-terminal coiled-coil region
19 SQSTM1oncoprotein31.0000PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
20 TERF2IPprotein found in more fusions31.0000BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
Histone_HNS (PF00816, IPR001801): H-NS histone family
Myb_DNA-bind_2 (PF08914, IPR015010): Rap1 Myb domain
Rap1_C (PF11626, IPR021661): TRF2-interacting telomeric protein/Rap1 - C terminal domain
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
21 TRAF2interactor200MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
22 USP54interactor21.0000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
23 USP8interactor31.0000DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain
SET (PF00856, IPR001214, SM00317): SET domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain
24 VHLsuppressor200Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
VHL_C (PF17211): VHL box domain
25 XPO1interactor50.4006.000CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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