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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins6 (21.43 %)
The number (and %) of the tumor suppressors4 (14.29 %)
Total number of binary PPIs (saturation %)85 (22.49 %)
The number (and %) of affected PPIs28 (32.94 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI5.286
Assortativity coefficient-0.3467
The network average Clustering coefficient0.579
The number (and %) of a zero Clustering coefficients4 (14.29 %)
The number (and %) of a zero Betweenness Centrality12 (42.86 %)


List of the fusions

PPI for parental proteins: CHMP1A All fusions
: BF798523; BQ223078;
Proteins found in more fusions VPS4A (see 1 fusions); CHMP1A (see 2 fusions); NF2 (see 1 fusions); ZDHHC17 (see 2 fusions); MCM2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 CHMP1Aparental protein280.134491.600Snf7 (PF03357, IPR005024): Snf7
2 ATP6V1B1interactor41.0000ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
3 CHMP1Binteractor100.52811.400Snf7 (PF03357, IPR005024): Snf7
4 CHMP4Binteractor140.37234.300Snf7 (PF03357, IPR005024): Snf7
5 CLTConcoprotein70.5247.300Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
6 FBXL18interactor100LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
F-box (PF00646, IPR001810, SM00256): F-box domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
7 GOLT1Binteractor50.7003.000Got1 (PF04178, IPR007305): Got1/Sft2-like family
8 IST1interactor120.40925.300Ist1 (PF03398, IPR005061): Regulator of Vps4 activity in the MVB pathway
9 LHX4suppressor100LIM (PF00412, IPR001781, SM00132): LIM domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
10 LNPKinteractor21.0000zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
DUF4153 (PF13687, IPR025291): Domain of unknown function (DUF4153)
11 MCM2oncoprotein40.6670.400AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
12 MEOX1interactor21.0000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
13 MOV10interactor30.6670.400AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
14 NF2suppressor60.5002.800ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
15 NR1I2suppressor21.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
16 NXF1interactor80.28611.067NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
17 OAS3interactor100NTP_transf_2 (PF01909, IPR002934): Nucleotidyltransferase domain
OAS1_C (PF10421, IPR018952): 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
18 RAB5Concoprotein70.5247.300Ras (PF00071, IPR001806, SM00173): Ras family
19 RAB7Asuppressor41.0000Ras (PF00071, IPR001806, SM00173): Ras family
20 STAMBPinteractor41.0000USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
DUF3526 (PF12040, IPR021913): Domain of unknown function (DUF3526)
21 TFGoncoprotein60.7002.000ARS2 (PF04959, IPR007042): Arsenite-resistance protein 2
MucBP (PF06458, IPR009459): MucBP domain
PB1 (PF00564, IPR000270, SM00666): PB1 domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
22 UBE2Iinteractor60.4004.733UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
23 USP8interactor50.5001.833DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain
SET (PF00856, IPR001214, SM00317): SET domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain
24 VPS4Aprotein found in more fusions60.8001.167AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
TIP49 (PF06068, IPR010339): TIP49 C-terminus
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
YCII (PF03795, IPR005545): YCII-related domain
25 VPS4Binteractor50.5003.400AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
TIP49 (PF06068, IPR010339): TIP49 C-terminus
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
26 VSX2interactor21.0000OAR (PF03826, IPR003654): OAR domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
27 ZDHHC17protein found in more fusions31.0000zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)
28 ZNF524interactor100AT_hook (PF02178, IPR017956, SM00384): AT hook motif
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger

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