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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)32
The number (and %) of the onco-proteins3 (9.38 %)
The number (and %) of the tumor suppressors1 (3.12 %)
Total number of binary PPIs (saturation %)107 (21.57 %)
The number (and %) of affected PPIs32 (29.91 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI6.188
Assortativity coefficient-0.3915
The network average Clustering coefficient0.610
The number (and %) of a zero Clustering coefficients7 (21.88 %)
The number (and %) of a zero Betweenness Centrality15 (46.88 %)


List of the fusions

PPI for parental proteins: CENPQ All fusions
Proteins found in more fusions KDM1A (see 2 fusions); VPS4A (see 1 fusions); APP (see 4 fusions); CENPQ (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 CENPQparental protein320.146673.660CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
2 APPprotein found in more fusions110.31129.333APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
3 C19orf57interactor31.0000DUF4671 (PF15710, IPR031441): Domain of unknown function (DUF4671)
4 CCNL2interactor100Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
5 CDC42BPAinteractor100CNH (PF00780, IPR001180, SM00036): CNH domain
DivIC (PF04977, IPR007060): Septum formation initiator
DMPK_coil (PF08826, IPR014930): DMPK coiled coil domain like
PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
XkdW (PF09636, IPR019094): XkdW protein
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
6 CENPCinteractor31.0000CENP-C_C (PF11699, IPR025974): Mif2/CENP-C like
CENP-C_mid (PF15620, IPR028931): Centromere assembly component CENP-C middle DNMT3B-binding region
CENP_C_N (PF15622, IPR028052): Kinetochore assembly subunit CENP-C N-terminal
7 CENPHinteractor80.9050.571CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
8 CENPIinteractor90.7504.721CENP-I (PF07778, IPR012485): Mis6
9 CENPKinteractor70.8570.821CENP-K (PF11802, IPR020993): Centromere-associated protein K
10 CENPMinteractor90.6676.105CENP-M (PF11111, IPR020987): Centromere protein M (CENP-M)
11 CENPNinteractor90.8611.393CENP-N (PF05238, IPR007902): Kinetochore protein CHL4 like
12 CENPOinteractor120.59115.926CENP-O (PF09496, IPR018464): Cenp-O kinetochore centromere component
Takusan (PF04822, IPR006907): Takusan
MnmE_helical (PF12631, IPR025867): MnmE helical domain
13 CENPPinteractor80.8930.821CENP-P (PF13096, IPR027801): CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P
14 CENPTinteractor60.7331.817CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
CENP-T_N (PF16171, IPR032373): Centromere kinetochore component CENP-T N-terminus
15 CENPUinteractor130.50028.926Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
XhlA (PF10779, IPR019715): Haemolysin XhlA
CENP-U (PF13097, IPR025214): CENP-A nucleosome associated complex (NAC) subunit
16 CENPXinteractor31.0000CENP-X (PF09415, IPR018552): CENP-S associating Centromere protein X
17 HIST1H4Ainteractor100CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
18 HIST2H3PS2interactor100Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
19 ITGB3BPinteractor110.57813.338CENP-R (PF06729, IPR009601): Kinetochore component, CENP-R
20 KDM1Aprotein found in more fusions31.0000Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
21 PLK1suppressor30.6670.400Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
22 RPL10Ainteractor70.7625.000Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
23 RPL18interactor61.0000Ribosomal_L18 (PF17135): Ribosomal protein 60S L18 and 50S L18e
24 RPL9interactor61.0000Ribosomal_L6 (PF00347, IPR020040): Ribosomal protein L6
25 RPS11interactor70.8571.500Ribosomal_S17 (PF00366, IPR000266): Ribosomal protein S17
Ribosomal_S17_N (PF16205, IPR032440): Ribosomal_S17 N-terminal
26 RPS14interactor80.7144.833Ribosomal_S11 (PF00411, IPR001971): Ribosomal protein S11
27 RPS16interactor80.7144.833Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
28 SEC24Cinteractor21.0000Gelsolin (PF00626, IPR007123): Gelsolin repeat
Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
29 SUPT16Hinteractor200Nop14 (PF04147, IPR007276): Nop14-like family
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Rtt106 (PF08512, IPR013719): Histone chaperone Rttp106-like
SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
FACT-Spt16_Nlob (PF14826, IPR029148): FACT complex subunit SPT16 N-terminal lobe domain
30 TSR1interactor31.0000AARP2CN (PF08142, IPR012948, SM00785): AARP2CN (NUC121) domain
RIBIOP_C (PF04950, IPR007034): 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal
NUSAP (PF16006, IPR026756): Nucleolar and spindle-associated protein
31 VPS4Aprotein found in more fusions200AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
TIP49 (PF06068, IPR010339): TIP49 C-terminus
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
YCII (PF03795, IPR005545): YCII-related domain
32 ZFXinteractor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Zfx_Zfy_act (PF04704, IPR006794): Zfx / Zfy transcription activation region
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain

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