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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CEACAM6, CEACAM5 (from a repository: Wed Jul 24 15:54:11 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)10
The number (and %) of the onco-proteins3 (30.00 %)
The number (and %) of the tumor suppressors1 (10.00 %)
Total number of binary PPIs (saturation %)18 (40.00 %)
The number (and %) of affected PPIs11 (61.11 %)
The number of possible different fusions4
PPI diameter3
PPI radius2
The average degree of PPI2.600
Assortativity coefficient-0.2610
The network average Clustering coefficient0.377
The number (and %) of a zero Clustering coefficients4 (40.00 %)
The number (and %) of a zero Betweenness Centrality7 (70.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CEACAM6,CEACAM5 All fusions
Proteins found in more fusions EWSR1 (see 1 fusions); APP (see 5 fusions); CEACAM6/CEACAM5 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CEACAM6parental protein70.26731.000V-set (PF07686, IPR013106): Immunoglobulin V-set domain
DUF3129 (PF11327, IPR021476): Protein of unknown function (DUF3129)
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
2 CEACAM5parental protein50.10042.000Podoplanin (PF05808, IPR008783): Podoplanin
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
3 APPprotein found in more fusions200APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 CARTPTinteractor21.0000CART (PF06373, IPR009106): Cocaine and amphetamine regulated transcript protein (CART)
5 CD209interactor200Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
DGCR6 (PF07324, IPR010849): DiGeorge syndrome critical region 6 (DGCR6) protein
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
DUF2730 (PF10805, IPR020269): Protein of unknown function (DUF2730)
6 CEACAM1suppressor60.40015.000ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
CYYR1 (PF10873, IPR022640): Cysteine and tyrosine-rich protein 1
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
7 CEACAM7oncoprotein21.0000V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
8 CEACAM8interactor21.0000V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
9 EWSR1oncoprotein200RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
10 UQCC2interactor100Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)

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