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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SH3KBP1, CDKL5 (from a repository: Thu Nov 17 12:12:37 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)215
The number (and %) of the onco-proteins69 (32.09 %)
The number (and %) of the tumor suppressors19 (8.84 %)
Total number of binary PPIs (saturation %)1028 (4.47 %)
The number (and %) of affected PPIs215 (20.91 %)
The number of possible different fusions30
PPI diameter5
PPI radius3
The average degree of PPI8.967
Assortativity coefficient-0.2537
The network average Clustering coefficient0.497
The number (and %) of a zero Clustering coefficients30 (13.95 %)
The number (and %) of a zero Betweenness Centrality59 (27.44 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: CDKL5,SH3KBP1 All fusions
: DA672235; DA670155;
Proteins found in more fusions PPFIBP1 (see 1 fusions); CKAP4 (see 5 fusions); CBL (see 1 fusions); PLEKHA5 (see 1 fusions); GRB2 (see 1 fusions); FYN (see 1 fusions); MYC (see 1 fusions); TNFRSF1A (see 2 fusions); PIK3R1 (see 1 fusions); PAK2 (see 2 fusions); UBC (see 1 fusions); RPA1 (see 1 fusions); ITSN2 (see 1 fusions); LYN (see 2 fusions); SH3GL2 (see 1 fusions); FRS3 (see 1 fusions); PABPC1 (see 2 fusions); PDCD6 (see 1 fusions); LCK (see 1 fusions); IMPDH2 (see 2 fusions); CD2AP (see 1 fusions); KHDRBS1 (see 1 fusions); SH3KBP1 (see 1 fusions); EGFR (see 2 fusions); HNRNPC (see 1 fusions); PTK2 (see 2 fusions); DDX17 (see 3 fusions); ATP5A1 (see 1 fusions); CBLB (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CDKL5parental protein150.0331271.977Pkinase (PF00069, IPR000719): Protein kinase domain
2 SH3KBP1parental protein2000.03734730.751Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
3 ABL1oncoprotein170.55831.562Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
4 ACTC1interactor40.6671.167Actin (PF00022, IPR004000, SM00268): Actin
5 ANAPC4interactor71.0000ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
ANAPC4 (PF12896, IPR024790): Anaphase-promoting complex, cyclosome, subunit 4
6 ANAPC5interactor70.7624.667TPR_4 (PF07721, IPR011717): Tetratricopeptide repeat
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
7 ANAPC7interactor80.7624.167TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_21 (PF09976, IPR018704): Tetratricopeptide repeat-like domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
8 ANLNoncoprotein160.31794.403Anillin (PF08174, IPR012966): Cell division protein anillin
PH (PF00169, IPR001849, SM00233): PH domain
Anillin_N (PF16018, IPR031970): Anillin N-terminus
9 ARAP1interactor40.6671.630ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
PH (PF00169, IPR001849, SM00233): PH domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
10 ARAP3interactor21.0000ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
PH (PF00169, IPR001849, SM00233): PH domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
11 ARHGAP17interactor110.41826.705BAR (PF03114, IPR004148, SM00721): BAR domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
12 ARHGAP27interactor100PH (PF00169, IPR001849, SM00233): PH domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
WW (PF00397, IPR001202, SM00456): WW domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
13 ARHGEF1interactor31.0000RGS-like (PF09128, IPR015212): Regulator of G protein signalling-like domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
Syntaxin_2 (PF14523): Syntaxin-like protein
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
14 ASAP1interactor90.63914.206ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
PH (PF00169, IPR001849, SM00233): PH domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
BAR_3 (PF16746): BAR domain of APPL family
15 ASAP2interactor60.6002.416ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
PH (PF00169, IPR001849, SM00233): PH domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
BAR_3 (PF16746): BAR domain of APPL family
16 ATAD3Ainteractor30.6671.333AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
DUF3523 (PF12037, IPR021911): Domain of unknown function (DUF3523)
17 ATP5A1protein found in more fusions90.42916.947ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
18 ATXN2interactor110.32728.709LsmAD (PF06741, IPR009604): LsmAD domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
Spt20 (PF12090, IPR021950): Spt20 family
SM-ATX (PF14438, IPR025852): Ataxin 2 SM domain
19 BCAR1oncoprotein150.57116.522Serine_rich (PF08824, IPR014928): Serine rich protein interaction domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513)
Caskin1-CID (PF16600): Caskin1 CASK-interaction domain
20 BIRC2oncoprotein90.6075.522BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
21 BLNKsuppressor70.6195.106SH2 (PF00017, IPR000980, SM00252): SH2 domain
22 CAPZA2interactor210.219625.912F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
23 CAPZBinteractor100.46715.833Cytochrom_B562 (PF07361, IPR009155): Cytochrome b562
F_actin_cap_B (PF01115, IPR001698): F-actin capping protein, beta subunit
24 CARMIL1interactor40.6673.240LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
IL34 (PF15036, IPR020415): Interleukin 34
CARMIL_C (PF16000, IPR031943): CARMIL C-terminus
25 CASKIN2interactor100SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Caskin1-CID (PF16600): Caskin1 CASK-interaction domain
Caskin-tail (PF16632, IPR032117): C-terminal region of Caskin
Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
26 CBLsuppressor380.269315.980Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
27 CBLBoncoprotein190.45139.049Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
PRIMA1 (PF16101): Proline-rich membrane anchor 1
28 CD2interactor50.6001.236C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
29 CD2APprotein found in more fusions370.141493.338SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
30 CDAoncoprotein21.0000dCMP_cyt_deam_1 (PF00383, IPR002125): Cytidine and deoxycytidylate deaminase zinc-binding region
dCMP_cyt_deam_2 (PF08211, IPR013171): Cytidine and deoxycytidylate deaminase zinc-binding region
31 CDC16interactor90.52821.984Dynein_light (PF01221, IPR001372): Dynein light chain type 1
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
SRP_TPR_like (PF17004, IPR031545): Putative TPR-like repeat
32 CDC23interactor100.52824.410ANAPC8 (PF04049, IPR007192): Anaphase promoting complex subunit 8 / Cdc23
DUF772 (PF05598, IPR008490): Transposase domain (DUF772)
Menin (PF05053, IPR007747): Menin
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
33 CDC27oncoprotein71.0000TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
34 CDK16oncoprotein21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
35 CIZ1suppressor100Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
AAA_23 (PF13476): AAA domain
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
FAM163 (PF15069, IPR029379): FAM163 family
Zf_RING (PF16744, IPR031946): KIAA1045 RING finger
36 CKAP4protein found in more fusions70.4005.710DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
FPP (PF05911, IPR008587): Filament-like plant protein, long coiled-coil
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
37 CLTConcoprotein220.225359.778Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
38 CRKoncoprotein230.3871102.040SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
39 CSNK1A1suppressor90.36125.381Pkinase (PF00069, IPR000719): Protein kinase domain
40 CSTF2interactor70.33310.947RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
CSTF_C (PF14304, IPR026896): Transcription termination and cleavage factor C-terminal
CSTF2_hinge (PF14327, IPR025742): Hinge domain of cleavage stimulation factor subunit 2
41 CTSBoncoprotein30.6671.000Peptidase_C1 (PF00112, IPR000668, SM00645): Papain family cysteine protease
Propeptide_C1 (PF08127, IPR012599): Peptidase family C1 propeptide
42 CYGBsuppressor100Globin (PF00042, IPR000971): Globin
43 DAB1interactor21.0000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
44 DAB2suppressor140.30856.761PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
zf-C2H2_assoc3 (PF16637): Putative zinc-finger between two C2H2 zinc-fingers on Patz
45 DAG1interactor60.8001.382DAG1 (PF05454, IPR008465): Dystroglycan (Dystrophin-associated glycoprotein 1)
46 DDNinteractor100Dendrin (PF15498, IPR026500): Nephrin and CD2AP-binding protein, Dendrin
ACTH_assoc (PF16102, IPR032246): ACTH-associated domain
47 DDX17protein found in more fusions110.53311.238CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Ferritin (PF00210, IPR008331): Ferritin-like domain
GRP (PF07172, IPR010800): Glycine rich protein family
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
48 DDX28interactor100DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
49 DHX16interactor40.333115.806DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF4629 (PF15442, IPR027898): Domain of unknown function (DUF4629)
50 DHX38interactor50.200273.859DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956)
51 DNM1interactor90.5366.191Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PH (PF00169, IPR001849, SM00233): PH domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
52 DNM2interactor100.5566.642Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PH (PF00169, IPR001849, SM00233): PH domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
53 DNMT1suppressor30118.368BAH (PF01426, IPR001025, SM00439): BAH domain
DMAP_binding (PF06464, IPR010506, SM01137): DMAP1-binding Domain
DNA_methylase (PF00145, IPR001525): C-5 cytosine-specific DNA methylase
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
DNMT1-RFD (PF12047, IPR022702): Cytosine specific DNA methyltransferase replication foci domain
54 EGFRoncoprotein390.219762.008Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
55 ELAVL1oncoprotein500.0821524.856RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
56 ELMSAN1interactor31.0000ELM2 (PF01448, IPR000949): ELM2 domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
57 ENO1oncoprotein120.24247.133Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
58 ERC1oncoprotein50.5004.244RBD-FIP (PF09457, IPR019018): FIP domain
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
Cast (PF10174, IPR019323): RIM-binding protein of the cytomatrix active zone
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
59 FAM83Ginteractor40.5001.667DUF1669 (PF07894, IPR012461): Protein of unknown function (DUF1669)
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
60 FAPinteractor100DPPIV_N (PF00930, IPR002469): Dipeptidyl peptidase IV (DPP IV) N-terminal region
Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
61 FBXO25suppressor70.286435.450Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
62 FGRoncoprotein60.5332.205Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
63 FRS3suppressor70.6003.060IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
64 FYNoncoprotein200.29871.683Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
65 GAS2L1interactor21.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
GAS2 (PF02187, IPR003108, SM00243): Growth-Arrest-Specific Protein 2 Domain
SPX (PF03105, IPR004331): SPX domain
66 GPALPP1interactor100TFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha
DUF3752 (PF12572, IPR022226): Protein of unknown function (DUF3752)
67 GRB2oncoprotein580.1431178.016SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
68 GTSE1interactor100.46717.233GTSE1_N (PF15259, IPR032768): G-2 and S-phase expressed 1
69 HCKoncoprotein120.43920.156Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
70 HDGFRP2interactor21.0000DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
PWWP (PF00855, IPR000313, SM00293): PWWP domain
DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956)
LEDGF (PF11467, IPR021567): Lens epithelium-derived growth factor (LEDGF)
SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex
ACTH_assoc (PF16102, IPR032246): ACTH-associated domain
71 HGSinteractor150.34352.416FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
72 HIP1Rinteractor60.5338.767ANTH (PF07651, IPR011417): ANTH domain
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fez1 (PF06818): Fez1
Laminin_II (PF06009, IPR010307): Laminin Domain II
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
I_LWEQ (PF01608, IPR002558, SM00307): I/LWEQ domain
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
73 HNRNPCprotein found in more fusions150.308478.953APG6 (PF04111, IPR007243): Autophagy protein Apg6
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
74 HNRNPKoncoprotein190.32071.348ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
75 HRASoncoprotein80.46413.418Ras (PF00071, IPR001806, SM00173): Ras family
76 IMPDH1interactor21.0000IMPDH (PF00478, IPR001093): IMP dehydrogenase / GMP reductase domain
77 IMPDH2protein found in more fusions70.4009.582IMPDH (PF00478, IPR001093): IMP dehydrogenase / GMP reductase domain
78 INPP5Dinteractor110.45518.608Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
SH2 (PF00017, IPR000980, SM00252): SH2 domain
79 INPPL1oncoprotein120.66714.622Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
80 IRF2BP1interactor21.0000zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
IRF-2BP1_2 (PF11261, IPR022750): Interferon regulatory factor 2-binding protein zinc finger
81 IRF2BP2oncoprotein21.0000zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
IRF-2BP1_2 (PF11261, IPR022750): Interferon regulatory factor 2-binding protein zinc finger
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
Bd3614_N (PF14442, IPR025854): Bd3614-like deaminase N-terminal
82 ITSN1interactor220.210320.201C2 (PF00168, IPR000008, SM00239): C2 domain
VIT1 (PF01988, IPR008217): VIT family
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FmdE (PF02663, IPR003814): FmdE, Molybdenum formylmethanofuran dehydrogenase operon
GSH_synthase (PF03199, IPR004887): Eukaryotic glutathione synthase
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
INTAP (PF16617): Intersectin and clathrin adaptor AP2 binding region
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
83 ITSN2protein found in more fusions160.28650.824C2 (PF00168, IPR000008, SM00239): C2 domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26
VIR_N (PF15912, IPR031801): Virilizer, N-terminal
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
84 KATNA1interactor21.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
ABC_tran (PF00005, IPR003439): ABC transporter
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
AAA_22 (PF13401, IPR003593): AAA domain
85 KATNB1interactor31.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Katanin_con80 (PF13925, IPR028021): con80 domain of Katanin
86 KCTD10interactor40.5003.733BTB_2 (PF02214, IPR003131): BTB/POZ domain
87 KCTD3interactor100BTB_2 (PF02214, IPR003131): BTB/POZ domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
88 KHDRBS1protein found in more fusions210.242102.492KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
89 KIAA1522interactor100OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
NHS (PF15273, IPR024845): NHS-like
90 KIF23interactor120.28844.761DUF730 (PF05325, IPR007989): Protein of unknown function (DUF730)
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
MKLP1_Arf_bdg (PF16540, IPR032384): Arf6-interacting domain of mitotic kinesin-like protein 1
91 KIToncoprotein110.63611.376ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
92 KLF13interactor21.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
93 KLHL20interactor50.333651.968BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
94 LCKoncoprotein160.30531.070Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
95 LEMD2interactor100LEM (PF03020, IPR003887, SM00540): LEM domain
MSC (PF09402, IPR018996): Man1-Src1p-C-terminal domain
96 LIMCH1interactor50.7002.400LIM (PF00412, IPR001781, SM00132): LIM domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
DUF3435 (PF11917, IPR021842): Protein of unknown function (DUF3435)
DUF4757 (PF15949, IPR031865): Domain of unknown function (DUF4757)
97 LOXsuppressor40.6670.750Lysyl_oxidase (PF01186, IPR001695): Lysyl oxidase
98 LYNoncoprotein160.35237.810Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
99 MACF1oncoprotein20116.679ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
CTV_P33 (PF07184, IPR010803): Citrus tristeza virus P33 protein
DnaI_N (PF07319, IPR009928): Primosomal protein DnaI N-terminus
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF19 (PF01579, IPR002542): Domain of unknown function (DUF19)
FliJ (PF02050, IPR012823): Flagellar FliJ protein
GAS2 (PF02187, IPR003108, SM00243): Growth-Arrest-Specific Protein 2 Domain
Laminin_II (PF06009, IPR010307): Laminin Domain II
Peptidase_S49 (PF01343, IPR002142): Peptidase family S49
Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
SYF2 (PF08231, IPR013260): SYF2 splicing factor
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Plectin (PF00681, IPR001101, SM00250): Plectin repeat
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
DUF3813 (PF12758, IPR024217): Protein of unknown function (DUF3813)
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
TEX12 (PF15219, IPR029193): Testis-expressed 12
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
100 MAP3K4suppressor40.6671.000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Pkinase (PF00069, IPR000719): Protein kinase domain
PLU-1 (PF08429, IPR013637): PLU-1-like protein
Radial_spoke_3 (PF06098, IPR009290): Radial spoke protein 3
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
DUF3958 (PF13125, IPR025014): Protein of unknown function (DUF3958)
101 MAP4oncoprotein50.5003.500SdiA-regulated (PF06977, IPR009722): SdiA-regulated
Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
102 MAP7interactor100Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
PH_5 (PF15405): Pleckstrin homology domain
103 MAP7D3interactor100DUF572 (PF04502, IPR007590): Family of unknown function (DUF572)
MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family
Sec62 (PF03839, IPR004728): Translocation protein Sec62
Nop25 (PF09805, IPR019186): Nucleolar protein 12 (25kDa)
ARGLU (PF15346): Arginine and glutamate-rich 1
104 MAP9interactor100LAP1C (PF05609, IPR008662): Lamina-associated polypeptide 1C (LAP1C)
Sec62 (PF03839, IPR004728): Translocation protein Sec62
DUF4207 (PF13904): Domain of unknown function (DUF4207)
105 MCM5oncoprotein70.5716.138MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
106 MECP2interactor30265.518K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
107 METoncoprotein90.7783.403Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
PSI (PF01437, IPR002165, SM00423): Plexin repeat
Sema (PF01403, IPR001627, SM00630): Sema domain
TIG (PF01833, IPR002909): IPT/TIG domain
108 MGMTinteractor2064.846DNA_binding_1 (PF01035, IPR014048): 6-O-methylguanine DNA methyltransferase, DNA binding domain
Methyltransf_1N (PF02870, IPR008332): 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
109 MICALL1interactor100CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
LIM (PF00412, IPR001781, SM00132): LIM domain
DUF3585 (PF12130, IPR022735): Protein of unknown function (DUF3585)
FAM70 (PF14967, IPR028014): FAM70 protein
110 MOV10interactor250.120513.534AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
111 MVB12Ainteractor40.8330.667DUF2464 (PF10240, IPR018798): Protein of unknown function (DUF2464)
112 MYConcoprotein200.170150.365HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
113 NPHS1interactor50.6671.286C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
DUF4643 (PF15485, IPR028004): Domain of unknown function (DUF4643)
114 NPHS2interactor31.0000P_C (PF06640, IPR010588): P protein C-terminus
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
115 NPLOC4interactor100.44414.491NPL4 (PF05021, IPR007717): NPL4 family
zf-NPL4 (PF05020, IPR007716): NPL4 family, putative zinc binding region
UN_NPL4 (PF11543, IPR024682): Nuclear pore localisation protein NPL4
116 NXF1interactor310.117680.907NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
117 PABPC1oncoprotein120.25536.585RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
YflT (PF11181, IPR025889): Heat induced stress protein YflT
118 PABPC4interactor70.4766.963ApbA_C (PF08546, IPR013752): Ketopantoate reductase PanE/ApbA C terminal
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
HHV-5_US34A (PF17087, IPR031384): Herpesvirus US34A protein family
119 PAK1oncoprotein90.39312.917PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
120 PAK2protein found in more fusions90.4299.573PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
121 PALMDinteractor21.0000Paralemmin (PF03285, IPR004965): Paralemmin
122 PDCD6oncoprotein110.178453.672EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
123 PDCD6IPinteractor170.35064.817BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
124 PDGFRBoncoprotein100.7504.835I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
Ig_3 (PF13927): Immunoglobulin domain
TonB_N (PF16031): TonB N-terminal region
125 PHACTR4suppressor40.6670.758RPEL (PF02755, IPR004018, SM00707): RPEL repeat
126 PHLDB1interactor100DUF501 (PF04417, IPR007511): Protein of unknown function (DUF501)
FHA (PF00498, IPR000253, SM00240): FHA domain
PH (PF00169, IPR001849, SM00233): PH domain
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
WD40_alt (PF14077, IPR026987): Alternative WD40 repeat motif
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
127 PHLDB2interactor60.5335.258DUF572 (PF04502, IPR007590): Family of unknown function (DUF572)
MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family
PH (PF00169, IPR001849, SM00233): PH domain
Synaptobrevin (PF00957, IPR001388): Synaptobrevin
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26
DUF4574 (PF15141, IPR027896): Domain of unknown function (DUF4574)
128 PIK3R1oncoprotein260.390113.791RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
129 PKP3interactor40.8330.500Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF383 (PF04063, IPR007205): Domain of unknown function (DUF383)
130 PLEKHA5protein found in more fusions40.6670.588PH (PF00169, IPR001849, SM00233): PH domain
WW (PF00397, IPR001202, SM00456): WW domain
MKLP1_Arf_bdg (PF16540, IPR032384): Arf6-interacting domain of mitotic kinesin-like protein 1
131 PNMA5interactor40.6670.667PNMA (PF14893, IPR026523): PNMA
132 POM121interactor100Ice_nucleation (PF00818, IPR000258): Ice nucleation protein repeat
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
POM121 (PF15229): POM121 family
133 PPFIBP1oncoprotein60.4003.282DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
XkdW (PF09636, IPR019094): XkdW protein
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
DUF3837 (PF12939, IPR024212): Domain of unknown function (DUF3837)
134 PRC1interactor30.6670.500VIT1 (PF01988, IPR008217): VIT family
MAP65_ASE1 (PF03999, IPR007145): Microtubule associated protein (MAP65/ASE1 family)
135 PRKG2interactor2058.817CpeT (PF06206, IPR010404): CpeT/CpcT family (DUF1001)
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
FeoB_N (PF02421, IPR011619): Ferrous iron transport protein B
Pkinase (PF00069, IPR000719): Protein kinase domain
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
136 PRRC2Ainteractor50.4003.433BAT2_N (PF07001, IPR009738): BAT2 N-terminus
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
137 PSIP1oncoprotein21.0000AT_hook (PF02178, IPR017956, SM00384): AT hook motif
BEX (PF04538, IPR021156): Brain expressed X-linked like family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
PGA2 (PF07543, IPR011431): Protein trafficking PGA2
PWWP (PF00855, IPR000313, SM00293): PWWP domain
LEDGF (PF11467, IPR021567): Lens epithelium-derived growth factor (LEDGF)
TERB2 (PF15101, IPR028065): Telomere-associated protein TERB2
138 PSMA3interactor80.5247.905Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
139 PSRC1interactor100GTSE1_N (PF15259, IPR032768): G-2 and S-phase expressed 1
140 PTK2protein found in more fusions170.53330.566FERM_M (PF00373, IPR019748): FERM central domain
Focal_AT (PF03623, IPR005189): Focal adhesion targeting region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
141 PTK2Binteractor140.53814.850FERM_M (PF00373, IPR019748): FERM central domain
Focal_AT (PF03623, IPR005189): Focal adhesion targeting region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
142 RAB11Aoncoprotein40.6671.255Ras (PF00071, IPR001806, SM00173): Ras family
143 RAB5Aoncoprotein80.321126.640Ras (PF00071, IPR001806, SM00173): Ras family
144 RABL6oncoprotein50.100261.233eIF3_subunit (PF08597, IPR013906): Translation initiation factor eIF3 subunit
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Ras (PF00071, IPR001806, SM00173): Ras family
145 RACGAP1interactor100.400151.054RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
146 RAF1oncoprotein170.22574.068Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
147 RAPH1oncoprotein21.0000PH (PF00169, IPR001849, SM00233): PH domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
BORG_CEP (PF14957, IPR029273): Cdc42 effector
FAM76 (PF16046, IPR032017): FAM76 protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
148 RASAL2suppressor40.6671.400C2 (PF00168, IPR000008, SM00239): C2 domain
FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus
PH (PF00169, IPR001849, SM00233): PH domain
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
DUF3498 (PF12004, IPR021887): Domain of unknown function (DUF3498)
149 RNF34interactor100Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
150 RPA1suppressor200.222117.823Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
151 RPGRIP1Linteractor80.53613.914bZIP_1 (PF00170, IPR004827): bZIP transcription factor
C2 (PF00168, IPR000008, SM00239): C2 domain
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FtsL (PF04999, IPR011922): Cell division protein FtsL
T3SS_needle_F (PF09392, IPR021123): Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
C2-C2_1 (PF11618, IPR021656): First C2 domain of RPGR-interacting protein 1
BNIP2 (PF12496, IPR022181): Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4497 (PF14924): Protein of unknown function (DUF4497)
152 RPS6KA4interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
153 SAMD1interactor30.6670.869CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
PRIMA1 (PF16101): Proline-rich membrane anchor 1
154 SAR1Binteractor2059.771Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
155 SEC24Cinteractor90.30626.178Gelsolin (PF00626, IPR007123): Gelsolin repeat
Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
156 SEC24Dinteractor31.0000Gelsolin (PF00626, IPR007123): Gelsolin repeat
Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain
Transp_Tc5_C (PF04236, IPR007350): Tc5 transposase C-terminal domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
157 SEPT10interactor60.9330.400Septin (PF00735, IPR000038): Septin
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
158 SEPT11interactor70.7624.033Septin (PF00735, IPR000038): Septin
DUF3080 (PF11279, IPR021431): Protein of unknown function (DUF3080)
159 SEPT2oncoprotein110.56415.439FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
Septin (PF00735, IPR000038): Septin
160 SEPT6oncoprotein90.69418.156Septin (PF00735, IPR000038): Septin
DUF2959 (PF11172, IPR021342): Protein of unknown function (DUF2959)
161 SEPT7interactor130.47438.786Fez1 (PF06818): Fez1
Septin (PF00735, IPR000038): Septin
162 SEPT8interactor80.6439.506IMD (PF08397, IPR013606): IRSp53/MIM homology domain
Septin (PF00735, IPR000038): Septin
DUF3987 (PF13148, IPR025048): Protein of unknown function (DUF3987)
163 SEPT9oncoprotein70.8102.550Septin (PF00735, IPR000038): Septin
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
164 SERPINB8interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
165 SERPINH1interactor60.40016.824Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
166 SH3BP2oncoprotein50.9000.133PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
167 SH3D19interactor31.0000SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
168 SH3GL2oncoprotein130.42426.504BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
169 SH3GL3interactor70.6675.167BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
170 SH3GLB1suppressor60.4005.882BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
171 SH3GLB2interactor21.0000BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
172 SH3PXD2Binteractor21.0000PX (PF00787, IPR001683, SM00312): PX domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
173 SHCBP1interactor40.8330.567Methyltransf_10 (PF05971, IPR010286): Protein of unknown function (DUF890)
DUF2408 (PF10303, IPR018810): Protein of unknown function (DUF2408)
Pectate_lyase_3 (PF12708, IPR024535): Pectate lyase superfamily protein
Beta_helix (PF13229): Right handed beta helix region
174 SHKBP1interactor21.0000BTB_2 (PF02214, IPR003131): BTB/POZ domain
175 SKIV2Linteractor30241.333DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
DSHCT (PF08148, IPR012961, SM01142): DSHCT (NUC185) domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF3516 (PF12029, IPR021904): Domain of unknown function (DUF3516)
rRNA_proc-arch (PF13234, IPR025696): rRNA-processing arch domain
176 SLAIN2interactor30.6671.000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
SLAIN (PF15301, IPR026179): SLAIN motif-containing family
177 SOS1oncoprotein150.46738.255Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
PH (PF00169, IPR001849, SM00233): PH domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
178 SPRY1interactor60.8001.556PAP1 (PF08601, IPR013910): Transcription factor PAP1
Sprouty (PF05210, IPR007875): Sprouty protein (Spry)
179 SPRY2suppressor150.30851.982KAR9 (PF08580, IPR013889): Yeast cortical protein KAR9
Sprouty (PF05210, IPR007875): Sprouty protein (Spry)
180 SRConcoprotein340.273233.948Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
181 SRGAP1interactor21.0000DASH_Dad3 (PF08656, IPR013965): DASH complex subunit Dad3
FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
FTZ (PF03867, IPR005567): Fushi tarazu (FTZ), N-terminal region
IncA (PF04156, IPR007285): IncA protein
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
Transposase_21 (PF02992, IPR004242): Transposase family tnp2
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
182 SRRM1interactor80.286216.280DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP)
Hepatitis_core (PF00906, IPR002006): Hepatitis core antigen
MAP65_ASE1 (PF03999, IPR007145): Microtubule associated protein (MAP65/ASE1 family)
PWI (PF01480, IPR002483, SM00311): PWI domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
183 SRRM2interactor110.382259.344cwf21 (PF08312, IPR013170, SM01115): cwf21 domain
DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Pap_E4 (PF02711, IPR003861): E4 protein
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
184 SRSF7interactor70.33313.543RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TP2 (PF01254, IPR000678): Nuclear transition protein 2
zf-CCHC (PF00098, IPR001878): Zinc knuckle
185 STAP1interactor41.0000PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
186 SYDE1oncoprotein100RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
187 SYNJ1interactor60.6003.653DUF1866 (PF08952, IPR015047, SM01165): Domain of unknown function (DUF1866)
Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
Syja_N (PF02383, IPR002013): SacI homology domain
YppG (PF14179, IPR025555): YppG-like protein
188 SYNJ2interactor40.6670.284DUF1866 (PF08952, IPR015047, SM01165): Domain of unknown function (DUF1866)
Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
Syja_N (PF02383, IPR002013): SacI homology domain
TSKS (PF15358, IPR028214): Testis-specific serine kinase substrate
189 SYNPOinteractor100.46719.964Calsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin)
190 TAF6interactor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
Spo0A_C (PF08769, IPR014879): Sporulation initiation factor Spo0A C terminal
TAF (PF02969, IPR004823, SM00803): TATA box binding protein associated factor (TAF)
191 TGFBR1oncoprotein60.5335.738Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
192 TGFBR2suppressor60.6002.905ecTbetaR2 (PF08917, IPR015013): Transforming growth factor beta receptor 2 ectodomain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
193 TJP2oncoprotein30.6670.917PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
194 TNFRSF1Aoncoprotein160.43841.416Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
195 TRAoncoprotein21.0000NA
196 TRADDinteractor51.0000Death (PF00531, IPR000488, SM00005): Death domain
TRADD_N (PF09034, IPR009095): TRADD, N-terminal domain
TPR_14 (PF13428): Tetratricopeptide repeat
197 TRAF1oncoprotein90.5717.638HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
SlyX (PF04102, IPR007236): SlyX
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
198 TRAF2interactor110.48920.206MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
199 TSG101suppressor180.28777.788APG6 (PF04111, IPR007243): Autophagy protein Apg6
Laminin_II (PF06009, IPR010307): Laminin Domain II
UEV (PF05743, IPR008883): UEV domain
Vps23_core (PF09454, IPR017916): Vps23 core domain
200 TTC38interactor21.0000TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_14 (PF13428): Tetratricopeptide repeat
201 TUBGCP2interactor70.38113.150Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
zf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger
202 TUBGCP3interactor70.33317.556Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
203 TUBGCP4interactor31.0000Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
204 UBAP2interactor21.0000Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J
API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
CUE (PF02845, IPR003892, SM00546): CUE domain
HlyE (PF06109, IPR027018): Haemolysin E (HlyE)
MGC-24 (PF05283, IPR007947): Multi-glycosylated core protein 24 (MGC-24), sialomucin
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
DUF3697 (PF12478, IPR022166): Ubiquitin-associated protein 2
UBA_4 (PF14555): UBA-like domain
205 UBCprotein found in more fusions340.205404.838ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
206 UBE2Iinteractor140.28244.167UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
207 UFD1Linteractor50.9000.345UFD1 (PF03152, IPR004854): Ubiquitin fusion degradation protein UFD1
208 VPS37Binteractor31.0000Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
209 WASLinteractor100.44414.938Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
WH2 (PF02205, IPR003124, SM00246): WH2 motif
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
210 WIPF1interactor70.4767.308CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GRP (PF07172, IPR010800): Glycine rich protein family
WH2 (PF02205, IPR003124, SM00246): WH2 motif
211 WIPF2interactor40.8330.167CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
WH2 (PF02205, IPR003124, SM00246): WH2 motif
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
212 WTAPoncoprotein21.0000DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043)
SOSSC (PF15925, IPR031821): SOSS complex subunit C
Wtap (PF17098, IPR029732): Pre-mRNA-splicing regulator WTAP
213 ZBTB7Binteractor31.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GAGA (PF09237, IPR015318): GAGA factor
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
214 ZFP36suppressor50.5004.333zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
215 ZNF219interactor21.0000Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CDKL5parental proteinPkinase (PF00069, IPR000719): Protein kinase domainDA672235
2 GPALPP1interactorTFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha
DUF3752 (PF12572, IPR022226): Protein of unknown function (DUF3752)
DA672235
3 MGMTinteractorDNA_binding_1 (PF01035, IPR014048): 6-O-methylguanine DNA methyltransferase, DNA binding domain
Methyltransf_1N (PF02870, IPR008332): 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
DA672235
4 SH3KBP1parental proteinTmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
DA672235
5 TRAoncoproteinNADA672235

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