Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins CDK9 (from a repository: Thu Nov 10 14:59:26 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 178 The number (and %) of the onco-proteins 81 (45.51 %) The number (and %) of the tumor suppressors 5 (2.81 %) Total number of binary PPIs (saturation %) 1298 (8.24 %) The number (and %) of affected PPIs 178 (13.71 %) The number of possible different fusions 34 PPI diameter 2 PPI radius 1 The average degree of PPI 13.798 Assortativity coefficient -0.2456 The network average Clustering coefficient 0.531 The number (and %) of a zero Clustering coefficients 4 (2.25 %) The number (and %) of a zero Betweenness Centrality 23 (12.92 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: CDK9	All fusions : BF751344; BI024596;
Proteins found in more fusions	AFF1 (see 1 fusions); AFF1/KMT2A (see 66 fusions); CUL1 (see 3 fusions); MYC (see 1 fusions); SART3 (see 2 fusions); RNF40 (see 2 fusions); GSS (see 1 fusions); MLLT1/KMT2A (see 18 fusions); IMMT (see 4 fusions); MYBL2 (see 4 fusions); DDX5 (see 1 fusions); ELL/KMT2A (see 8 fusions); MSH2 (see 1 fusions); TP53 (see 3 fusions); SNW1 (see 1 fusions); CNOT9 (see 1 fusions); HSP90AA1 (see 2 fusions); TRIM28 (see 1 fusions); TRIM33 (see 1 fusions); HSP90AB1 (see 1 fusions); SQSTM1 (see 5 fusions); HINT1 (see 3 fusions); STAT3 (see 2 fusions); HNRNPD (see 1 fusions); PCBP2 (see 3 fusions); KMT2A (see 15 fusions); UBR5 (see 4 fusions); MLLT3/KMT2A (see 17 fusions); POLR2A (see 2 fusions); FGFR1 (see 1 fusions); CDC37 (see 2 fusions); SMAD3 (see 3 fusions); CDK9 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	CDK9	parental protein	178	0.067	20118.532	Pkinase (PF00069, IPR000719): Protein kinase domain
2	ACTL6A	interactor	8	0.643	5.173	Actin (PF00022, IPR004000, SM00268): Actin
3	AFF1	oncoprotein	15	0.549	20.595	AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
4	AFF3	oncoprotein	2	1.000	0	AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
5	AFF4	oncoprotein	15	0.505	34.450	AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
6	AIP	suppressor	5	0.900	0.286	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
7	ANXA2	interactor	7	0.476	3.269	Annexin (PF00191, IPR018502, SM00335): Annexin
8	AR	oncoprotein	26	0.247	149.281	Androgen_recep (PF02166, IPR001103): Androgen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
9	ARID3B	interactor	3	0.667	0.667	ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain Phycobilisome (PF00502, IPR012128): Phycobilisome protein TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
10	ATM	oncoprotein	20	0.327	60.693	FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
11	ATP1A1	interactor	4	1.000	0	Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase Tetraspannin (PF00335, IPR018499): Tetraspanin family Cation_ATPase (PF13246): Cation transport ATPase (P-type)
12	ATR	oncoprotein	12	0.564	12.354	FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1 THP2 (PF09432, IPR018557): Tho complex subunit THP2 TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat UME (PF08064, IPR012993, SM00802): UME (NUC010) domain PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) HEAT_EZ (PF13513): HEAT-like repeat SgrT (PF15894, IPR031767): Inhibitor of glucose uptake transporter SgrT
13	ATRIP	interactor	5	1.000	0	Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
14	BARD1	oncoprotein	19	0.320	52.087	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) zf-RING_6 (PF14835): zf-RING of BARD1-type protein BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
15	BCL10	oncoprotein	6	0.600	2.667	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
16	BRCA1	oncoprotein	39	0.225	300.689	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
17	BRD4	oncoprotein	14	0.341	35.932	Caldesmon (PF02029, IPR006018): Caldesmon Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region Stm1_N (PF09598, IPR019084): Stm1 SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain BET (PF17035, IPR027353): Bromodomain extra-terminal - transcription regulation BRD4_CDT (PF17105, IPR031354): C-terminal domain of bromodomain protein 4
18	BRDT	interactor	2	1.000	0	Allexi_40kDa (PF05549, IPR008398): Allexivirus 40kDa protein Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain DUF2079 (PF09852, IPR018650): Predicted membrane protein (DUF2079) Nop25 (PF09805, IPR019186): Nucleolar protein 12 (25kDa) Bromodomain (PF00439, IPR001487, SM00297): Bromodomain BET (PF17035, IPR027353): Bromodomain extra-terminal - transcription regulation BRD4_CDT (PF17105, IPR031354): C-terminal domain of bromodomain protein 4
19	CASK	interactor	5	0.500	3.567	L27 (PF02828, IPR014775, SM00569): L27 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Pkinase (PF00069, IPR000719): Protein kinase domain SH3_2 (PF07653, IPR011511): Variant SH3 domain Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
20	CCAR2	suppressor	13	0.423	20.918	DREPP (PF05558, IPR008469): DREPP plasma membrane polypeptide IncA (PF04156, IPR007285): IncA protein RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 DBC1 (PF14443, IPR025954, SM01122): DBC1 S1-like (PF14444, IPR025223): S1-like
21	CCDC87	interactor	5	0.700	1.833	MAP65_ASE1 (PF03999, IPR007145): Microtubule associated protein (MAP65/ASE1 family)
22	CCNH	oncoprotein	9	0.694	3.349	5_3_exonuc_N (PF02739, IPR020046): 5'-3' exonuclease, N-terminal resolvase-like domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain Cyclin_C_2 (PF16899, IPR031658): Cyclin C-terminal domain
23	CCNK	interactor	7	0.762	1.769	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
24	CCNT1	oncoprotein	34	0.189	329.699	Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region RP-C_C (PF11800, IPR021760): Replication protein C C-terminal region CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit MDFI (PF15316, IPR026134): MyoD family inhibitor
25	CCNT2	interactor	12	0.348	22.111	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
26	CCT3	interactor	14	0.516	19.397	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
27	CCT4	interactor	14	0.538	17.262	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
28	CCT5	interactor	12	0.606	11.370	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
29	CCT8	interactor	16	0.483	26.111	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
30	CDC34	oncoprotein	9	0.321	10.921	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
31	CDC37	protein found in more fusions	17	0.350	45.183	CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
32	CDC5L	interactor	47	0.212	435.739	OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
33	CDC7	interactor	4	0.667	1.000	Pkinase (PF00069, IPR000719): Protein kinase domain
34	CDC73	oncoprotein	15	0.410	28.939	CDC73_C (PF05179, IPR007852): RNA pol II accessory factor, Cdc73 family, C-terminal CDC73_N (PF16050, IPR032041): Paf1 complex subunit CDC73 N-terminal
35	CDK12	oncoprotein	9	0.556	6.621	Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp) Mem_trans (PF03547, IPR004776): Membrane transport protein Pkinase (PF00069, IPR000719): Protein kinase domain SOBP (PF15279, IPR026092): Sine oculis-binding protein CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
36	CDK15	interactor	11	0.345	26.569	Pkinase (PF00069, IPR000719): Protein kinase domain ACT_5 (PF13710): ACT domain
37	CDK5R1	oncoprotein	2	1.000	0	CDK5_activator (PF03261, IPR004944): Cyclin-dependent kinase 5 activator protein
38	CDK7	oncoprotein	25	0.228	158.488	Pkinase (PF00069, IPR000719): Protein kinase domain
39	CENPA	interactor	11	0.378	15.071	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
40	CKAP5	interactor	6	0.800	0.170	HEAT (PF02985, IPR000357): HEAT repeat PAS_6 (PF08348, IPR013559): YheO-like PAS domain UME (PF08064, IPR012993, SM00802): UME (NUC010) domain CLASP_N (PF12348, IPR024395): CLASP N terminal Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
41	CLSPN	interactor	4	0.667	2.000	Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) NinG (PF05766, IPR008713): Bacteriophage Lambda NinG protein Presenilin (PF01080, IPR001108): Presenilin PTS_IIB (PF02302, IPR003501): PTS system, Lactose/Cellobiose specific IIB subunit XAP5 (PF04921, IPR007005): XAP5, circadian clock regulator Adaptin_binding (PF10199, IPR019341): Alpha and gamma adaptin binding protein p34 Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
42	CNOT9	protein found in more fusions	6	0.700	0.576	Rcd1 (PF04078, IPR007216): Cell differentiation family, Rcd1-like
43	CSNK2B	interactor	15	0.330	36.882	CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
44	CTDP1	interactor	8	0.571	6.219	Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme FCP1_C (PF09309, IPR015388): FCP1, C-terminal NIF (PF03031, IPR004274): NLI interacting factor-like phosphatase SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain TFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A PTCB-BRCT (PF12738, IPR001357): twin BRCT domain HlyD_D23 (PF16576, IPR032317): Barrel-sandwich domain of CusB or HlyD membrane-fusion
45	CTR9	interactor	14	0.418	30.675	DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702) Pap_E4 (PF02711, IPR003861): E4 protein SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68) TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat DUF2175 (PF09943, IPR018686): Uncharacterized protein conserved in archaea (DUF2175) TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_14 (PF13428): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
46	CUL1	oncoprotein	46	0.272	336.499	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
47	DDX5	oncoprotein	21	0.500	42.849	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase P68HR (PF08061, IPR012587): P68HR (NUC004) repeat ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
48	DTYMK	interactor	3	0.667	0.083	Thymidylate_kin (PF02223): Thymidylate kinase
49	EAF1	suppressor	10	0.622	8.971	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Peroxin-3 (PF04882, IPR006966): Peroxin-3 EAF (PF09816, IPR019194): RNA polymerase II transcription elongation factor
50	ELAVL1	oncoprotein	44	0.169	523.173	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
51	ELL	oncoprotein	9	0.667	5.571	Occludin_ELL (PF07303, IPR010844): Occludin homology domain ELL (PF10390, IPR019464): RNA polymerase II elongation factor ELL
52	ELL2	interactor	11	0.636	11.890	Occludin_ELL (PF07303, IPR010844): Occludin homology domain Wbp11 (PF09429, IPR019007): WW domain binding protein 11 ELL (PF10390, IPR019464): RNA polymerase II elongation factor ELL
53	EXOSC5	interactor	2	1.000	0	RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1 RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
54	FBXO25	suppressor	16	0.317	42.261	Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
55	FGFR1	oncoprotein	4	1.000	0	I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
56	FGFR4	oncoprotein	3	1.000	0	APH (PF01636, IPR002575): Phosphotransferase enzyme family I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ig_3 (PF13927): Immunoglobulin domain
57	FGR	oncoprotein	3	1.000	0	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
58	FKBP5	interactor	10	0.556	11.591	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat NuDC (PF16273, IPR032572): Nuclear distribution C domain
59	GATA6	interactor	1	0	0	GATA-N (PF05349, IPR008013): GATA-type transcription activator, N-terminal OrfB_Zn_ribbon (PF07282, IPR010095): Putative transposase DNA-binding domain DUF2387 (PF09526, IPR012658): Probable metal-binding protein (DUF2387) GATA (PF00320, IPR000679, SM00401): GATA zinc finger
60	GRN	oncoprotein	2	1.000	0	Granulin (PF00396, IPR000118, SM00277): Granulin Lustrin_cystein (PF14625, IPR028150): Lustrin, cysteine-rich repeated domain
61	GSS	protein found in more fusions	3	1.000	0	GSH_synth_ATP (PF03917, IPR005615): Eukaryotic glutathione synthase, ATP binding domain
62	GTF2F1	interactor	14	0.407	26.885	TFIIF_alpha (PF05793, IPR008851): Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
63	HEXIM1	oncoprotein	17	0.368	46.693	APG6 (PF04111, IPR007243): Autophagy protein Apg6 DivIC (PF04977, IPR007060): Septum formation initiator Shugoshin_N (PF07558, IPR011516): Shugoshin N-terminal coiled-coil region HEXIM (PF15313, IPR024872): Hexamethylene bis-acetamide-inducible protein
64	HEXIM2	interactor	7	0.733	1.272	bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper HEXIM (PF15313, IPR024872): Hexamethylene bis-acetamide-inducible protein GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
65	HINT1	suppressor	7	0.533	5.500	HIT (PF01230, IPR001310): HIT domain
66	HIST2H2BE	interactor	15	0.257	56.919	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
67	HLTF	oncoprotein	7	0.533	3.154	HIRAN (PF08797, IPR014905, SM00910): HIRAN domain SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
68	HNRNPA0	interactor	15	0.810	3.439	SAP130_C (PF16014, IPR031963): Histone deacetylase complex subunit SAP130 C-terminus
69	HNRNPA1	interactor	38	0.336	203.591	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
70	HNRNPA2B1	oncoprotein	21	0.481	42.943	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
71	HNRNPD	oncoprotein	23	0.489	44.051	CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Keratin_2_head (PF16208, IPR032444): Keratin type II head
72	HNRNPH1	oncoprotein	25	0.547	43.660	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
73	HNRNPK	oncoprotein	25	0.511	46.676	ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain KH_1 (PF00013, IPR004088, SM00322): KH domain
74	HNRNPR	interactor	22	0.537	44.127	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1
75	HNRNPU	interactor	35	0.383	145.914	CDC45 (PF02724, IPR003874): CDC45-like protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SAP (PF02037, IPR003034, SM00513): SAP domain SPRY (PF00622, IPR003877, SM00449): SPRY domain AAA_33 (PF13671): AAA domain WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
76	HSP90AA1	oncoprotein	41	0.232	377.171	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
77	HSP90AA4P	interactor	3	0.667	0.222	DUF11 (PF01345, IPR001434): Domain of unknown function DUF11 fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase (PF00069, IPR000719): Protein kinase domain PPAK (PF02818, IPR004168): PPAK motif Titin_Z (PF09042, IPR015129): Titin Z V-set (PF07686, IPR013106): Immunoglobulin V-set domain Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ig_3 (PF13927): Immunoglobulin domain
78	HSP90AA5P	interactor	5	0.900	0.222	NA
79	HSP90AB1	oncoprotein	27	0.332	110.922	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
80	HSP90AB3P	interactor	5	0.700	1.122	DUF11 (PF01345, IPR001434): Domain of unknown function DUF11 fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase (PF00069, IPR000719): Protein kinase domain PPAK (PF02818, IPR004168): PPAK motif Titin_Z (PF09042, IPR015129): Titin Z V-set (PF07686, IPR013106): Immunoglobulin V-set domain Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ig_3 (PF13927): Immunoglobulin domain
81	HSP90AB4P	interactor	3	0.667	0.222	DUF11 (PF01345, IPR001434): Domain of unknown function DUF11 fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase (PF00069, IPR000719): Protein kinase domain PPAK (PF02818, IPR004168): PPAK motif Titin_Z (PF09042, IPR015129): Titin Z V-set (PF07686, IPR013106): Immunoglobulin V-set domain Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ig_3 (PF13927): Immunoglobulin domain
82	HSPA1A	interactor	18	0.490	28.047	HSP70 (PF00012, IPR013126): Hsp70 protein
83	HSPA2	interactor	9	0.556	4.342	HSP70 (PF00012, IPR013126): Hsp70 protein
84	HSPA5	oncoprotein	31	0.379	120.037	HSP70 (PF00012, IPR013126): Hsp70 protein
85	HSPA6	interactor	11	0.564	5.227	HSP70 (PF00012, IPR013126): Hsp70 protein
86	HSPD1	oncoprotein	18	0.458	34.374	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
87	IGF2BP1	oncoprotein	10	0.689	2.824	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KH_1 (PF00013, IPR004088, SM00322): KH domain KH_4 (PF13083): KH domain MOEP19 (PF16005, IPR031952): KH-like RNA-binding domain
88	IGF2BP2	interactor	7	0.762	0.791	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KH_1 (PF00013, IPR004088, SM00322): KH domain KH_4 (PF13083): KH domain
89	IL6ST	oncoprotein	3	1.000	0	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain IL6Ra-bind (PF09240, IPR015321): Interleukin-6 receptor alpha chain, binding Lep_receptor_Ig (PF06328, IPR010457): Ig-like C2-type domain Pur_ac_phosph_N (PF16656, IPR015914): Purple acid Phosphatase, N-terminal domain
90	ILF2	interactor	18	0.575	20.366	DZF (PF07528, IPR006561, SM00572): DZF domain
91	ILKAP	interactor	1	0	0	PP2C (PF00481, IPR001932): Protein phosphatase 2C
92	IMMT	protein found in more fusions	7	0.400	4.133	Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
93	KLC4	interactor	2	1.000	0	Flagellin_N (PF00669, IPR001029): Bacterial flagellin N-terminal helical region Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat LUD_dom (PF02589): LUD domain
94	KMT2A	oncoprotein	15	0.484	24.029	AT_hook (PF02178, IPR017956, SM00384): AT hook motif DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) FYRC (PF05965, IPR003889, SM00542): F/Y rich C-terminus FYRN (PF05964, IPR003888, SM00541): F/Y-rich N-terminus Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal PHD (PF00628, IPR019787, SM00249): PHD-finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 SET (PF00856, IPR001214, SM00317): SET domain zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain zf-HC5HC2H (PF13771): PHD-like zinc-binding domain DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
95	KPNA2	interactor	18	0.307	58.322	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat IBB (PF01749, IPR002652): Importin beta binding domain Arm_3 (PF16186, IPR032413): Atypical Arm repeat
96	LANCL2	interactor	2	1.000	0	Glyco_hydro_127 (PF07944, IPR012878): Beta-L-arabinofuranosidase, GH127 LANC_like (PF05147, IPR007822): Lanthionine synthetase C-like protein
97	LARP7	interactor	13	0.449	23.037	Agouti (PF05039, IPR007733, SM00792): Agouti protein DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) La (PF05383, IPR006630, SM00715): La domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 (PF08777, IPR014886): RNA binding motif
98	MARS	oncoprotein	7	0.429	6.998	Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain tRNA-synt_1g (PF09334, IPR015413): tRNA synthetases class I (M) WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain GST_N_2 (PF13409, IPR004045): Glutathione S-transferase, N-terminal domain
99	MATR3	interactor	16	0.686	7.814	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAM60A (PF15396, IPR026065): Protein Family FAM60A
100	MBP	interactor	3	0.667	0.500	Myelin_MBP (PF01669, IPR000548): Myelin basic protein
101	MDFIC	interactor	3	1.000	0	SNAP-25 (PF00835, IPR000928): SNAP-25 family MDFI (PF15316, IPR026134): MyoD family inhibitor
102	MDM2	oncoprotein	22	0.295	67.609	Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
103	MED1	interactor	15	0.440	30.273	Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 Med1 (PF10744, IPR019680): Mediator of RNA polymerase II transcription subunit 1 DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614) PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
104	MED12	oncoprotein	6	0.800	1.452	Med12 (PF09497, IPR019035): Transcription mediator complex subunit Med12 Peptidase_S15 (PF02129, IPR000383): X-Pro dipeptidyl-peptidase (S15 family) DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19 DUF2877 (PF11392, IPR021530): Protein of unknown function (DUF2877) Med12-PQL (PF12144, IPR021989): Eukaryotic Mediator 12 catenin-binding domain Med12-LCEWAV (PF12145, IPR021990): Eukaryotic Mediator 12 subunit domain CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
105	MED26	interactor	18	0.399	64.098	Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain Med26_C (PF15693, IPR031416): Mediator complex subunit 26 C-terminal Med26_M (PF15694, IPR031417): Mediator complex subunit 26 middle domain
106	MED28	interactor	8	0.810	1.633	cwf21 (PF08312, IPR013170, SM01115): cwf21 domain Med28 (PF11594, IPR021640): Mediator complex subunit 28
107	MEPCE	interactor	50	0.155	671.481	Bin3 (PF06859, IPR010675): Bicoid-interacting protein 3 (Bin3) Methyltransf_23 (PF13489): Methyltransferase domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7
108	MLLT1	oncoprotein	14	0.571	20.157	DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) Peptidase_S64 (PF08192, IPR012985): Peptidase family S64 YEATS (PF03366, IPR005033): YEATS family DDRGK (PF09756, IPR019153, SM01128): DDRGK domain
109	MLLT3	oncoprotein	13	0.590	19.014	Peptidase_S64 (PF08192, IPR012985): Peptidase family S64 YEATS (PF03366, IPR005033): YEATS family DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446) Sox_N (PF12444, IPR022151): Sox developmental protein N terminal PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal NKAP (PF15692): NF-kappa-B-activating protein BET (PF17035, IPR027353): Bromodomain extra-terminal - transcription regulation
110	MRPS27	interactor	7	0.762	1.330	MRP-S27 (PF10037, IPR019266): Mitochondrial 28S ribosomal protein S27
111	MSH2	oncoprotein	17	0.375	32.983	MutS_I (PF01624, IPR007695): MutS domain I MutS_II (PF05188, IPR007860): MutS domain II MutS_V (PF00488, IPR000432, SM00534): MutS domain V MutS_III (PF05192, IPR007696, SM00533): MutS domain III AAA_27 (PF13514): AAA domain
112	MSL1	interactor	7	0.714	2.638	Herpes_UL6 (PF01763, IPR002660): Herpesvirus UL6 like KLRAQ (PF10205, IPR019343): Predicted coiled-coil domain-containing protein PEHE (PF15275, IPR029332): PEHE domain MSL1_dimer (PF16801, IPR031840): Dimerisation domain of Male-specific-Lethal 1
113	MSL2	interactor	7	0.762	1.841	MSL2-CXC (PF16682, IPR032049): CXC domain of E3 ubiquitin-protein ligase MSL2 zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2
114	MYBL2	oncoprotein	4	0.667	0.400	Cmyb_C (PF09316, IPR015395): C-myb, C-terminal Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
115	MYC	oncoprotein	54	0.175	654.508	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region
116	NUFIP1	interactor	5	0.600	1.200	NUFIP1 (PF10453, IPR019496): Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) DUF3395 (PF11875, IPR024586): Domain of unknown function (DUF3395) zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
117	OXSR1	interactor	5	0.700	1.300	Pkinase (PF00069, IPR000719): Protein kinase domain OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal DUF4423 (PF14394, IPR025537): Domain of unknown function (DUF4423)
118	P4HA1	interactor	4	0.667	0.404	P4Ha_N (PF08336, IPR013547): Prolyl 4-Hydroxylase alpha-subunit, N-terminal region TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat 2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
119	PAF1	oncoprotein	15	0.381	46.488	Paf1 (PF03985, IPR007133): Paf1 MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
120	PAXIP1	interactor	12	0.318	24.056	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase SURF6 (PF04935, IPR007019): Surfeit locus protein 6 DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance PTCB-BRCT (PF12738, IPR001357): twin BRCT domain BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
121	PCBP2	protein found in more fusions	18	0.382	38.764	Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein KH_2 (PF07650, IPR004044): KH domain KH_1 (PF00013, IPR004088, SM00322): KH domain
122	PGC	interactor	2	1.000	0	A1_Propeptide (PF07966, IPR012848): A1 Propeptide Asp (PF00026, IPR001461): Eukaryotic aspartyl protease
123	PLEC	oncoprotein	6	0.800	0.869	CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family FUSC (PF04632, IPR006726): Fusaric acid resistance protein family RNA_pol_Rbc25 (PF08292, IPR013238): RNA polymerase III subunit Rpc25 S10_plectin (PF03501, IPR005326): Plectin/S10 domain Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein DUF2229 (PF09989, IPR018709): CoA enzyme activase uncharacterised domain (DUF2229) Plectin (PF00681, IPR001101, SM00250): Plectin repeat YlqD (PF11068, IPR021297): YlqD protein Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
124	PMS1	oncoprotein	11	0.356	13.638	DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain HTH_Tnp_IS630 (PF01710, IPR002622): Transposase HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box MRP-L46 (PF11788, IPR021757): 39S mitochondrial ribosomal protein L46 HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
125	POLR2A	protein found in more fusions	32	0.245	225.040	RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
126	RAD21	oncoprotein	19	0.327	52.009	Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein FAM176 (PF14851): FAM176 family WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
127	RB1	oncoprotein	15	0.295	46.109	RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain Rb_C (PF08934, IPR015030): Rb C-terminal domain DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452) DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
128	RBM39	oncoprotein	9	0.667	3.731	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
129	RCHY1	oncoprotein	5	1.000	0	C1_2 (PF03107, IPR004146): C1 domain zf-CHY (PF05495, IPR008913): CHY zinc finger zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zinc_ribbon_6 (PF14599): Zinc-ribbon
130	RELA	oncoprotein	18	0.353	41.667	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
131	RFC4	interactor	14	0.418	21.919	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) Rad17 (PF03215): Rad17 cell cycle checkpoint protein Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain
132	RMND5B	interactor	1	0	0	Sec15 (PF04091, IPR007225): Exocyst complex subunit Sec15-like CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
133	RN7SK	interactor	10	0.600	8.092	NA
134	RNF20	interactor	16	0.324	48.533	Allexi_40kDa (PF05549, IPR008398): Allexivirus 40kDa protein Atrophin-1 (PF03154, IPR002951): Atrophin-1 family BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690) HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7) Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region Sox_N (PF12444, IPR022151): Sox developmental protein N terminal DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
135	RNF40	protein found in more fusions	17	0.325	50.561	BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745) ZapB (PF06005, IPR009252): Cell division protein ZapB EzrA (PF06160, IPR010379): Septation ring formation regulator, EzrA FlgN (PF05130, IPR007809): FlgN protein Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat SpoIIE (PF07228, IPR001932): Stage II sporulation protein E (SpoIIE) T5orf172 (PF10544, IPR018306, SM00974): T5orf172 domain XhlA (PF10779, IPR019715): Haemolysin XhlA ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin zf-RING_6 (PF14835): zf-RING of BARD1-type protein
136	RPN1	oncoprotein	12	0.470	14.448	Ribophorin_I (PF04597, IPR007676): Ribophorin I CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
137	RPS4X	interactor	12	0.621	4.476	KOW (PF00467, IPR005824, SM00739): KOW motif Ribosomal_S4e (PF00900, IPR013845): Ribosomal family S4e RS4NT (PF08071, IPR013843): RS4NT (NUC023) domain S4 (PF01479, IPR002942, SM00363): S4 domain 40S_S4_C (PF16121, IPR032277): 40S ribosomal protein S4 C-terminus
138	RUVBL1	oncoprotein	19	0.301	57.056	TIP49 (PF06068, IPR010339): TIP49 C-terminus
139	RUVBL2	oncoprotein	29	0.280	146.454	TIP49 (PF06068, IPR010339): TIP49 C-terminus
140	SART3	protein found in more fusions	7	0.467	4.089	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF1866 (PF08952, IPR015047, SM01165): Domain of unknown function (DUF1866) DUF1993 (PF09351, IPR018531): Domain of unknown function (DUF1993) Lsm_interact (PF05391, IPR008669): Lsm interaction motif Phage_GPD (PF05954): Phage late control gene D protein (GPD) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Suf (PF05843, IPR008847): Suppressor of forked protein (Suf) TPR_14 (PF13428): Tetratricopeptide repeat MRI (PF15325, IPR028278): Modulator of retrovirus infection LSM_int_assoc (PF16605): LSM-interacting associated unstructured
141	SEC31A	interactor	2	1.000	0	P3A (PF08727, IPR014838): Poliovirus 3A protein like SRA1 (PF07304, IPR009917): Steroid receptor RNA activator (SRA1) Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16 Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
142	SETD1B	interactor	3	0.667	0.400	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SET (PF00856, IPR001214, SM00317): SET domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein N-SET (PF11764, IPR024657): COMPASS (Complex proteins associated with Set1p) component N CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance 4HBT_3 (PF13622): Thioesterase-like superfamily SOBP (PF15279, IPR026092): Sine oculis-binding protein PRIMA1 (PF16101): Proline-rich membrane anchor 1
143	SKIV2L	interactor	1	0	0	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase DSHCT (PF08148, IPR012961, SM01142): DSHCT (NUC185) domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF3516 (PF12029, IPR021904): Domain of unknown function (DUF3516) rRNA_proc-arch (PF13234, IPR025696): rRNA-processing arch domain
144	SKP1	oncoprotein	11	0.582	7.465	Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
145	SKP2	oncoprotein	15	0.352	39.464	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRR_2 (PF07723, IPR013101): Leucine Rich Repeat LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) F-box-like (PF12937, IPR001810): F-box-like LRR_6 (PF13516, IPR001611): Leucine Rich repeat LRR_8 (PF13855, IPR001611): Leucine rich repeat
146	SMAD1	interactor	8	0.667	3.456	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
147	SMAD2	oncoprotein	11	0.556	11.100	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
148	SMAD3	oncoprotein	15	0.484	22.245	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
149	SMC2	interactor	10	0.511	12.703	SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
150	SMC4	interactor	8	0.750	1.914	SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins
151	SNRPD2P1	interactor	2	1.000	0	NA
152	SNW1	protein found in more fusions	52	0.224	520.662	SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain
153	SQSTM1	oncoprotein	11	0.444	15.913	PB1 (PF00564, IPR000270, SM00666): PB1 domain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type UBA_5 (PF16577, IPR015940): UBA domain
154	SRCAP	interactor	4	0.833	0.333	AT_hook (PF02178, IPR017956, SM00384): AT hook motif HSA (PF07529, IPR014012, SM00573): HSA RXT2_N (PF08595, IPR013904): RXT2-like, N-terminal SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DBINO (PF13892, IPR020838): DNA-binding domain PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
155	STAT3	oncoprotein	16	0.210	57.955	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
156	STIP1	interactor	12	0.394	24.283	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat Wtap (PF17098, IPR029732): Pre-mRNA-splicing regulator WTAP
157	SUPT16H	interactor	14	0.256	37.883	Nop14 (PF04147, IPR007276): Nop14-like family Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24 Rtt106 (PF08512, IPR013719): Histone chaperone Rttp106-like SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68) Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal FACT-Spt16_Nlob (PF14826, IPR029148): FACT complex subunit SPT16 N-terminal lobe domain
158	SUPT5H	interactor	17	0.324	45.818	KOW (PF00467, IPR005824, SM00739): KOW motif Ribonuc_P_40 (PF08584, IPR013893): Ribonuclease P 40kDa (Rpp40) subunit Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal DUF3912 (PF13051, IPR025023): Protein of unknown function (DUF3912)
159	SYNCRIP	interactor	20	0.521	42.846	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1
160	TAF7	interactor	4	0.667	0.900	DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) ELM2 (PF01448, IPR000949): ELM2 domain TAFII55_N (PF04658, IPR006751): TAFII55 protein conserved region XhlA (PF10779, IPR019715): Haemolysin XhlA Noelin-1 (PF12308, IPR022082): Neurogenesis glycoprotein
161	TAL1	oncoprotein	6	0.600	2.833	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
162	TCEA1	oncoprotein	11	0.455	17.605	Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain TFIIS_C (PF01096, IPR001222): Transcription factor S-II (TFIIS) TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain
163	TERF1	interactor	21	0.289	77.937	TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
164	TERF2	interactor	18	0.309	57.469	Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif
165	TP53	oncoprotein	58	0.166	804.443	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
166	TRAF2	interactor	6	0.500	3.417	MATH (PF00917, IPR002083, SM00061): MATH domain Sina (PF03145, IPR018121): Seven in absentia protein family SlyX (PF04102, IPR007236): SlyX zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
167	TRAP1	oncoprotein	7	0.524	4.173	HSP90 (PF00183, IPR001404): Hsp90 protein HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
168	TRIM28	protein found in more fusions	16	0.381	32.481	ASFV_J13L (PF05568, IPR008385): African swine fever virus J13L protein K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain PHD (PF00628, IPR019787, SM00249): PHD-finger FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
169	TRIM33	oncoprotein	8	0.476	6.500	PHD (PF00628, IPR019787, SM00249): PHD-finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Siva (PF05458, IPR022773): Cd27 binding protein (Siva) Spectrin (PF00435, IPR002017): Spectrin repeat TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger Bromodomain (PF00439, IPR001487, SM00297): Bromodomain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
170	TRIP12	interactor	4	0.667	0.187	Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup WWE (PF02825, IPR004170, SM00678): WWE domain SOG2 (PF10428, IPR019487): RAM signalling pathway protein HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central HEAT_2 (PF13646): HEAT repeats
171	TUBB4B	interactor	13	0.474	13.300	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
172	UBE2A	interactor	10	0.417	12.930	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
173	UBE2S	interactor	6	0.500	2.137	ALF (PF03752, IPR005506): Short repeats of unknown function UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
174	UBL4A	interactor	25	0.350	85.367	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
175	UBR5	protein found in more fusions	10	0.361	14.444	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain SDA1 (PF05285, IPR007949): SDA1 HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain E3_UbLigase_EDD (PF11547, IPR024725): E3 ubiquitin ligase EDD PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
176	XRCC3	oncoprotein	10	0.333	18.818	Rad51 (PF08423, IPR013632): Rad51 RNA_pol_A_CTD (PF03118, IPR011260): Bacterial RNA polymerase, alpha chain C terminal domain
177	YBX1	oncoprotein	19	0.468	34.348	CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
178	ZC3H13	interactor	8	0.571	8.400	FGF-BP1 (PF06473, IPR010510): FGF binding protein 1 (FGF-BP1) zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) PET117 (PF15786, IPR031568): PET assembly of cytochrome c oxidase, mitochondrial

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