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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SAP130, CDK5RAP2 (from a repository: Fri Apr 28 11:58:07 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)95
The number (and %) of the onco-proteins28 (29.47 %)
The number (and %) of the tumor suppressors13 (13.68 %)
Total number of binary PPIs (saturation %)422 (9.45 %)
The number (and %) of affected PPIs93 (22.04 %)
The number of possible different fusions19
PPI diameter5
PPI radius3
The average degree of PPI8.105
Assortativity coefficient-0.2732
The network average Clustering coefficient0.476
The number (and %) of a zero Clustering coefficients17 (17.89 %)
The number (and %) of a zero Betweenness Centrality22 (23.16 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: CDK5RAP2,SAP130 All fusions
: AA972005;
Proteins found in more fusions TUBG1 (see 1 fusions); SYN1 (see 1 fusions); MAPRE1 (see 1 fusions); RARA/PML (see 21 fusions); EEF1G (see 1 fusions); CUL4A (see 4 fusions); LUC7L2 (see 2 fusions); RARA (see 4 fusions); KAT5 (see 3 fusions); COPS5 (see 1 fusions); CUL1 (see 3 fusions); STK36 (see 1 fusions); DDB1 (see 2 fusions); PML (see 4 fusions); VHL (see 1 fusions); MYC (see 1 fusions); SMAD3 (see 3 fusions); SUZ12 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CDK5RAP2parental protein530.0603830.249APG6 (PF04111, IPR007243): Autophagy protein Apg6
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
DUF1993 (PF09351, IPR018531): Domain of unknown function (DUF1993)
IncA (PF04156, IPR007285): IncA protein
LPP (PF04728, IPR006817): Lipoprotein leucine-zipper
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
Tup_N (PF08581, IPR013890): Tup N-terminal
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
Cyclin_C_2 (PF16899, IPR031658): Cyclin C-terminal domain
2 SAP130parental protein400.2061531.804SAP130_C (PF16014, IPR031963): Histone deacetylase complex subunit SAP130 C-terminus
3 ABCA2interactor2015.559ABC_tran (PF00005, IPR003439): ABC transporter
ABC2_membrane_3 (PF12698): ABC-2 family transporter protein
AAA_21 (PF13304, IPR003959): AAA domain, putative AbiEii toxin, Type IV TA system
DUF4162 (PF13732, IPR025302): Domain of unknown function (DUF4162)
4 AKAP9oncoprotein110.41878.185ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
ZYG-11_interact (PF05884, IPR008574): Interactor of ZYG-11
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
Hema_stalk (PF08720, IPR014831): Influenza C hemagglutinin stalk
IncA (PF04156, IPR007285): IncA protein
Laminin_II (PF06009, IPR010307): Laminin Domain II
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
ApoO (PF09769, IPR019166): Apolipoprotein O
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
Macoilin (PF09726, IPR019130): Transmembrane protein
PACT_coil_coil (PF10495, IPR019528): Pericentrin-AKAP-450 domain of centrosomal targeting protein
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
FlxA (PF14282, IPR025577): FlxA-like protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
FAM76 (PF16046, IPR032017): FAM76 protein
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
5 ARID4Binteractor130.8465.604ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
CDC45 (PF02724, IPR003874): CDC45-like protein
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
E7 (PF00527, IPR000148): E7 protein, Early protein
NOA36 (PF06524, IPR010531): NOA36 protein
PWWP (PF00855, IPR000313, SM00293): PWWP domain
RBB1NT (PF08169, IPR012603): RBB1NT (NUC162) domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
6 BORCS6interactor30.6671.000DUF2365 (PF10157, IPR019314): Uncharacterized conserved protein (DUF2365)
7 C14orf1interactor21.0000Erg28 (PF03694, IPR005352): Erg28 like protein
8 CARD9interactor40.33333.880CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
IncA (PF04156, IPR007285): IncA protein
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
9 CDK5oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
10 CDK5R1oncoprotein30.33389.460CDK5_activator (PF03261, IPR004944): Cyclin-dependent kinase 5 activator protein
11 CEP152interactor90.36196.557bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
ZapB (PF06005, IPR009252): Cell division protein ZapB
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Ribosomal_S13 (PF00416, IPR001892): Ribosomal protein S13/S18
FAD-SLDH (PF12318, IPR024651): Membrane bound FAD containing D-sorbitol dehydrogenase
YtxH (PF12732, IPR024623): YtxH-like protein
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
12 CEP192interactor60.7333.000Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
TMEM131_like (PF12371, IPR022113): Transmembrane protein 131-like
MYCBPAP (PF14646, IPR032707): MYCBP-associated protein family
ASH (PF15780, IPR031549): Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
13 CEP68interactor30.6670.667Spectrin (PF00435, IPR002017): Spectrin repeat
14 CHMP4Binteractor31.0000Snf7 (PF03357, IPR005024): Snf7
15 COPS5protein found in more fusions160.286214.433JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
16 CRMP1interactor3015.652Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family
Amidohydro_3 (PF07969, IPR013108): Amidohydrolase family
17 CUL1suppressor170.225423.797Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
18 CUL2suppressor90.361109.670Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
19 CUL4Aprotein found in more fusions130.43957.776Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
20 CUL4Boncoprotein160.450188.472Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
21 DDB1protein found in more fusions180.449169.132CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
22 DTNBP1interactor30.6672.645Dysbindin (PF04440, IPR007531): Dysbindin (Dystrobrevin binding protein 1)
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
DUF2730 (PF10805, IPR020269): Protein of unknown function (DUF2730)
23 DYNLL1interactor90.32191.870Dynein_light (PF01221, IPR001372): Dynein light chain type 1
24 DYNLT1interactor21.0000Tctex-1 (PF03645, IPR005334): Tctex-1 family
25 EEF1Gprotein found in more fusions70.267122.528EF1G (PF00647, IPR001662): Elongation factor 1 gamma, conserved domain
GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain
SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
26 EMDinteractor70.26733.198LEM (PF03020, IPR003887, SM00540): LEM domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
27 FBXO25suppressor2015.652Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
28 FGFR1OPoncoprotein70.46765.573FOP_dimer (PF09398, IPR018993): FOP N terminal dimerisation domain
29 FGL2interactor21.0000FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
SPATA24 (PF15175, IPR029176): Spermatogenesis-associated protein 24
30 FOXK1interactor110.8733.599Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FHA (PF00498, IPR000253, SM00240): FHA domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
31 FOXK2interactor150.62927.328FHA (PF00498, IPR000253, SM00240): FHA domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
32 GPS1interactor80.60768.072RPN7 (PF10602, IPR019585): 26S proteasome subunit RPN7
PCI (PF01399, IPR000717, SM00088): PCI domain
33 H3F3Aoncoprotein40.6671.333Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
34 HAP1interactor40.6671.762HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
35 HDAC1suppressor280.319602.376FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
36 HDAC2suppressor230.463152.431Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
37 ING2suppressor110.8557.037PHD (PF00628, IPR019787, SM00249): PHD-finger
S1FA (PF04689, IPR006779): DNA binding protein S1FA
ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
38 KAT5suppressor110.200401.696MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
39 KIF20Ainteractor100Med9 (PF07544, IPR011425): RNA polymerase II transcription mediator complex subunit 9
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
PhoU (PF01895, IPR026022): PhoU domain
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
DUF4359 (PF14271, IPR025578): Domain of unknown function (DUF4359)
40 LUC7L2protein found in more fusions60.30063.864LUC7 (PF03194, IPR004882): LUC7 N_terminus
Paramyxo_ncap (PF00973, IPR002021): Paramyxovirus nucleocapsid protein
Methyltransf_32 (PF13679, IPR025714): Methyltransferase domain
41 MAGEH1interactor100MAGE (PF01454, IPR002190): MAGE family
42 MAPRE1oncoprotein90.42955.244CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EB1 (PF03271, IPR004953): EB1-like C-terminal motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
43 MAXsuppressor100.38952.835ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SlyX (PF04102, IPR007236): SlyX
44 MLF1oncoprotein21.0000Mlf1IP (PF10248, IPR019376): Myelodysplasia-myeloid leukemia factor 1-interacting protein
45 MUS81suppressor100ERCC4 (PF02732, IPR006166, SM00891): ERCC4 domain
MutL (PF13941, IPR006230): MutL protein
HHH_8 (PF14716, IPR010996): Helix-hairpin-helix domain
46 MXD1oncoprotein80.8212.290HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SlyX (PF04102, IPR007236): SlyX
47 MYConcoprotein200.234453.918HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
48 MZT2Ainteractor51.0000MOZART2 (PF12926, IPR024332): Mitotic-spindle organizing gamma-tubulin ring associated
49 MZT2Binteractor80.78638.376MOZART2 (PF12926, IPR024332): Mitotic-spindle organizing gamma-tubulin ring associated
50 NANOGinteractor100.306134.108Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
51 NME7interactor70.7627.772DUF1126 (PF06565, IPR010554): Repeat of unknown function (DUF1126)
NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
52 PCBD1interactor80.381202.768Pterin_4a (PF01329, IPR001533): Pterin 4 alpha carbinolamine dehydratase
53 PCNTinteractor150.229412.383Caldesmon (PF02029, IPR006018): Caldesmon
CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF1640 (PF07798, IPR024461): Protein of unknown function (DUF1640)
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
SlyX (PF04102, IPR007236): SlyX
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
PACT_coil_coil (PF10495, IPR019528): Pericentrin-AKAP-450 domain of centrosomal targeting protein
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
PP2C_C (PF07830, IPR012911, SM00332): Protein serine/threonine phosphatase 2C, C-terminal domain
Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2
Colicin-DNase (PF12639, IPR024622): DNase/tRNase domain of colicin-like bacteriocin
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
DUF4239 (PF14023, IPR025333): Protein of unknown function (DUF4239)
WD40_alt (PF14077, IPR026987): Alternative WD40 repeat motif
FlxA (PF14282, IPR025577): FlxA-like protein
FAM184 (PF15665): Family with sequence similarity 184, A and B
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
54 PLK4interactor51.0000ABC1 (PF03109, IPR004147): ABC1 family
Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
DUF4520 (PF15016, IPR027865): Domain of unknown function (DUF4520)
55 PMLsuppressor130.439104.081zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
56 PRKACAinteractor80.464113.916Pkinase (PF00069, IPR000719): Protein kinase domain
57 PRKACBinteractor80.57118.240Pkinase (PF00069, IPR000719): Protein kinase domain
58 PRKAR2Binteractor60.46763.119RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
59 PRPS1oncoprotein200Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
Pribosyltran_N (PF13793, IPR029099): N-terminal domain of ribose phosphate pyrophosphokinase
Pribosyl_synth (PF14572, IPR005946): Phosphoribosyl synthetase-associated domain
60 PTNoncoprotein31.0000PTN_MK_C (PF01091, IPR020090): PTN/MK heparin-binding protein family, C-terminal domain
PTN_MK_N (PF05196, IPR020089): PTN/MK heparin-binding protein family, N-terminal domain
61 PTTG1oncoprotein3015.652Securin (PF04856, IPR006940): Securin sister-chromatid separation inhibitor
62 RARAoncoprotein60.9005.266zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
63 RBBP7suppressor190.509381.528WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
64 RBM48interactor100DUF2284 (PF10050, IPR019271): Predicted metal-binding protein (DUF2284)
65 RPGRIP1Linteractor60.6005.312bZIP_1 (PF00170, IPR004827): bZIP transcription factor
C2 (PF00168, IPR000008, SM00239): C2 domain
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FtsL (PF04999, IPR011922): Cell division protein FtsL
T3SS_needle_F (PF09392, IPR021123): Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
C2-C2_1 (PF11618, IPR021656): First C2 domain of RPGR-interacting protein 1
BNIP2 (PF12496, IPR022181): Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4497 (PF14924): Protein of unknown function (DUF4497)
66 SAP25interactor70.8571.133SAP25 (PF15476, IPR029163): Histone deacetylase complex subunit SAP25
67 SAP30interactor160.65861.751Titin_Z (PF09042, IPR015129): Titin Z
zf-SAP30 (PF13866, IPR025717): SAP30 zinc-finger
SAP30_Sin3_bdg (PF13867, IPR025718): Sin3 binding region of histone deacetylase complex subunit SAP30
68 SENP2interactor100Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
69 SF3B1oncoprotein70.33338.984Dopey_N (PF04118, IPR007249): Dopey, N-terminal
HEAT (PF02985, IPR000357): HEAT repeat
SF3b1 (PF08920, IPR015016): Splicing factor 3B subunit 1
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
70 SIN3Aoncoprotein200.52661.108Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
71 SIN3Binteractor110.7828.370Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
72 SMAD3oncoprotein80.7147.870MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
73 SOCS6interactor2061.652SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
74 SOX2oncoprotein110.511141.943HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
75 STARD9interactor100START (PF01852, IPR002913, SM00234): START domain
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
Kinesin_assoc (PF16183, IPR032405): Kinesin-associated
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
76 STK36protein found in more fusions200Pkinase (PF00069, IPR000719): Protein kinase domain
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
77 SUDS3interactor150.8027.401Sds3 (PF08598, IPR013907): Sds3-like
78 SUPT3Hinteractor40.66712.654TFIID-18kDa (PF02269, IPR003195): Transcription initiation factor IID, 18kD subunit
DUF4093 (PF13331, IPR025156): Domain of unknown function (DUF4093)
79 SUZ12suppressor140.205550.512DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
80 SYN1protein found in more fusions306.956Synapsin_C (PF02750, IPR020898): Synapsin, ATP binding domain
Synapsin_N (PF10581, IPR019736): Synapsin N-terminal
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
Synapsin (PF02078, IPR020897): Synapsin, N-terminal domain
81 TAF10interactor30.6671.000TFIID_30kDa (PF03540, IPR003923): Transcription initiation factor TFIID 23-30kDa subunit
82 TAF3interactor21.0000Bromo_TP (PF07524, IPR006565): Bromodomain associated
GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family
DUF719 (PF05334, IPR007998): Protein of unknown function (DUF719)
FHIPEP (PF00771, IPR001712): FHIPEP family
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
NinG (PF05766, IPR008713): Bacteriophage Lambda NinG protein
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
PHD (PF00628, IPR019787, SM00249): PHD-finger
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
DUF3824 (PF12868, IPR024436): Domain of unknwon function (DUF3824)
83 TCEB2interactor50.60063.791ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
84 TFAP4oncoprotein60.73311.516DivIC (PF04977, IPR007060): Septum formation initiator
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF2407 (PF10302, IPR019413): DUF2407 ubiquitin-like domain
85 TPX2interactor100Aurora-A_bind (PF09041, IPR015128): Aurora-A binding
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
DUF2259 (PF10016, IPR018725): Predicted secreted protein (DUF2259)
TPX2_importin (PF12214, IPR027330): Cell cycle regulated microtubule associated protein
zf-TFIIIC (PF12660, IPR024764): Putative zinc-finger of transcription factor IIIC complex
DUF4337 (PF14235, IPR025570): Domain of unknown function (DUF4337)
86 TRIM37oncoprotein70.40042.727MATH (PF00917, IPR002083, SM00061): MATH domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
MRFAP1 (PF15155, IPR029254): MORF4 family-associated protein1
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
DUF5071 (PF16804, IPR031837): Domain of unknown function (DUF5071)
87 TSNAXinteractor40.5003.268Translin (PF01997, IPR002848): Translin family
88 TUBG1protein found in more fusions140.372300.115Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
89 TUBGCP2interactor130.397236.716Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
zf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger
90 TUBGCP3interactor110.52767.342Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
91 TUBGCP5interactor80.8571.533Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
GCP5-Mod21 (PF14609, IPR032797): gamma-Tubulin ring complex non-core subunit mod21
92 TUBGCP6interactor61.0000Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
93 USP43interactor100UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
94 VHLsuppressor110.378114.991Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
VHL_C (PF17211): VHL box domain
95 ZPR1interactor100zf-ZPR1 (PF03367, IPR004457, SM00709): ZPR1 zinc-finger domain

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 C14orf1interactorErg28 (PF03694, IPR005352): Erg28 like proteinAA972005
2 CDK5R1oncoproteinCDK5_activator (PF03261, IPR004944): Cyclin-dependent kinase 5 activator proteinAA972005
3 CDK5RAP2parental proteinAPG6 (PF04111, IPR007243): Autophagy protein Apg6
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
DUF1993 (PF09351, IPR018531): Domain of unknown function (DUF1993)
IncA (PF04156, IPR007285): IncA protein
LPP (PF04728, IPR006817): Lipoprotein leucine-zipper
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
Tup_N (PF08581, IPR013890): Tup N-terminal
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
Cyclin_C_2 (PF16899, IPR031658): Cyclin C-terminal domain
AA972005
4 DYNLT1interactorTctex-1 (PF03645, IPR005334): Tctex-1 familyAA972005
5 GPS1interactorRPN7 (PF10602, IPR019585): 26S proteasome subunit RPN7
PCI (PF01399, IPR000717, SM00088): PCI domain
AA972005
6 MZT2AinteractorMOZART2 (PF12926, IPR024332): Mitotic-spindle organizing gamma-tubulin ring associatedAA972005
7 MZT2BinteractorMOZART2 (PF12926, IPR024332): Mitotic-spindle organizing gamma-tubulin ring associatedAA972005
8 PCBD1interactorPterin_4a (PF01329, IPR001533): Pterin 4 alpha carbinolamine dehydrataseAA972005
9 PTTG1oncoproteinSecurin (PF04856, IPR006940): Securin sister-chromatid separation inhibitorAA972005
10 RBBP7suppressorWD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
AA972005
11 SAP130parental proteinSAP130_C (PF16014, IPR031963): Histone deacetylase complex subunit SAP130 C-terminusAA972005
12 SAP25interactorSAP25 (PF15476, IPR029163): Histone deacetylase complex subunit SAP25AA972005
13 SAP30interactorTitin_Z (PF09042, IPR015129): Titin Z
zf-SAP30 (PF13866, IPR025717): SAP30 zinc-finger
SAP30_Sin3_bdg (PF13867, IPR025718): Sin3 binding region of histone deacetylase complex subunit SAP30
AA972005
14 SENP2interactorPeptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domainAA972005
15 SF3B1oncoproteinDopey_N (PF04118, IPR007249): Dopey, N-terminal
HEAT (PF02985, IPR000357): HEAT repeat
SF3b1 (PF08920, IPR015016): Splicing factor 3B subunit 1
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
AA972005
16 SIN3AoncoproteinSin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
AA972005
17 SIN3BinteractorSin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
AA972005
18 SOX2oncoproteinHMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
AA972005
19 SUDS3interactorSds3 (PF08598, IPR013907): Sds3-likeAA972005
20 SUPT3HinteractorTFIID-18kDa (PF02269, IPR003195): Transcription initiation factor IID, 18kD subunit
DUF4093 (PF13331, IPR025156): Domain of unknown function (DUF4093)
AA972005
21 SYN1interactorSynapsin_C (PF02750, IPR020898): Synapsin, ATP binding domain
Synapsin_N (PF10581, IPR019736): Synapsin N-terminal
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
Synapsin (PF02078, IPR020897): Synapsin, N-terminal domain
AA972005
22 TAF10interactorTFIID_30kDa (PF03540, IPR003923): Transcription initiation factor TFIID 23-30kDa subunitAA972005
23 TAF3interactorBromo_TP (PF07524, IPR006565): Bromodomain associated
GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family
DUF719 (PF05334, IPR007998): Protein of unknown function (DUF719)
FHIPEP (PF00771, IPR001712): FHIPEP family
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
NinG (PF05766, IPR008713): Bacteriophage Lambda NinG protein
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
PHD (PF00628, IPR019787, SM00249): PHD-finger
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
DUF3824 (PF12868, IPR024436): Domain of unknwon function (DUF3824)
AA972005
24 TFAP4oncoproteinDivIC (PF04977, IPR007060): Septum formation initiator
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF2407 (PF10302, IPR019413): DUF2407 ubiquitin-like domain
AA972005
25 TUBGCP3interactorSpc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 familyAA972005
26 TUBGCP6interactorSpc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 familyAA972005
27 VHLsuppressorTrypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
VHL_C (PF17211): VHL box domain
AA972005
28 ZPR1interactorzf-ZPR1 (PF03367, IPR004457, SM00709): ZPR1 zinc-finger domainAA972005

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