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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)118
The number (and %) of the onco-proteins41 (34.75 %)
The number (and %) of the tumor suppressors17 (14.41 %)
Total number of binary PPIs (saturation %)1203 (17.43 %)
The number (and %) of affected PPIs121 (10.06 %)
The number of possible different fusions34
PPI diameter4
PPI radius2
The average degree of PPI19.339
Assortativity coefficient-0.1747
The network average Clustering coefficient0.454
The number (and %) of a zero Clustering coefficients4 (3.39 %)
The number (and %) of a zero Betweenness Centrality8 (6.78 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CDK11B,PCBP2 All fusions
: BE378162; BC033069;
Proteins found in more fusions VDR (see 2 fusions); GNPNAT1 (see 1 fusions); EEF1A1 (see 1 fusions); CUL7 (see 2 fusions); CUL1 (see 3 fusions); WDR77 (see 1 fusions); CUL3 (see 1 fusions); LGALS3 (see 2 fusions); YWHAZ (see 1 fusions); COPS5 (see 1 fusions); RACK1/FN1 (see 1 fusions); HDAC5 (see 1 fusions); FN1/YWHAG (see 1 fusions); UBC (see 1 fusions); PRPF40A (see 2 fusions); AP2M1 (see 3 fusions); PTBP1 (see 1 fusions); YWHAG (see 1 fusions); POU2F1 (see 1 fusions); HSP90AA1 (see 2 fusions); HUWE1 (see 2 fusions); PABPC1 (see 2 fusions); HNRNPL (see 2 fusions); HNRNPD (see 1 fusions); PCBP2 (see 3 fusions); ACAT2 (see 1 fusions); RANBP9 (see 2 fusions); MCM2 (see 1 fusions); RACK1 (see 3 fusions); QKI (see 3 fusions); CDC37 (see 2 fusions); TGM2 (see 4 fusions); CDK9 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CDK11Bparental protein340.146852.229DDHD (PF02862, IPR004177, SM01127): DDHD domain
DivIC (PF04977, IPR007060): Septum formation initiator
Pkinase (PF00069, IPR000719): Protein kinase domain
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
2 PCBP2parental protein870.1843257.366Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein
KH_2 (PF07650, IPR004044): KH domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
3 ACAT2protein found in more fusions60.8000.538Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
4 ADRB2interactor120.5457.0647tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
5 ANXA2interactor200.46328.982Annexin (PF00191, IPR018502, SM00335): Annexin
6 AP2M1protein found in more fusions130.45533.203Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
7 AP3D1interactor31.0000Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
AP3D1 (PF06375): AP-3 complex subunit delta-1
8 ARF4interactor140.45115.294Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
9 ARF5interactor50.7000.520Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
10 BARD1suppressor150.28672.888BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
11 BRCA1suppressor250.308218.236BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
12 CASKinteractor40.8330.287L27 (PF02828, IPR014775, SM00569): L27 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase (PF00069, IPR000719): Protein kinase domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
13 CCDC58interactor60.8000.423Cid2 (PF09774, IPR019171): Caffeine-induced death protein 2
14 CCDC8interactor220.50522.712Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
15 CCND3oncoprotein30.3335.555Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
16 CD81interactor150.54916.037Tetraspannin (PF00335, IPR018499): Tetraspanin family
17 CDC37protein found in more fusions120.52719.146CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
18 CDC5Linteractor400.345280.577OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
19 CDK11Aoncoprotein90.47211.116DDHD (PF02862, IPR004177, SM01127): DDHD domain
eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
Pkinase (PF00069, IPR000719): Protein kinase domain
RIO1 (PF01163, IPR018934): RIO1 family
DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355)
DHHW (PF14286, IPR025945): DHHW protein
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
20 CDK2suppressor400.291439.340Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
21 CDK9protein found in more fusions200.34551.961Pkinase (PF00069, IPR000719): Protein kinase domain
22 CEP250interactor120.6065.085ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
EHN (PF06441, IPR010497): Epoxide hydrolase N terminus
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
IncA (PF04156, IPR007285): IncA protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Endonuc_Holl (PF10107, IPR019287): Endonuclease related to archaeal Holliday junction resolvase
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
DGF-1_C (PF11040, IPR021053): Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
23 COPS5protein found in more fusions390.415154.753JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
24 CSNK2A2interactor140.31952.165Pkinase (PF00069, IPR000719): Protein kinase domain
25 CUL1suppressor360.422130.800Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
26 CUL2suppressor290.41188.135Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
27 CUL3protein found in more fusions460.333259.723Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
28 CUL7protein found in more fusions420.309194.745ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
29 DAZAP1interactor210.43344.925RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
30 EEDsuppressor250.36695.883WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
31 EEF1A1suppressor380.408143.607GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
32 EIF3Fsuppressor150.36251.160JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
33 ELAVL1oncoprotein430.305413.441RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
34 ESR1suppressor300.325158.921Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
35 FBXO6interactor320.298162.740FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
36 FN1oncoprotein430.277288.186fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
37 FTH1interactor50.5001.417Coat_F (PF07875, IPR012851): Coat F domain
Ferritin (PF00210, IPR008331): Ferritin-like domain
38 FUBP1oncoprotein220.46345.395DUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897)
KH_1 (PF00013, IPR004088, SM00322): KH domain
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
39 FUBP3interactor180.58212.932DUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897)
KH_1 (PF00013, IPR004088, SM00322): KH domain
40 FUSsuppressor280.63022.322Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
41 GBAinteractor60.4675.865Glyco_hydro_30 (PF02055, IPR001139): Glycosyl hydrolase family 30 TIM-barrel domain
Glyco_hydro_30C (PF17189): Glycosyl hydrolase family 30 beta sandwich domain
42 GNPNAT1protein found in more fusions31.0000Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
43 H2AFXsuppressor210.35760.255Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
44 HDAC5protein found in more fusions240.37553.383Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
45 HMGA1oncoprotein130.60329.831AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DUF2239 (PF09998, IPR018715): Uncharacterized protein conserved in bacteria (DUF2239)
46 HMGA2oncoprotein31.0000AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DUF1639 (PF07797, IPR012438): Protein of unknown function (DUF1639)
47 HNRNPA1interactor480.419200.302RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
48 HNRNPDoncoprotein350.43191.568CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
49 HNRNPKoncoprotein430.416165.615ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
50 HNRNPLprotein found in more fusions300.51752.528RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Dscam_C (PF12355, IPR021012): Down syndrome cell adhesion molecule C terminal
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
51 HSP90AA1oncoprotein360.328208.473HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
52 HSPA4interactor230.33691.787Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
53 HSPA8oncoprotein370.393187.634HSP70 (PF00012, IPR013126): Hsp70 protein
54 HUWE1oncoprotein260.44354.447BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
55 IFIH1interactor21.0000ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
RIG-I_C-RD (PF11648, IPR021673): C-terminal domain of RIG-I
CARD_2 (PF16739, IPR031964): Caspase recruitment domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
56 IGSF8oncoprotein100.55614.811V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
57 ITCHinteractor110.42220.447C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
58 ITGA4interactor380.342169.878FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
59 KAT2Ainteractor50.5000.572Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
NICE-1 (PF15845, IPR031698): Cysteine-rich C-terminal 1 family
60 KAT7interactor302.406MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
zf-C2HC (PF01530, IPR002515, SM00343): Zinc finger, C2HC type
zf-met (PF12874): Zinc-finger of C2H2 type
EFTUD2 (PF16004, IPR031950): 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
61 KIF2Cinteractor60.6000.991Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
62 KMT2Einteractor40.3332.932CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PHD (PF00628, IPR019787, SM00249): PHD-finger
SET (PF00856, IPR001214, SM00317): SET domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
DUF4124 (PF13511, IPR025392): Domain of unknown function (DUF4124)
PHD_3 (PF13922, IPR026905): PHD domain of transcriptional enhancer, Asx
DUF4666 (PF15697, IPR031421): Domain of unknown function (DUF4666)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
63 LGALS1interactor110.6557.714Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
64 LGALS3oncoprotein80.4297.896Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
65 MAGI3interactor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
WW (PF00397, IPR001202, SM00456): WW domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
PDZ_2 (PF13180, IPR001478): PDZ domain
MAGI_u1 (PF16663): Unstructured region on MAGI
66 MAVSinteractor40.6671.000Ice_nucleation (PF00818, IPR000258): Ice nucleation protein repeat
CARD_2 (PF16739, IPR031964): Caspase recruitment domain
67 MCM2oncoprotein440.368359.773AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
68 MEPCEinteractor150.41047.494Bin3 (PF06859, IPR010675): Bicoid-interacting protein 3 (Bin3)
Methyltransf_23 (PF13489): Methyltransferase domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7
69 MSNoncoprotein150.35234.618DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
70 NKAPinteractor50.3335.996SynMuv_product (PF06047, IPR009269): Ras-induced vulval development antagonist
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
NKAP (PF15692): NF-kappa-B-activating protein
71 NOS2interactor150.45110.903FAD_binding_1 (PF00667, IPR003097): FAD binding domain
Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain
72 NTRK1oncoprotein610.2471061.861I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
73 OBSL1interactor360.353155.648BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
74 PABPC1oncoprotein380.404134.745RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
YflT (PF11181, IPR025889): Heat induced stress protein YflT
75 PAXIP1interactor120.31829.669BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
SURF6 (PF04935, IPR007019): Surfeit locus protein 6
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
76 PCBP1oncoprotein450.336305.839Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein
KH_2 (PF07650, IPR004044): KH domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
77 PHF6suppressor31.0000zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
YqfQ (PF14181, IPR025571): YqfQ-like protein
78 PIN1suppressor120.33370.312Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
79 PNKPinteractor40.5001.907PNK3P (PF08645, IPR013954): Polynucleotide kinase 3 phosphatase
AAA_33 (PF13671): AAA domain
80 POLR3Hinteractor30.6670.438RNA_pol_Rbc25 (PF08292, IPR013238): RNA polymerase III subunit Rpc25
SHS2_Rpb7-N (PF03876, IPR005576): SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397
81 POU2F1protein found in more fusions80.38119.015Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
DUF3597 (PF12200, IPR022016): Domain of unknown function (DUF3597)
82 PPIBinteractor100.3115.991Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
83 PRPF40Aprotein found in more fusions180.34676.856FF (PF01846, IPR002713, SM00441): FF domain
MCR_alpha (PF02249, IPR009047): Methyl-coenzyme M reductase alpha subunit, C-terminal domain
Transformer (PF06495, IPR010519): Fruit fly transformer protein
WW (PF00397, IPR001202, SM00456): WW domain
YqzE (PF14038, IPR025622): YqzE-like protein
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
SRRM_C (PF15230, IPR029360): Serine/arginine repetitive matrix protein C-terminus
SOBP (PF15279, IPR026092): Sine oculis-binding protein
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
84 PSMA3interactor190.57512.350Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
85 PTBP1oncoprotein330.49086.244RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
86 QKIprotein found in more fusions110.7113.488KH_1 (PF00013, IPR004088, SM00322): KH domain
STAR_dimer (PF16544, IPR032377): Homodimerisation region of STAR domain protein
Quaking_NLS (PF16551, IPR032367): Putative nuclear localisation signal of quaking
87 RACK1suppressor340.402146.057WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
88 RANBP9suppressor90.4296.818Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
LisH (PF08513, IPR013720, SM00667): LisH
SPRY (PF00622, IPR003877, SM00449): SPRY domain
CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
89 RAP1Asuppressor40.6671.620Ras (PF00071, IPR001806, SM00173): Ras family
90 RBM25interactor140.28665.181Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
PWI (PF01480, IPR002483, SM00311): PWI domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
DUF3441 (PF11923, IPR021846): Domain of unknown function (DUF3441)
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4778 (PF16008, IPR031958): Domain of unknown function (DUF4778)
91 RNPS1interactor180.35957.028RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
Macoilin (PF09726, IPR019130): Transmembrane protein
92 RPS27Ainteractor110.30922.915DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
93 RUVBL1oncoprotein270.44640.811TIP49 (PF06068, IPR010339): TIP49 C-terminus
94 RUVBL2oncoprotein280.41055.399TIP49 (PF06068, IPR010339): TIP49 C-terminus
95 SCYL2interactor50.4001.450CENP-B_N (PF04218, IPR007889): CENP-B N-terminal DNA-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
96 SF3B2interactor120.364134.033DUF382 (PF04037, IPR007180): Domain of unknown function (DUF382)
PAPA-1 (PF04795, IPR006880): PAPA-1-like conserved region
PSP (PF04046, IPR006568, SM00581): PSP
SAP (PF02037, IPR003034, SM00513): SAP domain
Usp (PF00582, IPR006016): Universal stress protein family
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
Vma12 (PF11712, IPR021013): Endoplasmic reticulum-based factor for assembly of V-ATPase
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
97 SLU7interactor21.0000Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
Slu7 (PF11708, IPR021715): Pre-mRNA splicing Prp18-interacting factor
zf-CCHC_4 (PF14392, IPR025836): Zinc knuckle
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
98 SNRPAinteractor210.60516.340RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
99 STIP1interactor190.39271.784TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
Wtap (PF17098, IPR029732): Pre-mRNA-splicing regulator WTAP
100 TARDBPinteractor300.50556.344RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
101 TGM2protein found in more fusions110.51111.711Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
102 TIA1interactor120.5764.501Calcipressin (PF04847, IPR006931): Calcipressin
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter
103 TIAL1interactor140.53810.017RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
104 TPPPinteractor100DUF1018 (PF06252, IPR009363): Protein of unknown function (DUF1018)
p25-alpha (PF05517, IPR008907): p25-alpha
DUF4381 (PF14316, IPR025489): Domain of unknown function (DUF4381)
105 TRIP6interactor50.6001.286DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
LIM (PF00412, IPR001781, SM00132): LIM domain
106 UBCprotein found in more fusions370.354172.558ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
107 UBE2Minteractor130.4245.506UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
108 UBL4Ainteractor190.35733.530ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
109 VCAM1interactor350.346110.174C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
110 VDRsuppressor50.5004.508zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
111 WDR77oncoprotein110.4447.772LT-IIB (PF06453, IPR010503): Type II heat-labile enterotoxin , B subunit (LT-IIB)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
112 WDR83interactor30.6670.118WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
113 YWHABinteractor180.51030.61914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
114 YWHAEoncoprotein330.360191.34214-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
115 YWHAGprotein found in more fusions260.43362.51414-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
116 YWHAQinteractor320.407135.87814-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
117 YWHAZprotein found in more fusions320.40293.50614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
118 ZRSR2interactor203.392Band_3_cyto (PF07565, IPR013769): Band 3 cytoplasmic domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26

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