Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins CDC37 (from a repository: Thu Oct 17 13:48:19 2019)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 212 The number (and %) of the onco-proteins 80 (37.74 %) The number (and %) of the tumor suppressors 18 (8.49 %) Total number of binary PPIs (saturation %) 1536 (6.87 %) The number (and %) of affected PPIs 212 (13.80 %) The number of possible different fusions 41 PPI diameter 2 PPI radius 1 The average degree of PPI 13.651 Assortativity coefficient -0.1918 The network average Clustering coefficient 0.492 The number (and %) of a zero Clustering coefficients 11 (5.19 %) The number (and %) of a zero Betweenness Centrality 27 (12.74 %)

ACTIVE INTERACTORS MISSING INTERACTORS (in fusions)

List of the fusions
PPI for parental proteins: CDC37	All fusions : AI571632; BI464991;
Proteins found in more fusions	ABL2 (see 2 fusions); GRK5 (see 4 fusions); U2AF2 (see 2 fusions); NPM1 (see 1 fusions); PINK1 (see 3 fusions); MAP3K1 (see 1 fusions); CDK6 (see 1 fusions); AHCYL1 (see 3 fusions); EWSR1 (see 2 fusions); EIF2AK2 (see 1 fusions); IMMT (see 4 fusions); ULK1 (see 2 fusions); CTTN (see 1 fusions); IKBKB (see 2 fusions); STK36 (see 1 fusions); LRRK2 (see 1 fusions); DDX5 (see 1 fusions); MTOR (see 1 fusions); APP (see 4 fusions); TPM1 (see 2 fusions); LUC7L2 (see 2 fusions); VCP (see 4 fusions); HSP90AA1 (see 2 fusions); GFAP (see 3 fusions); NCOA5 (see 1 fusions); APOE (see 1 fusions); HSP90AB1 (see 1 fusions); A2M (see 2 fusions); SQSTM1 (see 5 fusions); SGK1 (see 2 fusions); OFD1 (see 1 fusions); FER (see 1 fusions); ERBB3 (see 2 fusions); EGFR (see 2 fusions); BRAF (see 3 fusions); STUB1 (see 1 fusions); MAP3K7 (see 7 fusions); DDX17 (see 3 fusions); CDC37 (see 2 fusions); CDK9 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	CDC37	parental protein	212	0.056	28243.209	CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
2	A2M	protein found in more fusions	26	0.277	129.292	A2M (PF00207, IPR001599): Alpha-2-macroglobulin family A2M_comp (PF07678, IPR011626): A-macroglobulin complement component A2M_N (PF01835, IPR002890): MG2 domain A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region A2M_recep (PF07677, IPR009048): A-macroglobulin receptor MP (PF01107, IPR028919): Viral movement protein (MP) SVA (PF05326, IPR007990): Seminal vesicle autoantigen (SVA) Thiol-ester_cl (PF10569, IPR019565): Alpha-macro-globulin thiol-ester bond-forming region
3	ABL2	oncoprotein	6	0.800	0.567	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain NHS (PF15273, IPR024845): NHS-like
4	AHCYL1	suppressor	9	0.500	8.677	AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515) Big_3_5 (PF16640, IPR032109): Bacterial Ig-like domain (group 3)
5	AHSA1	interactor	26	0.366	97.749	Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein
6	AIP	suppressor	10	0.422	13.511	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
7	AKT1	oncoprotein	35	0.299	191.200	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
8	APOE	protein found in more fusions	15	0.582	15.040	Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain TipAS (PF07739, IPR012925): TipAS antibiotic-recognition domain
9	APP	protein found in more fusions	55	0.131	878.311	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
10	AR	oncoprotein	22	0.314	60.681	Androgen_recep (PF02166, IPR001103): Androgen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
11	ARAF	oncoprotein	12	0.424	14.687	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
12	ATG101	interactor	4	0.500	2.067	ATG101 (PF07855, IPR012445): Autophagy-related protein 101
13	AURKA	oncoprotein	23	0.346	66.605	Pkinase (PF00069, IPR000719): Protein kinase domain MTBP_C (PF14920, IPR029418): MDM2-binding
14	AURKB	interactor	19	0.327	55.390	Pkinase (PF00069, IPR000719): Protein kinase domain
15	AURKC	interactor	6	0.800	1.182	Pkinase (PF00069, IPR000719): Protein kinase domain
16	BRAF	oncoprotein	14	0.628	7.090	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
17	BTBD10	interactor	1	0	0	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) BTB_3 (PF16017): BTB/POZ domain
18	C19orf44	interactor	1	0	0	DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
19	CC2D1A	interactor	5	0.600	2.067	C2 (PF00168, IPR000008, SM00239): C2 domain FUSC (PF04632, IPR006726): Fusaric acid resistance protein family Snf7 (PF03357, IPR005024): Snf7 DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) LELP1 (PF15042, IPR026076): Late cornified envelope-like proline-rich protein 1
20	CDC25C	oncoprotein	6	0.667	0.971	M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
21	CDC37L1	interactor	13	0.526	16.309	CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
22	CDCA5	interactor	6	0.400	1.934	Sororin (PF09666, IPR018605): Sororin protein
23	CDK1	oncoprotein	19	0.255	70.849	Pkinase (PF00069, IPR000719): Protein kinase domain
24	CDK11A	oncoprotein	5	0.600	2.122	DDHD (PF02862, IPR004177, SM01127): DDHD domain eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Pkinase (PF00069, IPR000719): Protein kinase domain RIO1 (PF01163, IPR018934): RIO1 family DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355) DHHW (PF14286, IPR025945): DHHW protein DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
25	CDK11B	oncoprotein	8	0.714	3.338	DDHD (PF02862, IPR004177, SM01127): DDHD domain DivIC (PF04977, IPR007060): Septum formation initiator Pkinase (PF00069, IPR000719): Protein kinase domain DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
26	CDK13	interactor	13	0.474	17.790	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Pkinase (PF00069, IPR000719): Protein kinase domain Macoilin (PF09726, IPR019130): Transmembrane protein THRAP3_BCLAF1 (PF15440, IPR029199): THRAP3/BCLAF1 family
27	CDK15	interactor	6	0.933	0.400	Pkinase (PF00069, IPR000719): Protein kinase domain ACT_5 (PF13710): ACT domain
28	CDK18	oncoprotein	11	0.545	8.137	APH (PF01636, IPR002575): Phosphotransferase enzyme family Pkinase (PF00069, IPR000719): Protein kinase domain
29	CDK4	oncoprotein	14	0.505	18.428	Pkinase (PF00069, IPR000719): Protein kinase domain
30	CDK5	oncoprotein	11	0.622	8.589	Pkinase (PF00069, IPR000719): Protein kinase domain
31	CDK6	suppressor	9	0.500	8.200	Pkinase (PF00069, IPR000719): Protein kinase domain
32	CDK7	oncoprotein	13	0.424	19.293	Pkinase (PF00069, IPR000719): Protein kinase domain
33	CDK9	protein found in more fusions	17	0.350	37.706	Pkinase (PF00069, IPR000719): Protein kinase domain
34	CDKL1	interactor	2	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
35	CDKL2	interactor	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
36	CEP104	interactor	6	0.467	4.400	ATP-synt_E_2 (PF08112, IPR012508): ATP synthase epsilon subunit zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding HEAT (PF02985, IPR000357): HEAT repeat PRP1_N (PF06424, IPR010491): PRP1 splicing factor, N-terminal UVR (PF02151, IPR001943): UvrB/uvrC motif zf-BED (PF02892, IPR003656, SM00614): BED zinc finger CLASP_N (PF12348, IPR024395): CLASP N terminal DZR (PF12773, IPR025874): Double zinc ribbon zf-C2H2_4 (PF13894): C2H2-type zinc finger
37	CHGA	oncoprotein	2	1.000	0	Granin (PF01271, IPR001990): Granin (chromogranin or secretogranin) PP1_bind (PF15276, IPR029334): Protein phosphatase 1 binding
38	CHORDC1	interactor	13	0.576	13.524	CHORD (PF04968, IPR007051): CHORD CS (PF04969, IPR007052): CS domain
39	CHUK	suppressor	21	0.416	44.899	Pkinase (PF00069, IPR000719): Protein kinase domain IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
40	CKS1B	oncoprotein	5	0.833	0.400	CKS (PF01111, IPR000789, SM01084): Cyclin-dependent kinase regulatory subunit
41	CKS2	oncoprotein	5	0.833	0.333	CKS (PF01111, IPR000789, SM01084): Cyclin-dependent kinase regulatory subunit
42	CLK3	interactor	11	0.467	10.601	Pkinase (PF00069, IPR000719): Protein kinase domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
43	CRYM	interactor	2	1.000	0	OCD_Mu_crystall (PF02423, IPR003462): Ornithine cyclodeaminase/mu-crystallin family
44	CTTN	oncoprotein	8	0.667	3.321	FadA (PF09403, IPR018543): Adhesion protein FadA HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
45	CYP2C9	interactor	3	1.000	0	p450 (PF00067, IPR001128): Cytochrome P450
46	DCTN1	interactor	11	0.289	18.847	Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain FlgN (PF05130, IPR007809): FlgN protein HOOK (PF05622, IPR008636): HOOK protein SlyX (PF04102, IPR007236): SlyX TSC22 (PF01166, IPR000580): TSC-22/dip/bun family DUF2443 (PF10398, IPR019469): Protein of unknown function (DUF2443) ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding Dynactin (PF12455, IPR022157): Dynein associated protein Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
47	DDR1	oncoprotein	4	0.667	0.216	Lamprin (PF06403, IPR009437): Lamprin Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain DUF4381 (PF14316, IPR025489): Domain of unknown function (DUF4381)
48	DDX17	protein found in more fusions	10	0.556	2.809	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Ferritin (PF00210, IPR008331): Ferritin-like domain GRP (PF07172, IPR010800): Glycine rich protein family Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
49	DDX5	oncoprotein	18	0.272	48.005	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase P68HR (PF08061, IPR012587): P68HR (NUC004) repeat ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
50	DEAF1	interactor	1	0	0	Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SAND (PF01342, IPR000770, SM00258): SAND domain zf-MYND (PF01753, IPR002893): MYND finger
51	DMWD	interactor	3	0.667	1.000	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
52	DNAJB1	suppressor	15	0.486	21.121	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
53	DNAJC7	interactor	15	0.514	23.692	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat Rapsyn_N (PF10579, IPR019568): Rapsyn N-terminal myristoylation and linker region ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_17 (PF13431): Tetratricopeptide repeat
54	ECSIT	interactor	23	0.338	88.088	ECSIT (PF06239, IPR010418): Evolutionarily conserved signalling intermediate in Toll pathway ECSIT_C (PF14784, IPR029342): C-terminal domain of the ECSIT protein
55	EEF1A1	suppressor	31	0.347	118.415	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
56	EEF1A1P5	interactor	3	0.667	0.200	NA
57	EEF1A2	oncoprotein	8	0.321	6.529	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
58	EGFR	oncoprotein	47	0.229	433.843	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
59	EIF2AK1	interactor	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain SlyX (PF04102, IPR007236): SlyX PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
60	EIF2AK2	oncoprotein	12	0.455	14.246	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Pkinase (PF00069, IPR000719): Protein kinase domain
61	EIF3B	interactor	7	0.429	3.705	eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal PALB2_WD40 (PF16756, IPR031920): Partner and localizer of BRCA2 WD40 domain Methyltr_RsmF_N (PF17125, IPR031341): N-terminal domain of 16S rRNA methyltransferase RsmF
62	ELAVL3	interactor	7	0.571	4.067	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
63	EMD	interactor	20	0.322	62.493	LEM (PF03020, IPR003887, SM00540): LEM domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
64	ERBB2	oncoprotein	12	0.545	11.786	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
65	ERBB3	oncoprotein	22	0.295	86.199	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
66	ESRRB	suppressor	22	0.290	90.918	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
67	EVC2	interactor	6	0.400	5.356	HBS1_N (PF08938, IPR015033): HBS1 N-terminus DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342) Histone_HNS (PF00816, IPR001801): H-NS histone family EVC2_like (PF12297, IPR022076): Ellis van Creveld protein 2 like protein
68	EWSR1	oncoprotein	26	0.257	119.731	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
69	EXOSC1	interactor	7	0.714	4.152	EXOSC1 (PF10447, IPR019495): Exosome component EXOSC1/CSL4 ECR1_N (PF14382, IPR025721): Exosome complex exonuclease RRP4 N-terminal region
70	FBXL12	interactor	8	0.607	6.043	F-box-like (PF12937, IPR001810): F-box-like
71	FBXO6	interactor	34	0.266	212.393	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like
72	FBXW4	oncoprotein	7	0.429	8.186	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat F-box-like (PF12937, IPR001810): F-box-like F-box_4 (PF15966, IPR001810): F-box
73	FER	protein found in more fusions	8	0.714	2.817	DivIC (PF04977, IPR007060): Septum formation initiator FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain Glyco_transf_28 (PF03033, IPR004276): Glycosyltransferase family 28 N-terminal domain PEP-utilisers_N (PF05524, IPR008731): PEP-utilising enzyme, N-terminal Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain Med29 (PF11568, IPR021018): Mediator complex subunit 29
74	FGFR3	oncoprotein	6	0.700	0.786	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ig_3 (PF13927): Immunoglobulin domain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
75	FKBP4	interactor	20	0.279	83.106	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
76	FKBP5	interactor	40	0.179	405.760	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat NuDC (PF16273, IPR032572): Nuclear distribution C domain
77	FKBP6	interactor	6	0.667	2.134	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat
78	FKBPL	interactor	8	0.500	5.931	BTAD (PF03704, IPR005158, SM01043): Bacterial transcriptional activator domain TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat
79	FTSJ1	interactor	4	0.500	2.500	FtsJ (PF01728, IPR002877): FtsJ-like methyltransferase
80	GCDH	interactor	9	0.639	8.421	Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
81	GCH1	interactor	4	1.000	0	GTP_cyclohydroI (PF01227, IPR020602): GTP cyclohydrolase I
82	GFAP	protein found in more fusions	12	0.400	14.760	Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
83	GLMN	oncoprotein	7	0.429	7.900	Kinetochor_Ybp2 (PF08568, IPR013877): Uncharacterised protein family, YAP/Alf4/glomulin
84	GRK5	protein found in more fusions	10	0.500	5.546	Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
85	HNRNPM	interactor	12	0.515	11.272	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNP_M (PF11532, IPR024666): Heterogeneous nuclear ribonucleoprotein M Collagen_mid (PF15984, IPR031929): Bacterial collagen, middle region
86	HSP90AA1	oncoprotein	110	0.110	3634.113	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
87	HSP90AB1	oncoprotein	66	0.185	831.923	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
88	HSPA1A	interactor	30	0.414	78.470	HSP70 (PF00012, IPR013126): Hsp70 protein
89	HSPA5	oncoprotein	33	0.369	120.966	HSP70 (PF00012, IPR013126): Hsp70 protein
90	HSPA8	oncoprotein	38	0.336	206.920	HSP70 (PF00012, IPR013126): Hsp70 protein
91	IFIT3	interactor	14	0.474	27.879	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
92	IFIT5	interactor	10	0.733	4.440	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16 TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_15 (PF13429): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
93	IKBKB	protein found in more fusions	19	0.444	32.017	FliT (PF05400, IPR008622): Flagellar protein FliT Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain Pkinase (PF00069, IPR000719): Protein kinase domain SlyX (PF04102, IPR007236): SlyX ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
94	IKBKE	interactor	10	0.611	6.726	IncA (PF04156, IPR007285): IncA protein Pkinase (PF00069, IPR000719): Protein kinase domain SlyX (PF04102, IPR007236): SlyX zf-RING_9 (PF13901, IPR025258): Putative zinc-RING and/or ribbon
95	IKBKG	interactor	29	0.291	124.984	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
96	IMMT	protein found in more fusions	11	0.333	12.929	Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
97	IRAK1	interactor	19	0.353	56.180	Death (PF00531, IPR000488, SM00005): Death domain Pkinase (PF00069, IPR000719): Protein kinase domain
98	IRAK2	oncoprotein	5	0.600	2.733	Death (PF00531, IPR000488, SM00005): Death domain Pkinase (PF00069, IPR000719): Protein kinase domain
99	LONP1	interactor	13	0.436	31.633	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) AAA_PrkA (PF08298, IPR013153, SM00763): PrkA AAA domain LON_substr_bdg (PF02190, IPR003111, SM00464): ATP-dependent protease La (LON) substrate-binding domain Lon_C (PF05362, IPR008269): Lon protease (S16) C-terminal proteolytic domain RuvB_N (PF05496, IPR008824): Holliday junction DNA helicase ruvB N-terminus AAA_23 (PF13476): AAA domain
100	LOXL4	oncoprotein	6	0.867	0.536	Lysyl_oxidase (PF01186, IPR001695): Lysyl oxidase SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain
101	LRRK1	interactor	4	0.667	0.400	Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain TniB (PF05621, IPR008868): Bacterial TniB protein Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
102	LRRK2	oncoprotein	14	0.551	16.467	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043) T2SSE (PF00437, IPR001482): Type II/IV secretion system protein Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) PQQ_2 (PF13360, IPR002372): PQQ-like domain LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
103	LUC7L2	protein found in more fusions	12	0.364	14.594	LUC7 (PF03194, IPR004882): LUC7 N_terminus Paramyxo_ncap (PF00973, IPR002021): Paramyxovirus nucleocapsid protein Methyltransf_32 (PF13679, IPR025714): Methyltransferase domain
104	MAP3K1	oncoprotein	12	0.382	18.927	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Pkinase (PF00069, IPR000719): Protein kinase domain zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
105	MAP3K11	interactor	9	0.821	1.007	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH3_9 (PF14604, IPR001452): Variant SH3 domain
106	MAP3K3	oncoprotein	10	0.556	3.914	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain
107	MAP3K7	oncoprotein	15	0.418	24.610	Mnd1 (PF03962, IPR005647): Mnd1 family Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
108	MAPK7	oncoprotein	12	0.636	4.372	Pkinase (PF00069, IPR000719): Protein kinase domain Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
109	MASP1	interactor	4	0.500	1.733	CUB (PF00431, IPR000859, SM00042): CUB domain Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat) Trypsin (PF00089, IPR001254, SM00020): Trypsin FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
110	MGEA5	oncoprotein	8	0.464	8.439	NAGidase (PF07555, IPR011496): beta-N-acetylglucosaminidase
111	MOV10	interactor	30	0.175	207.051	AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain
112	MTOR	oncoprotein	18	0.294	45.141	DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104) EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats TPR_19 (PF14559): Tetratricopeptide repeat
113	MYLK4	interactor	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
114	MZT2B	interactor	1	0	0	MOZART2 (PF12926, IPR024332): Mitotic-spindle organizing gamma-tubulin ring associated
115	NCOA5	suppressor	5	0.500	0.535	Macoilin (PF09726, IPR019130): Transmembrane protein
116	NEK6	interactor	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
117	NEK8	interactor	7	0.524	3.745	Pkinase (PF00069, IPR000719): Protein kinase domain RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
118	NOS3	interactor	13	0.470	17.921	FAD_binding_1 (PF00667, IPR003097): FAD binding domain Flavodoxin_1 (PF00258, IPR008254): Flavodoxin NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain HTH_15 (PF12324, IPR024259): Helix-turn-helix domain of alkylmercury lyase
119	NPM1	suppressor	34	0.316	175.486	Nucleoplasmin (PF03066): Nucleoplasmin SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
120	NTRK1	oncoprotein	74	0.136	1486.567	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
121	NUP98	suppressor	7	0.524	4.933	Nucleoporin2 (PF04096, IPR007230): Nucleoporin autopeptidase Nup96 (PF12110, IPR021967): Nuclear protein 96 ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region Keratin_2_head (PF16208, IPR032444): Keratin type II head
122	NXF1	interactor	34	0.170	270.751	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
123	OFD1	protein found in more fusions	16	0.267	49.914	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit GrpE (PF01025, IPR000740): GrpE NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein XhlA (PF10779, IPR019715): Haemolysin XhlA DUF3372 (PF11852, IPR024561): Domain of unknown function (DUF3372) LisH_2 (PF16045, IPR006594): LisH
124	OGFR	interactor	6	0.667	1.653	OGFr_III (PF04680, IPR006770): Opioid growth factor receptor repeat OGFr_N (PF04664, IPR006757): Opioid growth factor receptor (OGFr) conserved region SspP (PF08179, IPR012614): Small acid-soluble spore protein P family MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
125	PANX1	interactor	1	0	0	Innexin (PF00876, IPR000990): Innexin Pannexin_like (PF12534, IPR021040): Pannexin-like TM region of LRRC8
126	PATL1	interactor	4	0.833	0.087	PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
127	PCBP1	oncoprotein	15	0.562	13.614	Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein KH_2 (PF07650, IPR004044): KH domain KH_1 (PF00013, IPR004088, SM00322): KH domain
128	PDZK1	interactor	5	0.800	0.733	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DUF4265 (PF14085, IPR025361): Domain of unknown function (DUF4265)
129	PINK1	protein found in more fusions	10	0.611	4.319	Pkinase (PF00069, IPR000719): Protein kinase domain
130	PKM	oncoprotein	23	0.423	56.737	PK (PF00224, IPR015793): Pyruvate kinase, barrel domain PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
131	POC1B	interactor	2	1.000	0	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
132	PPHLN1	interactor	6	0.467	3.324	Lge1 (PF11488): Transcriptional regulatory protein LGE1 HERV-K_REC (PF15695): Rec (regulator of expression encoded by corf) of HERV-K-113
133	PPID	interactor	13	0.667	5.168	Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
134	PPP5C	interactor	15	0.457	18.070	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase PPP5 (PF08321, IPR013235): PPP5 TPR repeat region TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat
135	PPP6R3	interactor	9	0.528	6.621	SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
136	PRAM1	interactor	7	0.667	5.376	hSH3 (PF14603, IPR029294): Helically-extended SH3 domain
137	PRDX2	interactor	13	0.487	25.848	AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
138	PRKAA1	suppressor	13	0.474	19.260	Pkinase (PF00069, IPR000719): Protein kinase domain AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
139	PRKCI	interactor	11	0.455	11.011	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
140	PRMT1	interactor	11	0.400	8.823	Methyltransf_25 (PF13649): Methyltransferase domain
141	PRPF4	interactor	7	0.533	4.620	PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain WD40_like (PF17005, IPR031544): WD40-like domain
142	PSEN1	oncoprotein	17	0.367	45.444	Presenilin (PF01080, IPR001108): Presenilin LRRC37AB_C (PF14914, IPR029423): LRRC37A/B like protein 1 C-terminal domain
143	PSKH2	interactor	4	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
144	PSME1	interactor	5	0.500	0.868	PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit RNase_H2-Ydr279 (PF09468, IPR019024): Ydr279p protein family (RNase H2 complex component)
145	RAD23A	oncoprotein	15	0.319	40.000	UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
146	RAE1	interactor	6	0.467	4.206	Exonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
147	RAF1	oncoprotein	22	0.452	35.667	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
148	RASSF3	suppressor	3	0.667	0.500	RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
149	RHOBTB2	suppressor	6	0.700	1.000	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Ras (PF00071, IPR001806, SM00173): Ras family SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
150	RIPK3	interactor	3	0.667	0.167	Pkinase (PF00069, IPR000719): Protein kinase domain TrbM (PF07424, IPR009989): TrbM MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c RHIM (PF12721, IPR025735): RIP homotypic interaction motif
151	RNF32	interactor	24	0.360	84.255	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
152	RPAP3	interactor	13	0.359	24.574	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat RPAP3_C (PF13877, IPR025986): Potential Monad-binding region of RPAP3 Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
153	RPS15A	interactor	15	0.390	28.745	Ribosomal_S8 (PF00410, IPR000630): Ribosomal protein S8
154	RPS2	interactor	15	0.495	20.628	Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
155	RPS27	interactor	9	0.500	6.336	Ribosomal_S27e (PF01667, IPR000592): Ribosomal protein S27 DUF3795 (PF12675, IPR024227): Protein of unknown function (DUF3795)
156	RPS27L	interactor	7	0.667	1.615	E7 (PF00527, IPR000148): E7 protein, Early protein Ribosomal_S27e (PF01667, IPR000592): Ribosomal protein S27 zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type DUF3382 (PF11862, IPR021807): Domain of unknown function (DUF3382)
157	RPS6KA1	oncoprotein	6	0.867	0.733	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
158	RPS6KA3	interactor	7	0.667	4.567	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
159	RPS6KA4	interactor	1	0	0	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
160	RPS6KA6	suppressor	6	0.467	6.367	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
161	RPS6KB2	interactor	32	0.280	149.228	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
162	RSG1	interactor	1	0	0	Ras (PF00071, IPR001806, SM00173): Ras family
163	RYK	oncoprotein	5	0.600	1.241	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase WIF (PF02019, IPR003306, SM00469): WIF domain
164	SAFB	suppressor	4	1.000	0	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAP (PF02037, IPR003034, SM00513): SAP domain Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
165	SGK1	oncoprotein	11	0.556	5.597	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain PX (PF00787, IPR001683, SM00312): PX domain
166	SKP1	oncoprotein	16	0.250	58.197	Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
167	SLC25A5	interactor	12	0.500	6.954	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
168	SLC25A6	interactor	8	0.393	4.630	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
169	SMYD2	interactor	4	0.667	0.216	Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family) SET (PF00856, IPR001214, SM00317): SET domain TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat
170	SMYD3	oncoprotein	4	0.833	0.077	SET (PF00856, IPR001214, SM00317): SET domain
171	SNX5	oncoprotein	2	1.000	0	PX (PF00787, IPR001683, SM00312): PX domain Vps5 (PF09325, IPR015404): Vps5 C terminal like
172	SPTBN4	interactor	3	0.667	0.667	Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Laminin_II (PF06009, IPR010307): Laminin Domain II Spectrin (PF00435, IPR002017): Spectrin repeat PH_9 (PF15410): Pleckstrin homology domain
173	SQSTM1	oncoprotein	20	0.275	63.854	PB1 (PF00564, IPR000270, SM00666): PB1 domain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type UBA_5 (PF16577, IPR015940): UBA domain
174	SRC	oncoprotein	16	0.552	13.834	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
175	SSB	interactor	10	0.400	11.907	HMA (PF00403, IPR006121): Heavy-metal-associated domain La (PF05383, IPR006630, SM00715): La domain Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family Ribosomal_L6e (PF01159, IPR000915): Ribosomal protein L6e RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 (PF08777, IPR014886): RNA binding motif
176	STAMBPL1	interactor	5	0.900	0.154	CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
177	STIL	oncoprotein	12	0.273	27.015	STIL_N (PF15253, IPR026123): SCL-interrupting locus protein N-terminus
178	STK11	suppressor	11	0.400	16.526	Pkinase (PF00069, IPR000719): Protein kinase domain
179	STK32C	interactor	2	1.000	0	APH (PF01636, IPR002575): Phosphotransferase enzyme family Pkinase (PF00069, IPR000719): Protein kinase domain
180	STK33	interactor	4	0.833	0.077	Pkinase (PF00069, IPR000719): Protein kinase domain PARM (PF17061, IPR031431): PARM
181	STK36	protein found in more fusions	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
182	STK38L	oncoprotein	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
183	STK4	oncoprotein	6	0.400	4.515	Pkinase (PF00069, IPR000719): Protein kinase domain Mst1_SARAH (PF11629, IPR024205): C terminal SARAH domain of Mst1 DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
184	STUB1	suppressor	39	0.248	269.696	U-box (PF04564, IPR003613, SM00504): U-box domain ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_20 (PF14561): Tetratricopeptide repeat
185	SYNE2	oncoprotein	4	0.667	1.667	ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit Fez1 (PF06818): Fez1 Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family IncA (PF04156, IPR007285): IncA protein Laminin_II (PF06009, IPR010307): Laminin Domain II Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein Occludin_ELL (PF07303, IPR010844): Occludin homology domain SlyX (PF04102, IPR007236): SlyX Spectrin (PF00435, IPR002017): Spectrin repeat TMPIT (PF07851, IPR012926): TMPIT-like protein KASH (PF10541, IPR012315): Nuclear envelope localisation domain HD_5 (PF13487): HD domain DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain DUF4363 (PF14276, IPR025373): Domain of unknown function (DUF4363) Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167 TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation TRPM_tetra (PF16519, IPR032415): Tetramerisation domain of TRPM
186	TARS2	interactor	6	0.667	1.536	HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain TGS (PF02824, IPR004095): TGS domain tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T) tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
187	TBK1	interactor	16	0.390	31.553	DUF713 (PF05218, IPR007883): Protein of unknown function (DUF713) NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein Pkinase (PF00069, IPR000719): Protein kinase domain
188	TERF1	interactor	22	0.248	94.026	TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
189	TERF2	interactor	14	0.397	22.303	Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif
190	TOMM34	interactor	12	0.470	11.617	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat SHNi-TPR (PF10516, IPR019544): SHNi-TPR TPR_12 (PF13424): Tetratricopeptide repeat Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat DUF4919 (PF16266, IPR032578): Domain of unknown function (DUF4919)
191	TPM1	protein found in more fusions	11	0.356	14.179	Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
192	TTC4	suppressor	12	0.515	15.287	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
193	TTC9C	interactor	5	0.700	1.733	TPR_17 (PF13431): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat
194	TUBA1B	interactor	12	0.303	26.343	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
195	TUBA1C	interactor	18	0.444	34.277	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
196	TUBB	interactor	30	0.425	80.400	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
197	U2AF2	protein found in more fusions	29	0.312	141.551	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
198	UBE2I	interactor	16	0.257	47.567	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
199	ULK1	protein found in more fusions	6	0.600	3.167	Pkinase (PF00069, IPR000719): Protein kinase domain DUF3543 (PF12063, IPR022708): Domain of unknown function (DUF3543) RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
200	ULK3	interactor	5	0.400	2.100	MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain Pkinase (PF00069, IPR000719): Protein kinase domain
201	UNC45A	interactor	9	0.389	13.891	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central TPR_16 (PF13432): Tetratricopeptide repeat HEAT_2 (PF13646): HEAT repeats
202	UPF1	interactor	12	0.318	27.599	UPF1_Zn_bind (PF09416, IPR018999): RNA helicase (UPF2 interacting domain) AAA_11 (PF13086): AAA domain AAA_12 (PF13087): AAA domain
203	USP19	interactor	15	0.314	40.842	CS (PF04969, IPR007052): CS domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase USP19_linker (PF16602): Linker region of USP19 deubiquitinase
204	USP7	oncoprotein	16	0.286	45.084	MATH (PF00917, IPR002083, SM00061): MATH domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
205	VCP	protein found in more fusions	35	0.296	195.249	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain TniB (PF05621, IPR008868): Bacterial TniB protein Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
206	WDR6	interactor	6	0.533	4.571	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nsp3_PL2pro (PF12124, IPR022733): Coronavirus polyprotein cleavage domain Choline_sulf_C (PF12411, IPR025863): Choline sulfatase enzyme C terminal PQQ_3 (PF13570): PQQ-like domain
207	YWHAE	oncoprotein	30	0.287	140.430	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
208	YWHAQ	interactor	31	0.275	164.913	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
209	ZNF205	interactor	1	0	0	KRAB (PF01352, IPR001909, SM00349): KRAB box zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
210	ZNF235	interactor	1	0	0	KRAB (PF01352, IPR001909, SM00349): KRAB box zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
211	ZNF266	interactor	1	0	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger FANCM-MHF_bd (PF16783, IPR031879): FANCM to MHF binding domain
212	ZNF667	interactor	1	0	0	KRAB (PF01352, IPR001909, SM00349): KRAB box zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain YhfH (PF14149, IPR025432): YhfH-like protein

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List of missing interactors (in fusions)

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	CDC37	parental protein	CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding	BI464991
2	EEF1A1P5	interactor	NA	BI464991

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