Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins CDC37 (from a repository: Tue Aug 20 13:07:01 2019)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
Layout Tree Circle Radial Force Directed Preset
Export graph PNG file PDF file SVG file SIF file XML file GraphML file

Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 212 The number (and %) of the onco-proteins 80 (37.74 %) The number (and %) of the tumor suppressors 18 (8.49 %) Total number of binary PPIs (saturation %) 1536 (6.87 %) The number (and %) of affected PPIs 212 (13.80 %) The number of possible different fusions 41 PPI diameter 2 PPI radius 1 The average degree of PPI 13.651 Assortativity coefficient -0.1918 The network average Clustering coefficient 0.492 The number (and %) of a zero Clustering coefficients 11 (5.19 %) The number (and %) of a zero Betweenness Centrality 27 (12.74 %)

ACTIVE INTERACTORS MISSING INTERACTORS (in fusions)

List of the fusions
PPI for parental proteins: CDC37	All fusions : AI571632; BI464991;
Proteins found in more fusions	ABL2 (see 2 fusions); GRK5 (see 4 fusions); U2AF2 (see 2 fusions); NPM1 (see 1 fusions); PINK1 (see 3 fusions); MAP3K1 (see 1 fusions); CDK6 (see 1 fusions); AHCYL1 (see 3 fusions); EWSR1 (see 2 fusions); EIF2AK2 (see 1 fusions); IMMT (see 4 fusions); ULK1 (see 2 fusions); CTTN (see 1 fusions); IKBKB (see 2 fusions); STK36 (see 1 fusions); LRRK2 (see 1 fusions); DDX5 (see 1 fusions); MTOR (see 1 fusions); APP (see 4 fusions); TPM1 (see 2 fusions); LUC7L2 (see 2 fusions); VCP (see 4 fusions); HSP90AA1 (see 2 fusions); GFAP (see 3 fusions); NCOA5 (see 1 fusions); APOE (see 1 fusions); HSP90AB1 (see 1 fusions); A2M (see 2 fusions); SQSTM1 (see 5 fusions); SGK1 (see 2 fusions); OFD1 (see 1 fusions); FER (see 1 fusions); ERBB3 (see 2 fusions); EGFR (see 2 fusions); BRAF (see 3 fusions); STUB1 (see 1 fusions); MAP3K7 (see 7 fusions); DDX17 (see 3 fusions); CDC37 (see 2 fusions); CDK9 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	CDC37	parental protein	212	0.056	28243.209	CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
2	A2M	protein found in more fusions	26	0.277	129.292	A2M (PF00207, IPR001599): Alpha-2-macroglobulin family A2M_comp (PF07678, IPR011626): A-macroglobulin complement component A2M_N (PF01835, IPR002890): MG2 domain A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region A2M_recep (PF07677, IPR009048): A-macroglobulin receptor MP (PF01107, IPR028919): Viral movement protein (MP) SVA (PF05326, IPR007990): Seminal vesicle autoantigen (SVA) Thiol-ester_cl (PF10569, IPR019565): Alpha-macro-globulin thiol-ester bond-forming region
3	ABL2	oncoprotein	6	0.800	0.567	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain NHS (PF15273, IPR024845): NHS-like
4	AHCYL1	suppressor	9	0.500	8.677	AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515) Big_3_5 (PF16640, IPR032109): Bacterial Ig-like domain (group 3)
5	AHSA1	interactor	26	0.366	97.749	Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein
6	AIP	suppressor	10	0.422	13.511	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
7	AKT1	oncoprotein	35	0.299	191.200	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
8	APOE	protein found in more fusions	15	0.582	15.040	Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain TipAS (PF07739, IPR012925): TipAS antibiotic-recognition domain
9	APP	protein found in more fusions	55	0.131	878.311	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
10	AR	oncoprotein	22	0.314	60.681	Androgen_recep (PF02166, IPR001103): Androgen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
11	ARAF	oncoprotein	12	0.424	14.687	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
12	ATG101	interactor	4	0.500	2.067	ATG101 (PF07855, IPR012445): Autophagy-related protein 101
13	AURKA	oncoprotein	23	0.346	66.605	Pkinase (PF00069, IPR000719): Protein kinase domain MTBP_C (PF14920, IPR029418): MDM2-binding
14	AURKB	interactor	19	0.327	55.390	Pkinase (PF00069, IPR000719): Protein kinase domain
15	AURKC	interactor	6	0.800	1.182	Pkinase (PF00069, IPR000719): Protein kinase domain
16	BRAF	oncoprotein	14	0.628	7.090	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
17	BTBD10	interactor	1	0	0	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) BTB_3 (PF16017): BTB/POZ domain
18	C19orf44	interactor	1	0	0	DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
19	CC2D1A	interactor	5	0.600	2.067	C2 (PF00168, IPR000008, SM00239): C2 domain FUSC (PF04632, IPR006726): Fusaric acid resistance protein family Snf7 (PF03357, IPR005024): Snf7 DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) LELP1 (PF15042, IPR026076): Late cornified envelope-like proline-rich protein 1
20	CDC25C	oncoprotein	6	0.667	0.971	M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
21	CDC37L1	interactor	13	0.526	16.309	CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
22	CDCA5	interactor	6	0.400	1.934	Sororin (PF09666, IPR018605): Sororin protein
23	CDK1	oncoprotein	19	0.255	70.849	Pkinase (PF00069, IPR000719): Protein kinase domain
24	CDK11A	oncoprotein	5	0.600	2.122	DDHD (PF02862, IPR004177, SM01127): DDHD domain eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Pkinase (PF00069, IPR000719): Protein kinase domain RIO1 (PF01163, IPR018934): RIO1 family DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355) DHHW (PF14286, IPR025945): DHHW protein DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
25	CDK11B	oncoprotein	8	0.714	3.338	DDHD (PF02862, IPR004177, SM01127): DDHD domain DivIC (PF04977, IPR007060): Septum formation initiator Pkinase (PF00069, IPR000719): Protein kinase domain DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
26	CDK13	interactor	13	0.474	17.790	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Pkinase (PF00069, IPR000719): Protein kinase domain Macoilin (PF09726, IPR019130): Transmembrane protein THRAP3_BCLAF1 (PF15440, IPR029199): THRAP3/BCLAF1 family
27	CDK15	interactor	6	0.933	0.400	Pkinase (PF00069, IPR000719): Protein kinase domain ACT_5 (PF13710): ACT domain
28	CDK18	oncoprotein	11	0.545	8.137	APH (PF01636, IPR002575): Phosphotransferase enzyme family Pkinase (PF00069, IPR000719): Protein kinase domain
29	CDK4	oncoprotein	14	0.505	18.428	Pkinase (PF00069, IPR000719): Protein kinase domain
30	CDK5	oncoprotein	11	0.622	8.589	Pkinase (PF00069, IPR000719): Protein kinase domain
31	CDK6	suppressor	9	0.500	8.200	Pkinase (PF00069, IPR000719): Protein kinase domain
32	CDK7	oncoprotein	13	0.424	19.293	Pkinase (PF00069, IPR000719): Protein kinase domain
33	CDK9	protein found in more fusions	17	0.350	37.706	Pkinase (PF00069, IPR000719): Protein kinase domain
34	CDKL1	interactor	2	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
35	CDKL2	interactor	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
36	CEP104	interactor	6	0.467	4.400	ATP-synt_E_2 (PF08112, IPR012508): ATP synthase epsilon subunit zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding HEAT (PF02985, IPR000357): HEAT repeat PRP1_N (PF06424, IPR010491): PRP1 splicing factor, N-terminal UVR (PF02151, IPR001943): UvrB/uvrC motif zf-BED (PF02892, IPR003656, SM00614): BED zinc finger CLASP_N (PF12348, IPR024395): CLASP N terminal DZR (PF12773, IPR025874): Double zinc ribbon zf-C2H2_4 (PF13894): C2H2-type zinc finger
37	CHGA	oncoprotein	2	1.000	0	Granin (PF01271, IPR001990): Granin (chromogranin or secretogranin) PP1_bind (PF15276, IPR029334): Protein phosphatase 1 binding
38	CHORDC1	interactor	13	0.576	13.524	CHORD (PF04968, IPR007051): CHORD CS (PF04969, IPR007052): CS domain
39	CHUK	suppressor	21	0.416	44.899	Pkinase (PF00069, IPR000719): Protein kinase domain IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
40	CKS1B	oncoprotein	5	0.833	0.400	CKS (PF01111, IPR000789, SM01084): Cyclin-dependent kinase regulatory subunit
41	CKS2	oncoprotein	5	0.833	0.333	CKS (PF01111, IPR000789, SM01084): Cyclin-dependent kinase regulatory subunit
42	CLK3	interactor	11	0.467	10.601	Pkinase (PF00069, IPR000719): Protein kinase domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
43	CRYM	interactor	2	1.000	0	OCD_Mu_crystall (PF02423, IPR003462): Ornithine cyclodeaminase/mu-crystallin family
44	CTTN	oncoprotein	8	0.667	3.321	FadA (PF09403, IPR018543): Adhesion protein FadA HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
45	CYP2C9	interactor	3	1.000	0	p450 (PF00067, IPR001128): Cytochrome P450
46	DCTN1	interactor	11	0.289	18.847	Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain FlgN (PF05130, IPR007809): FlgN protein HOOK (PF05622, IPR008636): HOOK protein SlyX (PF04102, IPR007236): SlyX TSC22 (PF01166, IPR000580): TSC-22/dip/bun family DUF2443 (PF10398, IPR019469): Protein of unknown function (DUF2443) ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding Dynactin (PF12455, IPR022157): Dynein associated protein Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
47	DDR1	oncoprotein	4	0.667	0.216	Lamprin (PF06403, IPR009437): Lamprin Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain DUF4381 (PF14316, IPR025489): Domain of unknown function (DUF4381)
48	DDX17	protein found in more fusions	10	0.556	2.809	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Ferritin (PF00210, IPR008331): Ferritin-like domain GRP (PF07172, IPR010800): Glycine rich protein family Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
49	DDX5	oncoprotein	18	0.272	48.005	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase P68HR (PF08061, IPR012587): P68HR (NUC004) repeat ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
50	DEAF1	interactor	1	0	0	Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SAND (PF01342, IPR000770, SM00258): SAND domain zf-MYND (PF01753, IPR002893): MYND finger
51	DMWD	interactor	3	0.667	1.000	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
52	DNAJB1	suppressor	15	0.486	21.121	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
53	DNAJC7	interactor	15	0.514	23.692	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat Rapsyn_N (PF10579, IPR019568): Rapsyn N-terminal myristoylation and linker region ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_17 (PF13431): Tetratricopeptide repeat
54	ECSIT	interactor	23	0.338	88.088	ECSIT (PF06239, IPR010418): Evolutionarily conserved signalling intermediate in Toll pathway ECSIT_C (PF14784, IPR029342): C-terminal domain of the ECSIT protein
55	EEF1A1	suppressor	31	0.347	118.415	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
56	EEF1A1P5	interactor	3	0.667	0.200	NA
57	EEF1A2	oncoprotein	8	0.321	6.529	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
58	EGFR	oncoprotein	47	0.229	433.843	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
59	EIF2AK1	interactor	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain SlyX (PF04102, IPR007236): SlyX PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
60	EIF2AK2	oncoprotein	12	0.455	14.246	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Pkinase (PF00069, IPR000719): Protein kinase domain
61	EIF3B	interactor	7	0.429	3.705	eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal PALB2_WD40 (PF16756, IPR031920): Partner and localizer of BRCA2 WD40 domain Methyltr_RsmF_N (PF17125, IPR031341): N-terminal domain of 16S rRNA methyltransferase RsmF
62	ELAVL3	interactor	7	0.571	4.067	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
63	EMD	interactor	20	0.322	62.493	LEM (PF03020, IPR003887, SM00540): LEM domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
64	ERBB2	oncoprotein	12	0.545	11.786	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
65	ERBB3	oncoprotein	22	0.295	86.199	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
66	ESRRB	suppressor	22	0.290	90.918	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
67	EVC2	interactor	6	0.400	5.356	HBS1_N (PF08938, IPR015033): HBS1 N-terminus DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342) Histone_HNS (PF00816, IPR001801): H-NS histone family EVC2_like (PF12297, IPR022076): Ellis van Creveld protein 2 like protein
68	EWSR1	oncoprotein	26	0.257	119.731	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
69	EXOSC1	interactor	7	0.714	4.152	EXOSC1 (PF10447, IPR019495): Exosome component EXOSC1/CSL4 ECR1_N (PF14382, IPR025721): Exosome complex exonuclease RRP4 N-terminal region
70	FBXL12	interactor	8	0.607	6.043	F-box-like (PF12937, IPR001810): F-box-like
71	FBXO6	interactor	34	0.266	212.393	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like
72	FBXW4	oncoprotein	7	0.429	8.186	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat F-box-like (PF12937, IPR001810): F-box-like F-box_4 (PF15966, IPR001810): F-box
73	FER	protein found in more fusions	8	0.714	2.817	DivIC (PF04977, IPR007060): Septum formation initiator FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain Glyco_transf_28 (PF03033, IPR004276): Glycosyltransferase family 28 N-terminal domain PEP-utilisers_N (PF05524, IPR008731): PEP-utilising enzyme, N-terminal Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain Med29 (PF11568, IPR021018): Mediator complex subunit 29
74	FGFR3	oncoprotein	6	0.700	0.786	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ig_3 (PF13927): Immunoglobulin domain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
75	FKBP4	interactor	20	0.279	83.106	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
76	FKBP5	interactor	40	0.179	405.760	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat NuDC (PF16273, IPR032572): Nuclear distribution C domain
77	FKBP6	interactor	6	0.667	2.134	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat
78	FKBPL	interactor	8	0.500	5.931	BTAD (PF03704, IPR005158, SM01043): Bacterial transcriptional activator domain TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat
79	FTSJ1	interactor	4	0.500	2.500	FtsJ (PF01728, IPR002877): FtsJ-like methyltransferase
80	GCDH	interactor	9	0.639	8.421	Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
81	GCH1	interactor	4	1.000	0	GTP_cyclohydroI (PF01227, IPR020602): GTP cyclohydrolase I
82	GFAP	protein found in more fusions	12	0.400	14.760	Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
83	GLMN	oncoprotein	7	0.429	7.900	Kinetochor_Ybp2 (PF08568, IPR013877): Uncharacterised protein family, YAP/Alf4/glomulin
84	GRK5	protein found in more fusions	10	0.500	5.546	Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
85	HNRNPM	interactor	12	0.515	11.272	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNP_M (PF11532, IPR024666): Heterogeneous nuclear ribonucleoprotein M Collagen_mid (PF15984, IPR031929): Bacterial collagen, middle region
86	HSP90AA1	oncoprotein	110	0.110	3634.113	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
87	HSP90AB1	oncoprotein	66	0.185	831.923	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
88	HSPA1A	interactor	30	0.414	78.470	HSP70 (PF00012, IPR013126): Hsp70 protein
89	HSPA5	oncoprotein	33	0.369	120.966	HSP70 (PF00012, IPR013126): Hsp70 protein
90	HSPA8	oncoprotein	38	0.336	206.920	HSP70 (PF00012, IPR013126): Hsp70 protein
91	IFIT3	interactor	14	0.474	27.879	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
92	IFIT5	interactor	10	0.733	4.440	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16 TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_15 (PF13429): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
93	IKBKB	protein found in more fusions	19	0.444	32.017	FliT (PF05400, IPR008622): Flagellar protein FliT Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain Pkinase (PF00069, IPR000719): Protein kinase domain SlyX (PF04102, IPR007236): SlyX ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
94	IKBKE	interactor	10	0.611	6.726	IncA (PF04156, IPR007285): IncA protein Pkinase (PF00069, IPR000719): Protein kinase domain SlyX (PF04102, IPR007236): SlyX zf-RING_9 (PF13901, IPR025258): Putative zinc-RING and/or ribbon
95	IKBKG	interactor	29	0.291	124.984	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
96	IMMT	protein found in more fusions	11	0.333	12.929	Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
97	IRAK1	interactor	19	0.353	56.180	Death (PF00531, IPR000488, SM00005): Death domain Pkinase (PF00069, IPR000719): Protein kinase domain
98	IRAK2	oncoprotein	5	0.600	2.733	Death (PF00531, IPR000488, SM00005): Death domain Pkinase (PF00069, IPR000719): Protein kinase domain
99	LONP1	interactor	13	0.436	31.633	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) AAA_PrkA (PF08298, IPR013153, SM00763): PrkA AAA domain LON_substr_bdg (PF02190, IPR003111, SM00464): ATP-dependent protease La (LON) substrate-binding domain Lon_C (PF05362, IPR008269): Lon protease (S16) C-terminal proteolytic domain RuvB_N (PF05496, IPR008824): Holliday junction DNA helicase ruvB N-terminus AAA_23 (PF13476): AAA domain
100	LOXL4	oncoprotein	6	0.867	0.536	Lysyl_oxidase (PF01186, IPR001695): Lysyl oxidase SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain
101	LRRK1	interactor	4	0.667	0.400	Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain TniB (PF05621, IPR008868): Bacterial TniB protein Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
102	LRRK2	oncoprotein	14	0.551	16.467	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043) T2SSE (PF00437, IPR001482): Type II/IV secretion system protein Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) PQQ_2 (PF13360, IPR002372): PQQ-like domain LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
103	LUC7L2	protein found in more fusions	12	0.364	14.594	LUC7 (PF03194, IPR004882): LUC7 N_terminus Paramyxo_ncap (PF00973, IPR002021): Paramyxovirus nucleocapsid protein Methyltransf_32 (PF13679, IPR025714): Methyltransferase domain
104	MAP3K1	oncoprotein	12	0.382	18.927	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Pkinase (PF00069, IPR000719): Protein kinase domain zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
105	MAP3K11	interactor	9	0.821	1.007	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH3_9 (PF14604, IPR001452): Variant SH3 domain
106	MAP3K3	oncoprotein	10	0.556	3.914	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain
107	MAP3K7	oncoprotein	15	0.418	24.610	Mnd1 (PF03962, IPR005647): Mnd1 family Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
108	MAPK7	oncoprotein	12	0.636	4.372	Pkinase (PF00069, IPR000719): Protein kinase domain Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
109	MASP1	interactor	4	0.500	1.733	CUB (PF00431, IPR000859, SM00042): CUB domain Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat) Trypsin (PF00089, IPR001254, SM00020): Trypsin FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
110	MGEA5	oncoprotein	8	0.464	8.439	NAGidase (PF07555, IPR011496): beta-N-acetylglucosaminidase
111	MOV10	interactor	30	0.175	207.051	AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain
112	MTOR	oncoprotein	18	0.294	45.141	DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104) EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats TPR_19 (PF14559): Tetratricopeptide repeat
113	MYLK4	interactor	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
114	MZT2B	interactor	1	0	0	MOZART2 (PF12926, IPR024332): Mitotic-spindle organizing gamma-tubulin ring associated
115	NCOA5	suppressor	5	0.500	0.535	Macoilin (PF09726, IPR019130): Transmembrane protein
116	NEK6	interactor	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
117	NEK8	interactor	7	0.524	3.745	Pkinase (PF00069, IPR000719): Protein kinase domain RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
118	NOS3	interactor	13	0.470	17.921	FAD_binding_1 (PF00667, IPR003097): FAD binding domain Flavodoxin_1 (PF00258, IPR008254): Flavodoxin NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain HTH_15 (PF12324, IPR024259): Helix-turn-helix domain of alkylmercury lyase
119	NPM1	suppressor	34	0.316	175.486	Nucleoplasmin (PF03066): Nucleoplasmin SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
120	NTRK1	oncoprotein	74	0.136	1486.567	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
121	NUP98	suppressor	7	0.524	4.933	Nucleoporin2 (PF04096, IPR007230): Nucleoporin autopeptidase Nup96 (PF12110, IPR021967): Nuclear protein 96 ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region Keratin_2_head (PF16208, IPR032444): Keratin type II head
122	NXF1	interactor	34	0.170	270.751	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
123	OFD1	protein found in more fusions	16	0.267	49.914	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit GrpE (PF01025, IPR000740): GrpE NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein XhlA (PF10779, IPR019715): Haemolysin XhlA DUF3372 (PF11852, IPR024561): Domain of unknown function (DUF3372) LisH_2 (PF16045, IPR006594): LisH
124	OGFR	interactor	6	0.667	1.653	OGFr_III (PF04680, IPR006770): Opioid growth factor receptor repeat OGFr_N (PF04664, IPR006757): Opioid growth factor receptor (OGFr) conserved region SspP (PF08179, IPR012614): Small acid-soluble spore protein P family MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
125	PANX1	interactor	1	0	0	Innexin (PF00876, IPR000990): Innexin Pannexin_like (PF12534, IPR021040): Pannexin-like TM region of LRRC8
126	PATL1	interactor	4	0.833	0.087	PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
127	PCBP1	oncoprotein	15	0.562	13.614	Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein KH_2 (PF07650, IPR004044): KH domain KH_1 (PF00013, IPR004088, SM00322): KH domain
128	PDZK1	interactor	5	0.800	0.733	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DUF4265 (PF14085, IPR025361): Domain of unknown function (DUF4265)
129	PINK1	protein found in more fusions	10	0.611	4.319	Pkinase (PF00069, IPR000719): Protein kinase domain
130	PKM	oncoprotein	23	0.423	56.737	PK (PF00224, IPR015793): Pyruvate kinase, barrel domain PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
131	POC1B	interactor	2	1.000	0	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
132	PPHLN1	interactor	6	0.467	3.324	Lge1 (PF11488): Transcriptional regulatory protein LGE1 HERV-K_REC (PF15695): Rec (regulator of expression encoded by corf) of HERV-K-113
133	PPID	interactor	13	0.667	5.168	Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
134	PPP5C	interactor	15	0.457	18.070	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase PPP5 (PF08321, IPR013235): PPP5 TPR repeat region TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat
135	PPP6R3	interactor	9	0.528	6.621	SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
136	PRAM1	interactor	7	0.667	5.376	hSH3 (PF14603, IPR029294): Helically-extended SH3 domain
137	PRDX2	interactor	13	0.487	25.848	AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
138	PRKAA1	suppressor	13	0.474	19.260	Pkinase (PF00069, IPR000719): Protein kinase domain AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
139	PRKCI	interactor	11	0.455	11.011	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
140	PRMT1	interactor	11	0.400	8.823	Methyltransf_25 (PF13649): Methyltransferase domain
141	PRPF4	interactor	7	0.533	4.620	PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain WD40_like (PF17005, IPR031544): WD40-like domain
142	PSEN1	oncoprotein	17	0.367	45.444	Presenilin (PF01080, IPR001108): Presenilin LRRC37AB_C (PF14914, IPR029423): LRRC37A/B like protein 1 C-terminal domain
143	PSKH2	interactor	4	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
144	PSME1	interactor	5	0.500	0.868	PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit RNase_H2-Ydr279 (PF09468, IPR019024): Ydr279p protein family (RNase H2 complex component)
145	RAD23A	oncoprotein	15	0.319	40.000	UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
146	RAE1	interactor	6	0.467	4.206	Exonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
147	RAF1	oncoprotein	22	0.452	35.667	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
148	RASSF3	suppressor	3	0.667	0.500	RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
149	RHOBTB2	suppressor	6	0.700	1.000	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Ras (PF00071, IPR001806, SM00173): Ras family SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
150	RIPK3	interactor	3	0.667	0.167	Pkinase (PF00069, IPR000719): Protein kinase domain TrbM (PF07424, IPR009989): TrbM MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c RHIM (PF12721, IPR025735): RIP homotypic interaction motif
151	RNF32	interactor	24	0.360	84.255	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
152	RPAP3	interactor	13	0.359	24.574	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat RPAP3_C (PF13877, IPR025986): Potential Monad-binding region of RPAP3 Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
153	RPS15A	interactor	15	0.390	28.745	Ribosomal_S8 (PF00410, IPR000630): Ribosomal protein S8
154	RPS2	interactor	15	0.495	20.628	Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
155	RPS27	interactor	9	0.500	6.336	Ribosomal_S27e (PF01667, IPR000592): Ribosomal protein S27 DUF3795 (PF12675, IPR024227): Protein of unknown function (DUF3795)
156	RPS27L	interactor	7	0.667	1.615	E7 (PF00527, IPR000148): E7 protein, Early protein Ribosomal_S27e (PF01667, IPR000592): Ribosomal protein S27 zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type DUF3382 (PF11862, IPR021807): Domain of unknown function (DUF3382)
157	RPS6KA1	oncoprotein	6	0.867	0.733	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
158	RPS6KA3	interactor	7	0.667	4.567	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
159	RPS6KA4	interactor	1	0	0	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
160	RPS6KA6	suppressor	6	0.467	6.367	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
161	RPS6KB2	interactor	32	0.280	149.228	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
162	RSG1	interactor	1	0	0	Ras (PF00071, IPR001806, SM00173): Ras family
163	RYK	oncoprotein	5	0.600	1.241	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase WIF (PF02019, IPR003306, SM00469): WIF domain
164	SAFB	suppressor	4	1.000	0	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAP (PF02037, IPR003034, SM00513): SAP domain Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
165	SGK1	oncoprotein	11	0.556	5.597	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain PX (PF00787, IPR001683, SM00312): PX domain
166	SKP1	oncoprotein	16	0.250	58.197	Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
167	SLC25A5	interactor	12	0.500	6.954	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
168	SLC25A6	interactor	8	0.393	4.630	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
169	SMYD2	interactor	4	0.667	0.216	Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family) SET (PF00856, IPR001214, SM00317): SET domain TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat
170	SMYD3	oncoprotein	4	0.833	0.077	SET (PF00856, IPR001214, SM00317): SET domain
171	SNX5	oncoprotein	2	1.000	0	PX (PF00787, IPR001683, SM00312): PX domain Vps5 (PF09325, IPR015404): Vps5 C terminal like
172	SPTBN4	interactor	3	0.667	0.667	Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Laminin_II (PF06009, IPR010307): Laminin Domain II Spectrin (PF00435, IPR002017): Spectrin repeat PH_9 (PF15410): Pleckstrin homology domain
173	SQSTM1	oncoprotein	20	0.275	63.854	PB1 (PF00564, IPR000270, SM00666): PB1 domain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type UBA_5 (PF16577, IPR015940): UBA domain
174	SRC	oncoprotein	16	0.552	13.834	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
175	SSB	interactor	10	0.400	11.907	HMA (PF00403, IPR006121): Heavy-metal-associated domain La (PF05383, IPR006630, SM00715): La domain Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family Ribosomal_L6e (PF01159, IPR000915): Ribosomal protein L6e RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 (PF08777, IPR014886): RNA binding motif
176	STAMBPL1	interactor	5	0.900	0.154	CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
177	STIL	oncoprotein	12	0.273	27.015	STIL_N (PF15253, IPR026123): SCL-interrupting locus protein N-terminus
178	STK11	suppressor	11	0.400	16.526	Pkinase (PF00069, IPR000719): Protein kinase domain
179	STK32C	interactor	2	1.000	0	APH (PF01636, IPR002575): Phosphotransferase enzyme family Pkinase (PF00069, IPR000719): Protein kinase domain
180	STK33	interactor	4	0.833	0.077	Pkinase (PF00069, IPR000719): Protein kinase domain PARM (PF17061, IPR031431): PARM
181	STK36	protein found in more fusions	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
182	STK38L	oncoprotein	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
183	STK4	oncoprotein	6	0.400	4.515	Pkinase (PF00069, IPR000719): Protein kinase domain Mst1_SARAH (PF11629, IPR024205): C terminal SARAH domain of Mst1 DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
184	STUB1	suppressor	39	0.248	269.696	U-box (PF04564, IPR003613, SM00504): U-box domain ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_20 (PF14561): Tetratricopeptide repeat
185	SYNE2	oncoprotein	4	0.667	1.667	ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit Fez1 (PF06818): Fez1 Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family IncA (PF04156, IPR007285): IncA protein Laminin_II (PF06009, IPR010307): Laminin Domain II Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein Occludin_ELL (PF07303, IPR010844): Occludin homology domain SlyX (PF04102, IPR007236): SlyX Spectrin (PF00435, IPR002017): Spectrin repeat TMPIT (PF07851, IPR012926): TMPIT-like protein KASH (PF10541, IPR012315): Nuclear envelope localisation domain HD_5 (PF13487): HD domain DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain DUF4363 (PF14276, IPR025373): Domain of unknown function (DUF4363) Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167 TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation TRPM_tetra (PF16519, IPR032415): Tetramerisation domain of TRPM
186	TARS2	interactor	6	0.667	1.536	HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain TGS (PF02824, IPR004095): TGS domain tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T) tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
187	TBK1	interactor	16	0.390	31.553	DUF713 (PF05218, IPR007883): Protein of unknown function (DUF713) NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein Pkinase (PF00069, IPR000719): Protein kinase domain
188	TERF1	interactor	22	0.248	94.026	TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
189	TERF2	interactor	14	0.397	22.303	Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif
190	TOMM34	interactor	12	0.470	11.617	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat SHNi-TPR (PF10516, IPR019544): SHNi-TPR TPR_12 (PF13424): Tetratricopeptide repeat Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat DUF4919 (PF16266, IPR032578): Domain of unknown function (DUF4919)
191	TPM1	protein found in more fusions	11	0.356	14.179	Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
192	TTC4	suppressor	12	0.515	15.287	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
193	TTC9C	interactor	5	0.700	1.733	TPR_17 (PF13431): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat
194	TUBA1B	interactor	12	0.303	26.343	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
195	TUBA1C	interactor	18	0.444	34.277	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
196	TUBB	interactor	30	0.425	80.400	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
197	U2AF2	protein found in more fusions	29	0.312	141.551	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
198	UBE2I	interactor	16	0.257	47.567	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
199	ULK1	protein found in more fusions	6	0.600	3.167	Pkinase (PF00069, IPR000719): Protein kinase domain DUF3543 (PF12063, IPR022708): Domain of unknown function (DUF3543) RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
200	ULK3	interactor	5	0.400	2.100	MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain Pkinase (PF00069, IPR000719): Protein kinase domain
201	UNC45A	interactor	9	0.389	13.891	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central TPR_16 (PF13432): Tetratricopeptide repeat HEAT_2 (PF13646): HEAT repeats
202	UPF1	interactor	12	0.318	27.599	UPF1_Zn_bind (PF09416, IPR018999): RNA helicase (UPF2 interacting domain) AAA_11 (PF13086): AAA domain AAA_12 (PF13087): AAA domain
203	USP19	interactor	15	0.314	40.842	CS (PF04969, IPR007052): CS domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase USP19_linker (PF16602): Linker region of USP19 deubiquitinase
204	USP7	oncoprotein	16	0.286	45.084	MATH (PF00917, IPR002083, SM00061): MATH domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
205	VCP	protein found in more fusions	35	0.296	195.249	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain TniB (PF05621, IPR008868): Bacterial TniB protein Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
206	WDR6	interactor	6	0.533	4.571	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nsp3_PL2pro (PF12124, IPR022733): Coronavirus polyprotein cleavage domain Choline_sulf_C (PF12411, IPR025863): Choline sulfatase enzyme C terminal PQQ_3 (PF13570): PQQ-like domain
207	YWHAE	oncoprotein	30	0.287	140.430	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
208	YWHAQ	interactor	31	0.275	164.913	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
209	ZNF205	interactor	1	0	0	KRAB (PF01352, IPR001909, SM00349): KRAB box zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
210	ZNF235	interactor	1	0	0	KRAB (PF01352, IPR001909, SM00349): KRAB box zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
211	ZNF266	interactor	1	0	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger FANCM-MHF_bd (PF16783, IPR031879): FANCM to MHF binding domain
212	ZNF667	interactor	1	0	0	KRAB (PF01352, IPR001909, SM00349): KRAB box zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain YhfH (PF14149, IPR025432): YhfH-like protein

B a c k    t o    T o p ⇑

List of missing interactors (in fusions)

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	CDC37	parental protein	CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding	BI464991
2	EEF1A1P5	interactor	NA	BI464991

B a c k    t o    T o p ⇑