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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CDC37 (from a repository: Thu Oct 17 13:48:19 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)212
The number (and %) of the onco-proteins80 (37.74 %)
The number (and %) of the tumor suppressors18 (8.49 %)
Total number of binary PPIs (saturation %)1536 (6.87 %)
The number (and %) of affected PPIs212 (13.80 %)
The number of possible different fusions41
PPI diameter2
PPI radius1
The average degree of PPI13.651
Assortativity coefficient-0.1918
The network average Clustering coefficient0.492
The number (and %) of a zero Clustering coefficients11 (5.19 %)
The number (and %) of a zero Betweenness Centrality27 (12.74 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: CDC37 All fusions
: AI571632; BI464991;
Proteins found in more fusions ABL2 (see 2 fusions); GRK5 (see 4 fusions); U2AF2 (see 2 fusions); NPM1 (see 1 fusions); PINK1 (see 3 fusions); MAP3K1 (see 1 fusions); CDK6 (see 1 fusions); AHCYL1 (see 3 fusions); EWSR1 (see 2 fusions); EIF2AK2 (see 1 fusions); IMMT (see 4 fusions); ULK1 (see 2 fusions); CTTN (see 1 fusions); IKBKB (see 2 fusions); STK36 (see 1 fusions); LRRK2 (see 1 fusions); DDX5 (see 1 fusions); MTOR (see 1 fusions); APP (see 4 fusions); TPM1 (see 2 fusions); LUC7L2 (see 2 fusions); VCP (see 4 fusions); HSP90AA1 (see 2 fusions); GFAP (see 3 fusions); NCOA5 (see 1 fusions); APOE (see 1 fusions); HSP90AB1 (see 1 fusions); A2M (see 2 fusions); SQSTM1 (see 5 fusions); SGK1 (see 2 fusions); OFD1 (see 1 fusions); FER (see 1 fusions); ERBB3 (see 2 fusions); EGFR (see 2 fusions); BRAF (see 3 fusions); STUB1 (see 1 fusions); MAP3K7 (see 7 fusions); DDX17 (see 3 fusions); CDC37 (see 2 fusions); CDK9 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CDC37parental protein2120.05628243.209CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
2 A2Mprotein found in more fusions260.277129.292A2M (PF00207, IPR001599): Alpha-2-macroglobulin family
A2M_comp (PF07678, IPR011626): A-macroglobulin complement component
A2M_N (PF01835, IPR002890): MG2 domain
A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region
A2M_recep (PF07677, IPR009048): A-macroglobulin receptor
MP (PF01107, IPR028919): Viral movement protein (MP)
SVA (PF05326, IPR007990): Seminal vesicle autoantigen (SVA)
Thiol-ester_cl (PF10569, IPR019565): Alpha-macro-globulin thiol-ester bond-forming region
3 ABL2oncoprotein60.8000.567Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
NHS (PF15273, IPR024845): NHS-like
4 AHCYL1suppressor90.5008.677AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515)
Big_3_5 (PF16640, IPR032109): Bacterial Ig-like domain (group 3)
5 AHSA1interactor260.36697.749Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal
AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein
6 AIPsuppressor100.42213.511FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
7 AKT1oncoprotein350.299191.200PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
8 APOEprotein found in more fusions150.58215.040Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
TipAS (PF07739, IPR012925): TipAS antibiotic-recognition domain
9 APPprotein found in more fusions550.131878.311APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
10 ARoncoprotein220.31460.681Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
11 ARAFoncoprotein120.42414.687Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
12 ATG101interactor40.5002.067ATG101 (PF07855, IPR012445): Autophagy-related protein 101
13 AURKAoncoprotein230.34666.605Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
14 AURKBinteractor190.32755.390Pkinase (PF00069, IPR000719): Protein kinase domain
15 AURKCinteractor60.8001.182Pkinase (PF00069, IPR000719): Protein kinase domain
16 BRAFoncoprotein140.6287.090Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
17 BTBD10interactor100DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
BTB_3 (PF16017): BTB/POZ domain
18 C19orf44interactor100DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
19 CC2D1Ainteractor50.6002.067C2 (PF00168, IPR000008, SM00239): C2 domain
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
Snf7 (PF03357, IPR005024): Snf7
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
LELP1 (PF15042, IPR026076): Late cornified envelope-like proline-rich protein 1
20 CDC25Concoprotein60.6670.971M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
21 CDC37L1interactor130.52616.309CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
22 CDCA5interactor60.4001.934Sororin (PF09666, IPR018605): Sororin protein
23 CDK1oncoprotein190.25570.849Pkinase (PF00069, IPR000719): Protein kinase domain
24 CDK11Aoncoprotein50.6002.122DDHD (PF02862, IPR004177, SM01127): DDHD domain
eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
Pkinase (PF00069, IPR000719): Protein kinase domain
RIO1 (PF01163, IPR018934): RIO1 family
DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355)
DHHW (PF14286, IPR025945): DHHW protein
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
25 CDK11Boncoprotein80.7143.338DDHD (PF02862, IPR004177, SM01127): DDHD domain
DivIC (PF04977, IPR007060): Septum formation initiator
Pkinase (PF00069, IPR000719): Protein kinase domain
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
26 CDK13interactor130.47417.790K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Macoilin (PF09726, IPR019130): Transmembrane protein
THRAP3_BCLAF1 (PF15440, IPR029199): THRAP3/BCLAF1 family
27 CDK15interactor60.9330.400Pkinase (PF00069, IPR000719): Protein kinase domain
ACT_5 (PF13710): ACT domain
28 CDK18oncoprotein110.5458.137APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
29 CDK4oncoprotein140.50518.428Pkinase (PF00069, IPR000719): Protein kinase domain
30 CDK5oncoprotein110.6228.589Pkinase (PF00069, IPR000719): Protein kinase domain
31 CDK6suppressor90.5008.200Pkinase (PF00069, IPR000719): Protein kinase domain
32 CDK7oncoprotein130.42419.293Pkinase (PF00069, IPR000719): Protein kinase domain
33 CDK9protein found in more fusions170.35037.706Pkinase (PF00069, IPR000719): Protein kinase domain
34 CDKL1interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
35 CDKL2interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
36 CEP104interactor60.4674.400ATP-synt_E_2 (PF08112, IPR012508): ATP synthase epsilon subunit
zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
HEAT (PF02985, IPR000357): HEAT repeat
PRP1_N (PF06424, IPR010491): PRP1 splicing factor, N-terminal
UVR (PF02151, IPR001943): UvrB/uvrC motif
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
CLASP_N (PF12348, IPR024395): CLASP N terminal
DZR (PF12773, IPR025874): Double zinc ribbon
zf-C2H2_4 (PF13894): C2H2-type zinc finger
37 CHGAoncoprotein21.0000Granin (PF01271, IPR001990): Granin (chromogranin or secretogranin)
PP1_bind (PF15276, IPR029334): Protein phosphatase 1 binding
38 CHORDC1interactor130.57613.524CHORD (PF04968, IPR007051): CHORD
CS (PF04969, IPR007052): CS domain
39 CHUKsuppressor210.41644.899Pkinase (PF00069, IPR000719): Protein kinase domain
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
40 CKS1Boncoprotein50.8330.400CKS (PF01111, IPR000789, SM01084): Cyclin-dependent kinase regulatory subunit
41 CKS2oncoprotein50.8330.333CKS (PF01111, IPR000789, SM01084): Cyclin-dependent kinase regulatory subunit
42 CLK3interactor110.46710.601Pkinase (PF00069, IPR000719): Protein kinase domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
43 CRYMinteractor21.0000OCD_Mu_crystall (PF02423, IPR003462): Ornithine cyclodeaminase/mu-crystallin family
44 CTTNoncoprotein80.6673.321FadA (PF09403, IPR018543): Adhesion protein FadA
HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
45 CYP2C9interactor31.0000p450 (PF00067, IPR001128): Cytochrome P450
46 DCTN1interactor110.28918.847Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
FlgN (PF05130, IPR007809): FlgN protein
HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
DUF2443 (PF10398, IPR019469): Protein of unknown function (DUF2443)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Dynactin (PF12455, IPR022157): Dynein associated protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
47 DDR1oncoprotein40.6670.216Lamprin (PF06403, IPR009437): Lamprin
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
DUF4381 (PF14316, IPR025489): Domain of unknown function (DUF4381)
48 DDX17protein found in more fusions100.5562.809CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Ferritin (PF00210, IPR008331): Ferritin-like domain
GRP (PF07172, IPR010800): Glycine rich protein family
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
49 DDX5oncoprotein180.27248.005DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
P68HR (PF08061, IPR012587): P68HR (NUC004) repeat
ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
50 DEAF1interactor100Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAND (PF01342, IPR000770, SM00258): SAND domain
zf-MYND (PF01753, IPR002893): MYND finger
51 DMWDinteractor30.6671.000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
52 DNAJB1suppressor150.48621.121DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
53 DNAJC7interactor150.51423.692DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
Rapsyn_N (PF10579, IPR019568): Rapsyn N-terminal myristoylation and linker region
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_17 (PF13431): Tetratricopeptide repeat
54 ECSITinteractor230.33888.088ECSIT (PF06239, IPR010418): Evolutionarily conserved signalling intermediate in Toll pathway
ECSIT_C (PF14784, IPR029342): C-terminal domain of the ECSIT protein
55 EEF1A1suppressor310.347118.415GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
56 EEF1A1P5interactor30.6670.200NA
57 EEF1A2oncoprotein80.3216.529GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
58 EGFRoncoprotein470.229433.843Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
59 EIF2AK1interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
60 EIF2AK2oncoprotein120.45514.246dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Pkinase (PF00069, IPR000719): Protein kinase domain
61 EIF3Binteractor70.4293.705eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
PALB2_WD40 (PF16756, IPR031920): Partner and localizer of BRCA2 WD40 domain
Methyltr_RsmF_N (PF17125, IPR031341): N-terminal domain of 16S rRNA methyltransferase RsmF
62 ELAVL3interactor70.5714.067RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
63 EMDinteractor200.32262.493LEM (PF03020, IPR003887, SM00540): LEM domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
64 ERBB2oncoprotein120.54511.786Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
65 ERBB3oncoprotein220.29586.199Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
66 ESRRBsuppressor220.29090.918zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
67 EVC2interactor60.4005.356HBS1_N (PF08938, IPR015033): HBS1 N-terminus
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
Histone_HNS (PF00816, IPR001801): H-NS histone family
EVC2_like (PF12297, IPR022076): Ellis van Creveld protein 2 like protein
68 EWSR1oncoprotein260.257119.731RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
69 EXOSC1interactor70.7144.152EXOSC1 (PF10447, IPR019495): Exosome component EXOSC1/CSL4
ECR1_N (PF14382, IPR025721): Exosome complex exonuclease RRP4 N-terminal region
70 FBXL12interactor80.6076.043F-box-like (PF12937, IPR001810): F-box-like
71 FBXO6interactor340.266212.393FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
72 FBXW4oncoprotein70.4298.186WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
F-box-like (PF12937, IPR001810): F-box-like
F-box_4 (PF15966, IPR001810): F-box
73 FERprotein found in more fusions80.7142.817DivIC (PF04977, IPR007060): Septum formation initiator
FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
Glyco_transf_28 (PF03033, IPR004276): Glycosyltransferase family 28 N-terminal domain
PEP-utilisers_N (PF05524, IPR008731): PEP-utilising enzyme, N-terminal
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
Med29 (PF11568, IPR021018): Mediator complex subunit 29
74 FGFR3oncoprotein60.7000.786I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
75 FKBP4interactor200.27983.106FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
76 FKBP5interactor400.179405.760FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
NuDC (PF16273, IPR032572): Nuclear distribution C domain
77 FKBP6interactor60.6672.134FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
78 FKBPLinteractor80.5005.931BTAD (PF03704, IPR005158, SM01043): Bacterial transcriptional activator domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
79 FTSJ1interactor40.5002.500FtsJ (PF01728, IPR002877): FtsJ-like methyltransferase
80 GCDHinteractor90.6398.421Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
81 GCH1interactor41.0000GTP_cyclohydroI (PF01227, IPR020602): GTP cyclohydrolase I
82 GFAPprotein found in more fusions120.40014.760Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
83 GLMNoncoprotein70.4297.900Kinetochor_Ybp2 (PF08568, IPR013877): Uncharacterised protein family, YAP/Alf4/glomulin
84 GRK5protein found in more fusions100.5005.546Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
85 HNRNPMinteractor120.51511.272RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNP_M (PF11532, IPR024666): Heterogeneous nuclear ribonucleoprotein M
Collagen_mid (PF15984, IPR031929): Bacterial collagen, middle region
86 HSP90AA1oncoprotein1100.1103634.113HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
87 HSP90AB1oncoprotein660.185831.923HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
88 HSPA1Ainteractor300.41478.470HSP70 (PF00012, IPR013126): Hsp70 protein
89 HSPA5oncoprotein330.369120.966HSP70 (PF00012, IPR013126): Hsp70 protein
90 HSPA8oncoprotein380.336206.920HSP70 (PF00012, IPR013126): Hsp70 protein
91 IFIT3interactor140.47427.879TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
92 IFIT5interactor100.7334.440TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_15 (PF13429): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
93 IKBKBprotein found in more fusions190.44432.017FliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
94 IKBKEinteractor100.6116.726IncA (PF04156, IPR007285): IncA protein
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
zf-RING_9 (PF13901, IPR025258): Putative zinc-RING and/or ribbon
95 IKBKGinteractor290.291124.984CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
96 IMMTprotein found in more fusions110.33312.929Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
97 IRAK1interactor190.35356.180Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
98 IRAK2oncoprotein50.6002.733Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
99 LONP1interactor130.43631.633AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_PrkA (PF08298, IPR013153, SM00763): PrkA AAA domain
LON_substr_bdg (PF02190, IPR003111, SM00464): ATP-dependent protease La (LON) substrate-binding domain
Lon_C (PF05362, IPR008269): Lon protease (S16) C-terminal proteolytic domain
RuvB_N (PF05496, IPR008824): Holliday junction DNA helicase ruvB N-terminus
AAA_23 (PF13476): AAA domain
100 LOXL4oncoprotein60.8670.536Lysyl_oxidase (PF01186, IPR001695): Lysyl oxidase
SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain
101 LRRK1interactor40.6670.400Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
Pkinase (PF00069, IPR000719): Protein kinase domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
102 LRRK2oncoprotein140.55116.467Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043)
T2SSE (PF00437, IPR001482): Type II/IV secretion system protein
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
Pkinase (PF00069, IPR000719): Protein kinase domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
PQQ_2 (PF13360, IPR002372): PQQ-like domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
103 LUC7L2protein found in more fusions120.36414.594LUC7 (PF03194, IPR004882): LUC7 N_terminus
Paramyxo_ncap (PF00973, IPR002021): Paramyxovirus nucleocapsid protein
Methyltransf_32 (PF13679, IPR025714): Methyltransferase domain
104 MAP3K1oncoprotein120.38218.927zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
105 MAP3K11interactor90.8211.007APG6 (PF04111, IPR007243): Autophagy protein Apg6
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH3_9 (PF14604, IPR001452): Variant SH3 domain
106 MAP3K3oncoprotein100.5563.914PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
107 MAP3K7oncoprotein150.41824.610Mnd1 (PF03962, IPR005647): Mnd1 family
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
108 MAPK7oncoprotein120.6364.372Pkinase (PF00069, IPR000719): Protein kinase domain
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
109 MASP1interactor40.5001.733CUB (PF00431, IPR000859, SM00042): CUB domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Trypsin (PF00089, IPR001254, SM00020): Trypsin
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
110 MGEA5oncoprotein80.4648.439NAGidase (PF07555, IPR011496): beta-N-acetylglucosaminidase
111 MOV10interactor300.175207.051AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
112 MTORoncoprotein180.29445.141DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104)
EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain
V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
TPR_19 (PF14559): Tetratricopeptide repeat
113 MYLK4interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
114 MZT2Binteractor100MOZART2 (PF12926, IPR024332): Mitotic-spindle organizing gamma-tubulin ring associated
115 NCOA5suppressor50.5000.535Macoilin (PF09726, IPR019130): Transmembrane protein
116 NEK6interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
117 NEK8interactor70.5243.745Pkinase (PF00069, IPR000719): Protein kinase domain
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
118 NOS3interactor130.47017.921FAD_binding_1 (PF00667, IPR003097): FAD binding domain
Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain
HTH_15 (PF12324, IPR024259): Helix-turn-helix domain of alkylmercury lyase
119 NPM1suppressor340.316175.486Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
120 NTRK1oncoprotein740.1361486.567I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
121 NUP98suppressor70.5244.933Nucleoporin2 (PF04096, IPR007230): Nucleoporin autopeptidase
Nup96 (PF12110, IPR021967): Nuclear protein 96
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
Keratin_2_head (PF16208, IPR032444): Keratin type II head
122 NXF1interactor340.170270.751NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
123 OFD1protein found in more fusions160.26749.914APG6 (PF04111, IPR007243): Autophagy protein Apg6
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
GrpE (PF01025, IPR000740): GrpE
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
XhlA (PF10779, IPR019715): Haemolysin XhlA
DUF3372 (PF11852, IPR024561): Domain of unknown function (DUF3372)
LisH_2 (PF16045, IPR006594): LisH
124 OGFRinteractor60.6671.653OGFr_III (PF04680, IPR006770): Opioid growth factor receptor repeat
OGFr_N (PF04664, IPR006757): Opioid growth factor receptor (OGFr) conserved region
SspP (PF08179, IPR012614): Small acid-soluble spore protein P family
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
125 PANX1interactor100Innexin (PF00876, IPR000990): Innexin
Pannexin_like (PF12534, IPR021040): Pannexin-like TM region of LRRC8
126 PATL1interactor40.8330.087PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
127 PCBP1oncoprotein150.56213.614Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein
KH_2 (PF07650, IPR004044): KH domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
128 PDZK1interactor50.8000.733PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF4265 (PF14085, IPR025361): Domain of unknown function (DUF4265)
129 PINK1protein found in more fusions100.6114.319Pkinase (PF00069, IPR000719): Protein kinase domain
130 PKMoncoprotein230.42356.737PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
131 POC1Binteractor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
132 PPHLN1interactor60.4673.324Lge1 (PF11488): Transcriptional regulatory protein LGE1
HERV-K_REC (PF15695): Rec (regulator of expression encoded by corf) of HERV-K-113
133 PPIDinteractor130.6675.168Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
134 PPP5Cinteractor150.45718.070Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
PPP5 (PF08321, IPR013235): PPP5 TPR repeat region
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
135 PPP6R3interactor90.5286.621SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
136 PRAM1interactor70.6675.376hSH3 (PF14603, IPR029294): Helically-extended SH3 domain
137 PRDX2interactor130.48725.848AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
138 PRKAA1suppressor130.47419.260Pkinase (PF00069, IPR000719): Protein kinase domain
AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
139 PRKCIinteractor110.45511.011PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
140 PRMT1interactor110.4008.823Methyltransf_25 (PF13649): Methyltransferase domain
141 PRPF4interactor70.5334.620PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_like (PF17005, IPR031544): WD40-like domain
142 PSEN1oncoprotein170.36745.444Presenilin (PF01080, IPR001108): Presenilin
LRRC37AB_C (PF14914, IPR029423): LRRC37A/B like protein 1 C-terminal domain
143 PSKH2interactor41.0000Pkinase (PF00069, IPR000719): Protein kinase domain
144 PSME1interactor50.5000.868PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit
PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
RNase_H2-Ydr279 (PF09468, IPR019024): Ydr279p protein family (RNase H2 complex component)
145 RAD23Aoncoprotein150.31940.000UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
146 RAE1interactor60.4674.206Exonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
147 RAF1oncoprotein220.45235.667Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
148 RASSF3suppressor30.6670.500RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
149 RHOBTB2suppressor60.7001.000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Ras (PF00071, IPR001806, SM00173): Ras family
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
150 RIPK3interactor30.6670.167Pkinase (PF00069, IPR000719): Protein kinase domain
TrbM (PF07424, IPR009989): TrbM
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
151 RNF32interactor240.36084.255IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
152 RPAP3interactor130.35924.574TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
RPAP3_C (PF13877, IPR025986): Potential Monad-binding region of RPAP3
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
153 RPS15Ainteractor150.39028.745Ribosomal_S8 (PF00410, IPR000630): Ribosomal protein S8
154 RPS2interactor150.49520.628Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain
Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
155 RPS27interactor90.5006.336Ribosomal_S27e (PF01667, IPR000592): Ribosomal protein S27
DUF3795 (PF12675, IPR024227): Protein of unknown function (DUF3795)
156 RPS27Linteractor70.6671.615E7 (PF00527, IPR000148): E7 protein, Early protein
Ribosomal_S27e (PF01667, IPR000592): Ribosomal protein S27
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
DUF3382 (PF11862, IPR021807): Domain of unknown function (DUF3382)
157 RPS6KA1oncoprotein60.8670.733Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
158 RPS6KA3interactor70.6674.567Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
159 RPS6KA4interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
160 RPS6KA6suppressor60.4676.367Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
161 RPS6KB2interactor320.280149.228Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
162 RSG1interactor100Ras (PF00071, IPR001806, SM00173): Ras family
163 RYKoncoprotein50.6001.241Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
WIF (PF02019, IPR003306, SM00469): WIF domain
164 SAFBsuppressor41.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SAP (PF02037, IPR003034, SM00513): SAP domain
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
165 SGK1oncoprotein110.5565.597Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
166 SKP1oncoprotein160.25058.197Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain
Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
167 SLC25A5interactor120.5006.954Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
168 SLC25A6interactor80.3934.630Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
169 SMYD2interactor40.6670.216Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)
SET (PF00856, IPR001214, SM00317): SET domain
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
170 SMYD3oncoprotein40.8330.077SET (PF00856, IPR001214, SM00317): SET domain
171 SNX5oncoprotein21.0000PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
172 SPTBN4interactor30.6670.667Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Laminin_II (PF06009, IPR010307): Laminin Domain II
Spectrin (PF00435, IPR002017): Spectrin repeat
PH_9 (PF15410): Pleckstrin homology domain
173 SQSTM1oncoprotein200.27563.854PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
174 SRConcoprotein160.55213.834Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
175 SSBinteractor100.40011.907HMA (PF00403, IPR006121): Heavy-metal-associated domain
La (PF05383, IPR006630, SM00715): La domain
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
Ribosomal_L6e (PF01159, IPR000915): Ribosomal protein L6e
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_3 (PF08777, IPR014886): RNA binding motif
176 STAMBPL1interactor50.9000.154CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
177 STILoncoprotein120.27327.015STIL_N (PF15253, IPR026123): SCL-interrupting locus protein N-terminus
178 STK11suppressor110.40016.526Pkinase (PF00069, IPR000719): Protein kinase domain
179 STK32Cinteractor21.0000APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
180 STK33interactor40.8330.077Pkinase (PF00069, IPR000719): Protein kinase domain
PARM (PF17061, IPR031431): PARM
181 STK36protein found in more fusions31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
182 STK38Loncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
183 STK4oncoprotein60.4004.515Pkinase (PF00069, IPR000719): Protein kinase domain
Mst1_SARAH (PF11629, IPR024205): C terminal SARAH domain of Mst1
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
184 STUB1suppressor390.248269.696U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_20 (PF14561): Tetratricopeptide repeat
185 SYNE2oncoprotein40.6671.667ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
Fez1 (PF06818): Fez1
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
IncA (PF04156, IPR007285): IncA protein
Laminin_II (PF06009, IPR010307): Laminin Domain II
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Occludin_ELL (PF07303, IPR010844): Occludin homology domain
SlyX (PF04102, IPR007236): SlyX
Spectrin (PF00435, IPR002017): Spectrin repeat
TMPIT (PF07851, IPR012926): TMPIT-like protein
KASH (PF10541, IPR012315): Nuclear envelope localisation domain
HD_5 (PF13487): HD domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
DUF4363 (PF14276, IPR025373): Domain of unknown function (DUF4363)
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
TRPM_tetra (PF16519, IPR032415): Tetramerisation domain of TRPM
186 TARS2interactor60.6671.536HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
TGS (PF02824, IPR004095): TGS domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
187 TBK1interactor160.39031.553DUF713 (PF05218, IPR007883): Protein of unknown function (DUF713)
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Pkinase (PF00069, IPR000719): Protein kinase domain
188 TERF1interactor220.24894.026TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
189 TERF2interactor140.39722.303Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif
190 TOMM34interactor120.47011.617TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
SHNi-TPR (PF10516, IPR019544): SHNi-TPR
TPR_12 (PF13424): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
DUF4919 (PF16266, IPR032578): Domain of unknown function (DUF4919)
191 TPM1protein found in more fusions110.35614.179Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
192 TTC4suppressor120.51515.287TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
193 TTC9Cinteractor50.7001.733TPR_17 (PF13431): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
194 TUBA1Binteractor120.30326.343Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
195 TUBA1Cinteractor180.44434.277Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
196 TUBBinteractor300.42580.400Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
197 U2AF2protein found in more fusions290.312141.551RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
198 UBE2Iinteractor160.25747.567UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
199 ULK1protein found in more fusions60.6003.167Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3543 (PF12063, IPR022708): Domain of unknown function (DUF3543)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
200 ULK3interactor50.4002.100MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
Pkinase (PF00069, IPR000719): Protein kinase domain
201 UNC45Ainteractor90.38913.891Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
TPR_16 (PF13432): Tetratricopeptide repeat
HEAT_2 (PF13646): HEAT repeats
202 UPF1interactor120.31827.599UPF1_Zn_bind (PF09416, IPR018999): RNA helicase (UPF2 interacting domain)
AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain
203 USP19interactor150.31440.842CS (PF04969, IPR007052): CS domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP19_linker (PF16602): Linker region of USP19 deubiquitinase
204 USP7oncoprotein160.28645.084MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
205 VCPprotein found in more fusions350.296195.249AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
206 WDR6interactor60.5334.571WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nsp3_PL2pro (PF12124, IPR022733): Coronavirus polyprotein cleavage domain
Choline_sulf_C (PF12411, IPR025863): Choline sulfatase enzyme C terminal
PQQ_3 (PF13570): PQQ-like domain
207 YWHAEoncoprotein300.287140.43014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
208 YWHAQinteractor310.275164.91314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
209 ZNF205interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
210 ZNF235interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
211 ZNF266interactor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
FANCM-MHF_bd (PF16783, IPR031879): FANCM to MHF binding domain
212 ZNF667interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
YhfH (PF14149, IPR025432): YhfH-like protein

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CDC37parental proteinCDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
BI464991
2 EEF1A1P5interactorNABI464991

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