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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CD74 (from a repository: Thu Nov 10 14:59:26 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)11
The number (and %) of the onco-proteins4 (36.36 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)17 (30.91 %)
The number (and %) of affected PPIs11 (64.71 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI2.000
Assortativity coefficient-0.5164
The network average Clustering coefficient0.184
The number (and %) of a zero Clustering coefficients8 (72.73 %)
The number (and %) of a zero Betweenness Centrality10 (90.91 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CD74 All fusions
: AA262125; AA731479; BU618143; H20340; H20268; AW974280; H20291; AA593162; H42916; AW512420; H21087; H22438;
Proteins found in more fusions CD74 (see 12 fusions); APP (see 4 fusions); COPG1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CD74parental protein110.02288.000MHC2-interact (PF09307, IPR015386): CLIP, MHC2 interacting
MHCassoc_trimer (PF08831, IPR011988): Class II MHC-associated invariant chain trimerisation domain
Thyroglobulin_1 (PF00086, IPR000716, SM00211): Thyroglobulin type-1 repeat
2 APPprotein found in more fusions200APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
3 COPG1protein found in more fusions31.0000Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
COP-gamma_platf (PF08752, IPR013040): Coatomer gamma subunit appendage platform subdomain
Coatomer_g_Cpla (PF16381, IPR032154): Coatomer subunit gamma-1 C-terminal appendage platform
4 COPG2interactor31.0000Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
COP-gamma_platf (PF08752, IPR013040): Coatomer gamma subunit appendage platform subdomain
Coatomer_g_Cpla (PF16381, IPR032154): Coatomer subunit gamma-1 C-terminal appendage platform
5 HADHAinteractor1003HCDH (PF00725, IPR006108): 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
3HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
6 HLA-DPB1interactor100MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
7 HLA-DQA1interactor100MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
8 LAMTOR5interactor100LAMTOR5 (PF16672, IPR024135): Ragulator complex protein LAMTOR5
9 MAP3K1oncoprotein200zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
10 MIFoncoprotein200MIF (PF01187, IPR001398): Macrophage migration inhibitory factor (MIF)
11 TM4SF20interactor100L6_membrane (PF05805, IPR008661): L6 membrane protein
WBP-1 (PF11669, IPR021684): WW domain-binding protein 1

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