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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CD63, PUM1 (from a repository: Sat Mar 11 01:20:17 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)56
The number (and %) of the onco-proteins15 (26.79 %)
The number (and %) of the tumor suppressors3 (5.36 %)
Total number of binary PPIs (saturation %)190 (12.34 %)
The number (and %) of affected PPIs54 (28.42 %)
The number of possible different fusions7
PPI diameter5
PPI radius3
The average degree of PPI6.036
Assortativity coefficient-0.2909
The network average Clustering coefficient0.521
The number (and %) of a zero Clustering coefficients7 (12.50 %)
The number (and %) of a zero Betweenness Centrality20 (35.71 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: CD63,PUM1 All fusions
: BF814933; BF814941;
Proteins found in more fusions HSPB1 (see 4 fusions); RBFOX2 (see 2 fusions); LGALS3 (see 2 fusions); ATXN1 (see 3 fusions); VPS26A (see 1 fusions); EGFR (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CD63parental protein200.158470.924Tetraspannin (PF00335, IPR018499): Tetraspanin family
DUF4282 (PF14110, IPR025557): Domain of unknown function (DUF4282)
2 PUM1parental protein340.1191193.183K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PUF (PF00806, IPR001313, SM00025): Pumilio-family RNA binding repeat
YppG (PF14179, IPR025555): YppG-like protein
3 ANXA5oncoprotein31.0000Annexin (PF00191, IPR018502, SM00335): Annexin
4 ATP6V1B1interactor21.0000ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
5 ATXN1protein found in more fusions31.0000AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
6 AURKBinteractor41.0000Pkinase (PF00069, IPR000719): Protein kinase domain
7 BMI1oncoprotein41.0000zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
8 CAND1interactor80.57116.586Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
9 CCDC8interactor90.46444.736Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
10 CD81interactor90.42967.453Tetraspannin (PF00335, IPR018499): Tetraspanin family
11 CD82suppressor80.357162.597Tetraspannin (PF00335, IPR018499): Tetraspanin family
12 CD9oncoprotein90.389199.796Tetraspannin (PF00335, IPR018499): Tetraspanin family
13 CDKN1Asuppressor100CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
14 CLNS1Ainteractor50.40026.939Voldacs (PF03517): Regulator of volume decrease after cellular swelling
15 DSTNinteractor204.826Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
16 EGFRoncoprotein110.267266.485Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
17 EIF5interactor41.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region
eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5
W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
18 ELAVL1oncoprotein180.199522.552RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
19 FAM134Cinteractor2019.715Reticulon (PF02453, IPR003388): Reticulon
20 FBXO6interactor50.20053.538FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
21 FBXW11interactor60.50012.075WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
22 FOXG1oncoprotein30.6671.000SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
SPX (PF03105, IPR004331): SPX domain
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
23 FOXI2interactor100Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
24 FOXQ1interactor100Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
25 HLA-DMBinteractor31.0000MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
26 HLA-DOBinteractor21.0000MHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
27 HLA-DRAinteractor31.0000MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
28 HSPB1oncoprotein100.52825.933HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
29 ITGA4interactor100.194239.197FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
30 ITGB1suppressor120.182271.867EGF_2 (PF07974, IPR013111): EGF-like domain
Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain
Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain
PSI_integrin (PF17205): Integrin plexin domain
31 KIAA0753interactor21.0000MNR (PF15718, IPR031447): Protein moonraker
32 KIToncoprotein31.0000ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
33 LAGE3interactor21.0000Pcc1 (PF09341, IPR015419): Transcription factor Pcc1
34 LGALS3oncoprotein70.33346.958Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
35 LGALS8interactor70.23864.425Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
36 LGALS9interactor60.40034.273Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
37 MATR3interactor90.39319.463DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FAM60A (PF15396, IPR026065): Protein Family FAM60A
38 NTRK1oncoprotein170.300158.362I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
39 PAICSinteractor50.6671.067AIRC (PF00731, IPR000031, SM01001): AIR carboxylase
SAICAR_synt (PF01259, IPR028923): SAICAR synthetase
40 PRR12interactor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
DUF4211 (PF13926, IPR025451): Domain of unknown function (DUF4211)
41 PTGFRNinteractor80.35727.804V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
42 RBFOX2protein found in more fusions80.47620.094RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Fox-1_C (PF12414, IPR025670): Calcitonin gene-related peptide regulator C terminal
43 RNF13interactor40.5002.467DNA_ligase_ZBD (PF03119, IPR004149): NAD-dependent DNA ligase C4 zinc finger domain
PA (PF02225, IPR003137): PA domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
FAM176 (PF14851): FAM176 family
STAC2_u1 (PF16664): Unstructured on SH3 and cysteine-rich domain-containing protein 2
44 SAV1oncoprotein40.50011.174WW (PF00397, IPR001202, SM00456): WW domain
45 SDC1oncoprotein21.0000Herpes_TAF50 (PF03326, IPR004998): Herpesvirus transcription activation factor (transactivator)
Syndecan (PF01034, IPR027789): Syndecan domain
DUF3592 (PF12158, IPR021994): Protein of unknown function (DUF3592)
AJAP1_PANP_C (PF15298, IPR029198): AJAP1/PANP C-terminus
46 SDCBPinteractor60.267151.937PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
47 SEC16Ainteractor70.5245.586APC_r (PF05923): APC repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
48 SEPHS1interactor50.8331.133AIRS (PF00586, IPR000728): AIR synthase related protein, N-terminal domain
AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
49 SIRT7interactor50.6006.795DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
50 SMAD1interactor40.6671.000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
51 SRFinteractor200SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)
52 TSPAN3interactor30.6671.969Hum_adeno_E3A (PF05393, IPR008652): Human adenovirus early E3A glycoprotein
Tetraspannin (PF00335, IPR018499): Tetraspanin family
53 VKORC1interactor41.0000VKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase family
54 VPS26Aprotein found in more fusions41.0000Vps26 (PF03643, IPR005377): Vacuolar protein sorting-associated protein 26
55 XPO1interactor140.319112.785CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
56 YWHABinteractor80.50021.30814-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ANXA5oncoproteinAnnexin (PF00191, IPR018502, SM00335): AnnexinBF814933, BF814941
2 ATP6V1B1interactorATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
BF814933, BF814941
3 AURKBinteractorPkinase (PF00069, IPR000719): Protein kinase domainBF814933, BF814941
4 CD63parental proteinTetraspannin (PF00335, IPR018499): Tetraspanin family
DUF4282 (PF14110, IPR025557): Domain of unknown function (DUF4282)
BF814933, BF814941
5 CD81interactorTetraspannin (PF00335, IPR018499): Tetraspanin familyBF814933, BF814941
6 CD82suppressorTetraspannin (PF00335, IPR018499): Tetraspanin familyBF814933, BF814941
7 CD9oncoproteinTetraspannin (PF00335, IPR018499): Tetraspanin familyBF814933, BF814941
8 CDKN1AsuppressorCDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitorBF814933, BF814941
9 CLNS1AinteractorVoldacs (PF03517): Regulator of volume decrease after cellular swellingBF814933, BF814941
10 DSTNinteractorCofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding proteinBF814933, BF814941
11 ELAVL1oncoproteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)BF814933, BF814941
12 FAM134CinteractorReticulon (PF02453, IPR003388): ReticulonBF814933, BF814941
13 FBXO6interactorFBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
BF814933, BF814941
14 FBXW11interactorWD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
BF814933, BF814941
15 FOXI2interactorForkhead (PF00250, IPR001766, SM00339): Forkhead domainBF814933, BF814941
16 FOXQ1interactorForkhead (PF00250, IPR001766, SM00339): Forkhead domainBF814933, BF814941
17 HLA-DMBinteractorMHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
BF814933, BF814941
18 HLA-DOBinteractorMHC_II_beta (PF00969, IPR000353, SM00921): Class II histocompatibility antigen, beta domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
BF814933, BF814941
19 HLA-DRAinteractorMHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
BF814933, BF814941
20 HSPB1oncoproteinHSP20 (PF00011, IPR002068): Hsp20/alpha crystallin familyBF814933, BF814941
21 ITGB1suppressorEGF_2 (PF07974, IPR013111): EGF-like domain
Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain
Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain
PSI_integrin (PF17205): Integrin plexin domain
BF814933, BF814941
22 KIAA0753interactorMNR (PF15718, IPR031447): Protein moonrakerBF814933, BF814941
23 KIToncoproteinig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
BF814933, BF814941
24 LAGE3interactorPcc1 (PF09341, IPR015419): Transcription factor Pcc1BF814933, BF814941
25 LGALS3oncoproteinGal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectinBF814933, BF814941
26 LGALS8interactorGal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectinBF814933, BF814941
27 LGALS9interactorGal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
BF814933, BF814941
28 PRR12interactorCAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
DUF4211 (PF13926, IPR025451): Domain of unknown function (DUF4211)
BF814933, BF814941
29 PTGFRNinteractorV-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
BF814933, BF814941
30 PUM1parental proteinK_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PUF (PF00806, IPR001313, SM00025): Pumilio-family RNA binding repeat
YppG (PF14179, IPR025555): YppG-like protein
BF814933, BF814941
31 RNF13interactorDNA_ligase_ZBD (PF03119, IPR004149): NAD-dependent DNA ligase C4 zinc finger domain
PA (PF02225, IPR003137): PA domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
FAM176 (PF14851): FAM176 family
STAC2_u1 (PF16664): Unstructured on SH3 and cysteine-rich domain-containing protein 2
BF814933, BF814941
32 SAV1oncoproteinWW (PF00397, IPR001202, SM00456): WW domainBF814933, BF814941
33 SDC1oncoproteinHerpes_TAF50 (PF03326, IPR004998): Herpesvirus transcription activation factor (transactivator)
Syndecan (PF01034, IPR027789): Syndecan domain
DUF3592 (PF12158, IPR021994): Protein of unknown function (DUF3592)
AJAP1_PANP_C (PF15298, IPR029198): AJAP1/PANP C-terminus
BF814933, BF814941
34 SDCBPinteractorPDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)BF814933, BF814941
35 SIRT7interactorDUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
BF814933, BF814941
36 SRFinteractorSRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain)BF814933, BF814941
37 TSPAN3interactorHum_adeno_E3A (PF05393, IPR008652): Human adenovirus early E3A glycoprotein
Tetraspannin (PF00335, IPR018499): Tetraspanin family
BF814933, BF814941
38 VKORC1interactorVKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase familyBF814933, BF814941
39 VPS26AinteractorVps26 (PF03643, IPR005377): Vacuolar protein sorting-associated protein 26BF814933, BF814941
40 YWHABinteractor14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
BF814933, BF814941

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