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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CCDC102B (from a repository: Tue Nov 22 12:32:00 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)55
The number (and %) of the onco-proteins9 (16.36 %)
The number (and %) of the tumor suppressors2 (3.64 %)
Total number of binary PPIs (saturation %)149 (10.03 %)
The number (and %) of affected PPIs55 (36.91 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI4.764
Assortativity coefficient-0.4208
The network average Clustering coefficient0.541
The number (and %) of a zero Clustering coefficients11 (20.00 %)
The number (and %) of a zero Betweenness Centrality24 (43.64 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CCDC102B All fusions
Proteins found in more fusions EXOC5 (see 1 fusions); MCM7 (see 2 fusions); GOPC (see 2 fusions); CEP57L1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CCDC102Bparental protein550.0542312.833Filament (PF00038, IPR001664): Intermediate filament protein
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
2 ABI2suppressor50.5001.667Abi_HHR (PF07815, IPR012849): Abl-interactor HHR
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
SH3_9 (PF14604, IPR001452): Variant SH3 domain
TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
3 AK8interactor21.0000ADK (PF00406, IPR000850): Adenylate kinase
AAA_16 (PF13191): AAA ATPase domain
4 ARL4Ainteractor100Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
5 ARL4Dinteractor100Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
6 BYSLinteractor50.5001.867Bystin (PF05291, IPR007955): Bystin
MEA1 (PF06910, IPR009685): Male enhanced antigen 1 (MEA1)
7 CCDC102Ainteractor21.0000IncA (PF04156, IPR007285): IncA protein
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
THOC7 (PF05615, IPR008501): Tho complex subunit 7
Uds1 (PF15456, IPR029191): Up-regulated During Septation
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
8 CCDC120interactor100HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
DUF3338 (PF11819, IPR021774): Domain of unknown function (DUF3338)
9 CCDC33interactor70.3818.300C2 (PF00168, IPR000008, SM00239): C2 domain
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
SlyX (PF04102, IPR007236): SlyX
10 CCHCR1interactor50.6671.167HCR (PF07111, IPR009800): Alpha helical coiled-coil rod protein (HCR)
11 CDK18oncoprotein40.8330.133APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
12 CEP19interactor21.0000CEP19 (PF14933, IPR029412): CEP19-like protein
13 CEP57L1protein found in more fusions80.5247.133Cep57_MT_bd (PF06657, IPR024957): Centrosome microtubule-binding domain of Cep57
XhlA (PF10779, IPR019715): Haemolysin XhlA
YqzE (PF14038, IPR025622): YqzE-like protein
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
14 EHHADHinteractor30.6670.1332-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
3HCDH (PF00725, IPR006108): 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
3HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
15 ENKD1interactor21.0000Enkurin (PF13864, IPR027012): Calmodulin-binding
16 EXOC5protein found in more fusions200Sec10 (PF07393, IPR009976): Exocyst complex component Sec10
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
17 FAM127Binteractor100DUF4939 (PF16297, IPR032549): Domain of unknown function (DUF4939)
18 FAM127Cinteractor100DUF4939 (PF16297, IPR032549): Domain of unknown function (DUF4939)
19 FAM161Ainteractor60.5002.833YajC (PF02699, IPR003849): Preprotein translocase subunit
UPF0564 (PF10595, IPR019579): Uncharacterised protein family UPF0564
20 FBF1interactor30.6670.133DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Sacchrp_dh_NADP (PF03435, IPR005097): Saccharopine dehydrogenase NADP binding domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
YlqD (PF11068, IPR021297): YlqD protein
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
21 FNDC11interactor21.0000MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
22 GEMinteractor30.6670.133Ras (PF00071, IPR001806, SM00173): Ras family
AAA_22 (PF13401, IPR003593): AAA domain
23 GOPConcoprotein200DUF903 (PF06004, IPR010305): Bacterial protein of unknown function (DUF903)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
DUF3209 (PF11483, IPR021577): Protein of unknown function (DUF3209)
24 HMG20Binteractor30.6671.000IncA (PF04156, IPR007285): IncA protein
NEMP (PF10225, IPR019358): NEMP family
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
DUF3496 (PF12001, IPR021885): Domain of unknown function (DUF3496)
25 KIFC3oncoprotein160.27663.200Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
26 LENG1interactor50.8000.633Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
DUF3323 (PF11796, IPR024466): Protein of unknown function N-terminus (DUF3323)
27 LMO4interactor100LIM (PF00412, IPR001781, SM00132): LIM domain
zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger
28 LNX1interactor50.5003.000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
29 MAB21L2interactor100Mab-21 (PF03281, IPR024810): Mab-21 protein
30 MAGOHBinteractor21.0000Mago_nashi (PF02792, IPR004023): Mago nashi protein
31 MARK1interactor21.0000KA1 (PF02149, IPR001772): Kinase associated domain 1
Pkinase (PF00069, IPR000719): Protein kinase domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
32 MCM7protein found in more fusions60.6003.133MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
33 MOSoncoprotein40.8330.400Pkinase (PF00069, IPR000719): Protein kinase domain
34 NIF3L1interactor31.0000NIF3 (PF01784, IPR002678): NIF3 (NGG1p interacting factor 3)
35 NXT2interactor21.0000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
36 PNMA5interactor50.5002.333PNMA (PF14893, IPR026523): PNMA
37 POP5interactor100RNase_P_Rpp14 (PF01900, IPR002759): Rpp14/Pop5 family
38 PPP1R18interactor30.6670.133Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
DUF4124 (PF13511, IPR025392): Domain of unknown function (DUF4124)
Phostensin (PF13914, IPR025907): Phostensin PP1-binding and SH3-binding region
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
39 PSMA1interactor40.6670.667Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
40 RCOR3interactor50.4005.133ELM2 (PF01448, IPR000949): ELM2 domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_DNA-bind_7 (PF15963): Myb DNA-binding like
41 RSPH14interactor21.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
42 SDCBPinteractor40.5001.300PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
43 SFNsuppressor40.6671.00014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
44 SGF29interactor21.0000DUF1325 (PF07039, IPR010750): SGF29 tudor-like domain
Filament (PF00038, IPR001664): Intermediate filament protein
45 SLIRPinteractor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
46 SPG21interactor30.6670.333Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold
47 SYCE1interactor50.5004.400CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
SYCE1 (PF15233, IPR026676): Synaptonemal complex central element protein 1
48 TPM3oncoprotein60.7002.167Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
49 TRIM27oncoprotein220.129147.567IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
50 TRIM54interactor210.142127.800DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
zf-HIT (PF04438, IPR007529): HIT zinc finger
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
51 VPS26Binteractor21.0000Vps26 (PF03643, IPR005377): Vacuolar protein sorting-associated protein 26
52 WDYHV1interactor50.4004.467Nt_Gln_amidase (PF09764, IPR023128): N-terminal glutamine amidase
53 ZNF20interactor21.0000KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
YhfH (PF14149, IPR025432): YhfH-like protein
54 ZNF250interactor50.5002.133KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
55 ZNF572interactor50.7000.867C1_2 (PF03107, IPR004146): C1 domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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