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Visible interactions: all affected independent (normal) nothing (blank)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)65
The number (and %) of the onco-proteins13 (20.00 %)
The number (and %) of the tumor suppressors8 (12.31 %)
Total number of binary PPIs (saturation %)224 (10.77 %)
The number (and %) of affected PPIs65 (29.02 %)
The number of possible different fusions12
PPI diameter2
PPI radius1
The average degree of PPI6.123
Assortativity coefficient-0.2833
The network average Clustering coefficient0.604
The number (and %) of a zero Clustering coefficients8 (12.31 %)
The number (and %) of a zero Betweenness Centrality26 (40.00 %)


List of the fusions

Proteins found in more fusions UGP2 (see 1 fusions); PRKAR1A (see 2 fusions); NF2 (see 1 fusions); HSF1 (see 3 fusions); CTH (see 3 fusions); UBC (see 1 fusions); GOPC (see 2 fusions); PIAS1 (see 2 fusions); RANBP9 (see 2 fusions); ZDHHC17 (see 2 fusions); CBS (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 CBSparental protein650.0673058.250CBS (PF00571, IPR000644, SM00116): CBS domain
DUF1414 (PF07208, IPR009857): Protein of unknown function (DUF1414)
PALP (PF00291, IPR001926): Pyridoxal-phosphate dependent enzyme
2 ABATinteractor30.6670.667Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
3 AP1B1interactor31.0000Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
B2-adapt-app_C (PF09066, IPR015151, SM01020): Beta2-adaptin appendage, C-terminal sub-domain
4 ASNSoncoprotein80.5369.000Asn_synthase (PF00733, IPR001962): Asparagine synthase
GATase_7 (PF13537, IPR000583): Glutamine amidotransferase domain
5 CARSoncoprotein21.0000tRNA-synt_1e (PF01406, IPR024909): tRNA synthetases class I (C) catalytic domain
6 CBX4oncoprotein200Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
CBX7_C (PF17218): CBX family C-terminal motif
7 CDK2suppressor150.33046.633Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
8 COL4A3BPinteractor200Acyl_CoA_thio (PF02551, IPR025652): Acyl-CoA thioesterase
PH (PF00169, IPR001849, SM00233): PH domain
START (PF01852, IPR002913, SM00234): START domain
9 CTHprotein found in more fusions40.6671.000Cys_Met_Meta_PP (PF01053, IPR000277): Cys/Met metabolism PLP-dependent enzyme
10 DAXXoncoprotein70.4007.733Daxx (PF03344, IPR005012): Daxx N-terminal Rassf1C-interacting domain
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Nop14 (PF04147, IPR007276): Nop14-like family
RF-1 (PF00472, IPR000352): RF-1 domain
Vpu (PF00558, IPR008187): Vpu protein
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
11 DBNLinteractor80.42913.250RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
12 DERAinteractor100DeoC (PF01791, IPR002915, SM01133): DeoC/LacD family aldolase
13 EEF1A1suppressor100.47214.417GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
14 EHHADHinteractor21.00002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
3HCDH (PF00725, IPR006108): 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
3HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
15 ENOPH1interactor100Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
16 ERO1Ainteractor40.8330.667ERO1 (PF04137, IPR007266): Endoplasmic Reticulum Oxidoreductin 1 (ERO1)
17 FXR2interactor31.0000Agenet (PF05641, IPR008395, SM00743): Agenet domain
REV (PF00424, IPR000625): REV protein (anti-repression trans-activator protein)
KH_1 (PF00013, IPR004088, SM00322): KH domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
18 GON7interactor40.6671.500DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
19 GOPConcoprotein41.0000DUF903 (PF06004, IPR010305): Bacterial protein of unknown function (DUF903)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
DUF3209 (PF11483, IPR021577): Protein of unknown function (DUF3209)
20 GPN1interactor40.6671.667ATP_bind_1 (PF03029, IPR004130): Conserved hypothetical ATP binding protein
NB-ARC (PF00931, IPR002182): NB-ARC domain
21 GPSM1interactor41.0000GoLoco (PF02188, IPR003109, SM00390): GoLoco motif
TPR_12 (PF13424): Tetratricopeptide repeat
22 HGSinteractor60.4007.467FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
23 HID1interactor100Hid1 (PF12722): High-temperature-induced dauer-formation protein
24 HSF1protein found in more fusions80.42910.667DUF247 (PF03140, IPR004158): Plant protein of unknown function
Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor
HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
25 HSPE1interactor80.35716.000Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
26 IARSinteractor70.6674.400Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
27 IPO4interactor21.0000HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
UME (PF08064, IPR012993, SM00802): UME (NUC010) domain
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
28 IREB2interactor21.0000Aconitase (PF00330, IPR001030): Aconitase family (aconitate hydratase)
Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
29 LRSAM1interactor70.6004.833Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
30 NF2suppressor40.6670.667ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
31 NMD3interactor30.6670.500DUF1816 (PF08846, IPR014945): Domain of unknown function (DUF1816)
NMD3 (PF04981, IPR007064): NMD3 family
HGTP_anticodon2 (PF12745, IPR024435): Anticodon binding domain of tRNAs
32 NPLOC4interactor100.6897.683NPL4 (PF05021, IPR007717): NPL4 family
zf-NPL4 (PF05020, IPR007716): NPL4 family, putative zinc binding region
UN_NPL4 (PF11543, IPR024682): Nuclear pore localisation protein NPL4
33 NTRK1oncoprotein310.156331.567I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
34 NUCB1interactor21.0000DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104)
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
DUF2967 (PF11179, IPR021349): Protein of unknown function (DUF2967)
DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552)
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
35 OATinteractor31.0000Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
36 OTUB1interactor50.6001.967Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
37 PARP6interactor31.0000PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
38 PDLIM5interactor80.8930.983LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
39 PIAS1suppressor31.0000Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
UPF0544 (PF15749, IPR032739): Uncharacterised protein family UPF0544
40 PIAS3oncoprotein21.0000SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
41 PIN1suppressor70.4298.667Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
42 PKMoncoprotein110.61813.583PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
43 PLIN3interactor140.41039.367Perilipin (PF03036, IPR004279): Perilipin family
44 PRKAG1interactor100CBS (PF00571, IPR000644, SM00116): CBS domain
45 PRKAR1Asuppressor40.6670.500RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
46 PSMA1interactor51.0000Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
47 QARSinteractor70.6674.400tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain
tRNA-synt_1c_C (PF03950, IPR020059): tRNA synthetases class I (E and Q), anti-codon binding domain
tRNA_synt_1c_R1 (PF04558, IPR007639): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1
tRNA_synt_1c_R2 (PF04557, IPR007638): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
48 RAD23Bsuppressor130.42337.250K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
49 RANBP9suppressor60.6001.967Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
LisH (PF08513, IPR013720, SM00667): LisH
SPRY (PF00622, IPR003877, SM00449): SPRY domain
CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
50 RSU1interactor21.0000LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
51 RTFDC1interactor100Rtf2 (PF04641, IPR027799): Rtf2 RING-finger
52 SEC24Binteractor50.6003.167Gelsolin (PF00626, IPR007123): Gelsolin repeat
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
53 SEC31Ainteractor40.6672.000P3A (PF08727, IPR014838): Poliovirus 3A protein like
SRA1 (PF07304, IPR009917): Steroid receptor RNA activator (SRA1)
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
54 SKIV2Linteractor21.0000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
DSHCT (PF08148, IPR012961, SM01142): DSHCT (NUC185) domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF3516 (PF12029, IPR021904): Domain of unknown function (DUF3516)
rRNA_proc-arch (PF13234, IPR025696): rRNA-processing arch domain
55 SRP14interactor61.0000SRP14 (PF02290, IPR003210): Signal recognition particle 14kD protein
56 UBA2interactor120.51524.417ThiF (PF00899, IPR000594): ThiF family
UAE_UbL (PF14732, IPR028077): Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
UBA2_C (PF16195, IPR032426): SUMO-activating enzyme subunit 2 C-terminus
57 UBA5interactor60.6003.333Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
ThiF (PF00899, IPR000594): ThiF family
58 UBASH3Ainteractor31.0000His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Ste5 (PF11610, IPR021651): Scaffold protein Ste5-Fus5 binding region
SH3_9 (PF14604, IPR001452): Variant SH3 domain
59 UBCprotein found in more fusions150.27554.167ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
60 UBE2Iinteractor100.25022.500UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
61 UBE3Binteractor100EAL (PF00563, IPR001633, SM00052): EAL domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
62 UGP2protein found in more fusions60.7002.167UDPGP (PF01704, IPR002618): UTP--glucose-1-phosphate uridylyltransferase
63 VBP1interactor40.6671.333Prefoldin (PF02996, IPR004127): Prefoldin subunit
64 VTA1interactor30.6670.667Vta1 (PF04652): Vta1 like
65 ZDHHC17protein found in more fusions40.6671.000zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)

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