1 |
CBL | parental protein | 233 | 0.061 | 32363.102 | Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain |
2 |
ABI1 | oncoprotein | 7 | 0.714 | 1.853 | Abi_HHR (PF07815, IPR012849): Abl-interactor HHR Cytochrom_B558a (PF05038, IPR007732): Cytochrome Cytochrome b558 alpha-subunit SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF4124 (PF13511, IPR025392): Domain of unknown function (DUF4124) PRIMA1 (PF16101): Proline-rich membrane anchor 1 ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension |
3 |
ABL1 | oncoprotein | 46 | 0.302 | 289.826 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2 |
4 |
ACACA | interactor | 8 | 0.714 | 1.141 | ACC_central (PF08326, IPR013537): Acetyl-CoA carboxylase, central region Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme Carboxyl_trans (PF01039, IPR000022): Carboxyl transferase domain Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain DUF445 (PF04286, IPR007383): Protein of unknown function (DUF445) |
5 |
ACTA1 | interactor | 12 | 0.424 | 18.483 | Actin (PF00022, IPR004000, SM00268): Actin |
6 |
ACTB | oncoprotein | 19 | 0.451 | 39.797 | Actin (PF00022, IPR004000, SM00268): Actin |
7 |
ACTG2 | interactor | 1 | 0 | 0 | Actin (PF00022, IPR004000, SM00268): Actin |
8 |
ACTN1 | protein found in more fusions | 10 | 0.389 | 13.737 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Dak2 (PF02734, IPR004007, SM01120): DAK2 domain EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat EF-hand_7 (PF13499, IPR011992): EF-hand domain pair Uds1 (PF15456, IPR029191): Up-regulated During Septation |
9 |
APPL1 | interactor | 8 | 0.905 | 0.422 | ATP-synt_E (PF05680, IPR008386): ATP synthase E chain Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region PH (PF00169, IPR001849, SM00233): PH domain PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) BAR_3 (PF16746): BAR domain of APPL family |
10 |
ARHGEF6 | oncoprotein | 7 | 0.533 | 4.733 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1 PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_9 (PF14604, IPR001452): Variant SH3 domain betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil RhoGEF67_u2 (PF16614): Unstructured region two on RhoGEF 6 and 7 RhoGEF67_u1 (PF16615): Unstructured region one on RhoGEF 6 and 7 |
11 |
ARHGEF7 | interactor | 11 | 0.436 | 16.031 | Borrelia_lipo_1 (PF05714, IPR008421): Borrelia burgdorferi virulent strain associated lipoprotein CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_2 (PF07653, IPR011511): Variant SH3 domain RhoGEF67_u2 (PF16614): Unstructured region two on RhoGEF 6 and 7 RhoGEF67_u1 (PF16615): Unstructured region one on RhoGEF 6 and 7 |
12 |
ASAP1 | interactor | 10 | 0.711 | 2.632 | ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf PH (PF00169, IPR001849, SM00233): PH domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) BAR_3 (PF16746): BAR domain of APPL family |
13 |
AXL | oncoprotein | 6 | 0.733 | 0.627 | fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase DUF2627 (PF11118, IPR020138): Protein of unknown function (DUF2627) Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain |
14 |
BAG1 | oncoprotein | 6 | 0.667 | 2.667 | BAG (PF02179, IPR003103, SM00264): BAG domain Presenilin (PF01080, IPR001108): Presenilin ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082) |
15 |
BCAR1 | oncoprotein | 30 | 0.308 | 127.120 | Serine_rich (PF08824, IPR014928): Serine rich protein interaction domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513) Caskin1-CID (PF16600): Caskin1 CASK-interaction domain |
16 |
BCR | suppressor | 23 | 0.383 | 67.072 | Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain IQ_SEC7_PH (PF16453, IPR001849): PH domain |
17 |
BLK | oncoprotein | 5 | 0.800 | 0.800 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
18 |
BLNK | suppressor | 17 | 0.368 | 32.351 | SH2 (PF00017, IPR000980, SM00252): SH2 domain |
19 |
BTK | suppressor | 20 | 0.251 | 68.623 | BTK (PF00779, IPR001562, SM00107): BTK motif PH (PF00169, IPR001849, SM00233): PH domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
20 |
CAD | oncoprotein | 14 | 0.582 | 10.048 | Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 (PF02787, IPR005480, SM01096): Carbamoyl-phosphate synthetase large chain, oligomerisation domain CPSase_sm_chain (PF00988, IPR002474, SM01097): Carbamoyl-phosphate synthase small chain, CPSase domain GATase (PF00117, IPR017926): Glutamine amidotransferase class-I MGS (PF02142, IPR011607, SM00851): MGS-like domain OTCace (PF00185, IPR006131): Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N (PF02729, IPR006132): Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain ATPgrasp_Ter (PF15632, IPR011226): ATP-grasp in the biosynthetic pathway with Ter operon |
21 |
CALM1 | interactor | 14 | 0.319 | 28.845 | EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
22 |
CAPZA1 | interactor | 8 | 0.536 | 4.486 | F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit |
23 |
CBLB | oncoprotein | 38 | 0.290 | 244.189 | Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
24 |
CCT8 | interactor | 13 | 0.385 | 26.381 | Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family |
25 |
CD247 | interactor | 10 | 0.444 | 13.952 | ITAM (PF02189, IPR003110, SM00077): Immunoreceptor tyrosine-based activation motif TCR_zetazeta (PF11628, IPR021663): T-cell surface glycoprotein CD3 zeta chain |
26 |
CD2AP | protein found in more fusions | 15 | 0.407 | 27.960 | SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil |
27 |
CD33 | interactor | 3 | 0.667 | 0.200 | DUF998 (PF06197, IPR009339): Protein of unknown function (DUF998) ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain |
28 |
CD38 | interactor | 4 | 1.000 | 0 | Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain Rib_hydrolayse (PF02267, IPR003193): ADP-ribosyl cyclase |
29 |
CD40 | protein found in more fusions | 7 | 0.467 | 5.019 | Glycophorin_A (PF01102, IPR001195): Glycophorin A TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region |
30 |
CD5 | interactor | 6 | 0.800 | 0.500 | SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain Comm (PF15957, IPR031878): Commissureless |
31 |
CDC42 | oncoprotein | 16 | 0.267 | 46.775 | Ras (PF00071, IPR001806, SM00173): Ras family |
32 |
CEP128 | interactor | 10 | 0.311 | 17.236 | DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129) DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein SpoOE-like (PF09388, IPR018540): Spo0E like sporulation regulatory protein DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) TraF_2 (PF13729, IPR032811): F plasmid transfer operon, TraF, protein GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 |
33 |
CEP170 | interactor | 17 | 0.338 | 45.475 | FHA (PF00498, IPR000253, SM00240): FHA domain DUF4254 (PF14063, IPR025350): Protein of unknown function (DUF4254) CEP170_C (PF15308, IPR029300): CEP170 C-terminus |
34 |
CFTR | suppressor | 12 | 0.400 | 17.994 | ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region ABC_tran (PF00005, IPR003439): ABC transporter Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain |
35 |
CORO1C | oncoprotein | 10 | 0.667 | 4.625 | DUF1899 (PF08953, IPR015048, SM01166): Domain of unknown function (DUF1899) WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat WD40_4 (PF16300): Type of WD40 repeat |
36 |
CRK | oncoprotein | 67 | 0.199 | 825.486 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
37 |
CRKL | oncoprotein | 28 | 0.394 | 80.443 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
38 |
CSF1 | oncoprotein | 3 | 0.667 | 1.000 | CSF-1 (PF05337, IPR008001): Macrophage colony stimulating factor-1 (CSF-1) |
39 |
CSF1R | oncoprotein | 14 | 0.341 | 31.615 | ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain |
40 |
CSK | interactor | 12 | 0.576 | 10.595 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
41 |
CTNNB1 | oncoprotein | 27 | 0.242 | 149.350 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat |
42 |
CUBN | oncoprotein | 3 | 1.000 | 0 | B1 (PF02246, IPR003147): Protein L b1 domain CUB (PF00431, IPR000859, SM00042): CUB domain EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like EGF_3 (PF12947, IPR024731): EGF domain FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site |
43 |
DBNL | interactor | 4 | 0.667 | 0.452 | RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein SH3_9 (PF14604, IPR001452): Variant SH3 domain |
44 |
EEF1A1 | suppressor | 21 | 0.453 | 42.226 | GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain |
45 |
EGFR | oncoprotein | 94 | 0.157 | 2094.673 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
46 |
EPHA2 | suppressor | 11 | 0.689 | 6.150 | fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain |
47 |
EPHA8 | interactor | 3 | 0.667 | 1.000 | fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain |
48 |
EPHB1 | interactor | 4 | 0.667 | 0.533 | EGF_2 (PF07974, IPR013111): EGF-like domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain cEGF (PF12662, IPR026823): Complement Clr-like EGF-like EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain |
49 |
EPOR | oncoprotein | 16 | 0.508 | 19.616 | EpoR_lig-bind (PF09067, IPR015152): Erythropoietin receptor, ligand binding fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain |
50 |
EPS8 | oncoprotein | 11 | 0.400 | 19.402 | DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator PTB (PF08416, IPR013625): Phosphotyrosine-binding domain SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
51 |
ERBB2 | oncoprotein | 42 | 0.272 | 284.491 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
52 |
ERBB4 | suppressor | 15 | 0.604 | 12.775 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain DUF3951 (PF13131, IPR025028): Protein of unknown function (DUF3951) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
53 |
ERBIN | oncoprotein | 13 | 0.318 | 29.738 | LRR_1 (PF00560, IPR001611): Leucine Rich Repeat Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat |
54 |
FBF1 | interactor | 8 | 0.393 | 12.117 | DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737) OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Sacchrp_dh_NADP (PF03435, IPR005097): Saccharopine dehydrogenase NADP binding domain Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80 Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14 Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family YlqD (PF11068, IPR021297): YlqD protein KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term |
55 |
FCGR2A | interactor | 9 | 0.417 | 12.472 | DUF3827 (PF12877, IPR024606): Domain of unknown function (DUF3827) Ig_2 (PF13895, IPR007110): Immunoglobulin domain ECSCR (PF15820, IPR026247): Endothelial cell-specific chemotaxis regulator |
56 |
FGFR2 | oncoprotein | 10 | 0.361 | 11.785 | Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain |
57 |
FGR | oncoprotein | 8 | 0.714 | 1.354 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
58 |
FLOT1 | interactor | 12 | 0.227 | 33.090 | CrtC (PF07143, IPR010791): CrtC N-terminal lipocalin domain Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family Flot (PF15975, IPR031905): Flotillin |
59 |
FLT1 | oncoprotein | 5 | 0.700 | 0.972 | C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain |
60 |
FLT3 | suppressor | 5 | 0.667 | 0.444 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ig_3 (PF13927): Immunoglobulin domain EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain |
61 |
FRS2 | interactor | 12 | 0.439 | 18.296 | IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) |
62 |
FRS3 | suppressor | 8 | 0.524 | 3.982 | IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) |
63 |
FYB | interactor | 6 | 0.667 | 2.722 | PRP1_N (PF06424, IPR010491): PRP1 splicing factor, N-terminal SH3_2 (PF07653, IPR011511): Variant SH3 domain hSH3 (PF14603, IPR029294): Helically-extended SH3 domain DUF4651 (PF15513, IPR028105): Domain of unknown function (DUF4651) |
64 |
FYN | oncoprotein | 38 | 0.218 | 276.900 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
65 |
GAPDH | oncoprotein | 19 | 0.451 | 40.224 | Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain OstA (PF03968, IPR005653): OstA-like protein |
66 |
GAPVD1 | interactor | 6 | 0.600 | 1.806 | RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase VPS9 (PF02204, IPR003123, SM00167): Vacuolar sorting protein 9 (VPS9) domain |
67 |
GBA | interactor | 5 | 0.600 | 1.519 | Glyco_hydro_30 (PF02055, IPR001139): Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_30C (PF17189): Glycosyl hydrolase family 30 beta sandwich domain |
68 |
GIF | interactor | 2 | 1.000 | 0 | Cobalamin_bind (PF01122, IPR002157): Eukaryotic cobalamin-binding protein Gemini_AL3 (PF01407, IPR000657): Geminivirus AL3 protein DUF4430 (PF14478, IPR027954): Domain of unknown function (DUF4430) |
69 |
GRAP2 | interactor | 14 | 0.341 | 23.684 | NADH_dhqG_C (PF09326, IPR015405): NADH-ubiquinone oxidoreductase subunit G, C-terminal SH2 (PF00017, IPR000980, SM00252): SH2 domain DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076) SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
70 |
GRB2 | oncoprotein | 109 | 0.144 | 2804.427 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093) |
71 |
HCK | oncoprotein | 16 | 0.392 | 26.571 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
72 |
HRAS | oncoprotein | 9 | 0.361 | 13.644 | Ras (PF00071, IPR001806, SM00173): Ras family |
73 |
HSPA1B | interactor | 14 | 0.549 | 12.280 | HSP70 (PF00012, IPR013126): Hsp70 protein |
74 |
HSPA1L | interactor | 13 | 0.551 | 9.473 | HSP70 (PF00012, IPR013126): Hsp70 protein |
75 |
HSPA4 | interactor | 23 | 0.225 | 124.581 | Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5 |
76 |
HSPA5 | oncoprotein | 28 | 0.393 | 78.147 | HSP70 (PF00012, IPR013126): Hsp70 protein |
77 |
HSPA6 | interactor | 11 | 0.691 | 4.166 | HSP70 (PF00012, IPR013126): Hsp70 protein |
78 |
HSPA8 | oncoprotein | 34 | 0.355 | 156.864 | HSP70 (PF00012, IPR013126): Hsp70 protein |
79 |
HSPA9 | oncoprotein | 12 | 0.742 | 3.165 | HSP70 (PF00012, IPR013126): Hsp70 protein |
80 |
HTR2A | interactor | 2 | 1.000 | 0 | 7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) MscL (PF01741, IPR001185): Large-conductance mechanosensitive channel, MscL |
81 |
IGF1R | oncoprotein | 16 | 0.575 | 13.874 | fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain |
82 |
IL7R | interactor | 5 | 0.500 | 2.156 | fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain |
83 |
INPP5D | interactor | 16 | 0.533 | 14.384 | Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family SH2 (PF00017, IPR000980, SM00252): SH2 domain |
84 |
INPPL1 | oncoprotein | 44 | 0.288 | 296.197 | Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SH2 (PF00017, IPR000980, SM00252): SH2 domain |
85 |
IQGAP1 | interactor | 32 | 0.278 | 185.170 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF87 (PF01935, IPR002789): Domain of unknown function DUF87 IDEAL (PF08858, IPR014957, SM00914): IDEAL domain IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase RasGAP_C (PF03836, IPR000593): RasGAP C-terminus WW (PF00397, IPR001202, SM00456): WW domain |
86 |
IRF1 | suppressor | 2 | 1.000 | 0 | IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor |
87 |
IRF8 | suppressor | 4 | 0.667 | 1.000 | IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3 |
88 |
IRS1 | interactor | 21 | 0.424 | 44.556 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain |
89 |
ITCH | interactor | 23 | 0.203 | 129.070 | C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) |
90 |
ITGA4 | interactor | 38 | 0.222 | 255.573 | FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha |
91 |
ITGA5 | suppressor | 3 | 0.667 | 1.000 | FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella |
92 |
ITGAV | suppressor | 7 | 0.381 | 5.275 | FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Collectrin (PF16959, IPR031588): Renal amino acid transporter |
93 |
ITK | oncoprotein | 11 | 0.756 | 1.902 | BTK (PF00779, IPR001562, SM00107): BTK motif PH (PF00169, IPR001849, SM00233): PH domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
94 |
ITSN1 | interactor | 14 | 0.333 | 28.440 | C2 (PF00168, IPR000008, SM00239): C2 domain VIT1 (PF01988, IPR008217): VIT family DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) FmdE (PF02663, IPR003814): FmdE, Molybdenum formylmethanofuran dehydrogenase operon GSH_synthase (PF03199, IPR004887): Eukaryotic glutathione synthase RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) SH3_9 (PF14604, IPR001452): Variant SH3 domain DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748) INTAP (PF16617): Intersectin and clathrin adaptor AP2 binding region PH_13 (PF16652, IPR001849): Pleckstrin homology domain |
95 |
ITSN2 | protein found in more fusions | 8 | 0.619 | 4.033 | C2 (PF00168, IPR000008, SM00239): C2 domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) SH3_9 (PF14604, IPR001452): Variant SH3 domain MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26 VIR_N (PF15912, IPR031801): Virilizer, N-terminal PH_13 (PF16652, IPR001849): Pleckstrin homology domain |
96 |
KDR | oncoprotein | 8 | 0.679 | 3.741 | Ehrlichia_rpt (PF09528, IPR019048): Ehrlichia tandem repeat (Ehrlichia_rpt) Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain |
97 |
KIT | oncoprotein | 19 | 0.433 | 34.721 | ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain |
98 |
KRT1 | interactor | 14 | 0.736 | 5.312 | Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region Keratin_2_head (PF16208, IPR032444): Keratin type II head Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail |
99 |
KRT10 | interactor | 14 | 0.714 | 6.840 | Filament (PF00038, IPR001664): Intermediate filament protein FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 |
100 |
KRT14 | interactor | 11 | 0.709 | 5.090 | Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region Keratin_2_head (PF16208, IPR032444): Keratin type II head |
101 |
KRT16 | interactor | 10 | 0.889 | 0.630 | Filament (PF00038, IPR001664): Intermediate filament protein zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein Keratin_2_head (PF16208, IPR032444): Keratin type II head |
102 |
KRT17 | interactor | 9 | 0.806 | 1.571 | DUF1798 (PF08807, IPR014913): Bacterial domain of unknown function (DUF1798) Filament (PF00038, IPR001664): Intermediate filament protein |
103 |
KRT18 | interactor | 8 | 0.429 | 6.880 | Filament (PF00038, IPR001664): Intermediate filament protein Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein |
104 |
KRT2 | interactor | 11 | 0.873 | 1.357 | Filament (PF00038, IPR001664): Intermediate filament protein Keratin_2_head (PF16208, IPR032444): Keratin type II head |
105 |
KRT3 | interactor | 7 | 0.762 | 3.400 | Filament (PF00038, IPR001664): Intermediate filament protein Keratin_2_head (PF16208, IPR032444): Keratin type II head |
106 |
KRT5 | interactor | 15 | 0.648 | 17.041 | Filament (PF00038, IPR001664): Intermediate filament protein Keratin_2_head (PF16208, IPR032444): Keratin type II head |
107 |
KRT6A | interactor | 7 | 0.810 | 0.713 | Filament (PF00038, IPR001664): Intermediate filament protein Keratin_2_head (PF16208, IPR032444): Keratin type II head |
108 |
KRT6B | interactor | 4 | 1.000 | 0 | Filament (PF00038, IPR001664): Intermediate filament protein Keratin_2_head (PF16208, IPR032444): Keratin type II head |
109 |
KRT6C | interactor | 3 | 1.000 | 0 | Filament (PF00038, IPR001664): Intermediate filament protein Keratin_2_head (PF16208, IPR032444): Keratin type II head |
110 |
KRT79 | interactor | 5 | 0.900 | 0.067 | Filament (PF00038, IPR001664): Intermediate filament protein Keratin_2_head (PF16208, IPR032444): Keratin type II head |
111 |
KRT84 | interactor | 1 | 0 | 0 | Filament (PF00038, IPR001664): Intermediate filament protein Keratin_2_head (PF16208, IPR032444): Keratin type II head |
112 |
KRT9 | interactor | 10 | 0.822 | 0.883 | Filament (PF00038, IPR001664): Intermediate filament protein FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 |
113 |
LAT | interactor | 19 | 0.480 | 36.569 | LAT (PF15234, IPR008359): Linker for activation of T-cells |
114 |
LCK | oncoprotein | 27 | 0.240 | 131.489 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
115 |
LCP2 | interactor | 20 | 0.447 | 42.107 | SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SDA1 (PF05285, IPR007949): SDA1 SH2 (PF00017, IPR000980, SM00252): SH2 domain |
116 |
LOX | suppressor | 3 | 1.000 | 0 | Lysyl_oxidase (PF01186, IPR001695): Lysyl oxidase |
117 |
LRIG1 | suppressor | 5 | 0.800 | 0.533 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRR_2 (PF07723, IPR013101): Leucine Rich Repeat LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat Ig_3 (PF13927): Immunoglobulin domain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain |
118 |
LTK | interactor | 3 | 0.667 | 0.095 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Gly_rich (PF12810): Glycine rich protein FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site |
119 |
LYN | oncoprotein | 27 | 0.283 | 101.119 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
120 |
MAP3K11 | interactor | 5 | 0.500 | 1.833 | APG6 (PF04111, IPR007243): Autophagy protein Apg6 Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH3_9 (PF14604, IPR001452): Variant SH3 domain |
121 |
MAPK14 | oncoprotein | 11 | 0.311 | 13.947 | Pkinase (PF00069, IPR000719): Protein kinase domain |
122 |
MAPK8 | oncoprotein | 17 | 0.300 | 40.008 | DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530) Pkinase (PF00069, IPR000719): Protein kinase domain |
123 |
MET | oncoprotein | 13 | 0.513 | 11.185 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase PSI (PF01437, IPR002165, SM00423): Plexin repeat Sema (PF01403, IPR001627, SM00630): Sema domain TIG (PF01833, IPR002909): IPT/TIG domain |
124 |
MST1R | suppressor | 12 | 0.576 | 9.781 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase PSI (PF01437, IPR002165, SM00423): Plexin repeat Sema (PF01403, IPR001627, SM00630): Sema domain TIG (PF01833, IPR002909): IPT/TIG domain |
125 |
MYH10 | interactor | 13 | 0.526 | 9.829 | IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) |
126 |
MYH2 | interactor | 3 | 0.667 | 0.333 | IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail XhlA (PF10779, IPR019715): Haemolysin XhlA Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) |
127 |
MYH9 | suppressor | 28 | 0.320 | 131.128 | IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) |
128 |
MYO1C | interactor | 17 | 0.456 | 30.469 | IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) |
129 |
MZF1 | interactor | 1 | 0 | 0 | SCAN (PF02023, IPR003309, SM00431): SCAN domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain |
130 |
NCK1 | oncoprotein | 23 | 0.364 | 61.817 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain |
131 |
NCK2 | interactor | 22 | 0.267 | 81.151 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain |
132 |
NOTCH1 | suppressor | 11 | 0.333 | 17.272 | Ank (PF00023, IPR002110, SM00248): Ankyrin repeat EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_2 (PF07974, IPR013111): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain NOD (PF06816, IPR010660): NOTCH protein NODP (PF07684, IPR011656): NOTCH protein TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit Notch (PF00066, IPR000800, SM00004): LNR domain DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454) hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) |
133 |
NOTCH3 | suppressor | 5 | 0.500 | 4.067 | Ank (PF00023, IPR002110, SM00248): Ankyrin repeat EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain NOD (PF06816, IPR010660): NOTCH protein NODP (PF07684, IPR011656): NOTCH protein Notch (PF00066, IPR000800, SM00004): LNR domain DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454) hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) |
134 |
NPHP1 | interactor | 8 | 0.381 | 5.977 | SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FAM176 (PF14851): FAM176 family Speriolin_N (PF15058, IPR029385): Speriolin N terminus DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746) |
135 |
NTRK1 | oncoprotein | 77 | 0.164 | 1399.528 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain |
136 |
OSTF1 | interactor | 4 | 0.500 | 0.952 | SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) |
137 |
PDGFRA | oncoprotein | 15 | 0.462 | 19.576 | Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ig_3 (PF13927): Immunoglobulin domain LAT (PF15234, IPR008359): Linker for activation of T-cells |
138 |
PIK3CA | oncoprotein | 16 | 0.383 | 39.160 | PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2 PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF2321 (PF10083, IPR016891): Uncharacterized protein conserved in bacteria (DUF2321) PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase |
139 |
PIK3CB | oncoprotein | 11 | 0.691 | 3.827 | PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2 PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain) RWD (PF05773, IPR006575, SM00591): RWD domain PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase Tom37_C (PF11801, IPR019564): Tom37 C-terminal domain DUF4381 (PF14316, IPR025489): Domain of unknown function (DUF4381) |
140 |
PIK3R1 | oncoprotein | 56 | 0.253 | 558.363 | RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain |
141 |
PIK3R2 | oncoprotein | 54 | 0.244 | 481.325 | RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain |
142 |
PIK3R3 | interactor | 20 | 0.458 | 36.613 | SH2 (PF00017, IPR000980, SM00252): SH2 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain |
143 |
PLCG1 | oncoprotein | 30 | 0.317 | 131.936 | C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain PH_12 (PF16457, IPR001849): Pleckstrin homology domain |
144 |
POP1 | interactor | 4 | 1.000 | 0 | POP1 (PF06978, IPR009723): Ribonucleases P/MRP protein subunit POP1 POPLD (PF08170, IPR012590): POPLD (NUC188) domain |
145 |
PRKCA | interactor | 6 | 1.000 | 0 | C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
146 |
PRKCQ | interactor | 7 | 0.533 | 3.252 | Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
147 |
PRPSAP2 | interactor | 4 | 0.833 | 0.182 | Pribosyltran_N (PF13793, IPR029099): N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth (PF14572, IPR005946): Phosphoribosyl synthetase-associated domain |
148 |
PSMC1 | interactor | 7 | 0.524 | 4.142 | AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) DivIC (PF04977, IPR007060): Septum formation initiator DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815) Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain |
149 |
PSMC5 | protein found in more fusions | 11 | 0.444 | 13.869 | AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) Laminin_II (PF06009, IPR010307): Laminin Domain II RILP (PF11461, IPR021563): Rab interacting lysosomal protein AAA_16 (PF13191): AAA ATPase domain |
150 |
PTEN | suppressor | 29 | 0.145 | 204.569 | DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein |
151 |
PTK2 | protein found in more fusions | 37 | 0.343 | 157.453 | FERM_M (PF00373, IPR019748): FERM central domain Focal_AT (PF03623, IPR005189): Focal adhesion targeting region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein |
152 |
PTK2B | interactor | 22 | 0.395 | 58.414 | FERM_M (PF00373, IPR019748): FERM central domain Focal_AT (PF03623, IPR005189): Focal adhesion targeting region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase |
153 |
PTPN11 | suppressor | 31 | 0.354 | 125.252 | SH2 (PF00017, IPR000980, SM00252): SH2 domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase |
154 |
PTPN22 | interactor | 10 | 0.472 | 8.641 | Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase |
155 |
PTPN6 | suppressor | 22 | 0.394 | 61.729 | SH2 (PF00017, IPR000980, SM00252): SH2 domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase PolyA_pol_arg_C (PF12626, IPR025866): Polymerase A arginine-rich C-terminus |
156 |
PXN | oncoprotein | 22 | 0.398 | 49.291 | LIM (PF00412, IPR001781, SM00132): LIM domain Paxillin (PF03535): Paxillin family |
157 |
RAPGEF1 | oncoprotein | 9 | 0.806 | 1.246 | RasGEF (PF00617, IPR001895, SM00147): RasGEF domain RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif |
158 |
RET | oncoprotein | 13 | 0.667 | 9.038 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Cadherin (PF00028, IPR002126, SM00112): Cadherin domain |
159 |
RPS19 | interactor | 8 | 0.714 | 1.247 | Ribosomal_S19e (PF01090, IPR001266): Ribosomal protein S19e |
160 |
SERPINA5 | interactor | 2 | 1.000 | 0 | Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor) |
161 |
SFN | suppressor | 22 | 0.319 | 64.790 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
162 |
SH2B2 | oncoprotein | 9 | 0.679 | 2.602 | PH (PF00169, IPR001849, SM00233): PH domain Phe_ZIP (PF08916, IPR015012): Phenylalanine zipper SH2 (PF00017, IPR000980, SM00252): SH2 domain |
163 |
SH3BP2 | oncoprotein | 14 | 0.538 | 15.153 | PH (PF00169, IPR001849, SM00233): PH domain SH2 (PF00017, IPR000980, SM00252): SH2 domain |
164 |
SH3GL2 | oncoprotein | 10 | 0.472 | 10.119 | BAR (PF03114, IPR004148, SM00721): BAR domain SH3_2 (PF07653, IPR011511): Variant SH3 domain |
165 |
SH3GL3 | interactor | 7 | 0.533 | 5.119 | BAR (PF03114, IPR004148, SM00721): BAR domain SH3_2 (PF07653, IPR011511): Variant SH3 domain |
166 |
SH3KBP1 | protein found in more fusions | 38 | 0.269 | 255.699 | Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein SH3_9 (PF14604, IPR001452): Variant SH3 domain |
167 |
SHC1 | oncoprotein | 73 | 0.187 | 993.276 | PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017, IPR000980, SM00252): SH2 domain |
168 |
SIRT2 | suppressor | 4 | 0.500 | 1.619 | SIR2 (PF02146, IPR003000): Sir2 family RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding |
169 |
SLA | interactor | 10 | 0.533 | 9.494 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
170 |
SLA2 | interactor | 6 | 0.533 | 5.071 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
171 |
SMAD3 | oncoprotein | 17 | 0.242 | 55.849 | MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain |
172 |
SMAD7 | interactor | 8 | 0.464 | 10.456 | MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain |
173 |
SNX18 | interactor | 5 | 0.600 | 1.230 | PX (PF00787, IPR001683, SM00312): PX domain BAR_3_WASP_bdg (PF10456, IPR019497): WASP-binding domain of Sorting nexin protein SH3_9 (PF14604, IPR001452): Variant SH3 domain |
174 |
SORBS1 | interactor | 13 | 0.372 | 23.870 | SH3_2 (PF07653, IPR011511): Variant SH3 domain Sorb (PF02208, IPR003127, SM00459): Sorbin homologous domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain SCAB-ABD (PF16711, IPR032012): Actin-binding domain of plant-specific actin-binding protein |
175 |
SORBS2 | oncoprotein | 16 | 0.362 | 31.508 | Sorb (PF02208, IPR003127, SM00459): Sorbin homologous domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain |
176 |
SORBS3 | interactor | 5 | 0.500 | 2.333 | Sorb (PF02208, IPR003127, SM00459): Sorbin homologous domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain |
177 |
SOS1 | oncoprotein | 30 | 0.322 | 130.369 | Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 PH (PF00169, IPR001849, SM00233): PH domain RasGEF (PF00617, IPR001895, SM00147): RasGEF domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif |
178 |
SP7 | interactor | 2 | 1.000 | 0 | zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain |
179 |
SPRY1 | interactor | 8 | 0.536 | 4.037 | PAP1 (PF08601, IPR013910): Transcription factor PAP1 Sprouty (PF05210, IPR007875): Sprouty protein (Spry) |
180 |
SPRY2 | suppressor | 15 | 0.264 | 42.484 | KAR9 (PF08580, IPR013889): Yeast cortical protein KAR9 Sprouty (PF05210, IPR007875): Sprouty protein (Spry) |
181 |
SPRY4 | suppressor | 3 | 1.000 | 0 | Sprouty (PF05210, IPR007875): Sprouty protein (Spry) |
182 |
SPTA1 | interactor | 7 | 0.476 | 3.433 | EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat SH3_1 (PF00018, IPR001452, SM00326): SH3 domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
183 |
SPTAN1 | oncoprotein | 14 | 0.582 | 12.781 | EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Tetrabrachion (PF11401, IPR021535): Tetrabrachion EF-hand_7 (PF13499, IPR011992): EF-hand domain pair E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain |
184 |
SPTBN1 | suppressor | 14 | 0.571 | 14.784 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2 DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) Spectrin (PF00435, IPR002017): Spectrin repeat PH_9 (PF15410): Pleckstrin homology domain |
185 |
SRC | oncoprotein | 39 | 0.306 | 207.815 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
186 |
SSFA2 | interactor | 8 | 0.607 | 2.942 | KRAP_IP3R_bind (PF14722, IPR029325): Ki-ras-induced actin-interacting protein-IP3R-interacting domain SSFA2_C (PF14723, IPR029326): Sperm-specific antigen 2 C-terminus |
187 |
STAP2 | interactor | 4 | 0.667 | 0.404 | SH2 (PF00017, IPR000980, SM00252): SH2 domain |
188 |
STAT3 | suppressor | 27 | 0.338 | 93.607 | SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain |
189 |
STAT5A | suppressor | 12 | 0.455 | 14.875 | SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain |
190 |
SYK | suppressor | 40 | 0.313 | 192.958 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain |
191 |
SYNM | suppressor | 4 | 0.667 | 0.619 | Filament (PF00038, IPR001664): Intermediate filament protein CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167 |
192 |
TCN1 | interactor | 1 | 0 | 0 | Cobalamin_bind (PF01122, IPR002157): Eukaryotic cobalamin-binding protein DUF4430 (PF14478, IPR027954): Domain of unknown function (DUF4430) |
193 |
TCN2 | interactor | 1 | 0 | 0 | Cobalamin_bind (PF01122, IPR002157): Eukaryotic cobalamin-binding protein DUF4430 (PF14478, IPR027954): Domain of unknown function (DUF4430) |
194 |
TEK | oncoprotein | 1 | 0 | 0 | EGF_2 (PF07974, IPR013111): EGF-like domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ig_Tie2_1 (PF10430, IPR018941): Tie-2 Ig-like domain 1 Ig_3 (PF13927): Immunoglobulin domain Pur_ac_phosph_N (PF16656, IPR015914): Purple acid Phosphatase, N-terminal domain |
195 |
TGFBR2 | suppressor | 15 | 0.314 | 43.099 | ecTbetaR2 (PF08917, IPR015013): Transforming growth factor beta receptor 2 ectodomain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase |
196 |
TGM2 | protein found in more fusions | 8 | 0.476 | 4.483 | Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain Transglut_N (PF00868, IPR001102): Transglutaminase family Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily |
197 |
TNFRSF10A | suppressor | 2 | 1.000 | 0 | Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region TMIE (PF16038, IPR032006): TMIE protein |
198 |
TNFRSF10B | suppressor | 6 | 0.667 | 4.333 | Death (PF00531, IPR000488, SM00005): Death domain RskA (PF10099, IPR018764): Anti-sigma-K factor rskA TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region |
199 |
TNFRSF1A | oncoprotein | 14 | 0.551 | 12.970 | Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region |
200 |
TNS4 | interactor | 4 | 0.833 | 0.222 | PTB (PF08416, IPR013625): Phosphotyrosine-binding domain SH2 (PF00017, IPR000980, SM00252): SH2 domain |
201 |
TRAF4 | oncoprotein | 8 | 0.381 | 7.286 | MATH (PF00917, IPR002083, SM00061): MATH domain Sina (PF03145, IPR018121): Seven in absentia protein family zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger |
202 |
TRIM21 | interactor | 10 | 0.472 | 14.071 | DUF313 (PF03754, IPR005508): Domain of unknown function (DUF313) SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain Prok-RING_1 (PF14446): Prokaryotic RING finger family 1 zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING |
203 |
TRIM8 | interactor | 9 | 0.393 | 10.700 | dCache_2 (PF08269, IPR004010, SM01049): Cache domain CASP_C (PF08172, IPR012955): CASP C terminal zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger Zn_ribbon_recom (PF13408, IPR025827): Recombinase zinc beta ribbon domain zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING |
204 |
TRPV1 | oncoprotein | 4 | 1.000 | 0 | Ion_trans (PF00520, IPR005821): Ion transport protein Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) |
205 |
TUBA1A | oncoprotein | 20 | 0.421 | 42.594 | Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain |
206 |
TUBA1C | interactor | 17 | 0.478 | 26.694 | Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain |
207 |
TUBA4B | interactor | 9 | 0.861 | 0.936 | Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain |
208 |
TUBB | interactor | 29 | 0.406 | 85.980 | Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain |
209 |
TUBB4B | interactor | 18 | 0.542 | 20.183 | Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain |
210 |
TYK2 | interactor | 11 | 0.311 | 16.241 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase |
211 |
UBASH3A | interactor | 8 | 0.667 | 3.138 | His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1) UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Ste5 (PF11610, IPR021651): Scaffold protein Ste5-Fus5 binding region SH3_9 (PF14604, IPR001452): Variant SH3 domain |
212 |
UBASH3B | interactor | 46 | 0.230 | 376.170 | His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1) UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain 2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily SH3_9 (PF14604, IPR001452): Variant SH3 domain |
213 |
UBC | protein found in more fusions | 38 | 0.237 | 304.969 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
214 |
UBE2D1 | interactor | 11 | 0.489 | 10.383 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
215 |
UBE2D2 | oncoprotein | 14 | 0.385 | 30.921 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
216 |
UBE2D3 | interactor | 8 | 0.429 | 5.238 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
217 |
UBE2L3 | interactor | 11 | 0.400 | 16.756 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
218 |
UBE2M | interactor | 4 | 0.667 | 0.500 | UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
219 |
UBE4B | suppressor | 8 | 0.429 | 7.119 | DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region Ufd2P_core (PF10408, IPR019474): Ubiquitin elongating factor core U-box (PF04564, IPR003613, SM00504): U-box domain DUF4568 (PF15132, IPR027919): Domain of unknown function (DUF4568) |
220 |
USP21 | interactor | 5 | 0.500 | 1.486 | UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase |
221 |
VAV1 | oncoprotein | 29 | 0.337 | 126.965 | PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH2 (PF00017, IPR000980, SM00252): SH2 domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) SH3_1 (PF00018, IPR001452, SM00326): SH3 domain CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain |
222 |
VAV2 | oncoprotein | 12 | 0.439 | 19.262 | PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain CotJB (PF12652, IPR024207): CotJB protein |
223 |
VIM | suppressor | 13 | 0.394 | 20.128 | Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region |
224 |
WAS | oncoprotein | 22 | 0.338 | 66.156 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain WH1 (PF00568, IPR000697, SM00461): WH1 domain WH2 (PF02205, IPR003124, SM00246): WH2 motif PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
225 |
XPO1 | interactor | 29 | 0.278 | 156.598 | CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region |
226 |
XRCC5 | suppressor | 10 | 0.389 | 12.744 | Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain Ku_PK_bind (PF08785, IPR014893): Ku C terminal domain like |
227 |
YES1 | oncoprotein | 9 | 0.389 | 8.711 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain YdjC (PF04794, IPR006879): YdjC-like protein SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
228 |
YWHAB | interactor | 24 | 0.417 | 60.461 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor |
229 |
YWHAE | oncoprotein | 28 | 0.299 | 134.185 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
230 |
YWHAH | protein found in more fusions | 15 | 0.604 | 14.256 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
231 |
YWHAQ | interactor | 35 | 0.286 | 226.495 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
232 |
YWHAZ | protein found in more fusions | 28 | 0.362 | 104.648 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
233 |
ZAP70 | interactor | 28 | 0.359 | 111.499 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain |