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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins CBFA2T2 (from a repository: Thu Nov 10 14:59:26 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)26
The number (and %) of the onco-proteins12 (46.15 %)
The number (and %) of the tumor suppressors1 (3.85 %)
Total number of binary PPIs (saturation %)71 (21.85 %)
The number (and %) of affected PPIs26 (36.62 %)
The number of possible different fusions9
PPI diameter2
PPI radius1
The average degree of PPI4.615
Assortativity coefficient-0.2325
The network average Clustering coefficient0.626
The number (and %) of a zero Clustering coefficients4 (15.38 %)
The number (and %) of a zero Betweenness Centrality12 (46.15 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CBFA2T2 All fusions
Proteins found in more fusions RUNX1 (see 1 fusions); CBFA2T2 (see 1 fusions); RUNX1T1 (see 1 fusions); RUNX1/RUNX1T1 (see 21 fusions); ATN1 (see 1 fusions); APP (see 4 fusions); ID3 (see 1 fusions); CBFA2T2/RUNX1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CBFA2T2parental protein260.117457.467NHR2 (PF08788, IPR014896): NHR2 domain like
Remorin_C (PF03763, IPR005516): Remorin, C-terminal region
TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF
zf-MYND (PF01753, IPR002893): MYND finger
BBS1 (PF14779, IPR032728): Ciliary BBSome complex subunit 1
2 APPprotein found in more fusions31.0000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
3 ATN1protein found in more fusions50.5003.000Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
4 ATXN1Linteractor31.0000AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
5 CBFA2T3oncoprotein70.7143.233NHR2 (PF08788, IPR014896): NHR2 domain like
TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF
zf-MYND (PF01753, IPR002893): MYND finger
Efg1 (PF10153, IPR019310): rRNA-processing protein Efg1
PRIMA1 (PF16101): Proline-rich membrane anchor 1
6 FBXL19interactor100AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
F-box (PF00646, IPR001810, SM00256): F-box domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
RbpA (PF13397, IPR025182): RNA polymerase-binding protein
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
PHD_4 (PF16866, IPR019787): PHD-finger
7 GTF2E1interactor21.0000DUF1980 (PF09323, IPR015402): Domain of unknown function (DUF1980)
TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
TFIIE_alpha (PF02002, IPR024550): TFIIE alpha subunit
TFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha
8 HDAC3oncoprotein80.5718.333Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
9 ID3oncoprotein40.6670.667HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
10 LBPinteractor100LBP_BPI_CETP (PF01273, IPR017942, SM00328): LBP / BPI / CETP family, N-terminal domain
LBP_BPI_CETP_C (PF02886, IPR001124, SM00329): LBP / BPI / CETP family, C-terminal domain
11 MDFIinteractor40.6671.000MDFI (PF15316, IPR026134): MyoD family inhibitor
12 NCOR1oncoprotein70.6675.900BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
Hid1 (PF12722): High-temperature-induced dauer-formation protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
RBR (PF17208): RNA binding Region
13 NEUROG1interactor31.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Transformer (PF06495, IPR010519): Fruit fly transformer protein
14 NOTCH3interactor100Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
15 PDP1interactor100PP2C (PF00481, IPR001932): Protein phosphatase 2C
16 PRDM14interactor30.6670.667Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain
SET (PF00856, IPR001214, SM00317): SET domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
17 PRDM6interactor40.6670.500CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
SET (PF00856, IPR001214, SM00317): SET domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
18 REREoncoprotein21.0000Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
POPLD (PF08170, IPR012590): POPLD (NUC188) domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
19 RUNX1oncoprotein80.7622.467Runt (PF00853, IPR013524): Runt domain
RunxI (PF08504, IPR013711): Runx inhibition domain
DUF3037 (PF11236, IPR021398): Protein of unknown function (DUF3037)
20 RUNX1T1oncoprotein120.38229.900NHR2 (PF08788, IPR014896): NHR2 domain like
TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF
zf-MYND (PF01753, IPR002893): MYND finger
DUF3731 (PF12531, IPR021030): DNA-K related protein
21 SIN3Aoncoprotein50.8000.900Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
22 TAL1oncoprotein60.7001.567HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
23 TAL2oncoprotein31.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
24 TCF4suppressor80.39314.400CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
25 TCP1interactor21.0000Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
26 WDYHV1interactor21.0000Nt_Gln_amidase (PF09764, IPR023128): N-terminal glutamine amidase

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