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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)41
The number (and %) of the onco-proteins9 (21.95 %)
The number (and %) of the tumor suppressors3 (7.32 %)
Total number of binary PPIs (saturation %)70 (8.54 %)
The number (and %) of affected PPIs41 (58.57 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI2.878
Assortativity coefficient-0.3783
The network average Clustering coefficient0.346
The number (and %) of a zero Clustering coefficients22 (53.66 %)
The number (and %) of a zero Betweenness Centrality31 (75.61 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CAMK2D All fusions
: AI810957;
Proteins found in more fusions CAMK2D (see 1 fusions); NIN (see 1 fusions); HSP90AA1 (see 2 fusions); ECHS1 (see 1 fusions); MYC (see 1 fusions); HDAC4 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CAMK2Dparental protein410.0241488.667CaMKII_AD (PF08332, IPR013543): Calcium/calmodulin dependent protein kinase II association domain
Pkinase (PF00069, IPR000719): Protein kinase domain
2 ARHGAP25oncoprotein100PH (PF00169, IPR001849, SM00233): PH domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
3 ARL2BPinteractor100ARL2_Bind_BART (PF11527, IPR023379): The ARF-like 2 binding protein BART
4 ARRB2interactor30.6671.000Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
5 BANPsuppressor40.6671.000DUF1845 (PF08900, IPR014996): Domain of unknown function (DUF1845)
BEN (PF10523, IPR018379, SM01025): BEN domain
6 CAMK2Ainteractor40.6671.000CaMKII_AD (PF08332, IPR013543): Calcium/calmodulin dependent protein kinase II association domain
Pkinase (PF00069, IPR000719): Protein kinase domain
7 CDKN1Asuppressor40.6672.000CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
8 CEP170interactor40.5003.000FHA (PF00498, IPR000253, SM00240): FHA domain
DUF4254 (PF14063, IPR025350): Protein of unknown function (DUF4254)
CEP170_C (PF15308, IPR029300): CEP170 C-terminus
9 CEP76interactor40.6672.000Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
CEP76-C2 (PF15627, IPR028926): CEP76 C2 domain
10 CYLDsuppressor21.0000CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-HIT (PF04438, IPR007529): HIT zinc finger
CYLD_phos_site (PF16607): Phosphorylation region of CYLD, unstructured
11 DACT2interactor100Dapper (PF15268, IPR024843): Dapper
12 DNAL4oncoprotein100Dynein_light (PF01221, IPR001372): Dynein light chain type 1
13 ECHS1protein found in more fusions200ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
14 EPHA10interactor21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
15 FAM171Binteractor100DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702)
UPF0560 (PF10577, IPR018890): Uncharacterised protein family UPF0560
TERB2 (PF15101, IPR028065): Telomere-associated protein TERB2
16 FKBP1Binteractor100FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
17 FNDC3Binteractor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Pur_ac_phosph_N (PF16656, IPR015914): Purple acid Phosphatase, N-terminal domain
18 FXR2interactor200Agenet (PF05641, IPR008395, SM00743): Agenet domain
REV (PF00424, IPR000625): REV protein (anti-repression trans-activator protein)
KH_1 (PF00013, IPR004088, SM00322): KH domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
19 HAUS2interactor21.0000DpnII (PF04556, IPR007637): DpnII restriction endonuclease
HAUS2 (PF15003, IPR028346): HAUS augmin-like complex subunit 2
20 HDAC4oncoprotein31.0000Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
21 HNMTinteractor100Methyltransf_23 (PF13489): Methyltransferase domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
22 HSP90AA1oncoprotein80.38112.667HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
23 IFNGR2oncoprotein100Interfer-bind (PF09294, IPR015373): Interferon-alpha/beta receptor, fibronectin type III
Tissue_fac (PF01108, IPR003961): Tissue factor
24 IQCF1interactor100IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
DUF3176 (PF11374, IPR021514): Protein of unknown function (DUF3176)
25 MAGEB4interactor100MAGE (PF01454, IPR002190): MAGE family
Pap_E4 (PF02711, IPR003861): E4 protein
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
26 MOAP1interactor200PNMA (PF14893, IPR026523): PNMA
27 MRPL11interactor100Ribosomal_L11 (PF00298, IPR020783): Ribosomal protein L11, RNA binding domain
Ribosomal_L11_N (PF03946, IPR020784): Ribosomal protein L11, N-terminal domain
28 MYConcoprotein50.5003.000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
29 NDUFA8interactor21.0000CHCH (PF06747, IPR010625): CHCH domain
Pet191_N (PF10203, IPR018793): Cytochrome c oxidase assembly protein PET191
Cdd1 (PF11731, IPR021725): Pathogenicity locus
30 NINoncoprotein31.0000BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DivIC (PF04977, IPR007060): Septum formation initiator
DivIVA (PF05103, IPR007793): DivIVA protein
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
ZapB (PF06005, IPR009252): Cell division protein ZapB
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Rho_Binding (PF08912, IPR015008): Rho Binding
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF2205 (PF10224, IPR019357): Predicted coiled-coil protein (DUF2205)
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
FlxA (PF14282, IPR025577): FlxA-like protein
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
DUF4665 (PF15679, IPR031389): Domain of unknown function (DUF4665)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
31 RPS18interactor21.0000Ribosomal_S13 (PF00416, IPR001892): Ribosomal protein S13/S18
32 RPS4Xinteractor60.4677.667KOW (PF00467, IPR005824, SM00739): KOW motif
Ribosomal_S4e (PF00900, IPR013845): Ribosomal family S4e
RS4NT (PF08071, IPR013843): RS4NT (NUC023) domain
S4 (PF01479, IPR002942, SM00363): S4 domain
40S_S4_C (PF16121, IPR032277): 40S ribosomal protein S4 C-terminus
33 SCRN2interactor100AAT (PF03417, IPR005079): Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase
Peptidase_C69 (PF03577, IPR005322): Peptidase family C69
34 SPATA24interactor100SPATA24 (PF15175, IPR029176): Spermatogenesis-associated protein 24
35 SRPK1interactor21.0000FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
36 TIRAPinteractor200TIR_2 (PF13676, IPR000157): TIR domain
37 TNPO2interactor100Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Dopey_N (PF04118, IPR007249): Dopey, N-terminal
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
DUF2573 (PF10835, IPR020393): Protein of unknown function (DUF2573)
DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
38 TSHRoncoprotein1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRR_5 (PF13306, IPR026906): Leucine rich repeats (6 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
SSFA2_C (PF14723, IPR029326): Sperm-specific antigen 2 C-terminus
39 TTC5interactor21.0000TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
Abi_C (PF14355, IPR026001): Abortive infection C-terminus
TTC5_OB (PF16669, IPR032076): Tetratricopeptide repeat protein 5 OB fold domain
40 WASF3interactor100ChaB (PF06150, IPR009317): ChaB
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
WH2 (PF02205, IPR003124, SM00246): WH2 motif
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
41 WNT4interactor100MEF2_binding (PF09047, IPR015134): MEF2 binding
wnt (PF00110, IPR005817, SM00097): wnt family

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