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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)79
The number (and %) of the onco-proteins14 (17.72 %)
The number (and %) of the tumor suppressors9 (11.39 %)
Total number of binary PPIs (saturation %)279 (9.06 %)
The number (and %) of affected PPIs78 (27.96 %)
The number of possible different fusions14
PPI diameter3
PPI radius2
The average degree of PPI6.506
Assortativity coefficient-0.3818
The network average Clustering coefficient0.431
The number (and %) of a zero Clustering coefficients21 (26.58 %)
The number (and %) of a zero Betweenness Centrality29 (36.71 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: TM9SF4,CALD1 All fusions
: AW993553; AW993667;
Proteins found in more fusions ITSN2 (see 1 fusions); KIF11 (see 1 fusions); HSP90AA1 (see 2 fusions); CALD1/TM9SF4 (see 2 fusions); CALD1/HSP90AA1 (see 1 fusions); CUL7 (see 2 fusions); CSNK2A1 (see 1 fusions); SHC1 (see 1 fusions); ACTN1 (see 3 fusions); CSNK2A1/ELAVL1 (see 1 fusions); RPA1 (see 1 fusions); SACM1L (see 1 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 TM9SF4parental protein440.0272897.643EMP70 (PF02990, IPR004240): Endomembrane protein 70
DUF4229 (PF14012, IPR025323): Protein of unknown function (DUF4229)
2 CALD1parental protein350.1631688.447Caldesmon (PF02029, IPR006018): Caldesmon
DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
3 ABCF2interactor60.33339.285ABC_tran (PF00005, IPR003439): ABC transporter
VIT1 (PF01988, IPR008217): VIT family
Rop (PF01815, IPR000769): Rop protein
ABC_tran_Xtn (PF12848, IPR032781): ABC transporter
AAA_21 (PF13304, IPR003959): AAA domain, putative AbiEii toxin, Type IV TA system
4 ACTN1protein found in more fusions130.33378.706CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Dak2 (PF02734, IPR004007, SM01120): DAK2 domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
5 ARRB1interactor80.35734.545Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
6 ATP1B3interactor21.0000Na_K-ATPase (PF00287, IPR000402): Sodium / potassium ATPase beta chain
7 ATP5Hinteractor21.0000Mt_ATP-synt_D (PF05873, IPR008689): ATP synthase D chain, mitochondrial (ATP5H)
8 CALM1interactor80.60714.195EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
9 CDCA7Linteractor31.0000zf-4CXXC_R1 (PF10497, IPR018866): Zinc-finger domain of monoamine-oxidase A repressor R1
SpoIIIAH (PF12685, IPR024232): SpoIIIAH-like protein
10 CEP44interactor21.0000DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Utp12 (PF04003, IPR007148): Dip2/Utp12 Family
CEP44 (PF15007, IPR029157): Centrosomal spindle body, CEP44
11 CSNK2A1oncoprotein170.317145.708Pkinase (PF00069, IPR000719): Protein kinase domain
12 CUL7protein found in more fusions120.43645.541ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
13 ELAVL1oncoprotein280.145673.389RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
14 EPB41L2interactor21.00004_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD)
Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
DUF966 (PF06136, IPR010369): Domain of unknown function (DUF966)
FA (PF08736, IPR014847): FERM adjacent (FA)
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
SAB (PF04382, IPR007477): SAB domain
TCP (PF03634, IPR005333): TCP family transcription factor
15 ERMP1interactor21.0000DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129)
Peptidase_M28 (PF04389, IPR007484): Peptidase family M28
16 F3interactor31.0000Interfer-bind (PF09294, IPR015373): Interferon-alpha/beta receptor, fibronectin type III
Tissue_fac (PF01108, IPR003961): Tissue factor
TMEM154 (PF15102, IPR028064): TMEM154 protein family
17 FAM162Ainteractor2010.941DUF1075 (PF06388, IPR009432): Protein of unknown function (DUF1075)
18 FCF1interactor207.503Fcf1 (PF04900, IPR006984): Fcf1
19 FHsuppressor205.991Lyase_1 (PF00206, IPR022761): Lyase
FumaraseC_C (PF10415, IPR018951): Fumarase C C-terminus
20 FIGNL1interactor21.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
21 GPSM2interactor100GoLoco (PF02188, IPR003109, SM00390): GoLoco motif
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
22 H1FXinteractor60.20040.813IGPS (PF00218, IPR013798): Indole-3-glycerol phosphate synthase
23 H2AFVinteractor50.40056.793Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
24 HIST1H1Boncoprotein30.6672.450Pneumo_att_G (PF05539, IPR008781): Pneumovirinae attachment membrane glycoprotein G
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
25 HSP90AA1oncoprotein170.325129.306HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
26 IGF2Rsuppressor30.6676.896ATG27 (PF09451, IPR018939): Autophagy-related protein 27
CIMR (PF00878, IPR000479): Cation-independent mannose-6-phosphate receptor repeat
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
27 ISG15suppressor90.33341.438ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
28 ITSN2protein found in more fusions200C2 (PF00168, IPR000008, SM00239): C2 domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26
VIR_N (PF15912, IPR031801): Virilizer, N-terminal
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
29 KDM5Asuppressor100ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
FRG1 (PF06229, IPR010414): FRG1-like domain
JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
JmjN (PF02375, IPR003349, SM00545): jmjN domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
PLU-1 (PF08429, IPR013637): PLU-1-like protein
zf-C5HC2 (PF02928, IPR004198): C5HC2 zinc finger
UPF0542 (PF15086, IPR027877): Uncharacterised protein family UPF0542
30 KIF11protein found in more fusions60.60010.898Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Gag_p17 (PF00540, IPR000071): gag gene protein p17 (matrix protein)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF3510 (PF12022, IPR024603): Domain of unknown function (DUF3510)
Microtub_bind (PF13931, IPR025901): Kinesin-associated microtubule-binding
31 LAMP1interactor21.0000Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
32 LIMA1suppressor160.38381.725LIM (PF00412, IPR001781, SM00132): LIM domain
ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
33 LMAN2interactor70.23841.000Lectin_leg-like (PF03388, IPR005052): Legume-like lectin family
Tad (PF13400, IPR028087): Putative Flp pilus-assembly TadE/G-like
34 LRCH3interactor40.8331.143CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
35 LUZP4interactor70.5333.420Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
36 MKRN2interactor100RecR (PF02132, IPR023628): RecR protein
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
MKRN1_C (PF15815, IPR031644): E3 ubiquitin-protein ligase makorin-1, C-terminal
zf-RING_11 (PF17123, IPR001841): RING-like zinc finger
37 MYH9suppressor210.295232.674IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
38 MYO19interactor40.8330.486IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
39 NEFMinteractor100ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886)
DUF4637 (PF15470, IPR029174): Domain of unknown function (DUF4637)
40 NSMCE2interactor2010.365gpW (PF02831, IPR004174): gpW
zf-Nse (PF11789, IPR004181): Zinc-finger of the MIZ type in Nse subunit
Transpos_assoc (PF13963, IPR029480): Transposase-associated domain
41 NTRK1oncoprotein250.130489.954I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
42 OASLinteractor100PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
SCAN (PF02023, IPR003309, SM00431): SCAN domain
OAS1_C (PF10421, IPR018952): 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
43 OBSL1interactor100.47229.417BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
44 OTUB1interactor50.60010.363Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
45 PAN2interactor120.45574.478RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
46 PHAXinteractor100RNA_GG_bind (PF10258, IPR019385): PHAX RNA-binding domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
47 PHF14interactor100Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
BSP_II (PF05432, IPR008412): Bone sialoprotein II (BSP-II)
C1_2 (PF03107, IPR004146): C1 domain
Ctr (PF04145, IPR007274): Ctr copper transporter family
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
LicD (PF04991, IPR007074): LicD family
PHD (PF00628, IPR019787, SM00249): PHD-finger
Rrp15p (PF07890, IPR012459): Rrp15p
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
zf-PHD-like (PF15446): PHD/FYVE-zinc-finger like domain
48 POT1interactor60.7002.834POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
49 PRKACAinteractor30.6670.610Pkinase (PF00069, IPR000719): Protein kinase domain
50 RAB1Aoncoprotein140.264175.430Ras (PF00071, IPR001806, SM00173): Ras family
51 RIOK3interactor21.0000RIO1 (PF01163, IPR018934): RIO1 family
52 RNF170interactor307.503DpnI (PF06044, IPR010324): Dam-replacing family
DUF1232 (PF06803, IPR010652): Protein of unknown function (DUF1232)
Pkr1 (PF08636, IPR013945): ER protein Pkr1
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-LITAF-like (PF10601, IPR006629, SM00714): LITAF-like zinc ribbon domain
Cys_rich_CPXG (PF14255, IPR025990): Cysteine-rich CPXCG
53 RPA1suppressor160.46766.668Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
54 RPA2oncoprotein130.47461.508RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
55 RPA3interactor110.55623.261Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
56 RPAP3interactor40.33338.794TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
RPAP3_C (PF13877, IPR025986): Potential Monad-binding region of RPAP3
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
57 RPN2interactor30.3333.760Ribophorin_II (PF05817, IPR008814): Oligosaccharyltransferase subunit Ribophorin II
58 S100A6interactor309.683S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
59 SACM1Lprotein found in more fusions302.450DSS1_SEM1 (PF05160, IPR007834): DSS1/SEM1 family
Syja_N (PF02383, IPR002013): SacI homology domain
60 SCAMP3interactor50.40023.133SCAMP (PF04144, IPR007273): SCAMP family
61 SGPL1interactor30.6672.450Pyridoxal_deC (PF00282, IPR002129): Pyridoxal-dependent decarboxylase conserved domain
62 SHC1oncoprotein51.0000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
63 SIRT6suppressor30.33318.261SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
64 SLC25A12interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
65 SP140Linteractor100C1_2 (PF03107, IPR004146): C1 domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
SAND (PF01342, IPR000770, SM00258): SAND domain
HSR (PF03172, IPR004865): HSR domain; Sp100 domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
66 SPCS2interactor100SPC25 (PF06703, IPR009582): Microsomal signal peptidase 25 kDa subunit (SPC25)
67 STX12interactor60.53320.581PEP-utilisers_N (PF05524, IPR008731): PEP-utilising enzyme, N-terminal
SNARE (PF05739, IPR000727, SM00397): SNARE domain
DUF2776 (PF10951, IPR021240): Protein of unknown function (DUF2776)
Syntaxin_2 (PF14523): Syntaxin-like protein
68 STX7interactor41.0000SNARE (PF05739, IPR000727, SM00397): SNARE domain
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
Syntaxin_2 (PF14523): Syntaxin-like protein
69 TACC3oncoprotein31.0000TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
70 TERF1interactor90.57119.089TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
71 TERF2interactor120.49162.702Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif
72 TINF2interactor51.0000TINF2_N (PF14973, IPR029400): TERF1-interacting nuclear factor 2 N-terminus
73 TMED2interactor40.6670.906EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
74 TMEM161Ainteractor100Tmemb_161AB (PF10268, IPR019395): Predicted transmembrane protein 161AB
75 TMX2interactor100Thioredoxin (PF00085, IPR013766): Thioredoxin
76 TP53suppressor140.47477.659DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
77 UQCRFS1interactor100Rieske (PF00355, IPR017941): Rieske [2Fe-2S] domain
Ubiq-Cytc-red_N (PF09165, IPR015248): Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region
78 ZC3H15interactor60.40039.206zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
Torus (PF16131, IPR032297): Torus domain
DFRP_C (PF16543, IPR032378): DRG Family Regulatory Proteins, Tma46
79 ZNF800interactor21.0000Mucin (PF01456, IPR000458): Mucin-like glycoprotein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2H2_11 (PF16622, IPR007087): zinc-finger C2H2-type
zf-C2H2_assoc2 (PF16624): Unstructured region upstream of a zinc-finger

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