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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins C3, MT1G (from a repository: Thu Nov 10 14:59:26 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)25
The number (and %) of the onco-proteins4 (16.00 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)36 (12.00 %)
The number (and %) of affected PPIs23 (63.89 %)
The number of possible different fusions2
PPI diameter2
PPI radiusinf
The average degree of PPI2.560
Assortativity coefficient-0.2984
The network average Clustering coefficient0.358
The number (and %) of a zero Clustering coefficients14 (56.00 %)
The number (and %) of a zero Betweenness Centrality21 (84.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: C3,MT1G All fusions
: AF074681; AI110774;
Proteins found in more fusions TGM2 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 C3parental protein210.043393.000A2M (PF00207, IPR001599): Alpha-2-macroglobulin family
A2M_comp (PF07678, IPR011626): A-macroglobulin complement component
A2M_N (PF01835, IPR002890): MG2 domain
A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region
A2M_recep (PF07677, IPR009048): A-macroglobulin receptor
ANATO (PF01821, IPR000020, SM00104): Anaphylotoxin-like domain
NTR (PF01759, IPR018933, SM00206): UNC-6/NTR/C345C module
Thiol-ester_cl (PF10569, IPR019565): Alpha-macro-globulin thiol-ester bond-forming region
2 MT1Gparental protein202.000Metallothio (PF00131, IPR003019): Metallothionein
3 ASCC1interactor100AKAP7_NLS (PF10469, IPR019510): AKAP7 2'5' RNA ligase-like domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
4 C5interactor100A2M (PF00207, IPR001599): Alpha-2-macroglobulin family
A2M_comp (PF07678, IPR011626): A-macroglobulin complement component
A2M_N (PF01835, IPR002890): MG2 domain
A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region
A2M_recep (PF07677, IPR009048): A-macroglobulin receptor
ANATO (PF01821, IPR000020, SM00104): Anaphylotoxin-like domain
NTR (PF01759, IPR018933, SM00206): UNC-6/NTR/C345C module
DUF4369 (PF14289, IPR025380): Domain of unknown function (DUF4369)
5 CFBinteractor50.4006.000VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Trypsin (PF00089, IPR001254, SM00020): Trypsin
6 CFHinteractor100DUF1962 (PF09227, IPR015308): Domain of unknown function (DUF1962)
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
7 CFHR3interactor100Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
8 CFHR4interactor200Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
9 CFHR5interactor100DUF1962 (PF09227, IPR015308): Domain of unknown function (DUF1962)
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
10 CFIinteractor100SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Trypsin (PF00089, IPR001254, SM00020): Trypsin
VERL (PF11386, IPR021526): Vitelline envelope receptor for lysin
11 CFPoncoprotein21.0000TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
12 CPN1interactor100Peptidase_M14 (PF00246, IPR000834, SM00631): Zinc carboxypeptidase
CarboxypepD_reg (PF13620): Carboxypeptidase regulatory-like domain
13 DDX19Binteractor21.0000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
14 FN1oncoprotein40.5003.000fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
15 GDPD1interactor21.0000GDPD (PF03009, IPR004129): Glycerophosphoryl diester phosphodiesterase family
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
16 HNRNPA1interactor31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
17 ITGAXinteractor100FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
FG-GAP_2 (PF14312, IPR013517): FG-GAP repeat
18 ITGB2interactor100EGF_2 (PF07974, IPR013111): EGF-like domain
Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain
Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain
PSI_integrin (PF17205): Integrin plexin domain
19 MED20interactor31.0000Med20 (PF08612, IPR013921): TATA-binding related factor (TRF) of subunit 20 of Mediator complex
20 MED23interactor31.0000Med23 (PF11573, IPR021629): Mediator complex subunit 23
21 MED4interactor31.0000Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
22 RAD21interactor100Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein
Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
23 SHBGoncoprotein200Laminin_G_1 (PF00054, IPR001791): Laminin G domain
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
24 SPINK7interactor100Kazal_1 (PF00050, IPR002350): Kazal-type serine protease inhibitor domain
25 TGM2protein found in more fusions31.0000Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily

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