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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SFTPC, C15orf57 (from a repository: Wed Dec 7 13:23:31 2016)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)18
The number (and %) of the onco-proteins4 (22.22 %)
The number (and %) of the tumor suppressors1 (5.56 %)
Total number of binary PPIs (saturation %)37 (24.18 %)
The number (and %) of affected PPIs17 (45.95 %)
The number of possible different fusions6
PPI diameter5
PPI radius3
The average degree of PPI3.111
Assortativity coefficient-0.2211
The network average Clustering coefficient0.426
The number (and %) of a zero Clustering coefficients7 (38.89 %)
The number (and %) of a zero Betweenness Centrality10 (55.56 %)


List of the fusions

PPI for parental proteins: C15orf57,SFTPC All fusions
: BG529836;
Proteins found in more fusions HSPB1 (see 4 fusions); VCP (see 4 fusions); NEDD4 (see 1 fusions); SFTPC (see 1 fusions); WWP1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 C15orf57parental protein2032.000CCDC32 (PF14989, IPR028039): Coiled-coil domain containing 32
2 SFTPCparental protein150.099203.667BRICHOS (PF04089, IPR007084, SM01039): BRICHOS domain
SP_C-Propep (PF08999, IPR015091): Surfactant protein C, N terminal propeptide
3 CXCL9interactor21.0000MRP-S27 (PF10037, IPR019266): Mitochondrial 28S ribosomal protein S27
IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
SNARE (PF05739, IPR000727, SM00397): SNARE domain
VasL (PF12486, IPR021069): Type VI secretion system, EvfB, or VasL
4 DNAJB9interactor31.0000DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
5 DNAJC10interactor31.0000DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
6 HSPA5oncoprotein70.46733.667HSP70 (PF00012, IPR013126): Hsp70 protein
7 HSPB1oncoprotein50.16762.000HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
8 NEDD4suppressor200Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
9 POT1interactor200POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
10 PQBP1interactor100WW (PF00397, IPR001202, SM00456): WW domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
11 SEC22Ainteractor30.6671.000Longin (PF13774, IPR010908): Regulated-SNARE-like domain
12 SEC61Ginteractor100SecE (PF00584, IPR001901): SecE/Sec61-gamma subunits of protein translocation complex
13 SYNE4interactor30.6671.000KASH (PF10541, IPR012315): Nuclear envelope localisation domain
14 TMEM67interactor21.0000Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
Tme5_EGF_like (PF09064, IPR015149): Thrombomodulin like fifth domain, EGF-like
Meckelin (PF09773, IPR019170): Meckelin (Transmembrane protein 67)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
15 TMEM79interactor31.0000MAPEG (PF01124, IPR001129): MAPEG family
16 VCPprotein found in more fusions60.60024.667AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
17 WWP1oncoprotein3018.000C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
18 WWP2interactor200WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)

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