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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins BUB1 (from a repository: Thu Nov 17 02:16:06 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)39
The number (and %) of the onco-proteins15 (38.46 %)
The number (and %) of the tumor suppressors4 (10.26 %)
Total number of binary PPIs (saturation %)167 (22.54 %)
The number (and %) of affected PPIs39 (23.35 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI7.692
Assortativity coefficient-0.3054
The network average Clustering coefficient0.625
The number (and %) of a zero Clustering coefficients5 (12.82 %)
The number (and %) of a zero Betweenness Centrality12 (30.77 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: BUB1 All fusions
: BG403632;
Proteins found in more fusions ARIH2 (see 2 fusions); BUB1 (see 1 fusions); NDC80 (see 1 fusions); UBR5 (see 4 fusions); APC (see 1 fusions); RBPMS (see 2 fusions); SNW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BUB1parental protein390.159898.852Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
Pkinase (PF00069, IPR000719): Protein kinase domain
2 APCsuppressor51.0000APC_15aa (PF05972, IPR009240): APC 15 residue motif
APC_basic (PF05956, IPR009234): APC basic domain
APC_r (PF05923): APC repeat
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EB1_binding (PF05937, IPR009232): EB-1 Binding Domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
SAMP (PF05924, IPR009224): SAMP Motif
Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4
Arm_APC_u3 (PF16629): Armadillo-associated region on APC
APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs
APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions
APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP
APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
3 ARIH2protein found in more fusions200IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zinc_ribbon_12 (PF11331, IPR021480): Probable zinc-ribbon domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
4 BPTFinteractor100Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II
CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
DDT (PF02791, IPR004022, SM00571): DDT domain
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
GRP (PF07172, IPR010800): Glycine rich protein family
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
PHD (PF00628, IPR019787, SM00249): PHD-finger
SDA1 (PF05285, IPR007949): SDA1
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
WHIM1 (PF15612, IPR028942): WSTF, HB1, Itc1p, MBD9 motif 1
WSD (PF15613, IPR028941): Williams-Beuren syndrome DDT (WSD), D-TOX E motif
CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
5 BUB1Boncoprotein200.39272.619Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
Mad3_BUB1_II (PF08171, IPR012572): Mad3/BUB1 homology region 2
Pkinase (PF00069, IPR000719): Protein kinase domain
XhlA (PF10779, IPR019715): Haemolysin XhlA
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
6 BUB3interactor90.6117.686WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
7 CDC20oncoprotein120.45519.533WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
8 CDC5Linteractor140.44928.786OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
9 CDK1oncoprotein60.6002.452Pkinase (PF00069, IPR000719): Protein kinase domain
10 CDK2suppressor80.4769.500Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
11 CDKN2AIPinteractor31.0000XTBD (PF11952, IPR021859): XRN-Two Binding Domain, XTBD
12 CENPEinteractor50.6672.000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
VIT1 (PF01988, IPR008217): VIT family
DUF1515 (PF07439, IPR010889): Protein of unknown function (DUF1515)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ZapB (PF06005, IPR009252): Cell division protein ZapB
Fez1 (PF06818): Fez1
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
IncA (PF04156, IPR007285): IncA protein
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pepsin-I3 (PF06394, IPR010480): Pepsin inhibitor-3-like repeated domain
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
TrbI_Ftype (PF09677, IPR014115): Type-F conjugative transfer system protein (TrbI_Ftype)
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
AAA_13 (PF13166, IPR026866): AAA domain
DUF4023 (PF13215, IPR025097): Protein of unknown function (DUF4023)
HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
T3SSipB (PF16535, IPR032391): Type III cell invasion protein SipB
13 CRKoncoprotein100SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
14 DSN1interactor130.65415.900MIS13 (PF08202, IPR013218): Mis12-Mtw1 protein family
15 EIF4EBP1oncoprotein100eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
16 HDAC1suppressor51.0000FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
17 HPS5interactor100ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
18 KIF26Binteractor31.0000Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
Microtub_bd (PF16796, IPR031852): Microtubule binding
19 KNL1oncoprotein130.69212.833DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
20 MAD2L1oncoprotein70.7332.333HORMA (PF02301, IPR003511): HORMA domain
21 MIS12interactor100.9560.500DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
Mis12 (PF05859, IPR008685): Mis12 protein
22 MLF1oncoprotein51.0000Mlf1IP (PF10248, IPR019376): Myelodysplasia-myeloid leukemia factor 1-interacting protein
23 NDC80protein found in more fusions150.63718.033DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region
Ndc80_HEC (PF03801, IPR005550): HEC/Ndc80p family
SlyX (PF04102, IPR007236): SlyX
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
24 NSL1interactor110.8186.333Mis14 (PF08641, IPR013950): Kinetochore protein Mis14 like
25 NUF2interactor130.67914.000Nuf2 (PF03800, IPR005549): Nuf2 family
DUF2209 (PF09974, IPR014514): Uncharacterized protein conserved in archaea (DUF2209)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
26 NXF1interactor80.5247.333NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
27 PLEConcoprotein40.8330.500CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
RNA_pol_Rbc25 (PF08292, IPR013238): RNA polymerase III subunit Rpc25
S10_plectin (PF03501, IPR005326): Plectin/S10 domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
DUF2229 (PF09989, IPR018709): CoA enzyme activase uncharacterised domain (DUF2229)
Plectin (PF00681, IPR001101, SM00250): Plectin repeat
YlqD (PF11068, IPR021297): YlqD protein
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
28 PLK1suppressor60.8670.686Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
29 RABL6oncoprotein40.5002.500eIF3_subunit (PF08597, IPR013906): Translation initiation factor eIF3 subunit
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Ras (PF00071, IPR001806, SM00173): Ras family
30 RAE1interactor50.8000.900Exonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
31 RBPMSprotein found in more fusions40.6671.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
32 RDH12interactor21.0000adh_short (PF00106, IPR002198): short chain dehydrogenase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
33 SEH1Linteractor50.8001.000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
34 SNW1protein found in more fusions150.37439.600SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
35 SPC24interactor100.8892.000DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489)
36 SPC25interactor91.0000Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spindle_Spc25 (PF08234, IPR013255): Chromosome segregation protein Spc25
37 SVILinteractor30.6671.000Gelsolin (PF00626, IPR007123): Gelsolin repeat
VHP (PF02209, IPR003128, SM00153): Villin headpiece domain
DUF4695 (PF15766, IPR031521): Domain of unknown function (DUF4695)
38 UBR5protein found in more fusions70.7331.786CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SDA1 (PF05285, IPR007949): SDA1
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
E3_UbLigase_EDD (PF11547, IPR024725): E3 ubiquitin ligase EDD
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
39 ZWINTinteractor130.72712.333Zwint (PF15556, IPR029092): ZW10 interactor

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